Our Cranberry Pomegranate Synbiotic embodies a high potency and powerful ability for all sorts of bladder and UTI issues. But the combination of supernatant with ORNs, probiotics, cranberries, and pomegranates do so much more!
The phytonutrients are more concentrated, standardize to 6% quinic acid for the cranberry and 40% punicalagins for the pomegranate extract.
There are now five different organisms of probiotics in the formula. We grow them as whole organisms with their supernatant and ORNs. We selected organisms that have a natural antimicrobial abilities against hospital generated infections.
The supernatant component of the product is much more comprehensive, dramatically enhancing its benefits. It has our typical famous metabolites of the Lactobacillus bulgaricus and Streptococcus thermophilus plus the metabolites of our added three more organisms, five all together! Supernatant contains the food fermentation by-products (metabolites) that include lactic acids, amino acids, folates, bacterocins, biosurfactants and various beneficial enzymes such as bile salts hydrolase and lactase. And of course, the supernatant also has the ORNs (oligoribnucleotides- their shorter chains of microRNAs), which prime the immune system and activate the rapid growth of these powerful probiotic organisms.
The prebiotic per capsule is 100mg of organic chicory root inulin (the total amount of ingredients per capsule is 500mg). Since our probiotics wake up much more rapidly due to complete sets of ORNs, they need food to grow.
In research, these ingredients show a reduction, not only, to the risk of UTI associated conditions but for both colon and breast cancers as well.
- Vaginal eubiosis- Vaginal eubiosis is characterised by beneficial lactobacillus-dominated microbiota. In contrast, vaginal dysbiosis (e.g. bacterial vaginosis, BV), characterized by an overgrowth of multiple anaerobes, is associated with an increased risk of adverse urogenital and reproductive health outcomes. The Lactobaccilus sp. in our Cranberry Pomegranate Synbiotic are strong lactic acid producers.
- Biosurfactants- The role of Lactobacillusspecies in the female urogenital tract as a barrier to infection is of considerable interest. These organisms are believed to contribute to the control of vaginal microbiota by competing with other micro-organisms for adherence to epithelial cells and by producing biosurfactants (Rodrigues, L. et al., 2006). The good probiotics in this formula have demonstrated the ability to produce mucins as biosurfactants against bacterial, fungal and viral pathogens.
- Cancer Protection Support- Ou, J et al. (2012) in their paper, Association between low colonic short-chain fatty acids and high bile acid in high colon cancer risk populations, proposed that the influence of diet on colon cancer risk is mediated by the microbiota. Their results suggested that the higher risk of colon cancer in Americans may be partly explained by their high-fat and high-protein, low complex carbohydrate diet, which produces colonic residues that promote microbes such as Clostridia and E. coli to produce potentially carcinogenic secondary bile acids and less antineoplastic SCFAs. Our collection of good bacteria in this formula are SCFA producers and secondary bile acids reducers as you can see with one of their metabolites being the enzyme bile salts hydrolase. These good bugs also put out bacterocins agains Clostridiaand E. coli.
- Breast Cancer- Costarelli, V., and Sanders, T.A.B. (2002) found that the mean plasma secondary bile salt derivative DCA concentration were 52% higher in patients with breast cancer compared with controls. Reducing gut levels of DCA will reduce plasma levels. Thereby, reducing this risk factor.
- Colon Cancer- AJouz, H., Mukherjui, D., and Shamseddine, A. in their 2014 research paper stated that bile acids going into the intestines stimulate growth in the colon of Clostridia which convert primary to secondary bile acids, and secondary bile acids that were shown to be carcinogenic. Hence the important of our good bugs that produce bacterocins to reduce Clostridial populations.
- Animal Fat-Rich Diets- There is increasing evidence (Barrasa, J.I. et al. 2013) that the continous exposure to certain hydrophobic bile acids, due to a fat-rich diet may induce oxidative DNA damage that, in turn, may lead to colorectal carcinogenesis.
- Tachedjian, G., Aldunate, M., Bradshaw, C. S., & Cone, R. A. (2017). The role of lactic acid production by probiotic Lactobacillus species in vaginal health. Research in microbiology, 168(9-10), 782-792. https://www.sciencedirect.com/science/article/pii/S0923250817300839?via%3Dihub
- Rodrigues, L., Banat, I. M., Teixeira, J., & Oliveira, R. (2006). Biosurfactants: potential applications in medicine. Journal of Antimicrobial Chemotherapy, 57(4), 609-618. https://academic.oup.com/jac/article/57/4/609/669417
- Ou, J., DeLany, J. P., Zhang, M., Sharma, S., & O’Keefe, S. J. (2012). Association between low colonic short-chain fatty acids and high bile acids in high colon cancer risk populations. Nutrition and cancer, 64(1), 34-40.
- Costarelli, V., & Sanders, T. A. B. (2002). Plasma deoxycholic acid concentration is elevated in postmenopausal women with newly diagnosed breast cancer. European journal of clinical nutrition, 56(9), 925. https://www.nature.com/articles/1601396
- Ajouz, H., Mukherji, D., & Shamseddine, A. (2014). Secondary bile acids: an underrecognized cause of colon cancer. World journal of surgical oncology, 12(1), 164.
- Barrasa, J. I., Olmo, N., Lizarbe, M. A., & Turnay, J. (2013). Bile acids in the colon, from healthy to cytotoxic molecules. Toxicology in Vitro, 27(2), 964-977.
We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
Cranberry consumption has shown prophylactic effects against urinary tract infections (UTI). Anti-adhesive activity of cranberry phenolic compounds and their microbial-drived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures
González de Llano, D., Esteban-Fernández, A., Sánchez-Patán, F., Martínlvarez, P. J., Moreno-Arribas, M., & Bartolomé, B. (2015). Anti-adhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures. International journal of molecular sciences, 16(6), 12119-12130.
In the study sited below data indicated that both pomegranate aril and peel extracts have an effective antimicrobial activity, as evidenced by the inhibitory effect on the bacterial growth of two important human pathogens, including Staphylococcus aureus and Escherichia coli.
Pagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., & Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831. DOI: 10.1016/j.foodchem.2015.06.028
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