Detoxification Support

Dear Doctor

Let’s face it, we are not eating enough fiber. Recent published reviews continue to highlight the connection between eating enough fiber, especially from plants, to lower cholesterol and improve heart health.

Statins are prescribed to lower cholesterol, however, there are side-effects that are not tolerable.

Two review from the USA and the UK summarize our need to increase fiber, especially the kind that lowers cholesterol, like beta glucan.

In the USA, Dr. Ghada Soliman, an associate professor of Nutrition in the Department of Environmental, Occupational and Geospatial Health Sciences, concludes her review of the literature that higher intake of fiber can in fact lower the need for statins. Some people may need statins but in much lower dosage.

Here are other fiber functions in the article by Ghada A. Soliman:

Dietary fiber has several protective effects against chronic diseases, including cardiovascular disease, diabetes, metabolic syndrome, inflammatory bowel syndrome, diverticular disease, obesity, and colorectal cancer in the age-adjusted analysis [77,78,79,80,81,82,83,84]. For example, insoluble fiber binds to and adsorbs carcinogens, mutagens, and toxins, and therefore, prevents their harmful effects to the body, by preventing the toxins absorption and targeting them for elimination [83,85,86]. Other fiber properties include delayed colonic transit time, prolonged post-meal satiety and satiation, and induction of cholecystokinin satiety hormone [87,88]. The Academy of Nutrition and Dietetics position on fiber intake is to increase consumption of whole grains, fruits and vegetables, nuts and legumes, and that dietary fiber is associated with risk reduction of type 2 diabetes, cardiovascular disease, and select cancer types [89].

In the UK, Dr Charlotte Elizabeth Evans, an associate professor in nutritional epidemiology and public health nutrition, speaks highly of high fiber intake and the positive association between fiber and health benefits such as cardio-vascular health (2019).

Dietary fibre and cardiovascular health: a review of current evidence and policy

Charlotte Elizabeth Louise Evans:

Dietary fibre comprises many different, mainly plant-based, compounds that are not fully digested in the human gut. Insoluble fibres include cellulose, hemi-celluloses and lignin and soluble fibres include pectins, β-glucan and hydro-colloids. In the UK, the daily recommended amount has increased to 30 g but only 13 % of men and 4 % of women meet this recommendation. Currently the mean intake for adults is 21 g for men and 17 g for women. There is a wealth of epidemiological evidence based on systematic reviews of trials and cohorts to support the higher fibre recommendation. This includes evidence of reductions in the risk for CVD (both heart disease and stroke) and lower risk of type 2 diabetes, lower blood pressure, lower LDL-cholesterol, as well as some cancers. Beneficial effects of fibre operate via a diverse range of mechanisms throughout the digestive system including the mouth, stomach and small and large intestine; some of which are still not completely understood. The updated recommendation for fibre is a long way from a typical British diet and requires several daily portions of fruit and vegetables and wholegrain foods. Improving dietary fibre intakes will require a variety of actions and policies from stakeholders; however, there is currently more of a focus on reducing sugar than increasing fibre. In order to increase the number of adults meeting the fibre recommendation, social marketing and labeling of high-fibre foods are warranted as well as reformulation and wider availability of wholegrain versions of popular foods. 

References

  • Evans, C. E. L. (2019). Dietary fibre and cardiovascular health: a review of current evidence and policy. Proceedings of the Nutrition Society, 1-7.Article
  • Soliman, G. A. (2019). Dietary Fiber, Atherosclerosis, and Cardiovascular Disease. Nutrients11(5), 1155. Article

Beta Glucan Synbiotic: High Potency Cardiovascular and Metabolic Support provides these highly beneficial beta glucan and other important dietary fibers from beetroot and inulin from chicory root along with key pedigreed probiotic bacteria.

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To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Transformation to healthy diets by 2050 will require substantial dietary shifts.  Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits.  (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019)

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Longevity research teaches us that when we turn to a whole food plant-based diet, with less meat, dairy, and eggs (and refined, processed foods), we lower inflammation in every cell of our body. As we have discussed in our recent emails on the longevity field of study, inflammation is the root causative factor for most all of our chronic diseases.

Breakfast is a major meal, and hence our notoriously delicious breakfast drink that indeed lowers inflammation with a host of major nutrients that deeply nourish and energize your body. And the breakfast drink does so much more: it lubricates the bowels with fiber and polyphenols, lower cholesterol to benefits the heart, supports the liver, kidneys, immune system, brain, aids in blood sugar regulation, and fortifies bones and joints. It is an amazingly healthy drink.

Here is BioImmersion’s famous morning drink: a breakfast meal all by itself.

In a blender add: (for one person)

  • Be Regular:  Optimal Bowel Health-  1 heaping tbls.
  • Add Flax seed 1 tbls.
  • Bee Pollen- 1 tsp.
  • Fresh or frozen berries (depending on the season)- 1 cup
  • Banana or other fruit like melon, papaya, mango
  • Organic Apple juice, or pineapple, berry, or a juice of your choice- 1 cup.
  • Filtered water- 1 to 2 cups.

 

Dohrea Famous Drink

 

Further notes on Be Regular, Beta Glucan and No. 7 Systemic Booster

Be Regular

Be Regular is a gluten free, global blend of indigenous organic seeds, originating in ancient cultures from all around the world. The five organic seeds provide gentle yet effective fiber for everyday regularity.  One scoop of Be Regular offers over 7 grams of fiber towards your 25 to 35 grams a day.

We have formulated Be Regular with organic seeds from:  Amaranth, Buckwheat, Chia, Millet and Quinoa.  These seeds are ancient! They have been with us for thousands of years and globally used as foundational foods. Rich in both soluble and insoluble fibers, they contain essential nutrients such as amino acids, vitamins, minerals, complex carbohydrates with an overall low glycemic index.  Besides being organic and gluten free these seed are vegan, kosher, non GMO,

Beta Glucan

Beta Glucan is a great product for seeding the gut with good pedigreed bacteria, Supernatant and ORNs (microRNAs), along with prebiotic fibers that strongly support the integrity of the GI tract membrane, support the reduction of GI tract inflammation, support the strengthening and balancing of the immune system.

One heaping tablespoon provides 65 billion strong probiotic organisms, and our famous beta glucans with red beet root to lower cholesterol and support liver function, open and relax blood vessels, and energize the body. The beta glucans also are shown to support  prevention of variety of cancers.

No. 7 Systemic Booster

The No 7 contains:  Potent Phytonutrients– Organic berries, fruits, hardy vegetables, and green leafy vegetables: strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry, apple extract, pineapple, beet, broccoli florets, kale leaves, spinach leaves. BioImmersion Super Blend: ProbioticsBifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus, and Steptococcus thermophilus. Supernatant– probiotic metabolites, and ORNs. PrebioticsInulin from Chicory Root along with Fibers- from organic veggies, greens, fruits, and berries. VitalNutriceuticals– Fructo Borate, Vitamin B12, Vitamin D3, Folate, and Chromium.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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David Granet MD and Rob Knight PhD converse regarding the Microbiome. Some points by Knight:  Avoid fries and certain carbohydrates; but not all for fibers both soluble and insoluble are very important for microbiome health.  Also eat a rainbow of colored vegetables and fermented foods.

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Cellular Senescence means that cells cannot divide due to multiple reasons,  with inflammation posing as one of the greatest. Cellular Senescence hastens the development of chronic diseases like cardiovascular, diabetes, Alzheimer’s, dementias, cancer, immune and kidney dysfunction, IBD, and osteoarthritis among many others.

Current research has shown that certain plant polyphenols (i.e. quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential  for reducing and preventing senescence, which reduces the risk for developing chronic disease, and even reverses the onset of chronic illnesses and geriatric syndrome.  Research is now focused on the utilization of senolytic molecules in therapies.

The No. 7 Systemic Booster: the New Longevity contains both of these powerful phenolic flavonoids, quercetin and fisetin, within its high-active fruits and vegetables.  Daily dosing at 1 tsp supports the body’s ability to to fight against chronic disease.  (See Further Notes below)

 

No 7 Photo_2 copy

 

Further notes on cellular senescence: 

Chronic low-grade inflammation (LGI) in the body is an etiological factor in chronic disease and it is also a causative force in cells going into senescence.  Cellular senescence is characterized as a state where cells: (1) lose their ability to divide and renew their healthy functionality; (2) become resistant to apoptosis (cell death); and  (3) increase their production of reactive oxygen species (ROS), and secret into their external environment pro-inflammatory cytokines, bradykines, prostenoids, miRNAs, damage-associated molecular pattern proteins (DAMPs), and other pro-inflammatory mediators, chemokines that attract immune cells.  In other words, these cells create more inflammation; more collateral damage that can lead to pathology.  This condition is called a senescence-associated secretory phenotype (SASP).

Senescent cells have been identified at sites of pathology in multiple diseases.  They accumulate in adipose tissue in diabetes and with age-related metabolic dysfunction, osteoarthritic joints, the aorta in vascular hypo-reactivity and atherosclerosis and the lung in idiopathic pulmonary fibrosis.  Transplantation of small numbers senescent cells around the knee joint can cause osteoarthritis (Zhu, Y., et al. 2015).

Therefore, the discovery of strong senolytic molecules  present in certain vegetables and fruits that  are able to delay, prevent, or alleviate a number of chronic  diseases is very exciting. The No. 7 Systemic Booster: the New Longevity is a great starting point to reduce inflammation and deeply nourish our cells with the nutrients they need to function healthily.

References:

  • Kirkland, J. L., & Tchkonia, T. (2017). Cellular senescence: a translational perspective. EBioMedicine, 21, 21-28.
  • Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., … & Kirkland, J. L. (2017). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging (Albany NY), 9(3), 955.
  • Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., … & O’Hara, S. P. (2015). The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging cell, 14(4), 644-658.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Our findings here give support for the speculation that these agents [senolytics] may one day be used for treating cardiovascular disease, frailty, loss of resilience, including delayed recovery or dysfunction after chemotherapy or radiation, neurodegenerative disorders, osteoporosis, osteoarthritis, other bone and joint disorders, and adverse phenotypes related to chronologic aging.  Theoretically, other conditions such as diabetes and metabolic disorders, visual impairment, chronic lung disease, liver disease, renal and genitourinary dysfunction, skin disorders, and cancers could be alleviated with senolytics (Zhu,Y. et al., 2017).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Doctors and their patients are discovering the addictive taste of the No 7 Systemic Booster. The quality of this rich bitter chocolate taste comes alive with any juice: apple, orange, pineapple, any berry, and even carrot or beet. Taking the No 7 in just water produces a very dark, bitter, chocolate drink (although there is not chocolate in this mix!). But a little diluted juice, and the chocolate taste comes alive.

The No 7 Booster is a serious, uncompromisingly healthy drink. There are no sweeteners, fillers, or natural flavors to muck up the real power of the blend. Typically, artificial, natural, or even organic flavors have from 100-500 different components that are not required to be listed on the label. The No 7 is as pure as it is powerful.

The No 7 has our famous probiotic mix with its Supernatant and ORNs. For those of you who are waiting to have the LactORN back – we have the ORNs (known in the scientific literature as microRNAs) now in the No 7, High ORAC, Cranberry Pomegranate, and the Beta Glucan.  We have decided to pull the incredible immune boosting abilities of the microRNAs into our formulas.

Life is getting more polluted, and chronic illnesses more difficult to treat. The No 7 is an effective tool with high actives and polyphenols from purposely selected veggies, greens, fruits, berries, extracts, nutriceuticals, and our super probiotic mix.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The No 7 Longevity encompasses a great deal of research into better health. The scientific community has much more to discover, yet many of the findings do show a clear path toward health that is not riddled by chronic conditions that can be supported by a plant-based diet of whole foods, a cleaner home and office environments, exercise, toxic free personal and home cleaning products, organic or pesticides & herbicides free foods, and clean, researched based supplementations (see Living Well – Dying Well , Chapter 8).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

GS Photo JPEGBroccoli sprouts provide an exceptionally rich source of sulforaphane – a potent inducer of enzymes that protect against chemical carcinogens.  In fact, three-day-old sprouts of broccoli contain 10-100 times higher levels of glucoraphanin (the glucosinolate of sulforaphane) than do the mature broccoli plants.  Broccoli sprouts are the richest natural source for sulforaphanes, and the BioImmersion organic broccoli sprouts selected for the Glucosinolate & Sulforaphane are at the 100 fold level.

Our Glucosinolate & Sulforaphane replaces the Cruciferous Sprout Complex as it supplies 6-8 times the potency of the most important phytochemical, sulforaphane.

Glucosinolate & Sulforaphane comes in two sizes: the 120 capsule size as shown to the right and is in stock now, and the 60 capsule size bottle that will be available in three weeks.  With a dose being 1-2 capsules a day, the larger bottle will give a 2-4 month supply.

Food Science

Broccoli sprouts are a rich source of glucosinolates and isothiocyanates, shown in research to induce phase 2 detoxication enzymes, boost antioxidant status, and protect animals against chemically induced cancer.  Glucosinolates are hydrolyzed by myrosinase (an enzyme found in plants and bowel microflora) to form isothiocyanates.  Glucosinolates are inert as phase 2 enzyme inducers and must be hydrolyzed (break-down) to generate the active isothiocyanates (Shapiro et al., 2001).

Sulforaphane (SFN) is a compound derived from cruciferous vegetables with numerous bioactivities (Su et al., 2018). In fact, Broccoli and especially broccoli sprouts, accumulate significant amounts of the phytonutrient glucoraphanin, which is metabolized in vivo to the biologically active sulforaphane (SFN).  The preponderance of evidence available from in vitro, animal and human studies supports the association of sulforaphane with phase II enzyme induction (James et al., 2012), moreover, SFN strongly displays both anticarcinogenic and anticancer activity by modulating ‘key signaling pathways and genes involved in the induction of apoptosis, cell cycle arrest, and inhibition of angiogenesis’ (Su et al., 2018; see also Peng et al., 2015; Zhang & Tang, 2007).

SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN (Peng et al., 2015).

Sulforaphane is found in research to have many different health benefits:  Alzheimer’s (Kim et al., 2013), Cardiovascular Disorders (Angeloni et al., 2009), Diabetes (Bahadoran et al., 2012), Asthma- upper airway congestion, (Riedl et al., 2009) and Detoxification in all cells, and in particular with Liver Phase II detoxification enhancement (Riedl et al., 2009).

Sulforaphane (SFN) has been demonstrated to be an effective chemopreventive agent for many years (Shapiro et al., 2001), with positive effects against different kinds of cancers, such as cervical (Chen et al., 2016; Abdull et al., 2013), breast (Peng et al., 2015; Li et al., 2010), bladder (Leone et al., 2017), renal cell carcinoma (Juengel et al., 2016), non-small-cell lung cancer (Wang et al., 2017), and colon and prostate cancers (Clarke et al., 2008; Abdull et al., 2013).

We will continue to examine the research on this important food in the next few weeks.

References

Abdull Razis, A. F., Konsue, N., & Ioannides, C. (2018). Isothiocyanates and Xenobiotic Detoxification. Molecular nutrition & food research62(18), 1700916.

Abdull, R., Ahmad, F., & Noor, N. M. (2013). Cruciferous vegetables: dietary phytochemicals for cancer prevention. Asian Pacific Journal of cancer prevention, 14(3), 1565-1570.

Angeloni, C., Leoncini, E., Malaguti, M., Angelini, S., Hrelia, P., & Hrelia, S. (2009). Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential. Journal of agricultural and food chemistry57(12), 5615-5622.

Bahadoran, Z., Tohidi, M., Nazeri, P., Mehran, M., Azizi, F., & Mirmiran, P. (2012). Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. International journal of food sciences and nutrition63(7), 767-771.

Cheng, Y. M., Tsai, C. C., & Hsu, Y. C. (2016). Sulforaphane, a dietary isothiocyanate, induces G2/M arrest in cervical cancer cells through cyclinB1 downregulation and GADD45β/CDC2 association. International journal of molecular sciences, 17(9), 1530.

Clarke, J. D., Dashwood, R. H., & Ho, E. (2008). Multi-targeted prevention of cancer by sulforaphane. Cancer letters, 269(2), 291-304.

Fahey, J. W., Zhang, Y., & Talalay, P. (1997). Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proceedings of the National Academy of Sciences, 94(19), 10367-10372.  http://www.pnas.org/content/94/19/10367

James, D., Devaraj, S., Bellur, P., Lakkanna, S., Vicini, J., & Boddupalli, S. (2012). Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition reviews70(11), 654-665.

Juengel, E., Maxeiner, S., Rutz, J., Justin, S., Roos, F., Khoder, W., … & Blaheta, R. A. (2016). Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro. Oncotarget, 7(51), 85208.

Kim, H. V., Kim, H. Y., Ehrlich, H. Y., Choi, S. Y., Kim, D. J., & Kim, Y. (2013). Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model. Amyloid20(1), 7-12.

Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H. F., Newman, B., … & Sun, D. (2010). Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clinical Cancer Research, 1078-0432.

Peng, X., Zhou, Y., Tian, H., Yang, G., Li, C., Geng, Y., … & Wu, W. (2015). Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells. Oncology reports34(3), 1565-1572.

Riedl, M. A., Saxon, A., & Diaz-Sanchez, D. (2009). Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clinical immunology130(3), 244-251.

Shapiro, T. A., Fahey, J. W., Wade, K. L., Stephenson, K. K., & Talalay, P. (2001). Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.Cancer Epidemiology and Prevention Biomarkers, 10(5), 501-508.  http://cebp.aacrjournals.org/content/10/5/501.long

Su, X., Jiang, X., Meng, L., Dong, X., Shen, Y., & Xin, Y. (2018). Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity2018.

Wang, D. X., Zou, Y. J., Zhuang, X. B., Chen, S. X., Lin, Y., Li, W. L., … & Lin, Z. Q. (2017). Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways. Acta Pharmacologica Sinica, 38(2), 241.

Zhang, Y., & Tang, L. (2007). Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta pharmacologica Sinica, 28(9), 1343-1354.


Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The Environmental Working Group is a most important organization to get to know.  Their mission is to empower people to live healthier lives in a healthier environment. With breakthrough research and education, they drive consumer choice and civic action.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved