Therapeutic Food Supplements

Dear Friends

Atherosclerosis Cardiovascular Disease (ACD), or clogged arteries, is the leading cause of death in the world. Hypercholesterolemia, or high cholesterol levels in the blood, is one of the  major causative factor (Barquer et al., 2015) .  Hence, statins are among the top selling drugs.

High use of statins, however, comes with possible serious side effects.  Stroher et al. (2015) tested the possible advantages of combining lower doses of statins with a Blueberry Extract, or using Blueberry Extract on its own.  Her research group found that dosing hypercholesterolemic rats with a combination of Zocor (also called SIM) and Blueberry Extract (BE) brought better results. However, using Blueberry Extract alone also brought good results.

Thirty-six hypercholesterolemic rats were divided into six groups of six animals each, with  14 days of the following supplementation regime for each group: (1) Control (only got the high-fat diet), (2) Fat diet + SIM 10mg/kg, (3) Fat diet + BE  25mg/kg, (4) Fat diet + BE 50mg/kg, (5) Fat diet + BE 25mg/kg + SIM, (6) Fat diet + BE 50mg/kg + SIM.  Many beneficial results were found as is presented in bar graphs below.

This graph shows, after histological section, the thickness measurements of the aorta of hypercholesterolemic rats after treatment.  Notice here that groups 3-6 got better results. But the interesting part about this measurement is that group 4 got only 50mg of blueberry extract and has similar result to group 6 which got SIM drug and blueberry extract, 50mg.

Aorta thickness

To see the multitude of other bar graphs from their paper, graphically illustrating the various benefits derived from adding the Blueberry Extract, click the Stroher link in the References below.

After 14 days of supplementation with blueberry extract the levels of total cholesterol, LDLs, and triglycerides were decrease in hypercholesterolemic rats.  Histopathological analysis, analyzing the tissues after death, showed significant decrease of aortic lesions.  Oxidative parameters showed significant reductions in oxidative damage to lipids and proteins and an increase in activities of endogenous antioxidant enzymes such as catalase, superoxide dismutase and glutathione peroxidase.

In conclusion, Stroher et al. (2015) state that Blueberry Extract supplementation was able to protect against weight gain, improve the lipid profile, reduce the high levels of total cholesterol, LDL and triglycerides and showed an anti-atherogenic effect in these rats.  The Blueberry Extract also showed improved oxidative parameters, showing a decrease is oxidation of lipids and proteins.  They concluded that as nutraceutical blueberry extract may have great potential as people prefer natural therapies.

Therapeutic Food Blueberry Extract is a powerhouse not only for brain function but for heart health as well.  Recommended dose is 1-2 capsules daily- with 500mg of pure blueberry extract in each capsule. We also suggest 1-2 tablespoons of Beta Glucan Synbiotic for lowering LDL cholesterol, and a primarily whole food, plant-based diet which is shown in research to combat heart disease.

References:

  • Barquera, S., Pedroza-Tobías, A., Medina, C., Hernández-Barrera, L., Bibbins-Domingo, K., Lozano, R., & Moran, A. E. (2015). Global overview of the epidemiology of atherosclerotic cardiovascular disease. Archives of medical research, 46(5), 328-338.
  • Serino, A., & Salazar, G. (2019). Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease. Nutrients,11(1), 53.
  • Stroher, D. J., Piccoli, J. D. C. E., da Costa Güllich, A. A., Pilar, B. C., Coelho, R. P., Bruno, J. B., … & Manfredini, V. (2015). 14 Days of supplementation with blueberry extract shows anti-atherogenic properties and improves oxidative parameters in hypercholesterolemic rats model. Int J Food Sci Nutr, 66(5), 559-68.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Our diet is a major factor for heart health. We suggest eating a primarily whole food, plant-based diet, with organic meat, dairy, and eggs serving as condiments every so often. (Serino & Salazar, 2019).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Alzheimer’s has moved up to the number three cause of death in the United States just under cancer and heart disease (NIH- National Institute of Aging, 2019).

Julien et al. (2009) compared the concentration of SIRT1 in the brains of AD patients and controls. In the first group of 19 patients and 22 controls,  a significant reduction of SIRT1 in the parietal cortex of AD patients was found.  Further analyses in a second cohort of 36 subjects confirmed that cortical SIRT1 was decreased in AD but not in individuals with mild cognitive impairments.  A significant relationship between SIRT1 levels and global cognition scores proximate to death was also found. Collectively, their results indicate that loss of SIRT1 is closely associated with the accumulation of amyloid-beta and tau in the cerebral cortex of persons with AD.  Furthermore, autopsies of Alzheimer’s victims reveal that loss of sirtuin enzyme activity is closely associated with the accumulation of the plaques and tangles.

Plants (fruits, berries, veggies, and greens) contain key phytonutrients, namely polyphenols. In research, an increasing number of polyphenols are being found to turn on a family of our anti-aging genes called sirtuins.  Sirtuins, particularly SIRT1 expression, is shown to reduce and eliminate amyloid-B and tangles, two protein derangements that are symptomatic of Alzheimer’s.   High heat cooked meats and fats create a molecule called advanced glycation end products (AGEs) which when present in the blood turn off the sirtuin gene expression, thereby turning off the expression of these anti-aging genes (Julien et al., 2009).

The Therapeutic Food Supplements  boost our body with key plant polyphenols that turn on the sirtuins.  Each of the four products is designed to supply ample amounts of phytonutrients and in particular polyphenols such as resveratrol, quercetin, and catechins to  enhance brain function.

For preventing cognitive decline and beginning stages of dementia, add to your protocol the High ORAC Synbiotic  with standardized high levels of  resveratrol and quercetin.

For a progressive decline and Alzheimer’s, add to the High ORAC a more robust protocol of powerful polyphenols to regenerate neurons in the brain:

References:

  • Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017). Sirtuins, a promising target in slowing down the ageing process. Biogerontology,18(4), 447-476.
  • Julien, C., Tremblay, C., Emond, V., Lebbadi, M., Salem Jr, N., Bennett, D. A., & Calon, F. (2009). Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 68(1), 48-58.
  • Uribarri, Jaime, Sandra Woodruff, Susan Goodman, Weijing Cai, Xue Chen, Renata Pyzik, Angie Yong, Gary E. Striker, and Helen Vlassara. (2010). “Advanced glycation end products in foods and a practical guide to their reduction in the diet.” Journal of the American Dietetic Association110, no. 6: 911-916.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Our diet is a major factor in whether we succumb to Alzheimers or not.  Eating primarily a whole-foods plant-based diet with meat and fat being more like a condiment puts the odds highly in one’s favor on not becoming its victim (Uribarri et al., 2010).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Longevity research teaches us that when we turn to a whole food plant-based diet, with less meat, dairy, and eggs (and refined, processed foods), we lower inflammation in every cell of our body. As we have discussed in our recent emails on the longevity field of study, inflammation is the root causative factor for most all of our chronic diseases.

Breakfast is a major meal, and hence our notoriously delicious breakfast drink that indeed lowers inflammation with a host of major nutrients that deeply nourish and energize your body. And the breakfast drink does so much more: it lubricates the bowels with fiber and polyphenols, lower cholesterol to benefits the heart, supports the liver, kidneys, immune system, brain, aids in blood sugar regulation, and fortifies bones and joints. It is an amazingly healthy drink.

Here is BioImmersion’s famous morning drink: a breakfast meal all by itself.

In a blender add: (for one person)

  • Be Regular:  Optimal Bowel Health-  1 heaping tbls.
  • Add Flax seed 1 tbls.
  • Bee Pollen- 1 tsp.
  • Fresh or frozen berries (depending on the season)- 1 cup
  • Banana or other fruit like melon, papaya, mango
  • Organic Apple juice, or pineapple, berry, or a juice of your choice- 1 cup.
  • Filtered water- 1 to 2 cups.

 

Dohrea Famous Drink

 

Further notes on Be Regular, Beta Glucan and No. 7 Systemic Booster

Be Regular

Be Regular is a gluten free, global blend of indigenous organic seeds, originating in ancient cultures from all around the world. The five organic seeds provide gentle yet effective fiber for everyday regularity.  One scoop of Be Regular offers over 7 grams of fiber towards your 25 to 35 grams a day.

We have formulated Be Regular with organic seeds from:  Amaranth, Buckwheat, Chia, Millet and Quinoa.  These seeds are ancient! They have been with us for thousands of years and globally used as foundational foods. Rich in both soluble and insoluble fibers, they contain essential nutrients such as amino acids, vitamins, minerals, complex carbohydrates with an overall low glycemic index.  Besides being organic and gluten free these seed are vegan, kosher, non GMO,

Beta Glucan

Beta Glucan is a great product for seeding the gut with good pedigreed bacteria, Supernatant and ORNs (microRNAs), along with prebiotic fibers that strongly support the integrity of the GI tract membrane, support the reduction of GI tract inflammation, support the strengthening and balancing of the immune system.

One heaping tablespoon provides 65 billion strong probiotic organisms, and our famous beta glucans with red beet root to lower cholesterol and support liver function, open and relax blood vessels, and energize the body. The beta glucans also are shown to support  prevention of variety of cancers.

No. 7 Systemic Booster

The No 7 contains:  Potent Phytonutrients– Organic berries, fruits, hardy vegetables, and green leafy vegetables: strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry, apple extract, pineapple, beet, broccoli florets, kale leaves, spinach leaves. BioImmersion Super Blend: ProbioticsBifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus, and Steptococcus thermophilus. Supernatant– probiotic metabolites, and ORNs. PrebioticsInulin from Chicory Root along with Fibers- from organic veggies, greens, fruits, and berries. VitalNutriceuticals– Fructo Borate, Vitamin B12, Vitamin D3, Folate, and Chromium.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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David Granet MD and Rob Knight PhD converse regarding the Microbiome. Some points by Knight:  Avoid fries and certain carbohydrates; but not all for fibers both soluble and insoluble are very important for microbiome health.  Also eat a rainbow of colored vegetables and fermented foods.

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Cellular Senescence means that cells cannot divide due to multiple reasons,  with inflammation posing as one of the greatest. Cellular Senescence hastens the development of chronic diseases like cardiovascular, diabetes, Alzheimer’s, dementias, cancer, immune and kidney dysfunction, IBD, and osteoarthritis among many others.

Current research has shown that certain plant polyphenols (i.e. quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential  for reducing and preventing senescence, which reduces the risk for developing chronic disease, and even reverses the onset of chronic illnesses and geriatric syndrome.  Research is now focused on the utilization of senolytic molecules in therapies.

The No. 7 Systemic Booster: the New Longevity contains both of these powerful phenolic flavonoids, quercetin and fisetin, within its high-active fruits and vegetables.  Daily dosing at 1 tsp supports the body’s ability to to fight against chronic disease.  (See Further Notes below)

 

No 7 Photo_2 copy

 

Further notes on cellular senescence: 

Chronic low-grade inflammation (LGI) in the body is an etiological factor in chronic disease and it is also a causative force in cells going into senescence.  Cellular senescence is characterized as a state where cells: (1) lose their ability to divide and renew their healthy functionality; (2) become resistant to apoptosis (cell death); and  (3) increase their production of reactive oxygen species (ROS), and secret into their external environment pro-inflammatory cytokines, bradykines, prostenoids, miRNAs, damage-associated molecular pattern proteins (DAMPs), and other pro-inflammatory mediators, chemokines that attract immune cells.  In other words, these cells create more inflammation; more collateral damage that can lead to pathology.  This condition is called a senescence-associated secretory phenotype (SASP).

Senescent cells have been identified at sites of pathology in multiple diseases.  They accumulate in adipose tissue in diabetes and with age-related metabolic dysfunction, osteoarthritic joints, the aorta in vascular hypo-reactivity and atherosclerosis and the lung in idiopathic pulmonary fibrosis.  Transplantation of small numbers senescent cells around the knee joint can cause osteoarthritis (Zhu, Y., et al. 2015).

Therefore, the discovery of strong senolytic molecules  present in certain vegetables and fruits that  are able to delay, prevent, or alleviate a number of chronic  diseases is very exciting. The No. 7 Systemic Booster: the New Longevity is a great starting point to reduce inflammation and deeply nourish our cells with the nutrients they need to function healthily.

References:

  • Kirkland, J. L., & Tchkonia, T. (2017). Cellular senescence: a translational perspective. EBioMedicine, 21, 21-28.
  • Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., … & Kirkland, J. L. (2017). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging (Albany NY), 9(3), 955.
  • Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., … & O’Hara, S. P. (2015). The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging cell, 14(4), 644-658.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Our findings here give support for the speculation that these agents [senolytics] may one day be used for treating cardiovascular disease, frailty, loss of resilience, including delayed recovery or dysfunction after chemotherapy or radiation, neurodegenerative disorders, osteoporosis, osteoarthritis, other bone and joint disorders, and adverse phenotypes related to chronologic aging.  Theoretically, other conditions such as diabetes and metabolic disorders, visual impairment, chronic lung disease, liver disease, renal and genitourinary dysfunction, skin disorders, and cancers could be alleviated with senolytics (Zhu,Y. et al., 2017).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Can a diversity of fruits and vegetables in one’s diet reduce the risk of developing the number one killer in the world – CVD (Cardiovascular Disease).  Can diet really help?

The UK Women’s Cohort Study analyzed the dietary habits of 30,458 women between the ages of 35-69.  The women answered a 217 – item Food Frequency Questionnaire. The conclusion was that total fruit intake rather than intake of a specific type of fruit is more protective against CVD.

The woman who ate a greater variety of fruits, include berries such as blackberries, raspberries, black raspberries and blueberries, grapes, citrus fruit, pomegranates, strawberries and apples had less cardiovascular disease.  These fruits are rich in polyphenols like flavanols, flavonols, anthocyanins, procyanidins, sterols, carotenoids, and hydroycinnamic acids (Lai et al., 2015) – the very phytonutrients needed to reduce inflammation in the body and to turn on the longevity genes (Serino & Salazar, 2019).

See Green Facts for more on the longevity genes.

Therapeutic Food Support:

  • No. 7 Systemic Booster:  The New Longevity-  1 tsp daily includes a concentration of 8 fruits and berries, plus greens from cruciferous veggies: broccoli, kale, spinach, and beet. (Along with probiotics and key nutraceuticals).

Suggestions:  Add one tsp No. 7 to your smoothie, or to your shot glass of diluted juice.

References:

  • Serino, A., & Salazar, G. (2019). Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease. Nutrients,11(1),
  • Lai, H. T. M., Threapleton, D. E., Day, A. J., Williamson, G., Cade, J. E., & Burley, V. J. (2015). Fruit intake and cardiovascular disease mortality in the UK Women’s Cohort StudyEuropean journal of epidemiology30(9), 1035-1048.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

For a wonderful review and overview of the critical importance of plant polyphenolic diversity to be a regular part of our daily diet click on the following excellent the 2019 meta-analysis:  Serino, A., & Salazar, G. (2019). Protective role of polyphenols against vascular inflammation, aging and cardiovascular diseaseNutrients,11(1),

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©2005 – 2019 BioImmersion Inc. All Rights Reserved