Anti-carcinogenic Support

October 9, 2017

Dear Friends                                                                                                                                                 Phyto Power High Rez 2

Phyto Power is formulated with several species of blueberry, rosehip, and dandelion, shown in research to support DNA and cellular integrity, suppressing or interfering with oncogenic transformation, bolstering antioxidant and anti-inflammatory defenses, and contributing significantly to nerve re-generation.

Blueberries, rose hip, and dandelion are showing great potential in research on many different cancers, such as gastrointestinal tract (Bishayee et al., 2016), breast (Jeyabalan et al., 2014; Adams et al., 2010; Ries-Filho, 2008), brain (Cagle et al., 2012), breast and prostate (Sigsted et al., 2008), skin cancers (Chatterjee et al., 1011; Aggarwal et al., 2004), colon (Jiménez et al., 2016), and more.

Plant phenols have been researched for many years.  Johnson et al. (1994) found plants and their biologically active constituents contribute protective and anti-carcinogenic effects (see Table 1, p. 193).

More recently, Zhan et al. (2016) found that blueberries effect the migration, invasion, proliferation and cell cycle and apoptosis in hepatocellular carcinoma cells. Li et al. (2009), Seeram, (2008), and Serram et al. (2006) have researched different berries for many years to discover their effect on a variety of cancer cells. Yang & Li (2015) have shown that dandelion extract protects human skin fibroblast from UVB damage, while Sigstedt et al. (2008) studies dandelion leaves, flower and roots and their anti-carcinogenic effect on breast and prostate cancers. Rosehip is found to have antiproliferative and anti-oxidant effect (Jiménez et al., 2016), as well as reduce brain tumor proliferation and apoptosis (Cagle, 2012).

Phyto Power utilizes several varieties and the whole plants of blueberries, rosehips, and dandelions. Grown in remote regions of Alaska, these plants and berries are more powerful with high actives due to the pure, harsh and challenging environment of Alaska (Grace et al., 2014; Youself et al., 2013; Dinstel et al., 2013).

Phyto Power is a wildcrafted wonder! Take 1-2 capsules a day.

References

  • Adams, L.S., Phung, S. Yee, N., Sheeram, N.P., Li, L., & Chen, S. (2010).Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, 70(9), 3594-605.DOI: 10.1158/0008-5472.CAN-09-3565
  • Aggarwal, B. B., Bhardwaj, A., Aggarwal, R. S., Seeram, N. P., Shishodia, S., & Takada, Y. (2004). Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer research, 24(5A), 2783-2840.
  • Bishayee, A., Haskell, Y., Do, C., Siveen, K.S., Mohandas, N., Sethi, & G., Stoner, G.D. (2016). Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence. Crit Rev Food Sci Nutr, 56(10), 1753-75. DOI: 10.1080/10408398.2014.982243
  • Cagle, P., Idassi, O., Carpenter, J., Minor, R., Goktepe, I., & Martin, P. (2012). Effect of Rosehip (Rosa canina) extracts on human brain tumor cell proliferation and apoptosis. Journal of Cancer Therapy, 3(5), 13. . DOI:10.4236/jct.2012.35069
  • Chatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., & Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evid Based Complement Alternat Med, 129045.DOI: 10.1155/2011/129045
  • Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI: 10.3402/ijch.v72i0.21188
  • Grace, M.H., Esposito D., Dunlap K.L., & Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries. J Agric Food Chem, 62(18), 4007-17. doi:10.1021/jf403810y . Johnson, I.T., Williamson, G., & Musk, S.R.R. (1994). Anticarcinogenic factors in plant foods: A new class of nutrients?Nutr Res Rev,7, 175–204. DOI: 10.1079/NRR19940011
  • Jeyabalan, J., Aqil, F., Munagala, R., Annamalai, L., Vadhanam, M.V., Gupta, R.C. (2014). Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer.J. Agric. Food Chem, 62, 3963-3971. DOI: 10.1021/jf403734j
  • Li, L., Adams, L.S., Chen, S., Killan, C., Ahmed, A., & Seeram, N.P. (2009). Eugenia jambolana Lam. [purple berries] berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. J Agric Food Chem, 57(3), 826-31. DOI: 10.1021/jf803407q
  • Seeram N.P. (2008). Berry fruits for cancer prevention: current status and future prospects. J Agric Food Chem; 56(3): 630-5. DOI: 10.1021/jf072504n
  • Seeram, N.P., Adam, L.S., Zhang, Y., Lee, R., Sand, D., Scheuller, H.S., & Heber, D. (2006). Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem, 54 (25), 9329-39.DOI: 10.1021/jf061750g
  • Sigstedt, S.C., Hooten, C.J., Callewaert, M.C., Jenkins, A.R., Romero, A.E., Pullin, M.J…. Steelant, W.F. (2008). Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. Int J Oncol. 32(5), 1085-90. https://doi.org/10.3892/ijo.32.5.1085
  • Yang, Y., & Li, S. (2015). Dandelion extracts protect human skin fibroblasts from UVB damage and cellular senescence. Oxid Med Cell Longev, 619560. http://dx.doi.org/10.1155/2015/619560
  • Yousef, G.G., Brown, A.F., Funakoshi, Y., Mbeunkui, F., Grace, M.H., Ballington, J.R., Loraine, A., & Lila, M.A. (2013). Efficient quantification of the health-relevant anthocyanin and phenolic acid profiles in commercial cultivars and breeding selections of blueberries (Vaccinium spp.). J Agric Food Chem, 61(20), 4806-15. DOI: 10.1021/jf400823s
  • Zhan, W., Liao, X., Yu, L., Tian, T., Liu, X, Liu, J., … Yang, Q. (2016). Effects of blueberries on migration, invasion, proliferation, the cell cycle and apoptosis in hepatocellular carcinoma cells.Biomed Rep, 5(5), 579-584. DOI: 10.3892/br.2016.774

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Alaskan berries are known for their phenolic power:

Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI: 10.3402/ijch.v72i0.21188

In the last few years, antioxidants have become the stars of the nutritional world. Antioxidants are important in terms of their ability to protect against oxidative cell damage that can lead to conditions, such as Alzheimer’s disease, cancer and heart disease – conditions also linked with chronic inflammation. The antioxidant and anti-inflammatory effects of Alaska’s wild berries may have the potential to help prevent these diseases.

Objective: To discover the antioxidant levels of Alaska wild berries and the ways these antioxidant levels translate when preservation methods are applied to the berry.

Design: This research centred on both the raw berries and products made from the berries. In the first year, a variety of wild berries were tested to discover their oxygen radical absorption capacity (ORAC) in the raw berries. The second level of the research project processed 4 different berries – blueberries, lingonberries, salmonberries, highbush cranberries – into 8 or 9 products made from these berries. The products were tested for both ORAC as well as specific antioxidants.

Results: The Alaska wild berries collected and tested in the first experiment ranged from 3 to 5 times higher in ORAC value than cultivated berries from the lower 48 states. For instance, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. This is also higher than lower 48 wild blueberries, which had a score of 61. All of the Alaskan berries tested have a level of antioxidant considered nutritionally valuable, ranging from 19 for watermelon berries to 206 for lingonberries on the ORAC scale. With the processed products made from 4 Alaska wild berries, one of the unexpected outcomes of the research was that the berries continued to have levels of antioxidants considered high, despite the effects of commonly used heat-processing techniques. When berries were dehydrated, per gram ORAC values increased.

Conclusion: Alaska wild berries have extraordinarily high antioxidant levels. Though cooking lowered the antioxidant level, and adding ingredients such as sugar diluted the antioxidant concentration, products made from berries are high sources of antioxidants.

 

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends
Phyto Power High Rez
Stull’s (2016) review, Blueberries’ Impact on Insulin Resistance and Glucose Intolerance, highlighted a multitude of in vivo and in vitro studies that demonstrated another of blueberries important attributes — the anti-diabetic effects of blueberries and berry extracts in insulin-resistant rodent, human, and cell culture models.

The scientific evidence in support of the anti-diabetic health benefits of blueberries and blueberry extract is encouraging. Epidemiological studies reported that consumption of foods rich in anthocyanins, especially from blueberries, were associated with a lower risk of type 2 diabetes (T2DM) and of peripheral insulin resistance.

Prediabetes is a condition in which blood glucose levels are higher than normal, but not high enough to be classified as T2DM.  Although the prediabetes stage is when corrective actions need to be implemented to prevent the possible development of T2DM, many studies find blueberries to have an anti-diabetic effect. See the references below.

Dinstel et al. (2013) found the blueberries in Alaska to have the highest anthocyanins content. See Green Facts below. Our Phyto Power utilizes Alaskan blueberries’ potent levels of plant phenols.

Phyto Power is comprised of several species of wildcrafted blueberries, Rose hip, and Dandelion, including their leaves, stems, roots, and flowers. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan Natives have used these power-filled berries and plants for their daily nourishment as well as ceremonial and medicinal purposes

Learn how to use Phyto Power in our research and description tabs.

References:

  • Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI: 10.3402/ijch.v72i0.21188
  • Haffner, S.M. (1996). The insulin resistance syndrome revisited. Diabetes Care,19:275-277. doi: 10.2337/diacare.19.3.275.
  • Jennings, A., Welch, A. A., Spector, T., Macgregor, A., & Cassidy, A. (2014). Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. The Journal of nutrition, 144(2), 202-208.
  • Muraki, I., Imamura, F., Manson, J. E., Hu, F. B., Willett, W. C., van Dam, R. M., & Sun, Q. (2013). Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies. Bmj, 347, f5001.
  • Stull, A. J. (2016). Blueberries’ Impact on Insulin Resistance and Glucose Intolerance. Antioxidants, 5(4), 44. doi:  10.3390/antiox5040044
  • Wedick N.M., Pan A., Cassidy A., Rimm E.B., Sampson L., Rosner B., Willett W., Hu F.B., Sun Q., van Dam R.M. (2012). Dietary flavonoid intakes and risk of type 2 diabetes in US men and women.  Am. J. Clin. Nutr, 95:925–933. doi: 10.3945/ajcn.111.028894.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.*
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends
Phyto Power High Rez
Phyto Power is comprised of several species of wildcrafted blueberries, Rose hip, and Dandelion, including their leaves, stems, roots, and flowers. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan Natives have used these power-filled berries and plants for their daily nourishment as well as ceremonial and medicinal purposes.

  • Three species of Rosehip, wildcrafted, whole fruit and seeds (100% w/w), refractory dried, three Rosa species, 200mg per capsule.
  • Four species of Dandelion, wildcrafted, aerial parts (90% w/w), root (10% w/w) with flower, refractory dried, four Taraxacum species, 200mg per capsule.
  • Four species of Blueberry, wildcrafted, fruit (>90% w/w), leaves and stem (<5% w/w), refractory dried, four Vaccinium species, 100mg per capsule.

Food Science

Alaskan wildcrafted berries and plants supply ample antioxidants, anti-inflammatory, and anti-microbial factors (Grace et al., 2014; Youself et al., 2013).

Phyto Power is indeed powerful. In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.

The Alaskan red Rose hip fruit and seeds, blue-purple Blueberries with twigs and leaves, and the Dandelion’s green leaves, stems, roots and yellow flowers are filled with potent phytonutrients. These vibrant and nutritious phytochemicals protect and enhance the health of both plants and humans (Joseph, Nadeau, & Underwood, 2003). James Duke’s (2000) substantial USDA phytochemical database illustrates the mechanism of the world of plants in the support and maintenance of our health (p. 2).

Scientific evidence links the lack of sufficient nutrients and colorful phytochemicals in our daily diets to the rise of chronic inflammation, one of the causes of metabolic syndrome, which includes cardiovascular, type 2 diabetes, as well as various cancers (Joseph, 2003; Ridker et al., 2000, 2003; Kristo et al., 2016, Ovadje et al., 2016, respectively). For this reason, García-Lafuente et al. (2009) conclude that flavonoids from berries and plants behave as anti-inflammatory agents in our body, calling for more research on the implication of these effects as protection against cancer and cardiovascular issues.

The effect of Blueberries, Rose hip, and Dandelion on Metabolic Syndrome’s risk markers is well documented and researched (Choi et al., 2010; Basu et al., 2012). For example, Andersson et al. (2011) demonstrated in a randomized, double-blind, crossover study* with 31 obese individuals that daily consumption of rose hip (drink) significantly decreased plasma cholesterol and systolic blood pressure, effectting the risk markers of type 2 diabetes and cardiovascular disease. In 2012, Andersson et al. conducted a study with lean and obese mice that were fed high-fat diet and a dietary supplement of rose hip powder. The supplement of rose hip prevented and reversed the increase in body weight. Andersson et al. (2012) concluded that rose hip supports the prevention of diabetic state in the mouse and that downregulation of the hepatic lipogenic program is one of the mechanisms underlying this antidiabetic effect.

Choi et al.’s (2010) demonstrated that supplementing rabbits that are fed with high cholesterol diets with dandelion leaf and root positively changed plasma antioxidant enzyme activities and lipid profiles, offering “hypolipidemic and antioxidant effects.”

These research findings are not new amongst scientists. Johnson et al. (1994) discovered that plants and their biologically active constituents contribute protective and anti-carcinogenic effects (Table 1, p. 193). These ‘dietary phytoprotectants’ in foods (p. 194) have continually shown in research to impart an important anti-inflammatory effect (Vendrame et al., 2015; Joseph et al., 2014), act as powerful anti-oxidants (Jedrejek et al., 2017; Skrovankova et al., 2015), and offer protection and inhibition of certain cancers (Zhan et al., 2016; Yang & Li, 2015; Li et al., 2009; Seeram, 2008; Sigstedt et al., 2008).

Although the exact mechanisms and reasons (the why) of these promising effects are still in the process of discovery, the findings suggest a regular habit of dietary supplementation with these plants and berries.

Blueberries, Rose hip, and Dandelion demonstrate in research a potential effect on different cancers. For example, blueberries are shown to inhibit growth and metastatic potential (Adams et al., 2010; Liu et al., 2013), and manage gastrointestinal tract cancers (Bishayee et al., 2016). Rose hip has shown to effect human brain cell proliferation (Cagle et al., 2012) and offer antiproliferation effect on Caco-2 human colon cancer (Jiménez et al., 2016). Dandelion was found to induce apoptosis in drug-resistant human melanoma cells (Chatterjee et al., 2011; see also Jeon et al., 2008 and Hu et al., 2003 for further reading on dandelion).

The Rose hip has a rich phytochemical profile shown to also support many different mechanisms in the human body. For example, the red berry of Rose hip is known for its antioxidant protection (Widen et al., 2012), supporting weight loss by a possible mechanism of decreasing abdominal visceral fat (Nagatomo et al., 2015). Andersson et al. (2011) examined the Rose hip antidiabetic effect, as well as the effect of Rose hip on risk markers of type 2 diabetes and cardiovascular disease in obese persons (Andersson et al., 2012). Rose hip is also found to support the liver (Nagatomo et al., 2013; Sadeghi et al., 2016), and offer relief from joint pain (Christensen et al., 2008; Willich et al., 2010; Winther et al., 2005).

For further study of the Rosa canina see Chrubasik et al. for a systemic review and clinical efficacy of the Rose hip (2008; 2006, respectively).

Dandelion is shown to have a great antioxidant activity (Hu et al., 2003), exhibiting diverse biological activities that promote energy, weight loss, and reduced risk of metabolic syndrome (Jedrejek et al., 2017; González-Castejón et al., 2012; Jeon et al., 2008). Ovadje et al. (2016) conclude that dandelion root extract effects colorectal cancer proliferation which may occur through the activation of ‘multiple death signalling pathways,’ and a selective induction of apoptosis and autophagy in human pancreatic cancer cells (2012; 2012a). Signstedt (2008) found similar results with extract of Taraxacum officinale on the growth and invasion of breast and prostate cancer cells, while Yang et al. (2015) demonstrated that Dandelion extract protects human skin fibroblasts from uvb damage.

For further study of the Taraxacum (Dandelion), see Schütz, Carle, & Schieber (2006) for a systemic review on its phytochemical and pharmacological profile.

Blueberries are rich with anthocyanins and a wide variety of phytochemicals that have been shown to effect neuro-generation (Albarracin et al., 2012). Studies are showing that a neuro-generative effect also occurs with Parkinson (Chao et al., 2012; Gao et al., 2012; Strathearn et al., 2014). Blueberries regenerate neuronal aging (Shukitt-Hale, 2012), and support memory (Krikorian et al., 2010). For more on nerve regeneration, see the Research tab of Blueberry Extract.

A daily consumption of blueberries is shown to support a lower blood pressure and arterial stiffness (Johnson et al., 2015), increase natural killer cell counts (McAnulty et al., 2014), down-regulate hepatic lipogentic program (Andersson et al., 2011), and impact insulin resistance and glucose intolerance (Stull, 2016). Zhan et al. (2016) discovered the importance of blueberries on the migration, invasion, proliferation of hepatocellular carcinoma cells. Yang et al. has shown in 2001 the inhibition of carcinogenesis by dietary polyphenolic compounds.

These impressive findings support dietary supplementation with berries as a healthy approach to various Metabolic Syndrome concerns, including cancer (Vendrame et al., 2015; Seeram, N.P., 2008; Seeram et al., 2006, respectively).

The hormetic mechanism of phyto-nutrients is an exciting area of research. Scientists have discovered that small amounts of phytochemicals offer much more than nutrients. Phytochemicals offer a hormetic mechanism; a stimulation of many pathways in our body that prevents, repairs, or reverses aging and disease (Lee et al., 2014; Davinelli et al., 2012). The concept of hormesis is defined as an adoptive response of cells and organism to low dosages of phytochemicals. This adoptive response stimulates a beneficial effect in the body (Mattson, 2008, 2008a). Calabrese et al. conducted many studies on hormetic phytochemicals and vitagenes in aging and longevity, including the effect of antioxidants such as polyphenols on neuro-generation (2012, 2011, 2009). The vitagene network of genes involved in the process of repair and maintenance is thought of as the longevity assurance processes (Rattan, 2004, 1998).

Phyto Power as a dietary supplement offers a regular serving of several species of Blueberries, Rose hip, and Dandelion, including the leaves, stems, flower, and root.

See the Research tab for additional bibliography to further understand the research, findings, application and use of Blueberries, Rose hip, and Dandelion. Visit Resources on the tool bar to find helpful protocols (Library) and summaries (News).

*Double blind, crossover study: in a double blind study A study the participants and those in contract with them (assistants) are blind to the details of the study. A crossover is when at one point in the study the participants switch from taking an active substance (such as rose hip in the Andersson study) to a placebo or vice versa.

References:

Adams, L.S., Phung, S. Yee, N., Sheeram, N.P., Li, L., & Chen, S. (2010). Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, 70(9), 3594-605. DOI: 10.1158/0008-5472.CAN-09-3565

Albarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J….Barreto, G.E. (2012). Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci, 15, 1–9. DOI:10.1179/1476830511Y.0000000028

Andersson, U., Berger, K., Hogberg, A., Landin-Olsson, M., & Holm, C. (2012). Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr, 66, 585–590. DOI:10.1038/ejcn.2011.203

Andersson, U., Henriksson, E., Strom, K., Alenfall, J., Goransson, O., Holm, C. (2011). Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program. Am J Physiol Endocrinol Metab, 300, E111–121. DOI:10.1152/ajpendo.00268.2010

Basu, A., &  Lyons,  T.J. (2012). Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives. J Agric Food Chem, 60: 5687-92. DOI:10.1021/jf203488k

Bishayee, A., Haskell, Y., Do, C., Siveen, K.S., Mohandas, N., Sethi, & G., Stoner, G.D. (2016). Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence. Crit Rev Food Sci Nutr, 56(10), 1753-75. DOI: 10.1080/10408398.2014.982243

Cagle, P., Idassi, O., Carpenter, J., Minor, R., Goktepe, I., & Martin, P. (2012). Effect of Rosehip (Rosa canina) extracts on human brain tumor cell proliferation and apoptosis. Journal of Cancer Therapy, 3(5), 13. . DOI:10.4236/jct.2012.35069

Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Iavicoli, I., Di Paola, R., Koverech, A. … Calabrese, E.J. (2012). Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta, 1822(5), 753-83. DOI:10.1016/j.bbadis.2011.11.002

Calabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarell,i E., Calabrese, E.J. (2011). Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. Mol Aspects Med, 32(4-6):279-304. DOI:10.1016/j.mam.2011.10.007

Calabrese, V., Cornelius, C., Mancuso, C., Barone, E., Calafato, S., Bates, T., Rizzarelli, E., Kostova, A.T. (2009). Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases. Front Biosci, 14, 376-397. Abstract

Chao, J., Leung, Y., Wang, M., & Chang, R.C. (2012). Nutraceuticals and their preventive or potential therapeutic value in Parkinson’s disease. Nutr Rev, 70, 373–86. DOI:10.1111/j.1753-4887.2012.00484.x.

Chatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., & Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evid Based Complement Alternat Med, 129045. DOI:10.1155/2011/129045

Choi, U.K., Lee, O.H., Yim, J.H., Ch,o C.W., Rhee, Y.K., Lim, S.I., & Kim, Y.C. (2010). Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits. Int Mol Sci, 11(1), 67-78. doi:10.3390/ijms11010067.

Christensen, R., Bartels, E.M., Altman, R.D., Astrup, A., Bliddal, H. (2008). Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?–a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage, 16, 965–972. DOI:10.1016/j.joca.2008.03.001

Chrubasik, C., Roufogalis, B.D. Muller-Lander, U., & Chrubasik, S. (2008). A systematic review on the Rosa canina effect and efficacy profiles. Phytother Res, 22(6), 725-33. DOI:10.1002/ptr.2400

Chrubasik, C., Duke, R.K., Chrubasik, S. (2006). The evidence for clinical efficacy of rose hip and seed: a systematic review. Phytother Res, 20(1), 1-3. DOI:10.1002/ptr.1729

Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI:
10.3402/ijch.v72i0.21188

Davinelli, S., Willcox, D.C., & Scapagnini, G. (2012). Extending healthy aging: nutrient sensitive pathway and centenarian population. Immun Ageing, 9, 9. DOI:10.1186/1742-4933-9-9.

Gao, X., Cassidy, A., Schwarzschild, M.A., Rimm, E.B., & Ascherio, A. (2012). Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology, 78, 1138–45. doi:  10.1212/WNL.0b013e31824f7fc4

García-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M.A., & Martínez, J.A. (2009). Flavonoids as antiinflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res, 58, 537–552. DOI:10.1007/s00011-009-0037-3

Gonzalez-Castejon, M., Visioli, F., & Rodriguez-Casado, A. (2012). Diverse biological activities of dandelion. Nutr Rev, 70(9), 534-47. DOI:10.1111/j.1753-4887.2012.00509.x

Grace, M.H., Esposito D., Dunlap K.L., & Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries. J Agric Food Chem, 62(18), 4007-17. doi:10.1021/jf403810y.

Hu, C.,  & Kitts, D.D. (2003). Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro. Journal of Agricultural and Food Chemistry, 51, (1), 301–310. DOI:10.1021/jf0258858

Duke, J. (2000). The green pharmacy herbal handbook. Emmaus, PA: Rodale Inc.

Jedrejek, D., Kontek, B., Lis, B., Stochmal, A., Olas, B. (2017). Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe. Chem Biol Interact, 262, 29-37. DOI: 10.1016/j.cbi.2016.12.003

Jeon, H.J., Kang, H. J., JungH.J. Kant, Y.S., Lim, C.J., Kim, Y.M., & Park, E.H. (2008). Anti-inflammatory activity of Taraxacum officinale. Journal of Ethnopharmacology, 115 (1), 82–88. DOI:10.1016/j.jep.2007.09.006

Jiménez, S., Gascón, S., Luquin, A., Laguna, M., Ancin-Azpilicueta, C., Rodríguez-Yoldi, M.J. (2016). Rosa canina Extracts Have Antiproliferative and Antioxidant Effects on Caco-2 Human Colon Cancer. PLoS One, 11(7), e0159136. https://doi.org/10.1371/journal.pone.0159136

Johnson, I.T., Williamson, G., & Musk, S.R.R. (1994). Anticarcinogenic factors in plant foods: A new class of nutrients? Nutr Res Rev,7, 175–204. DOI:10.1079/NRR19940011

Johnson, S.A., Figueroa, A., Navae, N. Wong, A., Ralfon, R., Ormsbee, L.T…. Arjmandi, B.H. (2015). Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. J. Acad Nutr Diet, 115(3), 369-77. DOI:10.1016/j.jand.2014.11.001

Joseph, S.V., Edirisinghe, I., & Burton-Freeman, B.M. (2014). Berries: anti-inflammatory effects in humans. J Agric Food Chem, 7; 62(18), 3886-903. DOI:10.1021/jf4044056

Joseph, J., Nadeau, D., & Underwood, A. (2003). The color code: A revolutionary eating plan for optimum health. New York, NY: The Philip Lief Group, Inc. Book

Kristo, A.S., Klimis-Zacas, D., Sikalidis, A.K. (2016). Protective Role of Dietary Berries in Cancer. Antioxidants (Basel), 5(4), 37. doi:10.3390/antiox5040037

Krikorian, R., Shidler, M.D., Nash, T.A., Kalt, W., Vingvist-tymchuk, M.R., Shukitt-Hale, B., Joseph, J.A. (2010).  Blueberry supplementation improves memory in older adults. J. Agric Food Chem, 58, 3996-4000. DOI:10.1021/jf9029332

Lee, J., Jo, D.G., Park, D., Chung, H.Y., Mattson, M.P. (2014). Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.
Pharmacol Rev, 66(3), 815-68. DOI:10.1124/pr.113.007757

Li, L., Adams, L.S., Chen, S., Killan, C., Ahmed, A., & Seeram, N.P. (2009). Eugenia jambolana Lam. [purple berries] berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. J Agric Food Chem, 57(3), 826-31. DOI:10.1021/jf803407q

Liu, W., Lu, X., He, G., Gao, X., Xu, M., Zhang, J… Luo, C. (2013). Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Int Mol Sci, 14(11), 21447-62. DOI:10.3390/ijms141121447

Mattson, M.P. (2008). Hormesis defined. Ageing Res Rev, 7(1), 1-7. doi:  10.1016/j.arr.2007.08.007

Mattson M.P. (2008). Dietary factors, hormesis and health. Ageing Res Rev, 7(1), 43-48. doi:  10.1016/j.arr.2007.08.004

McAnulty, L.S., Collier, S.R., Landram, M.J., Whittaker, D.S., Isaacs, S.E., Klemka, J.M…  McAnulty, S.R. (2014). Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females. Nutr Res, 34(7), 577-84. DOI:10.1016/j.nutres.2014.07.002

Nagatomo, A., Nishida, N., Fukuhara, I., Noro, A., Kozai, Y., Sato, H., & Matsuura, Y. (2015). Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial. Diabetes Metab Syndr Obes, 8, 147–156. DOI:10.2147/DMSO.S78623

Nagatomo, A., Nishida, N., Matsuura, Y., & Shibata, N. (2013). Rosehip Extract Inhibits Lipid Accumulation in White Adipose Tissue by Suppressing the Expression of Peroxisome Proliferator-activated Receptor Gamma. Prev Nutr Food Sci, 18, 85–91. doi:  10.3746/pnf.2013.18.2.085

Ovadje, P., Ammar, S., Guerrero, J.A., Arnason, J.T., Pandey, S. (2016). Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. Oncotarget, 7(45):73080-73100. DOI:
10.18632/oncotarget.11485

Ovadje, P., Chochkeh, M., Akbari-Asl, P., Hamm, C., Pandey, S. (2012). Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells. Pancreas, 41(7), 1039-47. DOI: 10.1097/MPA.0b013e31824b22a2

Ovadje, P., Hamm, C., Pandey, S. (2012a). Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells.
PLoS One, 7(2), e30604. doi:  10.1371/journal.pone.0030604

Rattan SI. (2008). Hormesis in aging. Ageing Res Rev, 7(1), 63-78. DOI:
10.1016/j.arr.2007.03.002

Rattan, S.I. (1998). The nature of gerontogenes and vitagenes: Antiaging effects of repeated heat shock on human fibroblasts. Annals of the New York Academy of Sciences, 854, 54-60. doi:10.1111/j.1749-6632.1998.tb09891.

Ridker, P.M., Buring, J.E., Cook, N.R., & Rifai, N. (2003). C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation, 107(3), 391-7. DOI:org/10.1161/01.CIR.0000055014.62083.05

Ridker, P.M., Hennekens, C.H., Buring, J.E., & Rifai, N. (2000). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med, 342(12), 836-43. DOI:10.1056/NEJM200003233421202

Sadeghi, H., Hosseinzadeh, S., Akbartabar Touri, M., Ghavamzadeh, M., Jafari Barmak, M., Sayahi, M., & Sadeghi, H. (2016). Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat. Avicenna J Phytomed, 6(2), 181-8. DOI: 10.22038/ajp.2016.5481

Schütz, K, Reinhold, C., & Schieber, A. (2006). Taraxacum—A review on its phytochemical and pharmacological profile. J Ethnopharmacol, 107, 313–323. DOI: 10.1016/j.jep.2006.07.021
Seeram N.P. (2008). Berry fruits for cancer prevention: current status and future prospects. J Agric Food Chem; 56(3): 630-5. DOI:10.1021/jf072504n

Seeram, N.P., Adam, L.S., Zhang, Y., Lee, R., Sand, D., Scheuller, H.S., & Heber, D. (2006). Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem, 54(25), 9329-39. DOI:10.1021/jf061750g

Shukitt-Hale, B. (2012).  Blueberries and neuronal aging. Gerontology, 58, 518-523. DOI:10.1159/000341101

Sigstedt, S.C., Hooten, C.J., Callewaert, M.C., Jenkins, A.R., Romero, A.E., Pullin, M.J…. Steelant, W.F. (2008). Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. Int J Oncol. 32(5), 1085-90. https://doi.org/10.3892/ijo.32.5.1085

Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., Sochor, J.(2015). Bioactive Compounds and Antioxidant Activity in Different Types of Berries. Int J Mol Sci, 16(10), 24673-706. doi:10.3390/ijms161024673

Strathearn, K.E., Youself, G.G., Grace, M.H., Roy S.L., Tambe, M.A., Ferruzzi, M.G., Wu, Q.L., … Rochet, J.C. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson’s disease. Brain Research, 1555(25), 60-77. DOI:10.1016/j.brainres.2014.01.047

Vendrame, S., & Klimis-Zacas, D. (2015). Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades. Nutr Rev, 73(6), 348-58. DOI:10.1093/nutrit/nuu066.

Widen, C., Ekholm, A., Coleman, M.D., Renvert, S., Rumpunen, K. (2012). Erythrocyte antioxidant protection of rose hips (Rosa spp.) Oxid Med Cell Longev, 621579. http://dx.doi.org/10.1155/2012/621579

Willich, S.N., Rossnagel, K., Roll, S., Wagner, A., Mune, O., Erlendson, J…Winther, K. (2010). Rose hip herbal remedy in patients with rheumatoid arthritis – a randomised controlled trial. Phytomedicine, 17(2), 87-93. DOI:10.1016/j.phymed.2009.09.003

Winther, K., Apel, K., & Thamsborg, G. (2005). A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol, 34(4), 302-8. DOI:10.1080/03009740510018624

Yang, Y.,  & Li, S. (2015). Dandelion extracts protect human skin fibroblasts from UVB damage and cellular senescence. Oxid Med Cell Longev, 619560. http://dx.doi.org/10.1155/2015/619560

Yang, C.S., Landau, J.M., Huang, M.T., & Newmark, H.L. (2001). Inhibition of carcinogenesis by dietary polyphenolic compounds. Ann Rev Nutr, 21, 381–406. DOI:
10.1146/annurev.nutr.21.1.381

Yousef, G.G., Brown, A.F., Funakoshi, Y., Mbeunkui, F., Grace, M.H., Ballington, J.R., Loraine, A., & Lila, M.A. (2013). Efficeint quantification of the health-relevant anthocyanin and phenolic acid profiles in commercial cultivars and breeding selections of blueberries (Vaccinium spp.). J Agric Food Chem, 61(20), 4806-15. DOI:
10.1021/jf400823s

Zhan, W., Liao, X., Yu, L., Tian, T., Liu, X, Liu, J., … Yang, Q. (2016). Effects of blueberries on migration, invasion, proliferation, the cell cycle and apoptosis in hepatocellular carcinoma cells. Biomed Rep, 5(5), 579-584. DOI:
10.3892/br.2016.774

Article by Dohrea Bardell, PhD.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.Green Facts:

Globe_Home 3Understanding the concept of hormesis and its relationship to plant phytonutrients opens the door to a whole new medical paradigm for reducing chronic oxidative stress.  Chronic oxidative stress increases cancer, metabolic and neurodegenerative disease risk.

See Callbrese et al. (2010) illuminating paper on this most important concept:

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Phyto Power and Cancer

April 19, 2017

Dear Friends

Phyto Power is a wildcrafted wonder from Alaska.  Grown in harsh yet pure and fertile environments, Alaskan wild berries and plants are strong and potent (Grace et al., 2014).

Alaskan potent wildcrafted berries and plants supply an abundance of antioxidants, anti-inflammatory, and anti-microbial factors shown to promote and maintain a healthy functioning body (Grace et al., 2014; Youself et al., 2013).

In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high. Alaska wild berries ranged from 3 to 5 times higher in ORAC values than cultivated berries from the lower 48 states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values even increased.

There is abundance research in the peer-reviewed journals today on health benefits of the individual constituents within Phyto Power as being important to consider for a whole host of conditions—from metabolic syndrome, to cognitive decline, to fatty liver, to high blood pressure, etc … in this Forward Thinking we will focus on cancer.

Therapeutic Food Protocol for Cancer Support.

Food Science

Blueberries, Rose hip, and Dandelion show a great potential as a daily nutritional supplement due to vast research on their effect on different cancers. For example, blueberries are shown to inhibit growth and metastatic potential (Adams et al., 2010), and manage gastrointestinal tract cancers (Bishayee et al., 2016). Rose hip has shown to effect human brain cell proliferation (Cagle et al., 2012) and antiproliferation effect on Caco-2 human colon cancer (Jiménez et al., 2016), while Dandelion was found to induce apoptosis in drug-resistant human melanoma cells (Chatterjee et al., 2011; see also Hu et al., 2003 and Jeon et al., 2008, for further reading on dandelion). Research has shown great promise for their various effects on cancer.

Phyto Power is comprised of several species of wildcrafted blueberries, Rose hips, and Dandelions. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan natives have used these power-filled berries and plants for their daily meals as well as ceremonial and medicinal purposes.

Phyto Power is potent because of its Alaskan red Rose hip fruit and seeds, blue-purple blueberries, with twigs and leaves, and the Dandelion’s green leaves, stems, roots, and yellow flowers. These vibrant phytochemicals protect and enhance the health of both plants and humans (Joseph, Nadeau, & Underwood, 2003). James Duke’s (2000) substantial USDA phytochemical database was compiled to illustrate how (and why) the world of plants heals and protects (p. 2).

Bibliography

  • Adams, L.S., Phung, S. Yee, N., Sheeram, N.P., Li, L., & Chen, S. (2010).Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, 70(9), 3594-605.
  • Bishayee, A., Haskell, Y., Do, C., Siveen, K.S., Mohandas, N., Sethi, & G., Stoner, G.D. (2016). Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence. Crit Rev Food Sci Nutr, 56(10), 1753-75.
  • Cagle, P., Idassi, O., Carpenter, J., Minor, R., Goktepe, I., & Martin, P. (2012). Effect of Rosehip (Rosa canina) extracts on human brain tumor cell proliferation and apoptosis. Journal of Cancer Therapy,3(5), 13.
  • Chatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., & Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evid Based Complement Alternat Med, 129045. doi: 10.1155/2011/129045.
  • Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. doi:10.3402/ijch.v7210.21188.
  • García-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M.A., & Martínez, J.A. (2009). Flavonoids as antiinflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res, 58, 537–552.
  • Grace, M.H., Esposito D., Dunlap K.L., & Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries. J Agric Food Chem, 62(18), 4007-17. doi: 10.1021/jf403810y.
  • Jeon, H.J., Kang, H. J., JungH.J. Kant, Y.S., Lim, C.J., Kim, Y.M., & Park, E.H. (2008). Anti-inflammatory activity of Taraxacum officinale. Journal of Ethnopharmacology, 115 (1), 82–88.
  • Jiménez, S., Gascón, S., Luquin, A., Laguna, M., Ancin-Azpilicueta, C., Rodríguez-Yoldi, M.J. (2016). Rosa canina Extracts Have Antiproliferative and Antioxidant Effects on Caco-2 Human Colon Cancer. PLoS One, 11(7), e0159136.
  • Johnson, I.T., Williamson, G., & Musk, S.R.R. (1994). Anticarcinogenic factors in plant foods: A new class of nutrients? Nutr Res Rev,7, 175–204.
  • Joseph, J., Nadeau, D., & Underwood, A. (2003). The color code: A revolutionary eating plan for optimum health. New York, NY: The Philip Lief Group, Inc.
  • Kristo, A.S., Klimis-Zacas, D., Sikalidis, A.K. (2016). Protective Role of Dietary Berries in Cancer. Antioxidants (Basel), 5(4), 37. doi:10.3390/antiox5040037
  • Ovadje, P., Ammar, S., Guerrero, J.A., Arnason, J.T., Pandey, S. (2016). Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. Oncotarget, 7(45):73080-73100.
  • Yousef, G.G., Brown, A.F., Funakoshi, Y., Mbeunkui, F., Grace, M.H., Ballington, J.R., Loraine, A., & Lila, M.A. (2013). Efficient quantification of the health-relevant anthocyanin and phenolic acid profiles in commercial cultivars and breeding selections of blueberries (Vaccinium spp.). J Agric Food Chem, 61(20), 4806-15. doi: 10.1021/jf400823s.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3
Watch the new trailer An Inconvenient Sequel: Truth to Power.    The sequel to An Inconvenient Truth.  In theatres July 28, 2017.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Neuro-regeneration

April 9, 2017

Dear Friends,

Cognitive decline, memory loss, and foggy thinking are on the rise and do not automatically accompany old age but affect all ages (Joseph, 2009).

Plant polyphenols and a healthy microbiome in the GI tract have shown to strongly support a healthy functioning nervous system, regenerate nerve tissue and protect against the onset of neuro-degenerative decline (Brewer et al., 2010; Burokas et al., 2015).

Therapeutic Food Protocol for Cognitive Support.

Food Science

A declining nervous system leads to the problematic onset of neurodegenerative diseases (Parkinson’s and Alzheimer’s).  Protecting against this decline, berry fruit polyphenols were examined, and in particular, blueberry extract anthocyanins for their multiplicity of actions that goes beyond the established antioxidant ability (Galli et al., 2002). The other possible mechanisms for the berry’s positive effects include: direct effects on signaling to enhance neuronal communication (Joseph et al., 2003), the ability to buffer against excess calcium (Joseph et al., 2004), enhancement of neuroprotective stress shock proteins (Galli et al., 2006), and reduction of stress signals such as nuclear factor B (NF-B) (Goyarzu et al., 2004).  Additionally, the anthocyanins contained in blueberries have been shown to enter the brain, and their concentrations were correlated with cognitive performance (Andres-Lacueva et al., 2005).

The brain-gut axis is a bidirectional communication system between the central nervous system (CNS) and the gastrointestinal tract. Regulation of the microbiota-brain-gut axis is essential for maintaining homeostasis, including that of the CNS. It is clear that the gut microbiota can be a key regulator of mood, cognition, pain, and obesity (Burokas et al., 2015; Borre et al., 2014).

Bibliography

  • Andres-Lacueva, C., Shukitt-Hale, B., Galli RL., Jauregui O., Lamuela-Reventos, RM., Joseph, J. (2005). Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci; 8:111-120.
  • Borre, Y.E., Moloney, R.D., Clarke, G., Dinana, T.G., Cryan, J.F. (2014). The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Adv Exp Med Biol, 817, 373-403.
  • Brewer, G.J., Torricelli, J.R., Lindsey, A.L., Kunz, E.Z., Neuman, A., Fisher, D.R., & Joseph, J.A. (2010). Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem, 21, 991-998.
  • Burokas, A., Moloney, RD., Dinan, TG., Cryan, JF. (2015). Microbiotia regulation of the Mammalian gut-brain axis. Adv Appl Microbiol; 91(1): 1-62.
  • Galli, R.L., Shukitt-Hale, B., Youdim, K.A.. Joseph, J.A. (2002). Fruit polyphenolics and brain aging:  nutritional interventions targeting age-related neuronal and behavioral deficits. Ann NY Acad Sci; 959: 128-32.
  • Galli,RL., Bielinski, DF., Szprengiel, A., Shukitt-Ale, B., Joseph, J. (2006). Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection.  Neurobiol Aging; 27:344-350.
  • Goyarzu, P., Malin, DH., Lau FC., Taglialatela, G. Moon, WD., Jennings, R., Moy, E., et al. (2004).  Blueberry supplemented diet: effects on object recognition memory and nuclear factor kappa B levels in aged rats. Nutr Neurosci: 7:75-83.
  • Joseph, J., Denisova, NA., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003).  Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 6:153-162.
  • Joseph, J., Fisher, D.R., Carey, AN. (2004). Fruit extracts antagonize Abeta- or DA- induced deficits in Ca2++ flux in M1-transfect COS-7 cells. J Alzheimers Dis; 6:403;discussion 443-9.
  • Joseph, J., Cole, G., Head, E., Ingram, D. (2009). Nutrition, brain aging, and neurodegeneration. J Neurosci; 29(41): 12795-801.
  • Joseph, J.A., Denisova, N.A., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003). Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci, 6, 153-162.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3
Have you tune into the Rocky Mountain Institute.  Their vision is a world thriving, verdant and secure, for all, for ever.  Their mission is to drive the efficient and restorative use of resources.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved