Blueberry Extract

Dear Doctor

Cognitive decline is a serious issue many aging and younger adults face. The CDC released A Call for Action bulletin with the estimate of 16 million people living with cognitive impairment. Over 5.1 million Americans live with Alzheimer’s disease (2014; 2011). Marcum et al.’s (2019) survey found that most people are aware of the risks associated with getting dementias but do not know what to do.

The research teams guided by James Joseph and Shukitt-Hale have studied blueberries and brain health for many years (e.g., 2010), with a recent study confirming that a daily supplementation of blueberries reverse age-related deficits in different groups of aged rats (2019). Both Travica et al. (2019) and Dodd et al. (2019) found blueberry supplementation in adults and children improve cognition performance, and in particular, improve short – and long-term memory.

Wilhelmina Kalt has also led many research teams to study the power of blueberries (e.g., 2013). In a recent article, her team (2019) reviewed current research on the health benefits of blueberries and concluded that it is widely agreed that regular consumption of blueberries can be unconditionally recommended.

Blueberries contain large amounts of phytochemicals, and in particular, blueberries are abundant with anthocyanin pigments, which according to Kalt et al. (2019) makes the greatest impact on brain health.

Our Blueberry Extract is highly concentrated: 80 kilos make 1 kilo of extract – a powerhouse of anthocyanins! Furthermore, the Blueberry Extract is pure: 100% free of any fillers, excipients or flowing agents.

1-2 capsules twice daily for two weeks to start an intensive program, and 1 capsule a day as a maintenance.

Order Now: Blueberry-Extract

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References

  • Centers for Disease Control and Prevention. (2017). Cognitive impairment: a call for action now 2011.
  • Dodd, G. F., Williams, C. M., Butler, L. T., & Spencer, J. P. (2019). Acute effects of flavonoid-rich blueberry on cognitive and vascular function in healthy older adults. Nutrition and Healthy Aging, (Preprint), 1-14.Article
  • Kalt, W., Cassidy, A., Howard, L. R., Krikorian, R., Stull, A. J., Tremblay, F., & Zamora-Ros, R. (2019). Recent Research on the Health Benefits of Blueberries and Their Anthocyanins. Advances in Nutrition.Article
  • Kalt, W., Lawand, C., Ryan, D. A., McDonald, J. E., Donner, H., & Forney, C. F. (2003). Oxygen radical absorbing capacity, anthocyanin and phenolic content of highbush blueberries (Vaccinium corymbosum L.) during ripening and storage. Journal of the American Society for Horticultural Science128(6), 917-923. Article
  • Krikorian, R., Shidler, M. D., Nash, T. A., Kalt, W., Vinqvist-Tymchuk, M. R., Shukitt-Hale, B., & Joseph, J. A. (2010). Blueberry supplementation improves memory in older adults. Journal of agricultural and food chemistry58(7), 3996-4000.Article
  • Marcum, Z. A., Hohl, S. D., Gray, S. L., Barthold, D., Crane, P. K., & Larson, E. B. (2019). Brain health and dementia prevention: A mixed-method analysis. American journal of health behavior43(2), 300-310.AbstractShukitt-Hale, B., Thangthaeng, N., Miller, M. G., Poulose, S. M., Carey, A. N., & Fisher, D. R. (2019). Blueberries Improve Neuroinflammation and Cognition differentially Depending on Individual Cognitive baseline Status. The Journals of Gerontology: Series A74(7), 977-983.Abstract
  • Travica, N., D’Cunha, N. M., Naumovski, N., Kent, K., Mellor, D. D., Firth, J., … & Marx, W. (2019). The effect of blueberry interventions on cognitive performance and mood: a systematic review of randomized controlled trials. Brain, behavior, and immunity.Abstract

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Transformation to healthy diets by 2050 will require substantial dietary shifts.  Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits.  (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019)

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Chronic Disease is the new norm.  We see it all around us:  obesity, metabolic syndrome, fatty liver, diabetes, CVD, cancer, COPD, asthma, Alzheimer’s, Parkinson’s, autism, IBD, IBS,  auto immune disease, arthritis, UTI, and many more.

Doctors, you are our heroes on the frontline in the battle for your patients’ health, and for helping them to prevent their occurrence in the first place.

Key finding in research for the root cause of these chronic illnesses: a continual low-grade inflammation (LGI), termed by scientists as “inflammageing” (Franceschi & Campisi, 2014).

Therapeutic Food Supplements were designed with powerful plant polyphenols, pedigreed probiotic strains  (with their metabolites and microRNAs), and key nutraceuticals to supports the reduction of LGI.  The results are easily measured:  lowering inflammatory markers.

Summary of the Therapeutic Food Offering:

Polyphenol products:  Garlic (antimicrobial, blood pressure regulation), Blueberry Extract (brain and nerve regeneration), Glucosinolates & Sulforaphanes (liver support), Chlorella (absorption of heavy metals and toxins), Be Regular (fiber from ancient seeds – a must have), and Phyto Power (DNA integrity).

Probiotic Products: Supernatant Synbiotic, and Original Synbiotic. Both powerfully effective for GI health

Probiotic + Polyphenols: High ORAC Synbiotic (post antibiotic therapy), Beta Glucan Synbiotic (Cardiovascular and GI support), No. 7 Systemic Booster (designed to combat the root cause of chronic illnesses), and Cranberry Pomegranate Synbiotic (UTI, and prostate support).

Nutraceuticals:  Fructo Borate Complex (bone and joints), Chromium (blood sugar control), Energy (plant ultra minerals), No. 7 (B12, Folate, chromium, D3, and Fructo Borate), Weight-Less (7 keto).

Nutraceuticals + Polyphenols:  Energy (increase ATP levels), Weight-less (weight loss and blood sugar control), and Chromium with high active Beet Root (blood sugar control, increase circulation), No 7 Systemic Booster.

All of our plant materials are eco-farmed, or wild-crafted, selected for their exceptional high-actives, many of which we standardize.  There are no excipients in our Therapeutic Food Supplement (e.g. flowing agents, sweeteners, natural flavors, emulsifiers, etc.).  We are purists in this regard, wanting to give you absolutely the strongest possible natural product for you restoring health.

References:

  • Boivin et al. (2009). Antiproliferative and antioxidant activities of common vegetables: A comparative Study. Food Chemistry; 112(20): 374-380. Article
  • Calder, P. C., Bosco, N., Bourdet-Sicard, R., Capuron, L., Delzenne, N., Doré, J., … & Visioli, F. (2017). Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing research reviews40, 95-119. Article
  • Franceschi, C., & Campisi, J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences69(Suppl_1), S4-S9. Article

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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BioImmersion Therapeutic Food Supplements are certainly a strong tool to facilitate the healing of our bodies; a healthy diet and a clean environment are its necessary partners.  How do we create a healthy environment? A healthy biosphere?  Biomimicry Institute provides some enlightened answers.

 

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Atherosclerosis Cardiovascular Disease (ACD), or clogged arteries, is the leading cause of death in the world. Hypercholesterolemia, or high cholesterol levels in the blood, is one of the  major causative factor (Barquer et al., 2015) .  Hence, statins are among the top selling drugs.

High use of statins, however, comes with possible serious side effects.  Stroher et al. (2015) tested the possible advantages of combining lower doses of statins with a Blueberry Extract, or using Blueberry Extract on its own.  Her research group found that dosing hypercholesterolemic rats with a combination of Zocor (also called SIM) and Blueberry Extract (BE) brought better results. However, using Blueberry Extract alone also brought good results.

Thirty-six hypercholesterolemic rats were divided into six groups of six animals each, with  14 days of the following supplementation regime for each group: (1) Control (only got the high-fat diet), (2) Fat diet + SIM 10mg/kg, (3) Fat diet + BE  25mg/kg, (4) Fat diet + BE 50mg/kg, (5) Fat diet + BE 25mg/kg + SIM, (6) Fat diet + BE 50mg/kg + SIM.  Many beneficial results were found as is presented in bar graphs below.

This graph shows, after histological section, the thickness measurements of the aorta of hypercholesterolemic rats after treatment.  Notice here that groups 3-6 got better results. But the interesting part about this measurement is that group 4 got only 50mg of blueberry extract and has similar result to group 6 which got SIM drug and blueberry extract, 50mg.

Aorta thickness

To see the multitude of other bar graphs from their paper, graphically illustrating the various benefits derived from adding the Blueberry Extract, click the Stroher link in the References below.

After 14 days of supplementation with blueberry extract the levels of total cholesterol, LDLs, and triglycerides were decrease in hypercholesterolemic rats.  Histopathological analysis, analyzing the tissues after death, showed significant decrease of aortic lesions.  Oxidative parameters showed significant reductions in oxidative damage to lipids and proteins and an increase in activities of endogenous antioxidant enzymes such as catalase, superoxide dismutase and glutathione peroxidase.

In conclusion, Stroher et al. (2015) state that Blueberry Extract supplementation was able to protect against weight gain, improve the lipid profile, reduce the high levels of total cholesterol, LDL and triglycerides and showed an anti-atherogenic effect in these rats.  The Blueberry Extract also showed improved oxidative parameters, showing a decrease is oxidation of lipids and proteins.  They concluded that as nutraceutical blueberry extract may have great potential as people prefer natural therapies.

Therapeutic Food Blueberry Extract is a powerhouse not only for brain function but for heart health as well.  Recommended dose is 1-2 capsules daily- with 500mg of pure blueberry extract in each capsule. We also suggest 1-2 tablespoons of Beta Glucan Synbiotic for lowering LDL cholesterol, and a primarily whole food, plant-based diet which is shown in research to combat heart disease.

References:

  • Barquera, S., Pedroza-Tobías, A., Medina, C., Hernández-Barrera, L., Bibbins-Domingo, K., Lozano, R., & Moran, A. E. (2015). Global overview of the epidemiology of atherosclerotic cardiovascular disease. Archives of medical research, 46(5), 328-338.
  • Serino, A., & Salazar, G. (2019). Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease. Nutrients,11(1), 53.
  • Stroher, D. J., Piccoli, J. D. C. E., da Costa Güllich, A. A., Pilar, B. C., Coelho, R. P., Bruno, J. B., … & Manfredini, V. (2015). 14 Days of supplementation with blueberry extract shows anti-atherogenic properties and improves oxidative parameters in hypercholesterolemic rats model. Int J Food Sci Nutr, 66(5), 559-68.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Our diet is a major factor for heart health. We suggest eating a primarily whole food, plant-based diet, with organic meat, dairy, and eggs serving as condiments every so often. (Serino & Salazar, 2019).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Alzheimer’s has moved up to the number three cause of death in the United States just under cancer and heart disease (NIH- National Institute of Aging, 2019).

Julien et al. (2009) compared the concentration of SIRT1 in the brains of AD patients and controls. In the first group of 19 patients and 22 controls,  a significant reduction of SIRT1 in the parietal cortex of AD patients was found.  Further analyses in a second cohort of 36 subjects confirmed that cortical SIRT1 was decreased in AD but not in individuals with mild cognitive impairments.  A significant relationship between SIRT1 levels and global cognition scores proximate to death was also found. Collectively, their results indicate that loss of SIRT1 is closely associated with the accumulation of amyloid-beta and tau in the cerebral cortex of persons with AD.  Furthermore, autopsies of Alzheimer’s victims reveal that loss of sirtuin enzyme activity is closely associated with the accumulation of the plaques and tangles.

Plants (fruits, berries, veggies, and greens) contain key phytonutrients, namely polyphenols. In research, an increasing number of polyphenols are being found to turn on a family of our anti-aging genes called sirtuins.  Sirtuins, particularly SIRT1 expression, is shown to reduce and eliminate amyloid-B and tangles, two protein derangements that are symptomatic of Alzheimer’s.   High heat cooked meats and fats create a molecule called advanced glycation end products (AGEs) which when present in the blood turn off the sirtuin gene expression, thereby turning off the expression of these anti-aging genes (Julien et al., 2009).

The Therapeutic Food Supplements  boost our body with key plant polyphenols that turn on the sirtuins.  Each of the four products is designed to supply ample amounts of phytonutrients and in particular polyphenols such as resveratrol, quercetin, and catechins to  enhance brain function.

For preventing cognitive decline and beginning stages of dementia, add to your protocol the High ORAC Synbiotic  with standardized high levels of  resveratrol and quercetin.

For a progressive decline and Alzheimer’s, add to the High ORAC a more robust protocol of powerful polyphenols to regenerate neurons in the brain:

References:

  • Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017). Sirtuins, a promising target in slowing down the ageing process. Biogerontology,18(4), 447-476.
  • Julien, C., Tremblay, C., Emond, V., Lebbadi, M., Salem Jr, N., Bennett, D. A., & Calon, F. (2009). Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 68(1), 48-58.
  • Uribarri, Jaime, Sandra Woodruff, Susan Goodman, Weijing Cai, Xue Chen, Renata Pyzik, Angie Yong, Gary E. Striker, and Helen Vlassara. (2010). “Advanced glycation end products in foods and a practical guide to their reduction in the diet.” Journal of the American Dietetic Association110, no. 6: 911-916.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Our diet is a major factor in whether we succumb to Alzheimers or not.  Eating primarily a whole-foods plant-based diet with meat and fat being more like a condiment puts the odds highly in one’s favor on not becoming its victim (Uribarri et al., 2010).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Parkinson’s is a neurological disease characterized by mitochondrial dysfunction and oxidative stress in the dopaminergic neurons of the mid brain, causing them to die, resulting in motor dysfunction.

Parkinson’s (PD) has been positively associated with two groups of pesticides, those that impair mitochondrial function and those that increase oxidative stress.  Two such pesticides are paraquat, which causes oxidative stress, and rotenone, which inhibits mitochondrial complex I, both induce loss of nigral dopaminergic neurons and behavioral changes associated with human PD.

Epidemiological findings suggest that the consumption of berries rich in anthocyanins and proanthocyanidins may reduce PD risk.  Strathearn et al. (2014) demonstrated powerful protective effects of blueberry extract in protecting the neurons from the oxidative damage of the pesticides.  In their study, they investigated whether extracts rich in anthocyanins, proanthocyanidins, or other polyphenols, suppress the neurotoxic effects of rotenone in a primary cell culture model of PD.

Extracts rich in anthocyanins and proanthocyanidins exhibited greater neuroprotective activity than extracts rich in other polyphenols, and a number of individual anthocyanins interfered with rotenone neurotoxicity.  The blueberry and grape seed extracts rescued rotenone-induced defects in mitochondrial respiration in a dopaminergic cell line.

Dr. Mary Ann Lila, one of the study’s team of scientists, and the director of North Carolina State University’s Plants for Human Health Institute stated:

Blueberries have both of these natural chemicals (anthocyanins and proanthocyanidins) in high concentrations, so they pack a more powerful, one-two punch.  They can have synergistic benefits that surpass many other fruits when it comes to protection against brain cell death, which in turn may reduce the risk of contracting Parkinson’s.(Moore, 2014)

A cup a day is a good routine for health, according to Lila, and it provides abundant amounts of vitamins A and C, fiber, manganese and phytonutrients, which have antioxidant and anti-inflammatory properties.  Blueberries are also a “brain food”, and have been shown to increase powers of concentration and slow cognitive degeneration.

Our  Blueberry Extract (1 capsule) has a cup and a quarter of blueberries, while the Phyto Power (2 capsules) has 200mg of four species of wild harvested blueberries plus 400 mg of rosehips with their powerful collection of flavonoids including proanthocyanidins.

We will focus on these cognitive benefits in our next Forward Thinking.

References

Moore, J. (2014). Blueberries reduce risk of Parkinson’s, boost brain function finds new study. Plants for human health institute, NC State. Article

Strathearn, K. E., Yousef, G. G., Grace, M. H., Roy, S. L., Tambe, M. A., Ferruzzi, M. G., … & Rochet, J. C. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson׳ s disease. Brain research, 1555, 60-77. Article

Tanner, C. M., Kamel, F., Ross, G. W., Hoppin, J. A., Goldman, S. M., Korell, M., … & Comyns, K. (2011). Rotenone, paraquat, and Parkinson’s disease. Environmental health perspectives, 119(6), 866-872. Article

Best,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

It is estimated that one million people suffer from Parkinson’s in the U.S., and although the disease itself is not fatal, complications arising from it can be, and the CDC states that these co-morbidities result in it being the 14th leading cause of death in the country (National Parkinson Foundation).

 

©2005 – 2019 BioImmersion Inc. All Rights Reserved