Original Synbiotic

Dear Friends

Research ascribes various etiologies to Autism Spectrum Disorder (ASD). There are exogenous factors such as iatrogenic drugs, pollutants of various kinds, and over use of antibiotics; and there are the endogenous factors such as dysbiosis of the GI Tract, mitochondrial dysfunction, and of course genetics. Interestingly, genetic causation is found to be in the low percentile, whereas dybiosis and mitochondrial dysfunction conditions present major links to ASD.

Let’s focus on dysbiosis. Overgrowth of clostridia, bacteriodes, and desulfovibrio are all ASD-associated bacterial populations. The overuse of antibiotics enables the clostridial family of bacteria to dominate because their spore forming ability resist many antibiotics and they can easily gain a foothold over good bacteria.

Clostridia is a big producer of the SCFA propionate. Too much propionate in the systemic circulation (which is able to cross the blood-brain barrier) becomes neurological and mitochondrial toxins, disrupting and causing the very symptoms that we see with autistic patients.

There is strong support in the literature for foundational probiotic organisms that reduce the overload of clostridium. These are the organisms we have chosen for our probiotics.

Research is showing that L. plantarum, L. casei rhamnosus, B. longum and even L. acidophilus can put out bacterocins against clostridia. Doctors who have used our Original Synbiotic and our Supernatant Synbiotic (either one works) found improvement in the behaviors of ASD patients.

I would recommend adding the Phyto Power for the high potency of polyphenolics grown in remote Alaskan regions. Phenols are shown in research as antimicrobials, inhibiting many pathogenic organisms including those implicated in ASD, yet at the same time, they enhance both the growth of the Bifido and Lactobacillus genera.

I suggest the following dosage:

Original Synbiotic: up to 1 tsp. daily. With very young patients start with an eight of a tsp and work up slowly adjusting the dosage. Back off just a little from a dosage that causes reaction. You be able to get up to a tsp dose in about a month of gradually ratcheting it up.

O F

As a reminder this product contains L. plantarum, L. casei rhamnosus, L. acidophilus, B. longum and S. thermophiles plus organic chicory root inulin which is very bifido and lacto genic. Each of the organism are good butyrate produces, and as we know, butyrate helps to heal a leaky gut which is a problem for ASD patients.

Phyto Power– 1 capsule daily (if they can’t take capsules then just open up the capsule and take the powder directly).

PP F copyPhyto Power is indeed powerful. Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. Typically, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.

References

  • Frye, R. E., Rose, S., Slattery, J., & MacFabe, D. F. (2015). Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microbial ecology in health and disease, 26(1), 27458.
  • MacFabe, D. F. (2015). Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders. Microbial ecology in health and disease, 26(1), 28177.
  • MacFabe, D. F. (2012). Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders. Microbial ecology in health and disease, 23(1), 19260.
  • Wang, H., Lee, I. S., Braun, C., & Enck, P. (2016). Effect of probiotics on central nervous system functions in animals and humans: a systematic review. Journal of neurogastroenterology and motility, 22(4), 589.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Dr. Bardell’s Approved List of products for beauty, body, and home is a curated list of excellent clean products for the whole family. Personal care and beauty products bring as many toxins to the home as cleaning products. Check out the list: Dr. Bardell’s Approved Products for Beauty, Body and Home.
 

©2005 – 2020 BioImmersion Inc. All Rights Reserved

 

Dear Doctor

Gram-negative bacteria (GNB) are among the most significant public health problems in the world due to their high resistance to antibiotics.

GNB can send people right into the intensive care unit and lead to high morbidity and mortality due to septic shock.

What causes GNB?  A high fat diet causes a change in the GI tract microbial population to one that is dominated by gram negative bacteria (GNB).  This is a problem because GNB tend to cause the GI tract to become more more permeable (Leaky Gut Syndrome).  Increased permeability enables an increase absorption of the lipopolysaccharides (LPS) coating of molecules that make up the outer membrane of gram negative bacteria.  These LPS molecules cause our immune system to overreact, manifesting as chronic inflammation in the body.  An overload of LPS molecules can cause septic shock and death.

The Solution? Fiber and Bifidobacteria.

Cani et al. (2007, 2007a, 2008, 2009) demonstrated in their research that adding to the diet soluble fibers such as inulin (e.g., inulin found in the Original Synbiotic) stimulates the growth of Bifidobacteria sp., which cause a reduction in the number of GNB, and a reduction in gut permeability, thereby reducing the levels of LPS systemically and reducing chronic inflammation.

O F

 

Bibliography:

  • Cani et al. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut; 58(8): 1091-1103
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Cani et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes; 56:1761-72.
  • Cani et al. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia; 50: 2374-83.
  • Oliveira, J., & Reygaert, W. C. (2019). Gram negative bacteria. In StatPearls [Internet]. StatPearls Publishing.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

 

Green Facts:

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Enterobacteriaceae are a heterogeneous group widely dispersed in nature. They account for about 80% of gram-negative isolates with a myriad of disease-causing general/species in humans, including urinary tract infections, pneumonia, diarrhea, meningitis, sepsis, endotoxic shock, and many others. The general/species that frequently affect humans are EscherichiaProteusEnterobacterKlebsiella, CitrobacterYersinia, Shigella, and Salmonella among others (Oliveira, J., and Reygaert, W.C., 2019).
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Dear Doctor

We live in an increasingly toxic world with novel and old virulent pathogens.  Your patients’ defense system must be ready and able to protecting their health.

High quality probiotics ingested on a regular basis can greatly add to the body’s defensive ability.  The Original Synbiotic strains are chosen for their strength, compatibility, safety and their 40 years of proven ability to neutralize food borne pathogens and xenobiotics (pollution, chemicals, drugs, and heavy metals).

O F

The Original’s probiotics are researched pedigreed strains of lactic acid bacteria that support the development of a healthy GI tract microbiome.

A healthy gut microbiome is dependent on strong and proven probiotics, such as the Original strains. The Original Synbiotic provides a powerful symbiotic combination of Lactobacillus acidophilus, Streptococcus thermophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium longum.

Suggested Use:  Take one tsp  daily

Research

The contamination of food with aflatoxins is a worldwide problem. Mold mycotoxins compromise the blood-brain barrier and induce neurodegenerative processes. L rhamnosus binds AFB1 in vivo and reduces bio-absorption of the toxin from the gut. L. acidophilus and B. longum neutralize AFB1 and AFM1 by binding mechanisms. S. thermophilus reduces content of ochratoxin A.

Mutagens cause impaired cell function, cell death or cell transformation into cancer cells. L. acidophilus, B. longum, L. rhamnosus, S. thermophilus and L. plantarum neutralize heterocyclic amines and nitrosamines, two of the most common and powerful mutagenic molecules found in our diet.

Verocytotoxin producing E. coli s0157 are emerging food borne pathogens worldwide. B. longum neutralizes this toxin.

Heavy metals are shown to be amongst the worst toxic chemicals. But research also shows the place of probiotics in detoxifying heavy metals.

The food and water we consume are often contaminated with a range of chemicals and heavy metals, such as lead, cadmium, arsenic, chromium and mercury, that are associated with numerous diseases.  Species such as Lactobacillus and Bifidobacterium, present in the mouth, gut, and vagina have the ability to bind and detoxify these metals.

Halttunen et al. (2007) showed that Lactobacillus and Bifidobacterium species can bind lead and cadmium to their cell surface, and hold on to them through defecation.  Singh and Sharma (2010) showed that L. acidophilus was able to bind and remove arsenic from water. Robinson and Tuovinen (1984) demonstrated that L. rhamnosus in yoghurt reduced the bioaccumulation of mercury and arsenic in pregnant women and children.  Shrivastava et al. (2003) showed that lactobacilli can transform chromium (CrVI) to its less toxic form (CrIII).

The collective ability of the Original probiotic organisms to protect the frontline border of our GI tract membrane from the aggressive enterovirulent pathoges is accomplished via: the production of bactercins, creation of an acid barrier, stimulation of the cell mediated immune system, and protective colonization of enterocytes.

Cani et al. (2008) found that a high animal fat diet changes the GI tract microbiome into a population of increasing numbers of Gram-negative bacteria, which raises the level of LPS endotoxins within the gut lumen and allows their passing through the GI tract membrane into the plasma.

The research team concluded that the plasma concentration of lipopolysaccharides (LPS) controls the inflammatory tone of the body.  This means that high concentrations of LPS set the stage for endotoxemia, resulting in metabolic diseases (obesity, diabetes, CVD) and cancer.  The Original strain of lactic acid bacteria reduce the levels of gram negative bacteria in the gut and support the tightening of a leaky GI tract membrane.

The Original Synbiotic is a collection of pedigreed strains of 5 lactic acid bacteria that help our body shore up its defenses against pathogenic bacteria, virus, molds, heavy metals and much more.

References

  • Arena, M. P., Silvain, A., Normanno, G., Grieco, F., Drider, D., Spano, G., & Fiocco, D. (2016). Use of Lactobacillus plantarum strains as a bio-control strategy against food-borne pathogenic microorganisms. Frontiers in Microbiology, 7, 464.
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Gratz, S., Wu, Q. K., El-Nezami, H., Juvonen, R. O., Mykkänen, H., & Turner, P. C. (2007). Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity in Caco-2 cells. Applied and environmental microbiology, 73(12), 3958-3964.
  • Halttunen et al. (2007) Rapid removal of lead and cadmium from water by specific lactic acid bacteria. Int. J. Food Microbiol; 114:30-35.
  • Monchese et al. (2012) Bioremediation and Tolerance of Humans to Heavy Metals through Microbial Processes: a Potential Role for Probiotic? AEM;78:6397-6404
  • Robinson JB, Tuovinen OH. (1984) Mechanisms of microbial resistance and detoxification of mercury and organomercury compounds: physiological, biochemical, and genetic analyses. Microbiol. Rev.; 48:95-124.
  • Shrivastava et al. (2003) Various cells of the immune system and intestine differ in their capacity to reduce hexavalent chromium. FEMS Immunol. Med. Microbiol;38:65-70.
  • Singh et al. (2010). Removal of arsenic (III) from waste water using Lactobacillus acidophilus. Bioremediat. J.;14:92-97.

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Transformation to healthy diets by 2050 will require substantial dietary shifts. Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits. (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019).

 

 

Dear Doctor

How can we best protect ourselves from invasion by COVID-19?

In 2006 I explained the dangers of microbial invasion under the section called “pandemic” in a monograph for the Original Synbiotic:

We live in a sea of a growing numbers of pollutants that weaken our immune systems, and increasingly virulent and hostile microbes waiting for opportunity to invade our bodies.  The most vulnerable areas in the body are the mucous membrane surfaces of the respiratory system and the gastrointestinal tract. (Bardell, S., 2006. Original Synbiotic Monograph).

Key to our protection is the mucous membrane of our GI tract,  respiratory system, nose, and eyes: our immune cells in the mucous membrane must be able to protect us.

We are protected in two ways: the first one is by having a healthy coating of mucous covering on the surface of the one-cell layer thick membranes of the GI tract and Respiratory tract. This is called the mucous membrane. And two, by having a sufficient amount of secretory IgA molecules within the mucous layers.

People with healthy levels of both mucous thickness and secretory IgA are able to block the viruses so that they can’t infect the lining epithelial cells and enter into our bodies.  In other words, we can be exposed to the virus without “catching it.”  However, individuals with compromised immunity caused by too much exposure to pollution, stress, faulty diets, or chronic diseases including obesity, diabetes, cancer and others, are at risk of invasion by viruses including Coronavirus.

One very good way to enhance a thickening of the mucous layer and an increase in secretory IgA production is through a regular consumption of excellent probiotic like our Original Synbiotic Formula.  We just created a brand new batch.

The Original contains five pedigreed strains of probiotics and organic chicory root as its prebiotic.  Take one teaspoon a day.

O F

References:

  • De Champs, C., Maroncle, N., Balestrino, Damien., Rich, C., Forestier, C. (2003). Persistence of Colonization of Intestinal Mucosa by A Probiotic Strain, Lactobacillus casei subsp rhamnosus Lcr35, after Oran Consumption. J Com Microbiol; 41(3): 1270-1273.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150315/
  • Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.
  • Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.
  • Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.
  • Panigrahi, P., Pradhan, L., Mohapatra, S.S., Misra, P.R., Johnson, J.A., Chaudhry, R., Taylor, S., Hanse, N.I., Gewolb, I.H. (2008). Long-term colonization of a Lactobacillus plantarum synbiotic preparation in the neonatal gut. J Pediatr Gastroenterol Nutr; 47(1):45-53. https://www.ncbi.nlm.nih.gov/pubmed/18607268
  • Sarem-Damerdji, L., Sarem, F., Marchal, L., Micolas, J.P. (1995). In vitro colonization ability of human colon mucosa by exogenous Lactobacillus strains. FEMS Microbiology Letters; 131(2):133-137. https://academic.oup.com/femsle/article-abstract/131/2/133/524865/In-vitro-colonization-ability-of-human-colon?redirectedFrom=PDF
  • Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of food science and technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0
  • Toscano, M., De Grandi, R., Stronati, L., De Vecchi, E., & Drago, L. (2017). Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study. World journal of gastroenterology, 23(15), 2696.
  • Underwood, M. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2015). Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatric research, 77, 229.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350908/

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Best to you,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Simplixity Medicine: Health Care Reimagined

Here is a superb and timely two hour seminar well worth your viewing with very tight half hour presentations by Jeffrey Bland PhD, Ari Vojdani PhD, Chengh Ruan MD and James Mastell.

 

Dear Doctor

The Covid-19 (Coronavirus) enters the respiratory track primarily through the nose. (Dr. Martin S. Hirsch, senior physician, Infectious Diseases, Mass General Hospital).

Once inside the body, it begins its journey of destruction, first infecting the nasal sinus on its way to the respiratory tree. Covid-19 moves fast into the air sacs of the lungs causing pneumonia for the affected person, unless it is stopped by the host’s immune system.  Younger patients have a more vigorous immune response compared to older patients.  No matter how healthy and active you are, your risk for getting pneumonia increases with age, although we are learning that younger people can suffer as much as older people.

Bottom line, we need a balanced and competent immune system response no matter how old or young we are.  A capable immune system quickly identifies and kills this viral intruder. As important, the immune system also needs to effectively manage its inflammatory response, so that it doesn’t overwhelm the lungs with collateral damage from using too much of its inflammatory weaponry. Balancing our immune response is key in the healing process of this flu.

How do we balance the immune system so it is healthy and appropriately responds to any viral invaders?

First, we need to pay attention to building a healthy mucous barrier against pathogens.  70% of our immune system resides around the outer walls of our intestines in the gastro-intestinal lymphoid tissues (GALT). The mucous membrane of our sinuses, lungs, and gastrointestinal tract are all connected to the blood system which carries immune system cells (e.g., natural killer cells, lymphocytes etc).

Probiotic organisms convert undigested soluble fibers (e.g., inulin, beta glucan, and pectin) into short chain fatty acids like butyric acid to energize the colon’s lining to healthily regenerate its cells and tighten up the junction (space) between the cells with the membrane. That is one of our goals – achieving a smooth and healthy mucosal barrier.

When these junctions are too wide, the loose space between the cells allows particles to get through and cause a chronic immune response. And as we know, immune response of any kind causes inflammation, and a chronic ongoing reaction weakens the immune system.

Second, Probiotic organisms love plant polyphenols and break their molecular chains so the phenolic molecules can be absorbed into the systemic circulation and turn on the repair and regenerative power of our cells. That is our second goal – to turn on the repair mechanism in our bodies, lower inflammation, and bring our system into balance (homeostasis).

For a measured combination of polyphenols and probiotics we suggest the High ORAC Synbiotic

HO F

And the No. 7 Systemic Booster

No.7 FTo add weaponry that is known as the Russian Penicillin due to its anti-microbial abilities, we suggest:   Garlic as a foundational supplements to support the immune system.

G F

If you are prone to respiratory conditions add the Fructo Borate Complex.

FB FReferences

  • Abbas, H. M. K., Kong, X., Wu, J., Ali, M., & Dong, W. (2019). Antimicrobial Potential of Genes from Garlic (Allium sativum L.). In Studies on Garlic. IntechOpen
  • Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P. (2013). Ageing and gut microbes: perspectives for health maintenance and longevity. Pharmacological Research, 69(1), 11-20.
  • Boor, P. P., De Ruiter, P. E., Asmawidjaja, P. S., Lubberts, E., van der Laan, L. J., & Kwekkeboom, J. (2017). JAK-inhibitor tofacitinib suppresses interferon alfa production by plasmacytoid dendritic cells and inhibits arthrogenic and antiviral effects of interferon alfa. Translational Research, 188, 67-79.
  • Catarino, M. D., Silva, A., & Cardoso, S. M. (2017). Fucaceae: A source of bioactive phlorotannins. International journal of molecular sciences, 18(6), 1327.
  • Ding, S., Jiang, H., & Fang, J. (2018). Regulation of Immune Function by Polyphenols. Journal of immunology research, 2018. https://doi.org/10.1155/2018/1264074
  • Hunter, J. M., Nemzer, B. V., Rangavajla, N., Biţă, A., Rogoveanu, O. C., Neamţu, J., … & Mogoşanu, G. D. (2019). The Fructoborates: Part of a Family of Naturally Occurring Sugar–Borate Complexes—Biochemistry, Physiology, and Impact on Human Health: a Review. Biological trace element research, 188(1), 11-25.
  • Lamarche, B., Paradis, M. È., & Couture, P. (2010). Study of the acute impact of polyphenols from brown seaweeds on glucose control in healthy men and women. The FASEB Journal, 24(1 Supplement), 209-4.
  • Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., & Manson, J. J. (2020). COVID-19: consider cytokine storm syndromes and immunosuppression. The Lancet.
  • Ritchie, A. I., & Singanayagam, A. (2020). Immunosuppression for hyperinflammation in COVID-19: a double-edged sword?. The Lancet.
  • Salehi, B., Zucca, P., Orhan, I. E., Azzini, E., Adetunji, C. O., Mohammed, S. A., … & Armstrong, L. (2019). Allicin and health: A comprehensive review. Trends in Food Science & Technology.
  • Singanayagam, A., Glanville, N., Girkin, J. L., Ching, Y. M., Marcellini, A., Porter, J. D., … & Zhu, J. (2018). Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations. Nature communications, 9(1), 1-16.
  • Takemura, M., Matsumoto, H., Niimi, A., Ueda, T., Matsuoka, H., Yamaguchi, M., … & Nakamura, T. (2006). High sensitivity C-reactive protein in asthma.European Respiratory Journal, 27(5), 908-91
  • Thomas, B. J., Porritt, R. A., Hertzog, P. J., Bardin, P. G., & Tate, M. D. (2014). Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon. Scientific reports, 4(1), 1-11.
  • Wilson, E. A., & Demmig-Adams, B. (2007). Antioxidant, anti-inflammatory, and antimicrobial properties of garlic and onions. Nutrition & food science, 37(3), 178-183.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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30 Days of Reconnection began Monday, and it is not too late for you to join in. Biomimicry has the answer to our existential dilemma, it lies in reconnecting with the natural world that surrounds us. For the next 28 days culminating on the Earth Day Celebration we will be guided in how we, the biosphere, can become whole and healthy.

 

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