Urogenital Support

Dear Doctor

Bader (2017) update on the status of urinary tract infections (UTIs) emphasizes the growing concern of UTIs caused by antibiotic-resistant Gram-negative bacteria, such as E. coli, Salmonella, Klebeiella– all part of the family Enterobacteriaceae. Treating UTIs with drugs like Fosfomycin tromethamine, amoxicillin, and others are the typical course of action, but what do we do when these drugs do not resolve the UTI?

Proanthocyanidin from Cranberries and Pomegranates have been used for many years as anti-adhesive agents in the treatment of UTI. Gupta et al. (2012) showed in his study that a drug resistant E. coli was sensitive to an extract from cranberries on bladder infection by inhibiting the adhesiveness of multi-drug resistant E. coli to the walls. In 2015 Kaspar et al. assessed the anti-adhesion effect of cranberry extract to improve urinary tract health. More recently, the research and reviews of Lima et al. (2019) and González de Llanoet al. (2019) showed new findings on the efficacy of cranberries against urinary tract infections due to the rich source of phenolic compounds.

Cranberry Pomegranate Synbiotic has the added antimicrobial activity of pomegranate, with probiotics, supernatant and microRNA. 2-4 capsule three times a day for three days as intensive support or until condition resolved.

Order Now: Cranberry Pomegranate Synbiotic

CP F

References

  • Bader, M. S., Loeb, M., & Brooks, A. A. (2017). An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgraduate medicine129(2), 242-258.Abstract
  • González de Llano, D., Liu, H., Khoo, C., Moreno-Arribas, M. V., & Bartolomé, B. (2019). Some New Findings Regarding the Antiadhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Bacteria. Journal of agricultural and food chemistry67(8), 2166-2174.Article
  • Gupta, A., Dwivedi, M., Mahdi, A.A., Nagana Gowda, G.A., Khetrapal, C.L., Bhandari, M. (2012). Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin. Urol Res, 40(2), 143-50. DOI: 10.1007/s00240-011-0398-2
  • Kaspar, K.L., Howell, A.B., & Khoo, C. (2015). A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages.Food Funct, 6(4), 1212-7. DOI: 10.1039/c4fo01018c
  • Lima, M. C., de Sousa, C. P., Fernandez-Prada, C., Harel, J., Dubreuil, J. D., & de Souza, E. L. (2019). A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria. Microbial pathogenesis.Abstract
  • Rodríguez-Pérez, C., Quirantes-Piné, R., Uberos, J., Jiménez-Sánchez, C., Peña, A., & Segura-Carretero, A. (2016). Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli. Food & function7(3), 1564-1573. Article
  • Wafa, B. A., Makni, M., Ammar, S., Khannous, L., Hassana, A. B., Bouaziz, M., … & Gdoura, R. (2017). Antimicrobial effect of the Tunisian Nana variety Punica granatum L. extracts against Salmonella enterica (serovars Kentucky and Enteritidis) isolated from chicken meat and phenolic composition of its peel extract. International journal of food microbiology241, 123-131. DOI: 10.1016/j.ijfoodmicro.2016.10.007

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Transformation to healthy diets by 2050 will require substantial dietary shifts.  Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits.  (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019)

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Cellular Senescence means that cells cannot divide due to multiple reasons,  with inflammation posing as one of the greatest. Cellular Senescence hastens the development of chronic diseases like cardiovascular, diabetes, Alzheimer’s, dementias, cancer, immune and kidney dysfunction, IBD, and osteoarthritis among many others.

Current research has shown that certain plant polyphenols (i.e. quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential  for reducing and preventing senescence, which reduces the risk for developing chronic disease, and even reverses the onset of chronic illnesses and geriatric syndrome.  Research is now focused on the utilization of senolytic molecules in therapies.

The No. 7 Systemic Booster: the New Longevity contains both of these powerful phenolic flavonoids, quercetin and fisetin, within its high-active fruits and vegetables.  Daily dosing at 1 tsp supports the body’s ability to to fight against chronic disease.  (See Further Notes below)

 

No 7 Photo_2 copy

 

Further notes on cellular senescence: 

Chronic low-grade inflammation (LGI) in the body is an etiological factor in chronic disease and it is also a causative force in cells going into senescence.  Cellular senescence is characterized as a state where cells: (1) lose their ability to divide and renew their healthy functionality; (2) become resistant to apoptosis (cell death); and  (3) increase their production of reactive oxygen species (ROS), and secret into their external environment pro-inflammatory cytokines, bradykines, prostenoids, miRNAs, damage-associated molecular pattern proteins (DAMPs), and other pro-inflammatory mediators, chemokines that attract immune cells.  In other words, these cells create more inflammation; more collateral damage that can lead to pathology.  This condition is called a senescence-associated secretory phenotype (SASP).

Senescent cells have been identified at sites of pathology in multiple diseases.  They accumulate in adipose tissue in diabetes and with age-related metabolic dysfunction, osteoarthritic joints, the aorta in vascular hypo-reactivity and atherosclerosis and the lung in idiopathic pulmonary fibrosis.  Transplantation of small numbers senescent cells around the knee joint can cause osteoarthritis (Zhu, Y., et al. 2015).

Therefore, the discovery of strong senolytic molecules  present in certain vegetables and fruits that  are able to delay, prevent, or alleviate a number of chronic  diseases is very exciting. The No. 7 Systemic Booster: the New Longevity is a great starting point to reduce inflammation and deeply nourish our cells with the nutrients they need to function healthily.

References:

  • Kirkland, J. L., & Tchkonia, T. (2017). Cellular senescence: a translational perspective. EBioMedicine, 21, 21-28.
  • Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., … & Kirkland, J. L. (2017). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging (Albany NY), 9(3), 955.
  • Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., … & O’Hara, S. P. (2015). The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging cell, 14(4), 644-658.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Our findings here give support for the speculation that these agents [senolytics] may one day be used for treating cardiovascular disease, frailty, loss of resilience, including delayed recovery or dysfunction after chemotherapy or radiation, neurodegenerative disorders, osteoporosis, osteoarthritis, other bone and joint disorders, and adverse phenotypes related to chronologic aging.  Theoretically, other conditions such as diabetes and metabolic disorders, visual impairment, chronic lung disease, liver disease, renal and genitourinary dysfunction, skin disorders, and cancers could be alleviated with senolytics (Zhu,Y. et al., 2017).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Doctors and their patients are discovering the addictive taste of the No 7 Systemic Booster. The quality of this rich bitter chocolate taste comes alive with any juice: apple, orange, pineapple, any berry, and even carrot or beet. Taking the No 7 in just water produces a very dark, bitter, chocolate drink (although there is not chocolate in this mix!). But a little diluted juice, and the chocolate taste comes alive.

The No 7 Booster is a serious, uncompromisingly healthy drink. There are no sweeteners, fillers, or natural flavors to muck up the real power of the blend. Typically, artificial, natural, or even organic flavors have from 100-500 different components that are not required to be listed on the label. The No 7 is as pure as it is powerful.

The No 7 has our famous probiotic mix with its Supernatant and ORNs. For those of you who are waiting to have the LactORN back – we have the ORNs (known in the scientific literature as microRNAs) now in the No 7, High ORAC, Cranberry Pomegranate, and the Beta Glucan.  We have decided to pull the incredible immune boosting abilities of the microRNAs into our formulas.

Life is getting more polluted, and chronic illnesses more difficult to treat. The No 7 is an effective tool with high actives and polyphenols from purposely selected veggies, greens, fruits, berries, extracts, nutriceuticals, and our super probiotic mix.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The No 7 Longevity encompasses a great deal of research into better health. The scientific community has much more to discover, yet many of the findings do show a clear path toward health that is not riddled by chronic conditions that can be supported by a plant-based diet of whole foods, a cleaner home and office environments, exercise, toxic free personal and home cleaning products, organic or pesticides & herbicides free foods, and clean, researched based supplementations (see Living Well – Dying Well , Chapter 8).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Our Cranberry Pomegranate Synbiotic embodies a high potency and powerful ability for all sorts of bladder and UTI issues. But the combination of supernatant with ORNs, probiotics, cranberries, and pomegranates do so much more!

NEW CP Jpeg Short 4

The phytonutrients are more concentrated, standardize to 6% quinic acid for the cranberry and 40% punicalagins for the pomegranate extract.

There are now five different organisms of probiotics in the formula. We grow them as whole organisms with their supernatant and ORNs.  We selected organisms that have a natural antimicrobial abilities against hospital generated infections.

The supernatant component of the product is much more comprehensive, dramatically enhancing its benefits.  It has our typical famous metabolites of the Lactobacillus bulgaricus and Streptococcus thermophilus plus the metabolites of our added three more organisms, five all together! Supernatant contains the food fermentation by-products (metabolites) that include lactic acids, amino acids, folates, bacterocins, biosurfactants and various beneficial enzymes such as bile salts hydrolase and lactase.  And of course, the supernatant also has the ORNs (oligoribnucleotides- their shorter chains of microRNAs), which prime the immune system and activate the rapid growth of these powerful probiotic organisms.

The prebiotic per capsule is 100mg of organic chicory root inulin (the total amount of ingredients per capsule is 500mg). Since our probiotics wake up much more rapidly due to complete sets of ORNs, they need food to grow.

In research, these ingredients show a reduction, not only, to the risk of UTI associated conditions but for both colon and breast cancers as well.

  • Vaginal eubiosis- Vaginal eubiosis is characterised by beneficial lactobacillus-dominated microbiota. In contrast, vaginal dysbiosis (e.g. bacterial vaginosis, BV), characterized by an overgrowth of multiple anaerobes, is associated with an increased risk of adverse urogenital and reproductive health outcomes.  The Lactobaccilus sp. in our Cranberry Pomegranate Synbiotic are strong lactic acid producers.
  • Biosurfactants- The role of Lactobacillusspecies in the female urogenital tract as a barrier to infection is of considerable interest.  These organisms are believed to contribute to the control of vaginal microbiota by competing with other micro-organisms for adherence to epithelial cells and by producing biosurfactants (Rodrigues, L. et al., 2006).  The good probiotics in this formula have demonstrated the ability to produce mucins as biosurfactants against bacterial, fungal and viral pathogens.
  • Cancer Protection Support- Ou, J et al. (2012) in their paper, Association between low colonic short-chain fatty acids and high bile acid in high colon cancer risk populations, proposed that the influence of diet on colon cancer risk is mediated by the microbiota.  Their results suggested that the higher risk of colon cancer in Americans may be partly explained by their high-fat and high-protein, low complex carbohydrate diet, which produces colonic residues that promote microbes such as Clostridia and E. coli to produce potentially carcinogenic secondary bile acids and less antineoplastic SCFAs.  Our collection of good bacteria in this formula are SCFA producers and secondary bile acids reducers as you can see with one of their metabolites being the enzyme bile salts hydrolase.  These good bugs also put out bacterocins agains Clostridiaand E. coli.
  • Breast Cancer- Costarelli, V., and Sanders, T.A.B. (2002) found that the mean plasma secondary bile salt derivative DCA concentration were 52% higher in patients  with breast cancer compared with controls.  Reducing gut levels of DCA will reduce plasma levels.  Thereby, reducing this risk factor.
  • Colon Cancer- AJouz, H., Mukherjui, D., and Shamseddine, A. in their 2014 research paper stated that bile acids going into the intestines stimulate growth in the colon of Clostridia which convert primary to secondary bile acids, and secondary bile acids that were shown to be carcinogenic.   Hence the important of our good bugs that produce bacterocins to reduce Clostridial populations.
  • Animal Fat-Rich Diets- There is increasing evidence (Barrasa, J.I. et al. 2013) that the continous exposure to certain hydrophobic bile acids, due to a fat-rich diet may induce oxidative DNA damage that, in turn, may lead to colorectal carcinogenesis.

References

  • Tachedjian, G., Aldunate, M., Bradshaw, C. S., & Cone, R. A. (2017). The role of lactic acid production by probiotic Lactobacillus species in vaginal health. Research in microbiology, 168(9-10), 782-792. https://www.sciencedirect.com/science/article/pii/S0923250817300839?via%3Dihub
  • Rodrigues, L., Banat, I. M., Teixeira, J., & Oliveira, R. (2006). Biosurfactants: potential applications in medicine. Journal of Antimicrobial Chemotherapy, 57(4), 609-618. https://academic.oup.com/jac/article/57/4/609/669417
  • Ou, J., DeLany, J. P., Zhang, M., Sharma, S., & O’Keefe, S. J. (2012). Association between low colonic short-chain fatty acids and high bile acids in high colon cancer risk populations. Nutrition and cancer, 64(1), 34-40.
  • Costarelli, V., & Sanders, T. A. B. (2002). Plasma deoxycholic acid concentration is elevated in postmenopausal women with newly diagnosed breast cancer. European journal of clinical nutrition, 56(9), 925.  https://www.nature.com/articles/1601396
  • Ajouz, H., Mukherji, D., & Shamseddine, A. (2014). Secondary bile acids: an underrecognized cause of colon cancer. World journal of surgical oncology, 12(1), 164.
  • Barrasa, J. I., Olmo, N., Lizarbe, M. A., & Turnay, J. (2013). Bile acids in the colon, from healthy to cytotoxic molecules. Toxicology in Vitro, 27(2), 964-977.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Cranberry consumption has shown prophylactic effects against urinary tract infections (UTI).  Anti-adhesive activity of cranberry phenolic compounds and their microbial-drived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures

González de Llano, D., Esteban-Fernández, A., Sánchez-Patán, F., Martínlvarez, P. J., Moreno-Arribas, M., & Bartolomé, B. (2015). Anti-adhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures. International journal of molecular sciences, 16(6), 12119-12130.

In the study sited below data indicated that both pomegranate aril and peel extracts have an effective antimicrobial activity, as evidenced by the inhibitory effect on the bacterial growth of two important human pathogens, including Staphylococcus aureus and Escherichia coli.

Pagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., & Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831. DOI: 10.1016/j.foodchem.2015.06.028

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Powerful UTI Care

July 31, 2018

Dear Friends

Cranberry Pomegranate Synbiotic is back!  And it is more powerful with a broad specturm anti-microbial ability.

NEW CP Jpeg Short 4

The raw materials are the same, but more powerful, and with supernatant from each of the probiotics plus their individual ORNs.

We standardized the Cranberry concentrate at 6%.  The 6% is refers to its amount of quinic acid, key for UTI issues.  The pomegranate is standardized at 40% with its punicalagins, offering more intensive anti-microibal, anti-oxidants, and cancer support. The probiotics work synergistically with the extracts, breaking them down into shorter phenolic molecules, which means they are bio-available to do their various tasks.

We have five probiotics now, with  newly added  L. bulgaricus and S. thermophilus.  The supernatant contains the metabolites of  L. bulgaricus and S. thermophilus, L. casei, L. acidophilus, and B. longum, including their ORNs (oligoribonucleotides).

Our new blend of naturally occurring whole probiotic organisms is grown to fully retain their oligoribonucleotides (ORNs) and mixed with their metabolites from their culture supernatant. The cultures are now able to grow faster without any delay (the term in microbiology is ‘lag-time’), and because of that they are more effective and generate a healthier microbiome balance.

This new Cranberry Pomegranate Synbiotic combines the power of our Supernatant Synbiotic and the LactORN Synbiotic products. With the polyphenol concentrates, the formula is truly a powerhouse for UTI care.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Cranberry consumption has shown prophylactic effects against urinary tract infections (UTI).  Anti-adhesive activity of cranberry phenolic compounds and their microbial-drived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures

González de Llano, D., Esteban-Fernández, A., Sánchez-Patán, F., Martínlvarez, P. J., Moreno-Arribas, M., & Bartolomé, B. (2015). Anti-adhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures. International journal of molecular sciences, 16(6), 12119-12130.

In the study sited below data indicated that both pomegranate aril and peel extracts have an effective antimicrobial activity, as evidenced by the inhibitory effect on the bacterial growth of two important human pathogens, including Staphylococcus aureus and Escherichia coli.

Pagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., & Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831. DOI: 10.1016/j.foodchem.2015.06.028

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved