Dear Friends

Research ascribes various etiologies to Autism Spectrum Disorder (ASD). There are exogenous factors such as iatrogenic drugs, pollutants of various kinds, and over use of antibiotics; and there are the endogenous factors such as dysbiosis of the GI Tract, mitochondrial dysfunction, and of course genetics. Interestingly, genetic causation is found to be in the low percentile, whereas dybiosis and mitochondrial dysfunction conditions present major links to ASD.

Let’s focus on dysbiosis. Overgrowth of clostridia, bacteriodes, and desulfovibrio are all ASD-associated bacterial populations. The overuse of antibiotics enables the clostridial family of bacteria to dominate because their spore forming ability resist many antibiotics and they can easily gain a foothold over good bacteria.

Clostridia is a big producer of the SCFA propionate. Too much propionate in the systemic circulation (which is able to cross the blood-brain barrier) becomes neurological and mitochondrial toxins, disrupting and causing the very symptoms that we see with autistic patients.

There is strong support in the literature for foundational probiotic organisms that reduce the overload of clostridium. These are the organisms we have chosen for our probiotics.

Research is showing that L. plantarum, L. casei rhamnosus, B. longum and even L. acidophilus can put out bacterocins against clostridia. Doctors who have used our Original Synbiotic and our Supernatant Synbiotic (either one works) found improvement in the behaviors of ASD patients.

I would recommend adding the Phyto Power for the high potency of polyphenolics grown in remote Alaskan regions. Phenols are shown in research as antimicrobials, inhibiting many pathogenic organisms including those implicated in ASD, yet at the same time, they enhance both the growth of the Bifido and Lactobacillus genera.

I suggest the following dosage:

Original Synbiotic: up to 1 tsp. daily. With very young patients start with an eight of a tsp and work up slowly adjusting the dosage. Back off just a little from a dosage that causes reaction. You be able to get up to a tsp dose in about a month of gradually ratcheting it up.

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As a reminder this product contains L. plantarum, L. casei rhamnosus, L. acidophilus, B. longum and S. thermophiles plus organic chicory root inulin which is very bifido and lacto genic. Each of the organism are good butyrate produces, and as we know, butyrate helps to heal a leaky gut which is a problem for ASD patients.

Phyto Power– 1 capsule daily (if they can’t take capsules then just open up the capsule and take the powder directly).

PP F copyPhyto Power is indeed powerful. Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. Typically, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.

References

  • Frye, R. E., Rose, S., Slattery, J., & MacFabe, D. F. (2015). Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome. Microbial ecology in health and disease, 26(1), 27458.
  • MacFabe, D. F. (2015). Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders. Microbial ecology in health and disease, 26(1), 28177.
  • MacFabe, D. F. (2012). Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders. Microbial ecology in health and disease, 23(1), 19260.
  • Wang, H., Lee, I. S., Braun, C., & Enck, P. (2016). Effect of probiotics on central nervous system functions in animals and humans: a systematic review. Journal of neurogastroenterology and motility, 22(4), 589.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Dr. Bardell’s Approved List of products for beauty, body, and home is a curated list of excellent clean products for the whole family. Personal care and beauty products bring as many toxins to the home as cleaning products. Check out the list: Dr. Bardell’s Approved Products for Beauty, Body and Home.
 

©2005 – 2020 BioImmersion Inc. All Rights Reserved

Dear Doctor

Why Polyphenols? Because they have molecules that act like generals – organizing and directing the body to repair, heal, protect, and so much more!

In this research article, we will look at how polyphenols improve cardiovascular health.

Lai et al. (2015) reported that total fruit intake (g/day) derived from a 217-item Food Frequency Questionnaire was obtained from 30,458 women (aged 35–69 years) at baseline from 1995–1998., the richest sources of phenolic compounds, correlated with improved cardiovascular health with an estimated 6–7% reduction in deaths from CVDs for every 80 g portion. This study concluded that total fruit intake rather than intake of a specific type of fruit is protective against CVD. In terms of specific types of fruits, commonly researched varieties include berries, such as blackberries, raspberries, black raspberries and blueberries, grapes, citrus fruit, pomegranates, strawberries and apples. These fruits are rich in polyphenols like flavanols, flavonols, anthocyanins, procyanidins, sterols, carotenoids, and hydroycinnamic acids.

Phyto Power- DNA & Cellular Health as a dietary supplement offers several species of especially potent wild-crafted, Alaskan Blueberries, Rosehips, and Dandelions, offering powerful hermetic benefits of polyphenols for DNA and cellular health.

Take two capsules daily.

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The wilds of Alaska provide an amazing environment for powerful plants and berries— fertile volcanic ash soil, and a harsh environment that challenges plants to put out high levels of phenols (e.g. flavonoids) to protect themselves.

To give you an idea on the impact a region has on the concentration of medically useful actives in its produce notice the different between an Alaskan rosehip and the typical European rosehip (the dog-rose) in terms of their phytonutrient load.  All of our fruits and vegetables used in our Therapeutic Food Supplement are sourced with this degree of thoughtfulness for high actives.

Flavonoids

  • Quercetin- 10.50 (Alaskan rosehip) verses 1.05 (European rosehip) in mg/g.
  • Hyperoside- 3.03 verses 4.30
  • Kaempferol- 1.62 verses 0.00
  • Isoquercitin- 0.78 verses 3.51
  • Naringenin- 0.26 verses 0.15
  • Rutin- 0.16 verses 0.67
  • Nothofagrin- 0.26 verses 0.07
  • Luteolin- 0.02 verses 0.01
  • Biochanin A- 0.02 verses 0.00

Catechins

  • Catechin- 72.5 verses 35.70
  • Epicatechin- 67.50 verses 33.70
  • gallocatechin- 0.93 verses 0.86
  • epicatechin gallate- 0.45 verses 0.15
  • catechin gallate- 0.25 verses 0.02.

Organic Acids

  • Ellagic acid- 48.30 verses 5.25
  • Gallic acid- 7.85 verses 0.14
  • p- Coumaric acid- 1.54 verses 0.16
  • Protocatachuic acid- 0.97 verses 0.18
  • Caffeic acid- 0.38 verses 0.00
  • Chlorogenic acid- 0.30 verses 0.05.
  • Salicylic acid- 0.22 verses 0.14
  • Fefulic acid- 0.06 verses 0.09

Vitamins

  • Vitamin C- 25.00 verses 10.00
  • Vitamin B3- 1.09 verses 0.19
  • Vitamin B2- 0.08 verses 0.11
  • Vitamin B1- 0.03 verses 0.01
  • Vitamin B6- 0.01 verses 0.00.

Carotenoids

  • Lycopene- 4.89 verses 2.98
  • b-Carotene- 1.15 verses1.53
  • Lutein- 0.21 verses 0.00
  • Zeaxanthin- 0.17 verses 0.19.

Phyto Power’s Alakan Rosehip provides high amount of catechins.  Two capsules gives one the equivalent of two squares of dark chocolate in catechins without the sugar.

 

References

  • Dower et al. (2015). Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized double-blind, placebo-controlled, crossover trial. Am J Clin Nutr; 101(5): 914-21.
  • Engler at al. (2004). Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr; 23:197-204.
  • Greenwald SE. (2007). Ageing of the conduit arteries. J Pathol; 211(2): 157-172.
  • Lai, H. T. M., Threapleton, D. E., Day, A. J., Williamson, G., Cade, J. E., & Burley, V. J. (2015). Fruit intake and cardiovascular disease mortality in the UK Women’s Cohort Study. European journal of epidemiology, 30(9), 1035-1048.
  • Lorenz et al. 2007. Addition of milk prevents vascular protective effects of tea. European Heart Journal; 28(2): 2219-2223.
  • Nagao et al. (2007). A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity; 15: 1473-1483.
  • Schroeter et al. (2006). Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. PNAS; 103:1024-1029.
  • Serino, A., & Salazar, G. (2019). Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease. Nutrients,11(1),
  • Tuso et al. (2013) Nutritional Update for Physicians: Plant-Based Diets.
  • WHO (World Health Organization) Cancer Statistics, Sept. (2016).

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The Game Changer, produced by James Cameron et al., is a revolutionary new documentary about meat, protein and strength.

It is an absolute must see. You’ll find it on Netflix.

.

©2005 – 2020 BioImmersion Inc. All Rights Reserved

Dear Doctor

What promotes repair in the body? Intense polyphenols.

Phyto Power supplies a broad diversity of polyphenols which are molecules that behave like Generals in the army, directing our body’s physiology into expressing longevity pathways. Longevity is the scientific field that studies root causes of chronic illness and what moves our body towards repair and healing, as well as reversing aging and disease (Lee et al., 2014; Davinelli et al., 2012).  This process is also defined by the word hormesis.

The concept of hormesis is described as the adaptive response of cells and organisms to low dosages of phytochemicals. This adaptive response stimulates a beneficial effect in the body (Mattson, 2008, 2008a). Calabrese et al. conducted many studies on hormetic phytochemicals and vitagenes (a group of genes that are responsible for cellular homeostasis during times of stress) in aging and longevity, including the effect of antioxidants such as polyphenols on neuro-generation (2012, 2011, 2009). The vitagene network of genes involved in the process of repair and maintenance is thought of as the longevity assurance processes: the efficient functioning of various maintenance and repair processes assuring our survival and health (Rattan, 1998; see also Cornelius et al., 2013; Calabrese et al., 2010; Rattan, 2010; 2004).

Phyto Power- DNA & Cellular Health—take two capsules daily.

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Phyto Power as a dietary supplement offers several species of especially potent wildcrafted Blueberries, Rose hip, and Dandelion, including the leaves, stems, flower, and root offering a powerful hermetic benefit for DNA and cellular health.

References

  • Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Iavicoli, I., Di Paola, R., Koverech, A. …Calabrese, E.J. (2012).Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta, 1822(5), 753-83.
  • Calabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarell,i E., Calabrese, E.J. (2011). Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. Mol Aspects Med, 32 (4-6):279-304.
  • Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Calabrese, E.J., Mattson, M.P. (2010). Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal, 13(11), 1763-811.
  • Calabrese, V., Cornelius, C., Mancuso, C., Barone, E., Calafato, S., Bates, T., Rizzarelli, E., Kostova, A.T. (2009). Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases.Front Biosci, 14, 376-397.
  • Cornelius, C., Perrota, R., graziano, A., Calbrese, E.J., Calabrese, V. (2013). Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondrea as a “chi.” Immunity & Aging,
  • Davinelli, S., Willcox, D.C., & Scapagnini, G. (2012). Extending healthy aging: nutrient sensitive pathway and centenarian population. Immun Ageing, 9, 9.
  • Lee, J., Jo, D.G., Park, D., Chung, H.Y., Mattson, M.P. (2014). Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system. Pharmacol Rev, 66 (3), 815-68.
  • Mattson, M.P. (2008). Hormesis defined. Ageing Res Rev, 7(1), 1-7.
  • Mattson M.P. (2008). Dietary factors, hormesis and health. Ageing Res Rev, 7(1), 43-48.
  • Rattan SI. (2010). Targeting the age-related occurrence, removal, and accumulation of molecular damage by hormesis. Ann N Y Acad Sci, 1197, 28-32.
  • Rattan SI. (2008).Hormesis in aging. Ageing Res Rev, 7(1), 63-78.
  • Rattan, S.I. (1998). The nature of gerontogenes and vitagenes: Antiaging effects of repeated heat shock on human fibroblasts. Annals of the New York Academy of Sciences, 854, 54-60.To your health,

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The Game Changer, produced by James Cameron et al., is a revolutionary new documentary about meat, protein and strength.

It is an absolute must see. You’ll find it on Netflix.

.

©2005 – 2019 BioImmersion Inc. All Rights Reserved

Your Regenerative Power

March 26, 2020

Dear Doctor

We find ourselves in a reflective space.  What critical changes must we all make to bring more harmony to our planet? And how do we protect ourselves from this viral pandemic?

With the news media creating more fear and anxiety, we forget what integrative medicine has known and practiced for decades.

Your body is a powerful regenerative machine.  Every one of your cells, the tissues that make up your body’s systems, is in a constant state of cellular death and renewal.  You regenerate trillions of cells to keep each of your body’s functional systems in good order.

A fine tuned body knows how to effectively handle and counteract viruses, bacteria, and other pathogens.

We have learned that the best defense comes through eating a diversified and primarily plant based organic diet, drinking plenty of fluids, sleeping at least 7 hours, exercising, and taking supplements to boost every system in our body, including our immune system.

Do you know that Blueberries have the capacity to regenerate nerve tissues in the memory center of the brain and in the frontal cortex of our brain, the thinking center?

Do you know that probiotic organisms convert undigested soluble fibers (e.g., inulin, beta glucan, and pectin) into short chain fatty acids like butyric acid to energize the colon’s lining to healthily regenerate its cells?

Do you know that probiotic organisms loves plant polyphenols and break their molecular chains so the phenolic molecules can be absorbed into the systemic circulation and turn on the repair, renewal, and regenerative powers of our cells?

Food is indeed therapeutic and your body is a powerful machine that utilizes foods to regenerate and keep you healthy.

Let’s take a look at some of our Therapeutic Foods Supplements:

Phyto Power has Blueberries for our brains, Rose hip for our hearts, dandelions for our livers. A great source of polyphenols for probiotics to digest and help the colon to regenerate!  A great regime is to combine the Phyto Power with the Original Synbiotic Formula for diversified probiotic organisms and prebiotic fiber which enables the probiotics (good bugs) to regenerate and increase their numbers even faster.

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We suggest the No. 7 Systemic Booster and the Garlic as a foundational supplements to support the immune system.

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If you are prone to respiratory conditions add the Fructo Borate Complex.

FB FReferences

  • Abbas, H. M. K., Kong, X., Wu, J., Ali, M., & Dong, W. (2019). Antimicrobial Potential of Genes from Garlic (Allium sativum L.). In Studies on Garlic. IntechOpen
  • Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P. (2013). Ageing and gut microbes: perspectives for health maintenance and longevity. Pharmacological Research, 69(1), 11-20.
  • Catarino, M. D., Silva, A., & Cardoso, S. M. (2017). Fucaceae: A source of bioactive phlorotannins. International journal of molecular sciences, 18(6), 1327.
  • Ding, S., Jiang, H., & Fang, J. (2018). Regulation of Immune Function by Polyphenols. Journal of immunology research, 2018. https://doi.org/10.1155/2018/1264074
  • Hunter, J. M., Nemzer, B. V., Rangavajla, N., Biţă, A., Rogoveanu, O. C., Neamţu, J., … & Mogoşanu, G. D. (2019). The Fructoborates: Part of a Family of Naturally Occurring Sugar–Borate Complexes—Biochemistry, Physiology, and Impact on Human Health: a Review. Biological trace element research, 188(1), 11-25.
  • Lamarche, B., Paradis, M. È., & Couture, P. (2010). Study of the acute impact of polyphenols from brown seaweeds on glucose control in healthy men and women. The FASEB Journal, 24(1 Supplement), 209-4.
  • Salehi, B., Zucca, P., Orhan, I. E., Azzini, E., Adetunji, C. O., Mohammed, S. A., … & Armstrong, L. (2019). Allicin and health: A comprehensive review. Trends in Food Science & Technology.
  • Takemura, M., Matsumoto, H., Niimi, A., Ueda, T., Matsuoka, H., Yamaguchi, M., … & Nakamura, T. (2006). High sensitivity C-reactive protein in asthma.European Respiratory Journal, 27(5), 908-91
  • Wilson, E. A., & Demmig-Adams, B. (2007). Antioxidant, anti-inflammatory, and antimicrobial properties of garlic and onions. Nutrition & food science, 37(3), 178-183.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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30 Days of Reconnection  began Monday, and it is not too late for you to join in.  Biomimicry has the answer to our existential dilemma, it lies in reconnecting with the natural world that surrounds us. For the next 28 days culminating on the Earth Day Celebration we will be guided in how we, the biosphere, can become whole and healthy.

 

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Doctor

Livngstone et al. (2019) review the different plant bio-actives and their help in preventing prostate cancer. Here is her abstract and a few suggestions:

Prostate cancer has become the most common form of non-cutaneous (internal) malignancy in men, accounting for 26% of all new male visceral cancer cases in the UK. The aetiology and pathogenesis of prostate cancer are not understood, but given the age-adjusted geographical variations in prostate cancer incidence quoted in epidemiological studies, there is increasing interest in nutrition as a relevant factor. In particular, foods rich in phytochemicals have been proposed to reduce the risk of prostate cancer. Epidemiological studies have reported evidence that plant-based foods including cruciferous vegetables, garlic, tomatoes, pomegranate and green tea are associated with a significant reduction in the progression of prostate cancer. However, while there is well-documented mechanistic evidence at a cellular level of the manner by which individual dietary components may reduce the risk of prostate cancer or its progression, evidence from intervention studies is limited. Moreover, clinical trials investigating the link between the dietary bioactives found in these foods and prostate cancer have reported varied conclusions. Herein, we review the plant bioactives for which there is substantial evidence from epidemiological and human intervention studies. The aim of this review is to provide important insights into how particular plant bioactives (e.g., sulfur-containing compounds, carotenoids and polyphenols) present in commonly consumed food groups may influence the development and progression of prostate cancer. View Full-Text

A few of the Phyto Nutrients Livingstone et al., (2019) considered:  Cruciferous and Alliaceous Vegetables,  such as broccoli sprouts (Glucosinolates & Sulforaphanes) and Garlic.  Polyphenols such as Resveratrol and Catechins, ingredients that are found in our High ORAC and Phyto Power.  Ellagitannins from Pomegranate,  such as the extracts in our Cranberry Pomegranate Synbiotic.

Here are key Therapeutic Foods Supplements to add to your diet:

Phyto Power- DNA & Cellular Health: Take two capsules daily

 

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Phyto Power

 

Glucosinolates & Sulforaphanes- Organic Broccoli Sprouts: take two capsules daily

 

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Glucosinolates & Sulforaphanes

 

References

  • Livingstone, T. L., Beasy, G., Mills, R. D., Plumb, J., Needs, P. W., Mithen, R., & Traka, M. H. (2019). Plant Bioactives and the Prevention of Prostate Cancer: Evidence from Human Studies. Nutrients11(9), 2245.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The Game Changer, produced by James Cameron et al., is a revolutionary new documentary about meat, protein and strength.

It is an absolute must see. You’ll find it on Netflix.

.

©2005 – 2019 BioImmersion Inc. All Rights Reserved