Chromium, Bio-organic

The Chromium is here!

January 9, 2019

Dear Doctor

Our new Chromium has arrived!

The formula 9 times stronger, with 50mcg of elemental trivalent chromium per capsule (6mcg in the old chromium), and with high active beet root, standardized to 10,000ppm nitrate.

The new Chromium is also trivalent:  the ligand on each of the chromium ion ports is a molecule of nicotinic acid (in other words, niacin), in contrast to the nucleotide sugars from brewers’ yeast.

The supplemental facts on the label lists only the weight of the elemental chromium (50mcg), rather than the whole Chromium polynicotinate molecule, which is 500mcg.

The High Active Beet Root is also very powerful: it is standardized to offer a minimum of 10,000ppm plant nitrate. Our bodies convert plant nitrate into nitric oxide, an important nutrient that relaxes blood vessel muscles, opening up circulation. And of course, the high active beet root offers betalains, a unique polyphenolic molecule in beet root with very strong antioxidant, antimicrobial, and anti-inflammatory properties.

Chromium Label Jpeg

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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In this fascinating website you can watch the numbers of births and the number of deaths growth in real time.  See Current World Population.  With the increasing numbers of people reaching sennescense and the mounting pandemic of chronic degenerative diseases, we need a sea-change in how we feed ourselves, to one that brings healthy longevity.


©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

GS Photo JPEGBroccoli sprouts provide an exceptionally rich source of sulforaphane – a potent inducer of enzymes that protect against chemical carcinogens.  In fact, three-day-old sprouts of broccoli contain 10-100 times higher levels of glucoraphanin (the glucosinolate of sulforaphane) than do the mature broccoli plants.  Broccoli sprouts are the richest natural source for sulforaphanes, and the BioImmersion organic broccoli sprouts selected for the Glucosinolate & Sulforaphane are at the 100 fold level.

Our Glucosinolate & Sulforaphane replaces the Cruciferous Sprout Complex as it supplies 6-8 times the potency of the most important phytochemical, sulforaphane.

Glucosinolate & Sulforaphane comes in two sizes: the 120 capsule size as shown to the right and is in stock now, and the 60 capsule size bottle that will be available in three weeks.  With a dose being 1-2 capsules a day, the larger bottle will give a 2-4 month supply.

Food Science

Broccoli sprouts are a rich source of glucosinolates and isothiocyanates, shown in research to induce phase 2 detoxication enzymes, boost antioxidant status, and protect animals against chemically induced cancer.  Glucosinolates are hydrolyzed by myrosinase (an enzyme found in plants and bowel microflora) to form isothiocyanates.  Glucosinolates are inert as phase 2 enzyme inducers and must be hydrolyzed (break-down) to generate the active isothiocyanates (Shapiro et al., 2001).

Sulforaphane (SFN) is a compound derived from cruciferous vegetables with numerous bioactivities (Su et al., 2018). In fact, Broccoli and especially broccoli sprouts, accumulate significant amounts of the phytonutrient glucoraphanin, which is metabolized in vivo to the biologically active sulforaphane (SFN).  The preponderance of evidence available from in vitro, animal and human studies supports the association of sulforaphane with phase II enzyme induction (James et al., 2012), moreover, SFN strongly displays both anticarcinogenic and anticancer activity by modulating ‘key signaling pathways and genes involved in the induction of apoptosis, cell cycle arrest, and inhibition of angiogenesis’ (Su et al., 2018; see also Peng et al., 2015; Zhang & Tang, 2007).

SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN (Peng et al., 2015).

Sulforaphane is found in research to have many different health benefits:  Alzheimer’s (Kim et al., 2013), Cardiovascular Disorders (Angeloni et al., 2009), Diabetes (Bahadoran et al., 2012), Asthma- upper airway congestion, (Riedl et al., 2009) and Detoxification in all cells, and in particular with Liver Phase II detoxification enhancement (Riedl et al., 2009).

Sulforaphane (SFN) has been demonstrated to be an effective chemopreventive agent for many years (Shapiro et al., 2001), with positive effects against different kinds of cancers, such as cervical (Chen et al., 2016; Abdull et al., 2013), breast (Peng et al., 2015; Li et al., 2010), bladder (Leone et al., 2017), renal cell carcinoma (Juengel et al., 2016), non-small-cell lung cancer (Wang et al., 2017), and colon and prostate cancers (Clarke et al., 2008; Abdull et al., 2013).

We will continue to examine the research on this important food in the next few weeks.


Abdull Razis, A. F., Konsue, N., & Ioannides, C. (2018). Isothiocyanates and Xenobiotic Detoxification. Molecular nutrition & food research62(18), 1700916.

Abdull, R., Ahmad, F., & Noor, N. M. (2013). Cruciferous vegetables: dietary phytochemicals for cancer prevention. Asian Pacific Journal of cancer prevention, 14(3), 1565-1570.

Angeloni, C., Leoncini, E., Malaguti, M., Angelini, S., Hrelia, P., & Hrelia, S. (2009). Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential. Journal of agricultural and food chemistry57(12), 5615-5622.

Bahadoran, Z., Tohidi, M., Nazeri, P., Mehran, M., Azizi, F., & Mirmiran, P. (2012). Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. International journal of food sciences and nutrition63(7), 767-771.

Cheng, Y. M., Tsai, C. C., & Hsu, Y. C. (2016). Sulforaphane, a dietary isothiocyanate, induces G2/M arrest in cervical cancer cells through cyclinB1 downregulation and GADD45β/CDC2 association. International journal of molecular sciences, 17(9), 1530.

Clarke, J. D., Dashwood, R. H., & Ho, E. (2008). Multi-targeted prevention of cancer by sulforaphane. Cancer letters, 269(2), 291-304.

Fahey, J. W., Zhang, Y., & Talalay, P. (1997). Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proceedings of the National Academy of Sciences, 94(19), 10367-10372.

James, D., Devaraj, S., Bellur, P., Lakkanna, S., Vicini, J., & Boddupalli, S. (2012). Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition reviews70(11), 654-665.

Juengel, E., Maxeiner, S., Rutz, J., Justin, S., Roos, F., Khoder, W., … & Blaheta, R. A. (2016). Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro. Oncotarget, 7(51), 85208.

Kim, H. V., Kim, H. Y., Ehrlich, H. Y., Choi, S. Y., Kim, D. J., & Kim, Y. (2013). Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model. Amyloid20(1), 7-12.

Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H. F., Newman, B., … & Sun, D. (2010). Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clinical Cancer Research, 1078-0432.

Peng, X., Zhou, Y., Tian, H., Yang, G., Li, C., Geng, Y., … & Wu, W. (2015). Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells. Oncology reports34(3), 1565-1572.

Riedl, M. A., Saxon, A., & Diaz-Sanchez, D. (2009). Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clinical immunology130(3), 244-251.

Shapiro, T. A., Fahey, J. W., Wade, K. L., Stephenson, K. K., & Talalay, P. (2001). Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.Cancer Epidemiology and Prevention Biomarkers, 10(5), 501-508.

Su, X., Jiang, X., Meng, L., Dong, X., Shen, Y., & Xin, Y. (2018). Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity2018.

Wang, D. X., Zou, Y. J., Zhuang, X. B., Chen, S. X., Lin, Y., Li, W. L., … & Lin, Z. Q. (2017). Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways. Acta Pharmacologica Sinica, 38(2), 241.

Zhang, Y., & Tang, L. (2007). Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta pharmacologica Sinica, 28(9), 1343-1354.

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The Environmental Working Group is a most important organization to get to know.  Their mission is to empower people to live healthier lives in a healthier environment. With breakthrough research and education, they drive consumer choice and civic action.


©2005 – 2018 BioImmersion Inc. All Rights Reserved

Coronary Heart Disease

August 8, 2016

Dear Friends

The number one cause of death for men and women in the US is Coronary Heart Disease (CHD).  And, the leading cause for CHD is Metabolic Syndrome. One-quarter of the American population has Metabolic Syndrome (see NIH: NHLBI, 2015).

CHD’s risk factors include high blood pressure, high blood cholesterol, high triglycerides, obesity, physical inactivity, diabetes, and stress (Saini et al., 2010; Serino et al., 2014).

What Therapeutic Food Supplements support a healthy heart?

Therapeutic Food protocol.

Beta Glucan High Potency Synbiotic– 1 heaping tablespoon BID, preferably before 2 largest meals, or 2 tablespoons in your protein shake once daily.

Phyto Power– 2 capsules daily.

Chromium Bio-organic with Beet– 1 capsule BID, preferably before 2 largest meals.

Food Science

Beta Glucan High Potency Synbiotic provides oat bran that is rich in soluble beta glucan fibers, red beet root soluble and insoluble fibers rich in the flavonoid betalain, the soluble chicory root fiber inulin, and pedigreed lactic acid probiotics—all healthy food ingredients shown by research to support the reduction in the risk markers for obesity, diabetes and CVD.

There is a multitude of research that strongly suggest dietary fiber reduces the risk of metabolic syndrome (Grooms, 2013).  The Beta Glutcan Synbiotic provides a diverse collection of fibers shown to nutritionally support healthy heart.

Whitehead et al. (2014) performed a meta-analysis on 28 randomized controlled trial son the effectiveness of oat bran beta glucans to lower LDL cholesterol.  Oat beta glucan reduced LDL and total cholesterol by 0.25 mmol/L and 0.30 mmol/L respectively at doses of 3g.d.

Data from multiple researches find strong support for the hypothesis that the fiber inulin (prebiotic) inhibits hepatic lipogenesis (formation of cėolesterol), inducing a significant hypotriglyceridemic effect (Saini, 2010).

DiRienzo (2014) reviewed 26 clinical studies and two meta-analyses and found amongst others that L. acidophilus plus inulin (prebiotic) significantly decreased LDL cholesterol.
Their conclusion was that probiotic intake as a therapeutic lifestyle change can have a positive effect on reduced CHD risk factors.

Phyto Power contains three species of wildcrafted rosehips (the whole fruit and seeds), four species of wildcrafted dandelions (aerial parts and flower), and four species of wildcrafted blueberry Fruit > 95% and leave and stems < 5%).  Alaska wild berries range from 3 to 5 times higher in ORAC value than cultivated berries from the lower 48 States.  For example, cultivated blueberries have an ORAC scale of 30.  Alaska’s wild dwarf blueberries measured 85 (Dinstel, 2013).

Phyto Power’s broad array of phytonutrients (catechins, organic acids, vitamins, flavonoids, carotenoids, anthocyanins, polyphenols) provide support as antioxidants, in cardiovascular protection, for anti-atherosclerosis, to improvement of endothelial function and for anti-inflammation; as well as supporting, anti-apoptosis, anti-aging, anti carcinogen, anti-microbial and neurological protection (Han, 2007). Pure anthocyanins are up to seven times more effective as antioxidants inhibiting lipid peroxidation than alpha tocopherol (Lila, 2004).

Research has shown that the catechin family of flavonoids provides protective phytonutrients particularly from catechin, epicatechins and epigallocatechin gallate.

Endothelial dysfunction, a prognostically relevant key event in atherosclerosis, is characterized by a decreased bioactivity of nitric oxide (NO) and impaired flow-mediated vasodilation (FMD).  Schroeter et al., (2006) showed in healthy male adults that the ingestion of flavanol-rich cocoa was associated with acute elevations in levels of circulating NO species, an enhanced FMD response of conduit arteries, and an augmented microcirculation.

Nagao et al., (2007) observed, in a protocol sample of 240 subjects, that green tea extract high in catechins reduces body fat and cardiovascular risks including a decrease in systolic blood pressure. Low-density lipoprotein cholesterol was also decreased to a greater extent in the catechin group.

Lorenz et al. (2007) investigated the effect of milk in preventing the beneficial effects of tea relative to vascular protection, and found that casein in milk binds to catechins inhibiting their beneficial functioning as antioxidants.  Their conclusion was that milk counteracts the favorable health effects of tea on vascular function.

The wilds of Alaska provide an amazing environment for powerful plants and berries— fertile volcanic ash soil, and a harsh environment that challenges plants to put out high levels of phenols (e.g. flavonoids) to protect themselves.

Chromium Bio-organic with Beet is a potent new form of trivalent chromium presented in a food-derived organic carrier. US Patent pending. Each capsule provides 500 micrograms of trivalent chromium and 250 mg of red beetroot with High Actives betalain content. Advanced freeze-drying technology. No excipients. 60 capsules per bottle. 250 mg per vegetarian capsule.

A strong body of evidence links chronic hyperglycemia to microvascular complications, such as retinopathy, neuropathy, and nephropathy, in persons with diabetes.  A metaregression analysis that combined more than 95,000 persons without diagnosed diabetes found a graded relationship between fasting and postprandial blood glucose levels and subsequent risk for a cardiovascular event (Selvin, 2004).

Chromium has been show to improve the glucose/insulin system in subjects with hypoglycemia, hyperglycemia, diabetes and hyperlipemia.  Chromium improves insulin binding, insulin receptor number, insulin internalization, beta cell sensitivity, and insulin receptor enzymes with overall increase in insulin sensitivity (Anderson, 1997).

The bottom-line, is that diabetics are 50% more likely to die of heart disease that non-diabetics, and chromium helps support in the lowering of the risk of diabetes.


  • Anderson RA. (1997). Nutritional factors influencing the glucose/insulin system: chromium. Journal of the American College of Nutrition; 16(5): 404-410.
  • Dower et al. (2015). Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized double-blind, placebo-controlled, crossover trial. Am J Clin Nutr; 101(5): 914-21.
  • Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health;72 doi:10.3402/ijch.v7210.21188.
  • DiRienzo D.B. (2014). Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets. Nutr Rev.;72(1):18-29.
  • Engler at al. (2004). Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr; 23:197-204.
  • Greenwald SE. (2007). Ageing of the conduit arteries. J Pathol; 211(2): 157-172.
  • Han et al. (2007). Meta-analysis: Dietary Polyphenols and their Biological Significance. Int J Mo Sci; 8(9): 950-988.
  • Lilla M.A. (2004). Plant pigments and their manipulation: Annual plant reviews; Vol. 14, Chapter 8. Oxford, UK: Blackwell Publishing.
  • Lorenz et al. (2007). Addition of milk prevents vascular protective effects of tea. European Heart Journal; 28(2): 2219-2223.
  • Nagao et al. (2007). A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity; 15: 1473-1483.
  • NIH. (2015). Coronary Heart Disease. National Heart, lung, and Blood Institute;
  • Schroeter et al. (2006). Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. PNAS; 103:1024-1029.
  • Saini et al. (2010). Potential of probiotics in controlling cardiovascular diseases. J. Cardiovasc Dis Res;1(4):213-214.
  • Serino et al. (2014). Far from the Eyes, Close to the Heart:  Dysbiosis of Gut Microbiota and Cardiovasuclar Consequences. Curr Cardiol Rep.; 16(11):540.
  • Saini et al. (2010). Potential of probiotics in controlling cardiovascular diseases. J. Cardiovasc Dis Res;14):213-214.
  • Tuso et al. (2013). Nutritional Update for Physicians: Plant-Based Diets. The Permanente Journal; 17(2); 61-66.
  • Whitehead et al. (2014) Cholesterol-lowering effects of oat Beta glucan: a meta-analysis of randomized controlled trials. Am j. Clin. Nutr.;100(6):1413-1421.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Kaiser Permantente has published a remarkable nutritional update for their 15,000 physicians who care for their 10 million members.  Kaiser is now telling doctors that healthy eating may best be achieved with a plant-based diet, defined as a regiment that “encourages whole, plant-based foods and discourages meats, dairy and eggs as well as all refined and processed junk food (Tuso, 2013).

Dear Friends

In industrialized countries isolated systolic hypertension (ISH) increases steeply with age. Many Americans over the age of 60 have ISH, which is increasingly recognized as a cardiovascular risk. Several studies have shown the strong association between ISH and stroke, kidney failure, cardiovascular morbidity and mortality (Gasowski et al, 2002; Vaccarino et al, 2001).
Reversing or stabilizing the increased arterial stiffness associated with age and disease by targeting any or all of its causes provides of a number of promising new approaches to treatment of systolic hyertension and its sequel, the main causes of mortality and morbidity (Greenwald SE, 2007).

Therapeutic Food supplements magnify the protective benefits of key phytonutrients that support the reduction of ISH.


Metabolic Syndrome

February 3, 2016

Dear Friends

Metabolic Syndrome is a disorder that now affects about 1/4 of the American population and has emerged as a worldwide epidemic.  It may soon replace smoking as the leading cause for Coronary Heart Disease—the number one cause of death for men and women in the US (NIH: NHLBI, 2015). Additionaly, Metabolic Syndrome is causative for diabetes, NAFLD and cancer.

The risk factors for Metabolic Syndrome are (Grundy 2004, McCullough 2011):

  • Abdominal obesity
  • Atherogenic dyslipidemia
  • Raised blood pressure
  • Insulin resistance
  • Proinflammatory state
  • Prothrombotic state

Therapeutic Food protocol for Metabolic Syndrome:

  • Beta Glucan High Potency Synbiotic – 1 heaping tbl BID before 2 largest meals.
  • No. 7 Systemic Booster 1 tsp before bed. 
  • Be Regular – 2 heaping tbl taken as a meal replacement three times a week.
  • Phyto Power – 2 capsules daily.
  • Chromium, Bio-organic with Beet – 1 capsule BID.

Food Science:

How can Therapeutic Foods help in the challenge to reduce of the above risk factors?

There is a multitude of research that strongly makes the point that as dietary fiber goes up the risk of Metabolic Syndrome goes down (Grooms, 2013). Beta Glucan Synbiotic, No. 7 Systemic Booster, Be Regular, and the Phyto Power together contain powerful soluble and insoluble fibers.  Click on their links to see more.

How does fiber do this?  It helps get rid of excess bile, feeds our good gut bacteria which enhances our SCFA production and reduces cholesterol synthesis, reduces macronutrient absorption, low energy density, gastric distension and increase satiety, delayed gastric emptying, effect on gut hormones, reduced post prandial responses.  All of this collectively helps to control body weight, cholesterol, blood sugar and blood pressure (Satija, 2012).

Reducing chronic inflammation is of course the major factor for reducing the above risks and the friendly probiotics, rich assortment of phyto nutrients (i.g. flavonoids,etc) in Beta Glucan Synbiotic, Be Regular, Phyto Power and No. 7 all makes this possible (Pan, 2010).


  • Ford et al. (2014). Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idopatahic constipation: sytematic review and meta-analysis. AM J Gastroenterol; 109(10): 1547-61.
  • Grooms et al. (2013). Dietary Fiber Intake and Cardiometablic Riks among US Adults: NHANES 1999-2010. Am J Med; 126(12): 1059-1067.
  • Pan et al. (2010). Anti-inflammatory activity of natural dietary flavonoids. Food Funct; 1: 15-31.
  • Satija A, Hu FB. (2012). Cardiovascular Benefits of Dietary Fiber. Curr Atheroscler Rep; 14:505-514.


Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health.  Please  use our products under the advisement of your doctor.

Green Facts:

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Michael Gregor maintains in Metaboic Syndrome and  Plant Based Diets that eating vegetarian cuts the odds of having metabolic syndrome by more than half.  Check out this 2 minute video.