Healthy Aging Support

Dear Friends

We have discussed the use of Garlic as an antimicrobial support for IBS and SIBO.

IBS sufferers also require a calming effect.

Probiotic and polyphenols have shown in research to offer relief from pain by reducing the irritating and pathogenic organisms of the microbiota (the community of the different organisms living in the GI Tract) with friendly and calming bacteria.  Probiotics simply competes with irritating or pathogenic bacteria and lowers their numbers. The immune system along with the nervous system relax as inflammation is lowered and with that pain is reduced. These friendly probiotic bacteria are hard workers! See the research below.

Select one or two of the top three calming and reparative Therapeutic Food Synbiotics:

SN F

CP F

HO F

Siebecker and Sandberg-Lewis, co-founders of the SIBO Center for Digestive Health at The National College of Natural Medicine (NCNM), state in their paper, Small Intestine Bacterial Overgrowth: Often-Ignored cause of Irritable Bowel Syndrome, that they have used various multistrain and single probiotics as well as yogurt and cultured vegetables with their SIBO patients with good results (2013).  They consider avoiding prebiotics such as FOS, inulin and GOS as the main ingredient.  However, they also state that these prebiotics may be tolerated in small amounts used as base ingredients.

Soifer and associates pilot study (2010) compared the short-term clinical efficacy of the drug metronidazole vs. a probiotic with people who have SIBO and functional chronic abdominal distension. The study population consisted of 50 patients with chronic abdominal distension (Rome III criteria) and diagnosis of SIBO made by a lactulose H2 breath test.

The participants were divided into 2 groups, 25 in the metronidazole group and 25 in the probiotic group.  The probiotic group received a blend of L. casei, L. plantarum, S. faecalis and B. brevis.  Both groups went on the same diet, which consisted in reduced consumption of alcohol, legumes, dairy products and leafy green vegetables.

The results showed that thirteen (52%) subjects receiving metronidazole and twenty (82%) receiving the probiotic showed clinical improvement after the treatment.  All the study patients completed treatment.  No adverse events leading to treament discontinuation were observed.

Their conclusion was that the probiotics used had a higher efficacy that metronidazol and may prove successful in treating SIBO.

 

Bibliography

  • Block, Eric (2010). Garlic and other Alliums: The Lore and the Science. Publisher: The Royal Society of Chemistry, Cambridge UK.
  • Hungin et al (2005). Irritable bowel syndrome in the United States: prevalence, symptoms patterns and impact. Alimentary Pharmacology and Therapeutics; 21(11): 1365-1375.
  • Jonkers et al. (1997).  Effect of Garlic on Vancomycin Resistant Enterococci. Antimicrobial Agents and Chemotherapy; 43(12): 30-45.
  • Lawson LD & Koch HP. (1996). Garlic:  The Science and Therapeutic Application of Allium sativum L. and Related Species. Publisher: Williams and Wilkins.
  • Pyleris et al. (2012). The Prevalence of Overgrowth by Aerobic Bacteria in the Small Intestine by Small Bowel Culture: Relationship with Irritable Bowel Syndrome. Digestive Diseases and Sciences; 57(5): 1321-1329.
  • Siebecker A, Sandberg-Lewis S. (2013). Small Intestine Bacterial Overgrowth: Often-Ignored Cause of Irritable Bowel Syndrome. Townsend Letter; Feb/Mar 2013.
  • Soifer LO, Peralta D, Dima G, Besasso H. (2010). Comparative clinical efficacy of a probiotic vs. an antibiotic in the treatment of patients with intestinal bacterial overgrowth and chronic abdominal functional distension: a pilot study. Acta Gastroenterol Latinoam; 40(4): 323–7.

 

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Dr. Bardell’s Approved List of products for beauty, body, and home is a curated list of excellent clean products for the whole family. Personal care and beauty products bring as many toxins to the home as cleaning products. Check out the list: Dr. Bardell’s Approved Products for Beauty, Body and Home.
 

©2005 – 2020 BioImmersion Inc. All Rights Reserved

 

Dear Doctor

Gram-negative bacteria (GNB) are among the most significant public health problems in the world due to their high resistance to antibiotics.

GNB can send people right into the intensive care unit and lead to high morbidity and mortality due to septic shock.

What causes GNB?  A high fat diet causes a change in the GI tract microbial population to one that is dominated by gram negative bacteria (GNB).  This is a problem because GNB tend to cause the GI tract to become more more permeable (Leaky Gut Syndrome).  Increased permeability enables an increase absorption of the lipopolysaccharides (LPS) coating of molecules that make up the outer membrane of gram negative bacteria.  These LPS molecules cause our immune system to overreact, manifesting as chronic inflammation in the body.  An overload of LPS molecules can cause septic shock and death.

The Solution? Fiber and Bifidobacteria.

Cani et al. (2007, 2007a, 2008, 2009) demonstrated in their research that adding to the diet soluble fibers such as inulin (e.g., inulin found in the Original Synbiotic) stimulates the growth of Bifidobacteria sp., which cause a reduction in the number of GNB, and a reduction in gut permeability, thereby reducing the levels of LPS systemically and reducing chronic inflammation.

O F

 

Bibliography:

  • Cani et al. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut; 58(8): 1091-1103
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Cani et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes; 56:1761-72.
  • Cani et al. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia; 50: 2374-83.
  • Oliveira, J., & Reygaert, W. C. (2019). Gram negative bacteria. In StatPearls [Internet]. StatPearls Publishing.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

 

Green Facts:

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Enterobacteriaceae are a heterogeneous group widely dispersed in nature. They account for about 80% of gram-negative isolates with a myriad of disease-causing general/species in humans, including urinary tract infections, pneumonia, diarrhea, meningitis, sepsis, endotoxic shock, and many others. The general/species that frequently affect humans are EscherichiaProteusEnterobacterKlebsiella, CitrobacterYersinia, Shigella, and Salmonella among others (Oliveira, J., and Reygaert, W.C., 2019).
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Dear Doctor

You must protect yourself from an increasing toxic and pathogenic world.

The front line of your body’s exposure to these xenobiotics and pestilences is one cell layer thick. A layer that lines the inside walls of your GI tract. That is a thin layer between our inside and the outside world.

Consider that when we stretch out the GI tract, the surface area is the size of one tennis court – that is how much exposure the outside world has that can mess with our body.  The outside world is brought to us also through food, and our average lifetime worth of food is around 60 tons. That is a lot of exposure to the outside world.

So how do you best protect yourself from possible toxins and pathogens?  By making sure the GI tract barrier is strong, healthy and well armed to fight for our life.

The No. 7 Systemic Booster: The New Longevity provides the necessary ingredients that the vast majority of our population overlook in their diets.  Read the science below.

The suggested does is 1-2 tsps daily.

No.7 F

The No 7 contains:  Potent Phytonutrients– Concentrates of Organic berries, fruits, hardy vegetables, and green leafy vegetables: strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry, apple extract, pineapple, beet, broccoli florets, kale leaves, spinach leaves; BioImmersion Super Blend: Probiotics– Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium lactic, Bifidobacterium longum, Streptococcus thermophilus and Lactobacillus bulgaricus, including their Supernatant– probiotic metabolites, and their ORNs;  PrebioticsInulin from Chicory Root along with Fibers- from organic veggies, greens, fruits, and berries; and VitalNutriceuticals– Fructo Borate, Vitamin B12, Vitamin D3, Folate, and Chromium.  It contains a 30 billion CFU per tsp.

Science

We used to think of the colon as a storage place for fecal matter, on its way out, whose function was to reabsorb water and minerals.  Now the human microbiome research has come to view the colon as a home to another “organ” inside our body- the GI Microbiome, whose metabolic capacity is 100 fold that of our liver.

A healthy gut microbiome, the community of organisms residing in the colon consumes the fibers (inulins, pectins, beta glucans, resistant starches) and polyphenols (from fruits and vegetables) to grow and thrive.  The microbiome breaks down the longer phenolic chains into shorter ones that are more bioavailable, enabling these phytochemicals to enter into our body and hormetically supply multitude of benefits towards the health of all bodily systems.

Therefore, seeding the digestive system with proven probiotic organisms and eating a healthy mix of plants, berries and fruits is an absolute must for our protection and the longevity of our health.

Your diet greatly influences the make up of your GI tract microbiome.  Research data show that eating the right foods to supply plenty fiber and polyphenols on a regular basis creates a healthy balance of human friendly bacteria within our gastrointestinal system (Claussen, 2012).

Health-promoting effects of the GI Microbiome may include immunostimulation, improved digestion and absorption, vitamin synthesis, inhibition of the growth of potential pathogens and lowering of gas distension.  Detrimental effects are carcinogen production, intestinal putrefaction, toxin production, diarrhoea/constipation and intestinal infections (Saulnier, 2009).

The No. 7 Systemic Booster: The New Longevity provides the necessary nutrients and fibers that the GI Microbiome needs to thrive and protect you from the outside toxic world.

References

  • Claesson MJ, Jeffery IB, Conde S, Power SE, O’Conner EM, Cusack S, Harris HM … et al. (2012). Gut microbiota composition correlates with diet and health in the elderly. Nature; 9,488(7410). 178-84.
  • Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015). Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition54(3), 325-341. https://link.springer.com/article/10.1007/s00394-015-0852-y
  • Goldsmith Jr, Sartor RB. (2014). The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications. J Gastroenterol, 49(5): 785-98.
  • Hwang, J. T., Kwon, D. Y., & Yoon, S. H. (2009). AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols. New biotechnology, 26(1-2), 17-22 https://www.sciencedirect.com/science/article/pii/S1871678409000557
  • Liu, Z., Li, N., & Neu, J. (2005). Tight junctions, leaky intestines, and pediatric diseases. Acta Paediatr, 94(4), 386-93.
  • Maukonen J, Saarela M. (2015). Human Gut microbiota:  Does diet matter? Proc Nutr Soc; 74(1): 23-36.
  • Possemiers, S., Bolca, S., Verstraete, W., & Heyerick, A. (2011). The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals. Fitoterapia82(1), 53-66. https://www.sciencedirect.com/science/article/pii/S0367326X10001899?via%3Dihub
  • Saulnier MD, Kolida S, Gibson GR. (2009). Microbiology of the human intestinal tract and approaches for its dietary modulation. Curr Pharm Des; 15(13): 1403-14.
  • Simoes CD, Maukonen J, Kaprio J, Rissanen A, Poetiainen KH, Saarela M. (2013). Habitual dietary intake is associated with stool microbiota composition in monzygotic twins. J Nutr; 143(4): 417-23.
  • Tuohy KM, Gougolias C, Shen Q, Fava F, Ramnani P. (2009). Studying the human gut microbiota in the trans-omics era–focus on metagenomics and metabonomics. Curr Pham Des 15(13): 1415-27.
  • Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA … et al. (2011).  Linking long-term dietary patterns with gut microbial enterotypes. Science; 334(6052): 105-8.

To Your Health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Transformation to healthy diets by 2050 will require substantial dietary shifts. Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits. (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019)
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Dear Doctor

Novel strategies for controlling influenza are needed, especially for susceptible subpopulations such as those with chronic disease, or with chronic exposure to airborne pollutants.

Muller et al (2016) and Noah et al (2014) showed us, in their respective randomized double-blind trials, that eating broccoli sprouts can reduce viral loads for influenza, decrease virus-induced inflammation, and boost your antiviral natural killer cell activity.  The active molecule within broccoli sprouts that accomplishes this is sulforaphane.

Our Glucosinolates & Sulforaphanes is a powerhouse, providing a four-fold increase in the phase 2 enzymes inducing and cancer preventing molecules for which it is named.

GS FMore Powerful:  Notice that the label above guarantees a Glucosinolate level of 15,000 ppm, a Glucoraphanin level of 10,000 ppm and a Sulforaphane potential of 4,000 ppm. However, as you can see in the Certificate of Analysis below, the actual levels of these three most important ingredients are much higher, with the Glucosinolates at 21,359 ppm, the Glucoraphanins at 19,407 ppm, and the Sulforaphane yield at 8,733 ppm.  Our old beloved our Glucosinolates & Sulforaphanes product offered a 1500 ppm sulforaphane potential yield.

Organic Broc Sprout CofA

Recommended dose:  one to two capsules a day. Preferably on empty stomach AM/PM.

Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer‐related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis.   Zhang and Tang (2007) review its discovery and development as a cancer chemopreventive agent.

The preponderance of evidence available from in vitro, animal, and human studies supports the association of sulforaphane with phase II enzyme inductions.  Broccoli sprouts are the richest source of glucoraphanin which is the direct precursor to sulforaphane.  Since broccoli sulforaphane is one of the most potent inducers of phase II enzymes, exploration into broccoli’s impact on other areas of human health, such as cardiovasucular health and upper airway immunity, has been suggested (James et al., 2012).

In Qidong, China, a region where exposures to food-and air-borne carcinogens has been considerable, clinical trials indicate that interventions with well characterized preparations of broccoli sprouts may enhance the detoxication of aflatoxins and air-borne toxins, which may in turn attenuate their associated health risks including cancer in exposed individuals (Kensler et al., 2012).

References

  • James, D., Devaraj, S., Bellur, P., Lakkanna, S., Vicini, J., & Boddupalli, S. (2012). Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition reviews, 70(11), 654-665.
  • Kensler, T. W., Egner, P. A., Agyeman, A. S., Visvanathan, K., Groopman, J. D., Chen, J. G., … & Talalay, P. (2012). Keap1–nrf2 signaling: a target for cancer prevention by sulforaphane. In Natural Products in Cancer Prevention and Therapy(pp. 163-177). Springer, Berlin, Heidelberg.
  • Müller, L., Meyer, M., Bauer, R. N., Zhou, H., Zhang, H., Jones, S., … & Jaspers, I. (2016). Effect of broccoli sprouts and live attenuated influenza virus on peripheral blood natural killer cells: a randomized, double-blind study. PloS one, 11(1), e0147742.
  • Noah, T. L., Zhang, H., Zhou, H., Glista-Baker, E., Müller, L., Bauer, R. N., … & Robinette, C. (2014). Effect of broccoli sprouts on nasal response to live attenuated influenza virus in smokers: a randomized, double-blind study. PloS one, 9(6), e98671.
  • Zhang, Y., & Tang, L. (2007). Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta pharmacologica Sinica, 28(9), 1343-1354.

To Your Health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Transformation to healthy diets by 2050 will require substantial dietary shifts. Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits. (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019)
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Dear Doctor

We live in an increasingly toxic world with novel and old virulent pathogens.  Your patients’ defense system must be ready and able to protecting their health.

High quality probiotics ingested on a regular basis can greatly add to the body’s defensive ability.  The Original Synbiotic strains are chosen for their strength, compatibility, safety and their 40 years of proven ability to neutralize food borne pathogens and xenobiotics (pollution, chemicals, drugs, and heavy metals).

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The Original’s probiotics are researched pedigreed strains of lactic acid bacteria that support the development of a healthy GI tract microbiome.

A healthy gut microbiome is dependent on strong and proven probiotics, such as the Original strains. The Original Synbiotic provides a powerful symbiotic combination of Lactobacillus acidophilus, Streptococcus thermophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium longum.

Suggested Use:  Take one tsp  daily

Research

The contamination of food with aflatoxins is a worldwide problem. Mold mycotoxins compromise the blood-brain barrier and induce neurodegenerative processes. L rhamnosus binds AFB1 in vivo and reduces bio-absorption of the toxin from the gut. L. acidophilus and B. longum neutralize AFB1 and AFM1 by binding mechanisms. S. thermophilus reduces content of ochratoxin A.

Mutagens cause impaired cell function, cell death or cell transformation into cancer cells. L. acidophilus, B. longum, L. rhamnosus, S. thermophilus and L. plantarum neutralize heterocyclic amines and nitrosamines, two of the most common and powerful mutagenic molecules found in our diet.

Verocytotoxin producing E. coli s0157 are emerging food borne pathogens worldwide. B. longum neutralizes this toxin.

Heavy metals are shown to be amongst the worst toxic chemicals. But research also shows the place of probiotics in detoxifying heavy metals.

The food and water we consume are often contaminated with a range of chemicals and heavy metals, such as lead, cadmium, arsenic, chromium and mercury, that are associated with numerous diseases.  Species such as Lactobacillus and Bifidobacterium, present in the mouth, gut, and vagina have the ability to bind and detoxify these metals.

Halttunen et al. (2007) showed that Lactobacillus and Bifidobacterium species can bind lead and cadmium to their cell surface, and hold on to them through defecation.  Singh and Sharma (2010) showed that L. acidophilus was able to bind and remove arsenic from water. Robinson and Tuovinen (1984) demonstrated that L. rhamnosus in yoghurt reduced the bioaccumulation of mercury and arsenic in pregnant women and children.  Shrivastava et al. (2003) showed that lactobacilli can transform chromium (CrVI) to its less toxic form (CrIII).

The collective ability of the Original probiotic organisms to protect the frontline border of our GI tract membrane from the aggressive enterovirulent pathoges is accomplished via: the production of bactercins, creation of an acid barrier, stimulation of the cell mediated immune system, and protective colonization of enterocytes.

Cani et al. (2008) found that a high animal fat diet changes the GI tract microbiome into a population of increasing numbers of Gram-negative bacteria, which raises the level of LPS endotoxins within the gut lumen and allows their passing through the GI tract membrane into the plasma.

The research team concluded that the plasma concentration of lipopolysaccharides (LPS) controls the inflammatory tone of the body.  This means that high concentrations of LPS set the stage for endotoxemia, resulting in metabolic diseases (obesity, diabetes, CVD) and cancer.  The Original strain of lactic acid bacteria reduce the levels of gram negative bacteria in the gut and support the tightening of a leaky GI tract membrane.

The Original Synbiotic is a collection of pedigreed strains of 5 lactic acid bacteria that help our body shore up its defenses against pathogenic bacteria, virus, molds, heavy metals and much more.

References

  • Arena, M. P., Silvain, A., Normanno, G., Grieco, F., Drider, D., Spano, G., & Fiocco, D. (2016). Use of Lactobacillus plantarum strains as a bio-control strategy against food-borne pathogenic microorganisms. Frontiers in Microbiology, 7, 464.
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Gratz, S., Wu, Q. K., El-Nezami, H., Juvonen, R. O., Mykkänen, H., & Turner, P. C. (2007). Lactobacillus rhamnosus strain GG reduces aflatoxin B1 transport, metabolism, and toxicity in Caco-2 cells. Applied and environmental microbiology, 73(12), 3958-3964.
  • Halttunen et al. (2007) Rapid removal of lead and cadmium from water by specific lactic acid bacteria. Int. J. Food Microbiol; 114:30-35.
  • Monchese et al. (2012) Bioremediation and Tolerance of Humans to Heavy Metals through Microbial Processes: a Potential Role for Probiotic? AEM;78:6397-6404
  • Robinson JB, Tuovinen OH. (1984) Mechanisms of microbial resistance and detoxification of mercury and organomercury compounds: physiological, biochemical, and genetic analyses. Microbiol. Rev.; 48:95-124.
  • Shrivastava et al. (2003) Various cells of the immune system and intestine differ in their capacity to reduce hexavalent chromium. FEMS Immunol. Med. Microbiol;38:65-70.
  • Singh et al. (2010). Removal of arsenic (III) from waste water using Lactobacillus acidophilus. Bioremediat. J.;14:92-97.

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Transformation to healthy diets by 2050 will require substantial dietary shifts. Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits. (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019).