Cran. Pom. Synbiotic

Chronic Bladder Infection

November 10, 2019

Dear Friends

Bladder infections can become a chronic condition that requires more and more antibiotics, without seeing a long-term resolution. Living with an irritated and at times painful bladder is very oppressive.

Cranberries and pomegranates have high concentrations of polyphenols with compounds that inhibit pathogenic invaders, such as E. coli and staphylococcus aureus, two known bacteria that cause bladder infections (Bader et al., 2017; Pagliarulo et al., 2016).

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Cranberries have excellent antimicrobial properties that inhibit and manage UTIs (Jensen et al., 2017), while Pomegranates contain 124 different phyto-nutrients and a high concentration of polyphenols that wield an inhibitory effect on pathogenic Staphylococcus aureus. Pomegranates have enjoyed an exalted status since ancient times (Pagliarulo et al., 2016; Parseh et al., 2012).

Together with the “anti-infective activities” of lactobacillus strains (Liévin-Le Moal et al., 2014), and especially for recurrent UTIs (Manzoor et al., 2016), the probiotics, Supernatant and MicroRNAs, add a potent antimicrobial supports to a healthy urogenital system.

Suggested use: 2-4 capsules twice to three times a day for two days, and then lower the dose to 1-2 a day, or as needed.

Cranberry Pomegranate Synbiotic

References:

  • Bader, M. S., Loeb, M., & Brooks, A. A. (2017). An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgraduate medicine, 129(2), 242-258.
  • Jensen, H.D., Carsten, S., Christensen, S.B., & Krogfelt, K.A. (2017). Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection. Front Microbiol, 8, 542.
  • Liévin-Le Moal, V., & Servin, A. L. (2014). Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents. Clinical microbiology reviews, 27(2), 167-199.
  • Manzoor, A., Ul-Haq, I., Baig, S., Qazi, J. I., & Seratlic, S. (2016). Efficacy of locally isolated lactic acid bacteria against antibiotic-resistant uropathogens. Jundishapur journal of microbiology, 9(1).
  • Pagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., & Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831.
  • Parseh, H., Hassanpour, S., Emam-Djome, Z., Lavasani, A. S., Mahmoodabady, H. Z., CHabok, M., … & Ghahsareh, A. M. (2012, April). Antimicrobial properties of Pomegranate (Punica granatum L.) as a Tannin rich Fruit: a review. In The 1st International and The 4th National Congress on Recycling of Organic Waste in Agriculture. Iran.

 

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The Game Changer, produced by James Cameron et al., is a revolutionary new documentary about meat, protein and strength.

It is an absolute must see.  The link above will connect you to their home page.

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Doctor

Bader (2017) update on the status of urinary tract infections (UTIs) emphasizes the growing concern of UTIs caused by antibiotic-resistant Gram-negative bacteria, such as E. coli, Salmonella, Klebeiella– all part of the family Enterobacteriaceae. Treating UTIs with drugs like Fosfomycin tromethamine, amoxicillin, and others are the typical course of action, but what do we do when these drugs do not resolve the UTI?

Proanthocyanidin from Cranberries and Pomegranates have been used for many years as anti-adhesive agents in the treatment of UTI. Gupta et al. (2012) showed in his study that a drug resistant E. coli was sensitive to an extract from cranberries on bladder infection by inhibiting the adhesiveness of multi-drug resistant E. coli to the walls. In 2015 Kaspar et al. assessed the anti-adhesion effect of cranberry extract to improve urinary tract health. More recently, the research and reviews of Lima et al. (2019) and González de Llanoet al. (2019) showed new findings on the efficacy of cranberries against urinary tract infections due to the rich source of phenolic compounds.

Cranberry Pomegranate Synbiotic has the added antimicrobial activity of pomegranate, with probiotics, supernatant and microRNA. 2-4 capsule three times a day for three days as intensive support or until condition resolved.

Order Now: Cranberry Pomegranate Synbiotic

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References

  • Bader, M. S., Loeb, M., & Brooks, A. A. (2017). An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgraduate medicine129(2), 242-258.Abstract
  • González de Llano, D., Liu, H., Khoo, C., Moreno-Arribas, M. V., & Bartolomé, B. (2019). Some New Findings Regarding the Antiadhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Bacteria. Journal of agricultural and food chemistry67(8), 2166-2174.Article
  • Gupta, A., Dwivedi, M., Mahdi, A.A., Nagana Gowda, G.A., Khetrapal, C.L., Bhandari, M. (2012). Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin. Urol Res, 40(2), 143-50. DOI: 10.1007/s00240-011-0398-2
  • Kaspar, K.L., Howell, A.B., & Khoo, C. (2015). A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages.Food Funct, 6(4), 1212-7. DOI: 10.1039/c4fo01018c
  • Lima, M. C., de Sousa, C. P., Fernandez-Prada, C., Harel, J., Dubreuil, J. D., & de Souza, E. L. (2019). A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria. Microbial pathogenesis.Abstract
  • Rodríguez-Pérez, C., Quirantes-Piné, R., Uberos, J., Jiménez-Sánchez, C., Peña, A., & Segura-Carretero, A. (2016). Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli. Food & function7(3), 1564-1573. Article
  • Wafa, B. A., Makni, M., Ammar, S., Khannous, L., Hassana, A. B., Bouaziz, M., … & Gdoura, R. (2017). Antimicrobial effect of the Tunisian Nana variety Punica granatum L. extracts against Salmonella enterica (serovars Kentucky and Enteritidis) isolated from chicken meat and phenolic composition of its peel extract. International journal of food microbiology241, 123-131. DOI: 10.1016/j.ijfoodmicro.2016.10.007

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Transformation to healthy diets by 2050 will require substantial dietary shifts.  Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits.  (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019)

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Chronic Disease is the new norm.  We see it all around us:  obesity, metabolic syndrome, fatty liver, diabetes, CVD, cancer, COPD, asthma, Alzheimer’s, Parkinson’s, autism, IBD, IBS,  auto immune disease, arthritis, UTI, and many more.

Doctors, you are our heroes on the frontline in the battle for your patients’ health, and for helping them to prevent their occurrence in the first place.

Key finding in research for the root cause of these chronic illnesses: a continual low-grade inflammation (LGI), termed by scientists as “inflammageing” (Franceschi & Campisi, 2014).

Therapeutic Food Supplements were designed with powerful plant polyphenols, pedigreed probiotic strains  (with their metabolites and microRNAs), and key nutraceuticals to supports the reduction of LGI.  The results are easily measured:  lowering inflammatory markers.

Summary of the Therapeutic Food Offering:

Polyphenol products:  Garlic (antimicrobial, blood pressure regulation), Blueberry Extract (brain and nerve regeneration), Glucosinolates & Sulforaphanes (liver support), Chlorella (absorption of heavy metals and toxins), Be Regular (fiber from ancient seeds – a must have), and Phyto Power (DNA integrity).

Probiotic Products: Supernatant Synbiotic, and Original Synbiotic. Both powerfully effective for GI health

Probiotic + Polyphenols: High ORAC Synbiotic (post antibiotic therapy), Beta Glucan Synbiotic (Cardiovascular and GI support), No. 7 Systemic Booster (designed to combat the root cause of chronic illnesses), and Cranberry Pomegranate Synbiotic (UTI, and prostate support).

Nutraceuticals:  Fructo Borate Complex (bone and joints), Chromium (blood sugar control), Energy (plant ultra minerals), No. 7 (B12, Folate, chromium, D3, and Fructo Borate), Weight-Less (7 keto).

Nutraceuticals + Polyphenols:  Energy (increase ATP levels), Weight-less (weight loss and blood sugar control), and Chromium with high active Beet Root (blood sugar control, increase circulation), No 7 Systemic Booster.

All of our plant materials are eco-farmed, or wild-crafted, selected for their exceptional high-actives, many of which we standardize.  There are no excipients in our Therapeutic Food Supplement (e.g. flowing agents, sweeteners, natural flavors, emulsifiers, etc.).  We are purists in this regard, wanting to give you absolutely the strongest possible natural product for you restoring health.

References:

  • Boivin et al. (2009). Antiproliferative and antioxidant activities of common vegetables: A comparative Study. Food Chemistry; 112(20): 374-380. Article
  • Calder, P. C., Bosco, N., Bourdet-Sicard, R., Capuron, L., Delzenne, N., Doré, J., … & Visioli, F. (2017). Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing research reviews40, 95-119. Article
  • Franceschi, C., & Campisi, J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences69(Suppl_1), S4-S9. Article

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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BioImmersion Therapeutic Food Supplements are certainly a strong tool to facilitate the healing of our bodies; a healthy diet and a clean environment are its necessary partners.  How do we create a healthy environment? A healthy biosphere?  Biomimicry Institute provides some enlightened answers.

 

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

What is the new longevity? Aging and chronic illness are often linked in research to inflammation from environmental toxins, pathogens, lack of exercise, too much sugar and fat in the diet, and lack of sleep. In short – ongoing stress that diminishes our body’s supply of stem cells. And, once our stem cells are used up, we deplete our ability to regenerate and heal.

Our new No. 7 Systemic Booster rejuvinates multiple systems in our body by reducing inflammation in the gut and body, so we do not use up our own stem cells to reduce inflammation, and keep us healthy.

Let’s have a look:

No. 7 Systemic Booster:  The New Longevity

  • The new longevity: In research, aging is linked to a variety of chronic illnesses that occur due to a continual inflammatory state in the body, which accelerates stem cells’ deterioration and ultimately lessens our ability to regenerate. 
  • The No 7 combination of Polyphenols (from high active berries, fruit, veggies, and greens), Fibers, Prebiotic, B12, Fructo Borate, Folate, Chromium, and the new blend of naturally occurring whole Probiotics with their Supernatant and ORNs (the Probiotic Super Blend) offer potent calming nutrients, protection and rejuvination.
  • The No 7 boosts many systems in the body: the Immune, GI Tract, Urogenital, Osteo-skeletal, Cardiovascular, Brain and Neurological, Detoxification, Metabolic, Digestive, and Energy.

No7_ 8.15.18

As you can see, the No. 7 taken on a regular basis provides a base of strength to build upon.  For example, its Probiotic Super Blend protects your GI tract with pedigreed strains of strong lactic acid bacteria, building a healthy eco-system within the GI tract microbiome that reduces inflammation in the gut.

The probiotic count (CFU) of the No. 7  is 15 billion per teaspoon.  To add more probiotic count to your daily dose, simply add one capsue of the new Supernatant Synbiotic which provides a CFU of 20 billion per capsule.  The Supernatant Synbiotic is, in fact, the Probiotic Super Blend itself.

No. 7 provides intense antioxidant, anti-inflammatory, and anti-microbial properties, all are agents of the longevity enducing power of organic plant polyphenols.  For more plant power,  add one capsule daily of the new High ORAC Synbiotic with a Total ORAC score of 40,000.  Plus it also has 20 billion CFU of the Probiotic Super Blend.

For UTI issues, add to your daily tsp dose of No. 7 one capsule of the new Cranberry Pomegranate Synbiotic, which will provide high active cranberry and pomegranate extracts plus 20 billion CFU of the Probiotic Super Blend.

A healthy plant based diet, along with good probiotic organisms and concentrated supplements of plant polyphenols all are critical for our daily health and longevity, reducing the risk of chronic degenerative disease now and later in our life.

References:

  • Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research11(10), 4781-4790.http://pubs.acs.org/doi/abs/10.1021/pr300581s.
  • Possemiers, S., Bolca, S., Verstraete, W., & Heyerick, A. (2011). The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals. Fitoterapia82(1), 53-66. https://www.sciencedirect.com/science/article/pii/S0367326X10001899?via%3Dihub
  • Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015). Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition54(3), 325-341. https://link.springer.com/article/10.1007/s00394-015-0852-y
  • Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F., & Loguercio, C. (2007). Chronic inflammation and oxidative stress in human carcinogenesis. International Journal of Cancer, 121(11), 2381-2386.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.cts under the advisement of your doctor.

Green Facts:

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One of the world’s great organization for learning how to work with nature is the Biomimicry Institute.  Check them out:  Global Design Challenge.  They are truly one of the bright rays of hope for bonding with Mother Nature and learning from her 3 billion years of life experience on Earth .condition and its down stream consequences.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

Our Cranberry Pomegranate Synbiotic embodies a high potency and powerful ability for all sorts of bladder and UTI issues. But the combination of supernatant with ORNs, probiotics, cranberries, and pomegranates do so much more!

NEW CP Jpeg Short 4

The phytonutrients are more concentrated, standardize to 6% quinic acid for the cranberry and 40% punicalagins for the pomegranate extract.

There are now five different organisms of probiotics in the formula. We grow them as whole organisms with their supernatant and ORNs.  We selected organisms that have a natural antimicrobial abilities against hospital generated infections.

The supernatant component of the product is much more comprehensive, dramatically enhancing its benefits.  It has our typical famous metabolites of the Lactobacillus bulgaricus and Streptococcus thermophilus plus the metabolites of our added three more organisms, five all together! Supernatant contains the food fermentation by-products (metabolites) that include lactic acids, amino acids, folates, bacterocins, biosurfactants and various beneficial enzymes such as bile salts hydrolase and lactase.  And of course, the supernatant also has the ORNs (oligoribnucleotides- their shorter chains of microRNAs), which prime the immune system and activate the rapid growth of these powerful probiotic organisms.

The prebiotic per capsule is 100mg of organic chicory root inulin (the total amount of ingredients per capsule is 500mg). Since our probiotics wake up much more rapidly due to complete sets of ORNs, they need food to grow.

In research, these ingredients show a reduction, not only, to the risk of UTI associated conditions but for both colon and breast cancers as well.

  • Vaginal eubiosis- Vaginal eubiosis is characterised by beneficial lactobacillus-dominated microbiota. In contrast, vaginal dysbiosis (e.g. bacterial vaginosis, BV), characterized by an overgrowth of multiple anaerobes, is associated with an increased risk of adverse urogenital and reproductive health outcomes.  The Lactobaccilus sp. in our Cranberry Pomegranate Synbiotic are strong lactic acid producers.
  • Biosurfactants- The role of Lactobacillusspecies in the female urogenital tract as a barrier to infection is of considerable interest.  These organisms are believed to contribute to the control of vaginal microbiota by competing with other micro-organisms for adherence to epithelial cells and by producing biosurfactants (Rodrigues, L. et al., 2006).  The good probiotics in this formula have demonstrated the ability to produce mucins as biosurfactants against bacterial, fungal and viral pathogens.
  • Cancer Protection Support- Ou, J et al. (2012) in their paper, Association between low colonic short-chain fatty acids and high bile acid in high colon cancer risk populations, proposed that the influence of diet on colon cancer risk is mediated by the microbiota.  Their results suggested that the higher risk of colon cancer in Americans may be partly explained by their high-fat and high-protein, low complex carbohydrate diet, which produces colonic residues that promote microbes such as Clostridia and E. coli to produce potentially carcinogenic secondary bile acids and less antineoplastic SCFAs.  Our collection of good bacteria in this formula are SCFA producers and secondary bile acids reducers as you can see with one of their metabolites being the enzyme bile salts hydrolase.  These good bugs also put out bacterocins agains Clostridiaand E. coli.
  • Breast Cancer- Costarelli, V., and Sanders, T.A.B. (2002) found that the mean plasma secondary bile salt derivative DCA concentration were 52% higher in patients  with breast cancer compared with controls.  Reducing gut levels of DCA will reduce plasma levels.  Thereby, reducing this risk factor.
  • Colon Cancer- AJouz, H., Mukherjui, D., and Shamseddine, A. in their 2014 research paper stated that bile acids going into the intestines stimulate growth in the colon of Clostridia which convert primary to secondary bile acids, and secondary bile acids that were shown to be carcinogenic.   Hence the important of our good bugs that produce bacterocins to reduce Clostridial populations.
  • Animal Fat-Rich Diets- There is increasing evidence (Barrasa, J.I. et al. 2013) that the continous exposure to certain hydrophobic bile acids, due to a fat-rich diet may induce oxidative DNA damage that, in turn, may lead to colorectal carcinogenesis.

References

  • Tachedjian, G., Aldunate, M., Bradshaw, C. S., & Cone, R. A. (2017). The role of lactic acid production by probiotic Lactobacillus species in vaginal health. Research in microbiology, 168(9-10), 782-792. https://www.sciencedirect.com/science/article/pii/S0923250817300839?via%3Dihub
  • Rodrigues, L., Banat, I. M., Teixeira, J., & Oliveira, R. (2006). Biosurfactants: potential applications in medicine. Journal of Antimicrobial Chemotherapy, 57(4), 609-618. https://academic.oup.com/jac/article/57/4/609/669417
  • Ou, J., DeLany, J. P., Zhang, M., Sharma, S., & O’Keefe, S. J. (2012). Association between low colonic short-chain fatty acids and high bile acids in high colon cancer risk populations. Nutrition and cancer, 64(1), 34-40.
  • Costarelli, V., & Sanders, T. A. B. (2002). Plasma deoxycholic acid concentration is elevated in postmenopausal women with newly diagnosed breast cancer. European journal of clinical nutrition, 56(9), 925.  https://www.nature.com/articles/1601396
  • Ajouz, H., Mukherji, D., & Shamseddine, A. (2014). Secondary bile acids: an underrecognized cause of colon cancer. World journal of surgical oncology, 12(1), 164.
  • Barrasa, J. I., Olmo, N., Lizarbe, M. A., & Turnay, J. (2013). Bile acids in the colon, from healthy to cytotoxic molecules. Toxicology in Vitro, 27(2), 964-977.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Cranberry consumption has shown prophylactic effects against urinary tract infections (UTI).  Anti-adhesive activity of cranberry phenolic compounds and their microbial-drived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures

González de Llano, D., Esteban-Fernández, A., Sánchez-Patán, F., Martínlvarez, P. J., Moreno-Arribas, M., & Bartolomé, B. (2015). Anti-adhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures. International journal of molecular sciences, 16(6), 12119-12130.

In the study sited below data indicated that both pomegranate aril and peel extracts have an effective antimicrobial activity, as evidenced by the inhibitory effect on the bacterial growth of two important human pathogens, including Staphylococcus aureus and Escherichia coli.

Pagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., & Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831. DOI: 10.1016/j.foodchem.2015.06.028

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved