Phyto Power

Dear Friends

Alzheimer’s has moved up to the number three cause of death in the United States just under cancer and heart disease (NIH- National Institute of Aging, 2019).

Julien et al. (2009) compared the concentration of SIRT1 in the brains of AD patients and controls. In the first group of 19 patients and 22 controls,  a significant reduction of SIRT1 in the parietal cortex of AD patients was found.  Further analyses in a second cohort of 36 subjects confirmed that cortical SIRT1 was decreased in AD but not in individuals with mild cognitive impairments.  A significant relationship between SIRT1 levels and global cognition scores proximate to death was also found. Collectively, their results indicate that loss of SIRT1 is closely associated with the accumulation of amyloid-beta and tau in the cerebral cortex of persons with AD.  Furthermore, autopsies of Alzheimer’s victims reveal that loss of sirtuin enzyme activity is closely associated with the accumulation of the plaques and tangles.

Plants (fruits, berries, veggies, and greens) contain key phytonutrients, namely polyphenols. In research, an increasing number of polyphenols are being found to turn on a family of our anti-aging genes called sirtuins.  Sirtuins, particularly SIRT1 expression, is shown to reduce and eliminate amyloid-B and tangles, two protein derangements that are symptomatic of Alzheimer’s.   High heat cooked meats and fats create a molecule called advanced glycation end products (AGEs) which when present in the blood turn off the sirtuin gene expression, thereby turning off the expression of these anti-aging genes (Julien et al., 2009).

The Therapeutic Food Supplements  boost our body with key plant polyphenols that turn on the sirtuins.  Each of the four products is designed to supply ample amounts of phytonutrients and in particular polyphenols such as resveratrol, quercetin, and catechins to  enhance brain function.

For preventing cognitive decline and beginning stages of dementia, add to your protocol the High ORAC Synbiotic  with standardized high levels of  resveratrol and quercetin.

For a progressive decline and Alzheimer’s, add to the High ORAC a more robust protocol of powerful polyphenols to regenerate neurons in the brain:

References:

  • Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017). Sirtuins, a promising target in slowing down the ageing process. Biogerontology,18(4), 447-476.
  • Julien, C., Tremblay, C., Emond, V., Lebbadi, M., Salem Jr, N., Bennett, D. A., & Calon, F. (2009). Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 68(1), 48-58.
  • Uribarri, Jaime, Sandra Woodruff, Susan Goodman, Weijing Cai, Xue Chen, Renata Pyzik, Angie Yong, Gary E. Striker, and Helen Vlassara. (2010). “Advanced glycation end products in foods and a practical guide to their reduction in the diet.” Journal of the American Dietetic Association110, no. 6: 911-916.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Our diet is a major factor in whether we succumb to Alzheimers or not.  Eating primarily a whole-foods plant-based diet with meat and fat being more like a condiment puts the odds highly in one’s favor on not becoming its victim (Uribarri et al., 2010).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Doctor

Aging is characterized by a condition of rising levels of free radicals that generates increasing cellular senescence.

Only recently has aging itself been viewed as a treatable condition, with an etiology related to excessive ROS levels that lead to cellular senescence, a process by which cells enter a permanent state of cell cycle arrest. Although senescent cells lost their proliferative capacity, they still are able to secrete a range of proinflammatory molecules through the senescence associated secretory phenotype (SASP).

Patients with coronary artery disease show increased expression of the proinflammatory molecules MCP-1, IL-6, IL-1β and tumor necrosis factor α (TNF-α), all of which are secreted by senescent cells through the SASP.

In Serino and Salazar’s 2019 review, Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease, they discuss molecular mechanisms by which polyphenols improve anti-oxidant capacity, mitochondrial function and autophagy, while reducing oxidative stress, inflammation and cellular senescence in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs). They also  discuss the therapeutic potential of polyphenols in reducing the effects of the SASP and the  incidence of CVD.

The following Therapeutic Food protocol makes sense in light of Serino and Salazar’s research. (See also Food Science below)

Therapeutic Food Support:

Suggestions:  Add one tsp No. 7 to your smoothy, or to your shot glass of diluted juice add one tsp No. 7 and swig down the Glucosinolate capsule and 2 capsule of Phyto Power.   Try it for a couple of months and see how you feel.

Food Science:

Lai et al. (2015) reported that total fruit intake (g/day) derived from a 217-item Food Frequency Questionnaire was obtained from 30,458 women (aged 35–69 years) at baseline from 1995–1998., the richest sources of phenolic compounds, correlated with improved cardiovascular health with an estimated 6–7% reduction in deaths from CVDs for every 80 g portion. This study concluded that total fruit intake rather than intake of a specific type of fruit is protective against CVD. In terms of specific types of fruits, commonly researched varieties include berries, such as blackberries, raspberries, black raspberries and blueberries, grapes, citrus fruit, pomegranates, strawberries and apples. These fruits are rich in polyphenols like flavanols, flavonols, anthocyanins, procyanidins, sterols, carotenoids, and hydroycinnamic acids.

The Therapeutic Food Supplement protocol above provides a rich diversity of high active fruits and vegetables.

References:

  • Serino, A., & Salazar, G. (2019). Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease. Nutrients,11(1),
  • Lai, H. T. M., Threapleton, D. E., Day, A. J., Williamson, G., Cade, J. E., & Burley, V. J. (2015). Fruit intake and cardiovascular disease mortality in the UK Women’s Cohort Study. European journal of epidemiology, 30(9), 1035-1048.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Kaiser Permantente has published a remarkable nutritional update for their 15,000 physicians who care for their 10 million members.  Kaiser is now telling doctors that healthy eating may best be achieved with a plant-based diet, defined as a regiment that “encourages whole, plant-based foods and discourages meats, dairy and eggs as well as all refined and processed junk food (Tuso, 2013).”

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Doctor

Over the next week or two we will focus on Heart Disease, still the No. 1 killer in the developed world. (WHO, 2016).

No.1 Cause of Death

The No. 1 killer in the industrial world is Heart Disease.  How can Therapeutic Food help to prevent HD?

In industrialized countries isolated systolic hypertension (ISH) increases steeply with age. Many Americans over the age of 60 have ISH, which is increasingly recognized as a cardiovascular risk. Several studies have shown the strong association between ISH and stroke, kidney failure, cardiovascular morbidity and mortality (Gasowski et al, 2002; Vaccarino et al, 2001).
Reversing or stabilizing the increased arterial stiffness associated with age and disease by targeting any or all of its causes provides of a number of promising new approaches to treatment of systolic hypertension and its sequel, the main causes of mortality and morbidity (Greenwald SE, 2007).

Therapeutic Food supplements magnify the protective benefits of key phytonutrients that support the reduction of ISH.

Therapeutic Food protocol to support protection from ISH:

  • Phyto Power, wild crafted– 2 capsules BID.
  • Be Regular– 2 heaping tbl taken as a meal replacement three times weekly.
  • No. 7 Systemic Booster– 1 tsp at breakfast
  • Beta Glucan High Potency Synbiotic– 1 heaping tbl BID before 2 largest meals.
  • Chromium, Bio-organic with Beet– 1 capsule BID.

Food Science:  In this email we’ll focus on the Phyto Power

Phyto Power copy

Research has shown that the catechin family of flavonoids provide protective phytonutrients particularily from catechin, epicatechins and epigallocatechin gallate.

Endothelial dysfunction, a prognostically relevant key event in atherosclerosis, is characterized by a decreased bioactivity of nitric oxide (NO) and impaired flow-mediated vasodilation (FMD).  Schroeter et al., (2006) showed in healthy male adults that the ingestion of flavanol-rich cocoa was associated with acute elevations in levels of circulating NO species, an enhanced FMD response of conduit arteries, and an augmented microcirculation.

Nagao et al., (2007) observed, in a protocol sample of 240 subjects, that green tea extract high in catechins reduces body fat and cardiovascular risks including a decrease in systolic blood pressure. Low-density lipoprotein cholesterol was also decreased to a greater extent in the catechin group.

Lorenz et al., (2007) investigated the effect of milk in preventing the beneficial effects of tea relative to vascular protection, and found that casein in milk binds to catechins inhibiting their beneficial functioning as antioxidants.  Their conclusion was that milk counteracts the favourable health effects of tea on vascular function.

The wilds of Alaska provide an amazing environment for powerful plants and berries— fertile volcanic ash soil, and a harsh environment that challenges plants to put out high levels of phenols (e.g. flavonoids) to protect themselves.

Notice the different between an Alaskan rosehip and the typical Europe rosehip (dog-rose) in terms of their phytonutrient load.

Flavonoids

  • Quercetin- 10.50 (Alaskan rosehip) verses 1.05 (European rosehip) in mg/g.
  • Hyperoside- 3.03 verses 4.30
  • Kaempferol- 1.62 verses 0.00
  • Isoquercitin- 0.78 verses 3.51
  • Naringenin- 0.26 verses 0.15
  • Rutin- 0.16 verses 0.67
  • Nothofagrin- 0.26 verses 0.07
  • Luteolin- 0.02 verses 0.01
  • Biochanin A- 0.02 verses 0.00

Catechins

  • Catechin- 72.5 verses 35.70
  • Epicatechin- 67.50 verses 33.70
  • gallocatechin- 0.93 verses 0.86
  • epicatechin gallate- 0.45 verses 0.15
  • catechin gallate- 0.25 verses 0.02.

Organic Acids

  • Ellagic acid- 48.30 verses 5.25
  • Gallic acid- 7.85 verses 0.14
  • p- Coumaric acid- 1.54 verses 0.16
  • Protocatachuic acid- 0.97 verses 0.18
  • Caffeic acid- 0.38 verses 0.00
  • Chlorogenic acid- 0.30 verses 0.05.
  • Salicylic acid- 0.22 verses 0.14
  • Fefulic acid- 0.06 verses 0.09

Vitamins

  • Vitamin C- 25.00 verses 10.00
  • Vitamin B3- 1.09 verses 0.19
  • Vitamin B2- 0.08 verses 0.11
  • Vitamin B1- 0.03 verses 0.01
  • Vitamin B6- 0.01 verses 0.00.

Carotenoids

  • Lycopene- 4.89 verses 2.98
  • b-Carotene- 1.15 verses1.53
  • Lutein- 0.21 verses 0.00
  • Zeaxanthin- 0.17 verses 0.19.

Phyto Power’s Alakan Rosehip provides high amount of catechins.  Two capsules gives one the equivalent of two squares of dark chocolate in catechins without the sugar.

References:

  • Dower et al. (2015). Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized double-blind, placebo-controlled, crossover trial. Am J Clin Nutr; 101(5): 914-21.
  • Engler at al. (2004). Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr; 23:197-204.
  • Greenwald SE. (2007). Ageing of the conduit arteries. J Pathol; 211(2): 157-172.
  • Lorenz et al. 2007. Addition of milk prevents vascular protective effects of tea. European Heart Journal; 28(2): 2219-2223.
  • Nagao et al. (2007). A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity; 15: 1473-1483.
  • Schroeter et al. (2006). Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. PNAS; 103:1024-1029.
  • Tuso et al. (2013) Nutritional Update for Physicians: Plant-Based Diets.
  • WHO (World Health Organization) Cancer Statistics, Sept. (2016).

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Kaiser Permantente has published a remarkable nutritional update for their 15,000 physicians who care for their 10 million members.  Kaiser is now telling doctors that healthy eating may best be achieved with a plant-based diet, defined as a regiment that “encourages whole, plant-based foods and discourages meats, dairy and eggs as well as all refined and processed junk food (Tuso, 2013).”

.

©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Parkinson’s is a neurological disease characterized by mitochondrial dysfunction and oxidative stress in the dopaminergic neurons of the mid brain, causing them to die, resulting in motor dysfunction.

Parkinson’s (PD) has been positively associated with two groups of pesticides, those that impair mitochondrial function and those that increase oxidative stress.  Two such pesticides are paraquat, which causes oxidative stress, and rotenone, which inhibits mitochondrial complex I, both induce loss of nigral dopaminergic neurons and behavioral changes associated with human PD.

Epidemiological findings suggest that the consumption of berries rich in anthocyanins and proanthocyanidins may reduce PD risk.  Strathearn et al. (2014) demonstrated powerful protective effects of blueberry extract in protecting the neurons from the oxidative damage of the pesticides.  In their study, they investigated whether extracts rich in anthocyanins, proanthocyanidins, or other polyphenols, suppress the neurotoxic effects of rotenone in a primary cell culture model of PD.

Extracts rich in anthocyanins and proanthocyanidins exhibited greater neuroprotective activity than extracts rich in other polyphenols, and a number of individual anthocyanins interfered with rotenone neurotoxicity.  The blueberry and grape seed extracts rescued rotenone-induced defects in mitochondrial respiration in a dopaminergic cell line.

Dr. Mary Ann Lila, one of the study’s team of scientists, and the director of North Carolina State University’s Plants for Human Health Institute stated:

Blueberries have both of these natural chemicals (anthocyanins and proanthocyanidins) in high concentrations, so they pack a more powerful, one-two punch.  They can have synergistic benefits that surpass many other fruits when it comes to protection against brain cell death, which in turn may reduce the risk of contracting Parkinson’s.(Moore, 2014)

A cup a day is a good routine for health, according to Lila, and it provides abundant amounts of vitamins A and C, fiber, manganese and phytonutrients, which have antioxidant and anti-inflammatory properties.  Blueberries are also a “brain food”, and have been shown to increase powers of concentration and slow cognitive degeneration.

Our  Blueberry Extract (1 capsule) has a cup and a quarter of blueberries, while the Phyto Power (2 capsules) has 200mg of four species of wild harvested blueberries plus 400 mg of rosehips with their powerful collection of flavonoids including proanthocyanidins.

We will focus on these cognitive benefits in our next Forward Thinking.

References

Moore, J. (2014). Blueberries reduce risk of Parkinson’s, boost brain function finds new study. Plants for human health institute, NC State. Article

Strathearn, K. E., Yousef, G. G., Grace, M. H., Roy, S. L., Tambe, M. A., Ferruzzi, M. G., … & Rochet, J. C. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson׳ s disease. Brain research, 1555, 60-77. Article

Tanner, C. M., Kamel, F., Ross, G. W., Hoppin, J. A., Goldman, S. M., Korell, M., … & Comyns, K. (2011). Rotenone, paraquat, and Parkinson’s disease. Environmental health perspectives, 119(6), 866-872. Article

Best,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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It is estimated that one million people suffer from Parkinson’s in the U.S., and although the disease itself is not fatal, complications arising from it can be, and the CDC states that these co-morbidities result in it being the 14th leading cause of death in the country (National Parkinson Foundation).

 

©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Senescence is the technical word for aging. It is the condition or process of deterioration with age- a loss of a cell’s power of division and growth. The question is, What does healthy ageing look like?

We certainly can see unhealthy ageing all around us- people ridden with chronic degenerative diseases.  Ageing is among the greatest known risk factors for most human diseases: of the roughly 150,000 people who die each day across the globe, about two thirds die from age-related causes (Dillin et al., 2014).

blueberry X 4So, what methods can be used today to support healthy ageing?  An ageing where our bodies may be slowing down but where our bodily systems are still functioning well.  How for example can we keep our brain sharp, even to the very end of our life?

Research suggests that the polyphenolic compounds found in fruits, such as blueberries, may exert protection against Alzheimer’s or Parkinson’s diseases; that they do indeed provide benefits for cognitive health, protection, and restoration (Joseph et al., 2007).

Spencer’s (2010) research, Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain, explores the potential inhibitory or stimulatory actions of flavonoids within three sytems:  The first, through their interactions with important neuronal and glial signaling cascades in the brain; second, through an ability to improve peripheral and cerebral blood flow and trigger angiogenesis and neurogenensis in the hippocampus; third, by their capacity to directly react with and scavenge neurotoxic species and pro-inflammatory agents produced in the brain as a result of both normal and abnormal brain senenscence.

Blueberry Extract is the most powerful blueberry extract on the market, our 100% North American blueberry (Vaccinium corymbosum) provides a comprehensive profile of anthocyanins.  Scientists describe blueberries as agents of neuro-regeneration. Research studies show that blueberry and blueberry extract offer a potent and effective brain food to support cognition, memory, and the general health of our nervous system.

  • Blueberry Extract- 1 capsule daily

Phyto Power Photo 10Phyto Power is formulated to support DNA and cellular integrity. A wildcrafted wonder from remote, pure, and fertile regions of Alaska, Phyto Power is filled with biologically high actives, creating a phenolic powerhouse. Blueberries, rose hip, and dandelion are shown in research to help maintain cellular integrity, suppressing or interfering with oncogenic transformation, bolstering antioxidant and anti-inflammatory defenses, and contributing significant re-generative health benefits.

  • Phyto Power- 2 capsules daily

References:

  • Dillin, A., Gottschling, D. E., & Nyström, T. (2014). The good and the bad of being connected: the integrons of aging. Current opinion in cell biology, 26, 107-112.
  • Joseph, J.A., Shukitt-Hale, B., & Lau, F.C. (2007). Fruit polyphenols and their effects on neuronal signaling and behavior in senescence . Ann NY Acd Sci, 1100, 470-85. DOI: 10.1196/annals.1395.052
  • Spencer, J. P. (2010). Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. Proceedings of the Nutrition Society, 69(2), 244-260 https://doi.org/10.1017/S0029665110000054

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

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The Food Revolution Summit 2018(April 26 to May 6) is over but you can still tap into the wonderful information and all the great presenters.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved