Dear Friends
HO Front Low Rez
We are very excited to present to you our High ORAC Synbiotic.  It’s back with an enhanced formula and a new look—a beautiful new label.

What’s new?

A higher probiotics count:  We’ve increased the CFUs (Colony Forming Units) to 25 billion per capsule.

More berries and extracts: We have added Quercetin, Resveratrol, and Strawberry.

Higher ORAC value:  The berry mixture provides 3000 ORAC (Oxygen Radical Absorbent Capacity)!

Let’s look at the new proprietary blend per capsule:

  • L. acidophilus & B. longum– 250mg
  • Grape Seed Extract, Wild Blueberry, Quercetin, Resveratrol, Wild Bliberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry & Inulin- 250mg.

Please notice that underneather the High ORAC Synbiotic name on the label it say:  “Post Antibiotic Care”.  (See Food Science and the References below for the scientific  conversation on this topic.)

Food Science:

The problem with antibiotics is that along with killing off the bad bacteria, antibiotics also kill the good gut bacteria — the protective bacteria such as Lactobaccilus and Bifidobacteria.  For many years researchers have warned us that antibiotics destroy the protective layer of good bacteria on our gut membrane, resulting in chronic inflammation (Barbut,f. & Petit, J.C., 2001; Bergogne-Berezin, E., 2000).

Both the Bifidobacteria longum and the Lactobacillus acidophilus strains are used in the High ORAC Synbiotic Formula to re-colonize and protect the GI membrane after antibiotic therapy. Bifidobacteria longum and Lactobacillus acidophilus colonize the GI tract membrane, thereby blocking out the pathogens; and also kill pathogenic microorganisms by producing antimicrobial peptides (bacterocins) against them (Hickson et al., 2007; Syngai et al., 2016).

The large offering of berry polyphenols, organic acids, and other phytochemicals offer a powerful antimicrobial and anti-inflammatory support (Grace et al., 2014; Nohynek et al., 2006) . Along with the inulin (a soluble fiber derived from organic chicory root), berries are also a great prebiotic for these good lactic acid bacteria (Puupponen-Pimia et al., 2005; Vendrame et al., 2011). (See the links to the references below for scientific support.)

References:

  • Barbut, F., & Petit, J. C. (2001). Epidemiology of Clostridium difficile‐associated infections. Clinical Microbiology and Infection, 7(8), 405-410.
  • Bergogne-Berezin, E. (2000). Treatment and prevention of antibiotic associated diarrhea. International journal of antimicrobial agents, 16(4), 521-526.
  • Cardona, F., Andrés-Lacueva, C., Tulipani, S., Tinahones, F. J., & Queipo-Ortuño, M. I. (2013). Benefits of polyphenols on gut microbiota and implications in human health. The Journal of nutritional biochemistry, 24(8), 1415-1422. http://www.sciencedirect.com/science/article/pii/S0955286313000946
  • Cremonini FI, Di Caro SI, Nista EC, Bartolozzi F, Capelli GI, Gasbarrini G, Gasbarrini AN. (2002). Meta‐analysis: the effect of probiotic administration on antibiotic‐associated diarrhoea. Alimentary pharmacology & therapeutics, 16(8), 1461-1467.
  • Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.
  • Grace, M.H., Esposito D., Dunlap K.L., & Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries. J Agric Food Chem, 62(18), 4007-17. doi: 10.1021/jf403810y.
  • Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.
  • Haslam, E., Lilley, T. H., Warminski, E., Liao, H., Cai, Y., Martin, R., … & Luck, G. (1992). Polyphenol complexation: a study in molecular recognition. ACS Publications.
  • Hattori, M., Kusumoto, I. T., Namba, T., Ishigami, T., & Hara, Y. (1990). Effect of tea polyphenols on glucan synthesis by glucosyltransferase from Streptococcus mutans. Chemical and Pharmaceutical Bulletin, 38(3), 717-720.
  • Joseph, S.V., Edirisinghe, I., & Burton-Freeman, B.M. (2014). Berries: anti-inflammatory effects in humans. J Agric Food Chem, 7; 62(18), 3886-903. DOI:10.1021/jf4044056
  • Kemperman, R.A., Bolca, S., Roger, L.C., Vaughan, E.E. (2010). Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities
    Microbiology, 156 (11), pp. 3224-3231
  • Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.
  • Nohynek, L. J., Alakomi, H. L., Kähkönen, M. P., Heinonen, M., Helander, I. M., Oksman-Caldentey, K. M., & Puupponen-Pimiä, R. H. (2006). Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens. Nutrition and cancer, 54(1), 18-32.
  • Puupponen-Pimiä, R., Nohynek, L., Hartman-Schmidlin, S., Kähkönen, M. Heinonen, M., Mata-Riihinen, K. et al.(2005). Berry phenolics selectively inhibit the growth of intestinal pathogens.  J. Appl Microbiol, 98, pp. 991-1000
  • Sirk, T. W., Friedman, M., & Brown, E. F. (2011). Molecular binding of black tea theaflavins to biological membranes: relationship to bioactivities. Journal of agricultural and food chemistry, 59(8), 3780-3787.
  • Sirk, T. W., Brown, E. F., Friedman, M., & Sum, A. K. (2009). Molecular binding of catechins to biomembranes: relationship to biological activity. Journal of agricultural and food chemistry, 57(15), 6720-6728.
  • Stapleton, P. D., Shah, S., Ehlert, K., Hara, Y., & Taylor, P. W. (2007). The β-lactam-resistance modifier (−)-epicatechin gallate alters the architecture of the cell wall of Staphylococcus aureus. Microbiology, 153(7), 2093-2103.
  • Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of Food Science and Technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0
  • Vendrame, S., & Klimis-Zacas, D. (2015). Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades. Nutr Rev, 73(6), 348-58. DOI:10.1093/nutrit/nuu066.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Bacteria in an average human body number ten times more than human cells, for a total of about 1000 more genes than are present in the human genome.  An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.   Check out NIH’s the Human Microbiome Projects 2017 website.
 

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