Dear Friends

Well, in just 12 days from today it’s the Hawaii Doc Talks Convention!, but who’s counting.

On Friday March 3rd we will host the breakfast in Maui and teach on a topic that gets right to the heart of the matter regarding food as medicine:  The Intelligence and Power of Therapeutic Food Supplements: Science, Research, and Protocol.

Click on the above link to the see our learning objectives for the doctors.  The third objective is: Discover the next generation probiotics — infection fighting Supernatant metabolites and immune boosting microRNA.

Remember, if you can’t join us this time around, I would be more than happy to meet you via the zoom meeting format online.  Just let me know and we’ll set it up.

The two photos below present our synbiotic formulas.  The top one highlighting our new LactORN Synbiotic and the photo below seven more probiotic offerings.

LactORNs

Understanding our microbiome is without a question one of the hottest topics in medicine. Hippocrates, 2400 years ago, said that all disease begins in the gut.  In a recent speech Dr. Francis Collins, past director of the Human Microbiome Project, and present director of the NIH said,

We are a chimera-like creatire whose healthy metabolic and physiologic functioning is governed by not only our 10 trillion human cells and their 22,000 genes but also by our human microbiome community that co-habitate our bodies, all 100 trillion of them with their 2 to 8 million genes—most of them bacteria living in our GI tract. (2015, Supercharging Science for the Superorganism)

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“An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.”  (HMP Home page).

The microbiome must be taken into account regarding metabolic diseases (Metabolic Syndrome, Obesity, Diabetes, Heart Disease), gastrointestinal disease (IBS, IBD), and neuroligical health.

Yours truly,

Seann Bardell CEO
BioImmersion Inc.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

  • Dr. Francis Collins, the Director of the NIH recently said “The time of the importance of the microbiome and human health has arrived.  Our gut microbiome is of central importance for our immune system health, our neural-transmitter health, our GI tract health, and our metabolic health.

Tired of Your Colds & Flu?

January 23, 2017

Dear Friends

We are in the midst of the season for colds and flu, and added stress certainly does not help the situation, or does it?

Suzanne Segerstrom and Gregory Miller (2004), Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry, examined more than 300 empirical articles describing a relationship between psychological stress and parameters of the immune system in human participants.

Segerstrom and Miller found that acute stressors (lasting minutes) were associated with potentially adaptive up-regulation of some parameters of natural immunity and down-regulation of some functions of specific immunity.  But chronic stressors on the other hand were associated with suppression of both cellular and humoral measures (see also Priyandarshini & Aich, 2012).

Chronic stress compromises our immune system putting us at risk to bacterial and viral infections; where as an acute momentary stressor can enhance/prime the innate immune system to more apply protect us from invading bacteria and viruses.  The trick is knowing how to prime our immune system successfully.

Do you have a tough time getting rid of your sore throat, cold, or flu?  Three BioImmersion products support the more robust functioning of our immune system to nip a cold. The garlic and No7 are famous for kicking out nasty sore throats and colds, while the LactORN alerts our immune system into action.

Recipe for Immune System support against colds and flu

  • LactORN- 1tsp. daily (held into the mouth until it dissolves). This paradigm shifter product kicks the fast acting (innate) immune system into gear!
  • No. 7 Systemic Booster- 1 tsp. daily (mix in a glass of water).
  • Organic Garlic- 1-2 capsules. For sore throats, open the capsules into a cup of water (or your mix with No7) and stir, let sit for one minutes and drink.

Both the LactORN and the No.7 Systemic Booster contain ingredients that challenge our immune system—namely, the oligoribonucleotides (ORNs) and the supernatant broth (whole dead-cells of probiotics, vitamins & minerals, enzymes, bacteriocin, ORNs, and more), respectively.  No.7 and LactORN also contain strong probiotic organisms that actually fight against pathogens. Garlic, especially when it is sourced with high allicin potential and manufactured correctly to preserve its high actives is known to offer a wonderful broad spectrum antimicrobial.  Hard on many pathogens but minimally so on good lactic acid bacteria in our probiotic mix, garlic is a perfect agent against colds and flu.

Food Science

Segerstrom and Miller (2004) divided stressors into 6 categories: Acute time-limited, Brief naturalistic, Event sequence, Chronic, Distant, and Life event.  Each type has a different effect on our immune system ability to defend us from colds and flus.

The Acute time-limited stressor category falls within the fight-or flight responses, an encounter more common to our ancestors.  Fighting and/or fleeing carries the risk of injury and subsequent entry of infectious agents into the bloodstream or skin.  Any wound in the skin is likely to contain pathogens that could multiply and cause infections (Williams & Leaper, 1998).  Stress-induced changes in the immune system that could accelerate wound repair and help prevent infections from taking hold would therefore be adaptive and selected along with other physiological changes that increased evolutionary fitness.

Cells involved in natural immunity do not provide defense against any particular pathogen; rather, they are all-purpose cells that can attack a number of different pathogens and do so in a relatively short time frame (minutes to hours) when challenged.

Bibliography:

  • Priyandarshini S, Aich P. (2012). Effects of Psychological Stress on Innate Immunity and Metabolism in humans:  A Systematic Analysis.
  • Segerstrom SC, Miller GE. (2004). Psychological Stress and the Human Immune System:  A Meta-Analytic study of 30 Years of inquiry. Psychol Bull; 130(3): 601-630.
  • Williams, N. A., & Leaper, D. J. (1998). Infection. In D. J. Leaper & K. G. Harding (Eds.), Wounds: Biology and management (pp. 71– 87). New York: Oxford University Press.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
Green Facts:

Globe_Home 3How can we deliver nutrition in a way that nourishes both planet and people?  See Janine Benyus, Dec 1, 2016 key note talk, Biomimicry as a Cooperative Inquiry, on nature-inspired breakthroughs in agriculture.

Dear Friends

For support against Traveler’s Diarrhea, and other pathogenic maladies that one can be exposed to and catch while traveling, a good garlic supplement, as well as along a potent probiotic can be your best friend.

Therapeutic Food recipes for Healthy Travels: 

Organic Garlic: 1 to 2 capsules daily
Supernatant Synbiotic: 1 capsule daily
LactORN: 1 level tsp. twice a week

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Dear Friends,

The world of the human microbiome is a part of the leading edge in medical research today.  Understanding the synergy between our human cells and our human friendly microbial cells is growing rapidly. The goal is achieving better health.

We have taught the importance of adding good probiotic bacteria and more fiber to our diet for over thirty years, with the aim of bridging the gap between the scientific research community and the practicing physician.

The Bioimmersion Therapeutic Food line is still a new medical framework. We use advanced technology that maintains the wholeness of foods for therapeutic purposes. Research demonstrates that foods behave medicinally in the body—repairing, healing, protecting and preventing. Our purpose therefore is to produce concentrated, powerfully nutritious food supplements.

We are very proud and excited to offer you our newest synbiotic formula—LactORN—and to educate you in how it beautifully fits in with our other very concentrated synbiotics, the Beta Glucan High Potency Synbiotic and the Supernatant Synbiotic.

But first here are some helpful definitions:

  • Synbiotic– refers to any nutritional supplement that provides both probiotics and prebiotics.  All three products are synbiotic formulas.  They provide the synergy of pre and probiotics.
  • Beta Glucan– refers to the beta glucan soluble fiber that we derive from oat bran, that delivers many positive benefits. (see benefits below)
  • High Potency– refers to the high count of good bacteria (CFUs) that the Beta Glucan High Potency Synbiotic provides- approximately 100 billion per heaping tablespoon.
  • Supernatant– refers to inactive probiotic cell populations of L. bulgaricus and S. thermophilus and their metabolites.  (Discussed more fully below)
  • LactORN– refers to Lactobacillus oligoribonucleotides.  This is our newest offering and one we are calling the next generation probiotic.  (See discussion below)

The History of BioImmersion Synbiotics

The development of each BioImmersion product represents our working in collaboration and partnership with many scientists, farmers, manufacturing experts and health practitioners from all over the world. Three of our crown jewels in this exciting birthing process are:
Beta Glucan High Potency Synbiotic, Supernatant Synbiotic and LactORN.

The Big Three 3 2

The Beta Glucan High Potency Synbiotic

The content of this product is prebiotic and probiotic— good fibers and good bacteria.

Its fibers are from three sources: organic chicory root, red beet root, and oat bran.  From the chicory we get the soluble fiber inulin which is very bifidogenic, the Bifidobacterium love it, and so do the Lactobacillus—they grow rapidly on it.  Yeast doesn’t.

10% of the oat bran is composed of the soluble beta glucan fibers.  They are a very viscous fiber and when taken with food will lower the glycemic load of the meal.  An obvious good thing for sugar challenged individuals.  Beta glucan fibers prime the GI tract immune system, they support in the prevention of mutation and cancer (Mantovani 2007), they lower bad cholesterol (LDLs), they create a matrix home for the good Lactic Acid Bacteria.

The organic red beet root fibers are both soluble and insoluble.  The soluble fiber are broken down into short chain fatty acids (SCFAs) and the insoluble fiber stimulate peristalsis.  Plus the red beet root supplies betalain, a very powerful anti-inflammatory and antioxidant.

The fermentation of the soluble fibers by the accompaning good bugs produces SCFAs. Butyric acid is use by the lining cells of the colon for energy and facilitating a healthy GI tract cell turnover which supports the prevention of leaky gut syndrome.  The propionic acid helps to curb the apetite thereby support weight loss.

Now let’s look at its good pedigreed bacteria.  They are Lactobacillus acidophilus, Lacto-bacillus rhamnosus, Lactobacillus plantarum, Strep. thermophilus and Bifido longum.  This powerful collection of good bacteria we call our American Collection of Pedigreed strains. They are ATCC identified strains.  ATCC is the largest repository for good bacteria in the world.  Click here—Beta Glucan High Potency Synbiotic—for more on these good bacteria.

The Supernatant Synbiotic Formula

The content of this product is good bugs and supernatant—with just a little bit of fiber.

The good bacteria are from our Bulgarian Collection of Pedigreed Strains and they are:
Lactobacillus acidophilus (multi-strains), Lactobacillus casei, Lactobacillus bulgaricus, Strep. thermophilus and Bifidobacterium longum (multi-strains).

To design this product, we worked together with our Bulgarian scientists. The research behind this product focused on helping hospital patients protect themselves from hospital generated infection like C. diff. caused colitis.

It took our Bulgarian team 3/4 of a year to trial for the strains with the best hit against Clostrium and other problematic organisms.  This has been a tremendously successful product as it provides a specific protection against C. diff and general protection, as well as providing digestive enzymes, B vitamins, bacteriocins, biosurfactants, and protective colonizing ability.  Inulin is used as a carrier for these good bacteria

What is supernatant?  It is the byproducts of bacterial fermentation that are normally disgarded when growing good bugs.  After growing and freeze drying our good bacteria for this product, we then take fresh broth and put a new culture of L bulgaricus and S. thermophilus in it.  This time we collect their metabolites and freeze dry them.  We then arrest the life of these two producing bacteria and mix the now inactiveated whole cells back in with their metabolite. This whole mixture is what we call supernatant. The whole dead cells stimulate in a good way the awakening of the GI tract immune cells; and, of course, the rest of the metabolites can benefit us right from the get-go of taking this product.

For more on this product in the words of my lead Bulgarian scientist click here.

LactORN: Lactobacillus ORNs

This is the next generation probiotics.  It fits within the probiotic family, yet it provides a very different function and prupose.

