Supernatant Synbiotic

Dear Friends

Cox and fellow researchers concluded in their paper, Lactobacillus casei Abundance is Associated with Profound Shifts in the Infant Gut Microbiome, that supplementing infants with Lactobacillus casei rhamnosus is positively associated with the promotion of a stable, even, and functionally redundant infant gastrointestinal community; and the reduced risk of atopy and asthma later in life (Cox et al., 2010).

Cox et al. (2010) hypothesize that Lactobacillus casei subsp. Rhamnosus  promote a clustering (a consortium of bugs that work well together) of known probiotic species within the infant gut that are more resistant to perturbation and outgrowth of pathogens (See Food Science below).

A randomized, controlled, double-blind study of 159 newborns, found that early feeding of Lactobacillus casei decrease the rate of atopic dermatitis at age two by 50% (Kalliomaki et al., 2001) and that this protective effect was sustained past infancy (Kalliomaki et al., 2003).

Colonization of the infant gut microorganisms over the first year of life is crucial for development of a balanced immune response; and, early alterations in the gastrointestinal microbiota of neonates has been linked with subsequent development of asthma and atopy in older children (Cox et al., 2010).

Therapeutic Food Protocol for the Neonate LactORN Bottle 2

  • LactORN– 1/8th of a tsp twice a week (one way is to offer LactORN on your fingertip).

Comment:  LactORN contains Lactobacillius casei rhamnosus. LactOrn is blended with inulin derived from organic chicory root, functioning as an important prebiotic fiber.  It has a naturally sweet taste that babies and adults love.

Others of our synbiotic formulas, that have proven to be powerful probiotic formulas for children, are the Original Synbiotic, the Beta Glucan Synbiotic, and the Supernatant Synbiotic.  Click on their links to see their ingredients.  They all contain L. casei rhamnosus plus other good bugs that L. casei promotes a clustering for a healthy and stronger microbiome.

Food Science

Cox et al.’s (2010)  research question centered upon whether the demonstrable positive effects of L. casei rhamnosus was the result of a species-specific increase in relative abundance that accounts for its protective benefits, or, if there is a global effect on the complex GI microbial consortium.  In other words, is it the L. casei rhamnosus all by itself that is doing the disease-reducing work? Or, is it the presence of L. casei that somehow promotes the growth of other good probiotic organisms, and all together as a consortium (cluster) they protect and enhence the baby’s microbiome. They concluded it was the later, it takes a village to raise a baby!

Analysis of the phylogenetic (physical form/identity) differences characteristic of samples with high L. casei rhamnosus revealed a large number of taxa (families of organism) increased in relative abundance in these communities.  These included a number of known beneficial species belonging to the Lactobacillaceae and Bifidobacteriaceae.  Community phylogenetic metrics demonstrated that the promoted taxa were strongly phylogenetically related; and, suggests functional redundancy with GI communities that possess L. casei rhamnosus in high abundance.

In summary the Cox et al. L. casei rhamnosus study demonstrates that high abundance of this probiotic organism is associated with a dramatic change in GI microbial community composition in infants, impacting the relative abundance of a large number of taxa that can be beneficial in reducing the risk of allergy and atopy later in life.


  • Cox, M.J., Huang, Y.J., Huang Y.J., Fujimura, K.E., Liu, J.T., McKean, M., Boushey, H.A., Segal, M.R., Brodie, E.L., Cabana, M.D., Lynch, S.V. (2010). Lactobacillus casei Abundance Is Associated with Profound Shifts in the Infant Gut Microbiome. PLOS| one; Tenth Anniversary. Full paper.
  • Kalliomaki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P. et al (2001). Probiotic in primary prevention of atopic disease: a randomized placebo-controlled trial. Lancet; 357: 1076-1079.
  • Kalliomaki, M., Salminen, S., Poussa, T., Arvilommi, H., Isolauri, E. (2003). Probiotics and prevention of atopic disease: 4-year follow-up of a randomized placebo-controlled trial. Lancet; 361: 1869-18

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Watch the new trailer An Inconvenient Sequel: Truth to Power.    The sequel to An Inconvenient Truth.  In theatres July 28, 2017.

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Well, in just 12 days from today it’s the Hawaii Doc Talks Convention!, but who’s counting.

On Friday March 3rd we will host the breakfast in Maui and teach on a topic that gets right to the heart of the matter regarding food as medicine:  The Intelligence and Power of Therapeutic Food Supplements: Science, Research, and Protocol.

Click on the above link to the see our learning objectives for the doctors.  The third objective is: Discover the next generation probiotics — infection fighting Supernatant metabolites and immune boosting microRNA.

Remember, if you can’t join us this time around, I would be more than happy to meet you via the zoom meeting format online.  Just let me know and we’ll set it up.

The two photos below present our synbiotic formulas.  The top one highlighting our new LactORN Synbiotic and the photo below seven more probiotic offerings.


Understanding our microbiome is without a question one of the hottest topics in medicine. Hippocrates, 2400 years ago, said that all disease begins in the gut.  In a recent speech Dr. Francis Collins, past director of the Human Microbiome Project, and present director of the NIH said,

We are a chimera-like creatire whose healthy metabolic and physiologic functioning is governed by not only our 10 trillion human cells and their 22,000 genes but also by our human microbiome community that co-habitate our bodies, all 100 trillion of them with their 2 to 8 million genes—most of them bacteria living in our GI tract. (2015, Supercharging Science for the Superorganism)


“An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.”  (HMP Home page).

The microbiome must be taken into account regarding metabolic diseases (Metabolic Syndrome, Obesity, Diabetes, Heart Disease), gastrointestinal disease (IBS, IBD), and neuroligical health.

Yours truly,

Seann Bardell CEO
BioImmersion Inc.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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  • Dr. Francis Collins, the Director of the NIH recently said “The time of the importance of the microbiome and human health has arrived.  Our gut microbiome is of central importance for our immune system health, our neural-transmitter health, our GI tract health, and our metabolic health.

Dear Friends

For support against Traveler’s Diarrhea, and other pathogenic maladies that one can be exposed to and catch while traveling, a good garlic supplement, as well as along a potent probiotic can be your best friend.

Therapeutic Food recipes for Healthy Travels: 

Organic Garlic: 1 to 2 capsules daily
Supernatant Synbiotic: 1 capsule daily
LactORN: 1 level tsp. twice a week


Candidiasis Support

April 12, 2016

Dear Friends

Did you know that nosocomal infections of multiply resistant pathogens kill more patients each year than breast cancer and HIV combined?  The war on pathogens with antibiotics is not a war that we are winning.  Picking a fight with natural selection is not a smart thing to do (Read, 2012).

The human gut contains a vast ecosystem of microorganisms, a flora that must be ecologically managed well by us, in order to be truly healthy.  The overuse and misuse of antibiotics in medicine, the practice of giving cattle low growth promoting doses of antibiotics has created grave gastrointestinal problems.  There are better ways to manage the ecosystem within our gut and control the overgrowth of pathogens, without antibiotics.


Heavy Metal Detox

November 18, 2015

Dear Friends

Heavy metals are shown to be amongst the worst toxic chemicals. But research also shows the place of probiotics in detoxifying heavy metals. For your consideration: add Bioimmersion’s probiotics. Here’s why.

  • Original Synbiotic Formula- one teaspoon daily.
  • Supernatant Synbiotic Formula- one capsule daily.


The food and water we consume are often contaminated with a range of chemicals and heavy metals, such as lead, cadmium, arsenic, chromium and mercury, that are associated with numerous diseases.  Species such as Lactobacillus and Bifidobacterium, present in the mouth, gut, and vagina have the ability to bind and detoxify these metals.

Halttunen et al. (2007) showed that Lactobacillus and Bifidobacterium species can bind lead and cadmium to their cell surface, and hold on to them through defecation.  Singh and Sharma (2010) showed that L. acidophilus was able to bind and remove arsenic from water. Robinson and Tuovinen (1984) demonstrated that L. rhamnosus in yoghurt reduced the bioaccumulation of mercury and arsenic in pregnant women and children.  Shrivastava et al. (2003) showed that lactobacilli can transform chromium (CrVI) to its less toxic form (CrIII).


  • Halttunen et al. (2007) Rapid removal of lead and cadmium from water by specific lactic acid bacteria. Int. J. Food Microbiol; 114:30-35.
  • Robinson JB, Tuovinen OH. (1984) Mechanisms of microbial resistance and detoxification of mercury and organomercury compounds: physiological, biochemical, and genetic analyses. Microbiol. Rev.; 48:95-124.
  • Singh et al. (2010). Removal of arsenic (III) from waste water using Lactobacillus acidophilus. Bioremediat. J.;14:92-97.
  • Shrivastava et al. (2003) Various cells of the immune system and intestine differ in their capacity to reduce hexavalent chromium. FEMS Immunol. Med. Microbiol;38:65-70.
  • Monchese et al. (2012) Bioremediation and Tolerance of Humans to Heavy Metals through Microbial Processes: a Potential Role for Probiotic? AEM;78:6397-6404

For further comments see Clinical Notes.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Clinical Notes:

Having both the Supernatant Synbiotic Formula and the Original Synbiotic Formula gives you the option of taking a capsule or a powder.  Both formulas provide excellent support for the chelation and detoxification of toxic heavy metals.  They both contain multiple, but different, species of Lactobacillus and Bifidobacterium.  If you want the maximum diversity of species take a capsule of Supernatant in the morning and a teaspoon of Original before bed (or vise versa).

Green Facts

Globe_Home 3Pollution is theft.  Listen to this interview with Robert Kennedy Jr., who is truly one of our great front-line fighters against the corporate giants that are polluting our world and sickening humanity.