The focus of this product is the delivery of the Lactobacillus ORNs into the oral cavity.

LactORN provides Lactobacillus casei plus its oligoribonucleotides (ORNs). We added the prebiotic inulin (derived from organic chicory root).

What are the ORNs and why are they the “the next generation probiotic”?

ORNs are the RNA fragments of varying lengths that naturally resides within the cytoplasm of all bacteria.  When a bacteria encounters a new environment like our mouth it releases its ORNs into the oral cavity.  This sends a message to the releasing bacteria to immediately divide and multiply in this new environment.  The ORNs themselves are stimulatory to our innate immune system in our mouth.

ORNs help our immune system to be more alert to possible invasion by viral or bacterial pathogens, but they also help protect our immune system for overreacting.  They help in the restoration of an immune system compromise by stress.

The optimal amount of ORNs is around 30 AUs (roughly comparible to 900 micrograms).  A cup of raw milk provides around 30 AUs of ORNs from the bacteria that is naturally present.  By the way, this product plus all of our synbiotic products are totally dairy and soy free.

Now, why the next generation?  As I said above when we grow probiotics organisms for supplementation, normally the supernatant is not retained.  In the case of our Supernatant Synbiotic we do put back the supernatant but the ORNs are still damaged in the process so they don’t have the same stimulatory effect as freshly released ORNs which is what the LactORN product provides.

We have stayed true to the pioneering work of Marshall (2007) who researched the beneficial use of Lactobacillus casei oligoribonucleotides for over 20 years in many families of animal groups, from shrimp to fish, mice, pig, cows, and humans.

ORNs are a very important new ingredient to be aware of for its powerful effect on the immune system.

For more on the LactORNs click here.

Between the Supernatant Synbiotic and the Beta Glucan High Potency Synbiotic you are offering to your GI tract microbiome 12 different strains of good bacteria.  By adding the LactORN at a dose of two level teaspoons a week you are supporting the maintenance of a strong immune system.  They all work beautifully together or individually as needed.

  • Mantovani et al. (2007). Beta Glucans in promoting health: PRevention against mutation and cancer. Mutation Research:658(3);154-161.
  • Marshall W. (2007). Oligoribonucleotides alert the immune system of animals to the imminence of microbial infections. US patent 7,189,834 B2

Sincerely yours,

Seann Bardell
BioImmersion.com

Clinical Note:

Diversity of good GI tract flora is important. It helps our microbiome resistant phage attacts and the assaults of other pathogens. Diversity of probiotics offer multi-faceted benefits—helping with our digestion, protecting our GI tract membrane, keeping bad population of possible gut microbe at bay, adding genomic diversity and functionality to our body at large, helping with weight management, and more.

Green Facts

Globe_Home 3New Additions to The Tree of LifeDid you know that the biomass of the microbial world exceeds that of the plant and animal world combined (Hogan CM. 2010).  Click on the title above and see the amazing array of colored photos of newly discovered microbial creatures from the oceans of the world.  They too are effected by warming seas.

Activating Probiotics

May 21, 2015

Dear Friends,

How do ORNs “activate” probiotics and modulate the immune system of animals and humans?

The LactORNs replace a nutritional ingredient lost in the Western diet due to all the processing of foods that we eat. Our bodies have evolved with ORNs from bacteria as an important component of our diet.  ORNs released in our mouth activate probiotics to grow and stimulates and balances our immune systems.  This has been shown in the immune systems of all animals tested—from shrimp to fish, mice, rats, pigs, cows, and humans (Marshall, 2007).

As we have learned last week, our diets lack in sufficient amounts of ORNs because we do not eat fermented foods. Furthermore, most of the yogurts and fermented vegetables available to us lack ORNs. This means that we are seriously deficient in this important nutritional element that helps our bodies fight infection.

All bacteria contain ORNs. Marshall (2007) has discovered that ORNs are small fragments of RNA weighing <10,000 Daltons. They are released immediately when bacteria are transferred from acidic culture media into saliva or pH neutral buffer.

Mice fed free <10kDaONRs released by L. casei, prior to a lethal injection of lipopolysaccharide (LPS) are protected from toxic shock death.

Exposure to <10kDaORNs stimulates innate and adaptive immune responses in hosts as diverse phylogenetically as teleosts and mammals.

In-vivo studies with shrimp and cattle show protection against infections when fed with <10kDaORNs released by Generally Recognized As Safe (GRAS) bacteria and yeasts.

The co-evolutionary release and immune modulation by exRNAs (external RNAs) appears to be well-conserved among the microbial and mammalian kingdoms.

Diets of pasteurized and processed foods do not provide sufficient amounts of GRAS organisms to release the exRNAs that modulate an immune response, nor do typical probiotics or commercial yogurts.

Since the discovery that eukaryotic cells release exRNAs that regulate expression of their genes as well as those of nearby cells, we felt it reasonable that a similar phenomenon might exist in bacteria and that the <10kDaORNs were exRNAs or transcriptional factors that control expression of their growth cycle genes.

Through co-evolution, mammalian immune cells adapted a response to them.  In-vitro studies in humans as well as in-vivo studies in mice, shrimp, fish and cattle fed <10kDaORNs released by GRAS organisms significantly increased their protection against infection and the lethality of septic shock.

The L. casei doesn’t have to be cultureable but remains viable but if it is and enters a human mouth with a neutral pH of 7 then the bacteria accomplishes two things:  it will release its ORNs which stimulates the oral immune system to respond, and two, the release of ORNs causes an immediate cell division by those bacteria for whom the release of ORNs has occurred when they are returned to an environment rich in nutrients.

If all the bacteria have not released their ORNs in the mouth, those that didn’t will release them when they again reach an area with an alkaline pH such as the small intestines.  They start to divide and multiply with no lag time.  If the pH of the mouth is more acidic than 5, only 1/3 of ORNs will be released.  One can add the LactORNs to a baking soda drink (the formula can be found on the back of a box of Arm and Hammer baking soda and gargle to insure that all LactORNs are released.

There is no toxicity to the ORNs.  They restore the immune system without causing chronic inflammation.  The cytokines released are IL-1, IL-6, IL-4 and TNF alpha.  To IL-1 and 6 control inflammation and IL-4 activates B-cells and antibody production.  IL-6 seems to protect the body from too much inflammation.  Overall low level of inflammation are incited to prepare the immune system for a more effective prevention of infection from bacteria and virus.

Dosage:  Individuals taking prescription drugs should inform their doctors before taking LActORNS.  A restored immune systme may be more sensitive  to  the drugs and the prescription might need to be changed.   For example statins may be need to be lowered or eliminated and HBP medication may need to be reduced as well as blood thinners.

Marshall W. 2007. Oligoribonucleotides alert the immune system of animals to the imminence of microbial infections. US patent 7,189,834 B2

LactORNs 3

Sincerely yours,

Seann Bardell
BioImmersion.com

Clinical Note:

Our LactORN is the only probiotic supplement in the market that specifically grows the ORNs. Take one level teaspoon two to five times a week, depending on the weakness of the immune system. Continue to take the one of the probiotics mixes for a diverse microbial support of the GI, such as Original, No 7, or Supernatant. Add fibers such as the Beta Glucan or Energy Sustain for even a greater nutritional support.

LactORN Bottle
ORN Supplemental Facts 2

Green Facts

Here’s more proof as to diet’s influence over our maintaining a healthy microbiome throughout our life. Just look at the elderly.

Claesson et al. (2012) state that, the gut microbiota composition correlates with diet and health in the elderly.  Their microbiota composition significantly correlates with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water.  The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers.  Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon aging.

Claesson et al. (2012). Gut microbiota composition correlates with diet and health in the elderly. Nature;488:178-184