Therapeutic Food Supplements

Blueberry and Cancer

June 25, 2018

Dear Friends

Blueberries have shown protective effects against liver and breast cancers.

Liver cancer was the fourth most common cause of mortality worldwide.  In China, greater than 90% of patients with primary liver cancer have hepatocellular carcinoma (HCC), which was the second-leading cause of cancer-associated mortality, influencing individuals of all ages.

The global overall survival of HCC patients remained particularly poor.  The majority of the poor prognoses were associated with recurrence and metastasis following treatment, including curative resection.

Zhan, W., et al. (2016) study investigate the effects of blueberry consumption on the migration, invasion, proliferation, cell cycle, and apoptosis in human hepatocellular carcinoma cells in order to provide clinical treatment and prevention strategies for liver cancer therapeutic agents.

In the present study, the blueberry components were not detected and the important components were not extracted from the fresh blueberries. However, fresh blueberry juice was fed to the rats and the serum was collected. The serum from the blueberry-fed rats was used for co-culturing with HEPG2 cells, and the proliferation, invasion, migration, cell cycle and apoptosis in HEPG2 cells was detected following culture with serums taken from rats fed with different concentrations of blueberry juice. The results indicated that the blueberry juice exerted significant antitumor and therapeutic effects on HEPG2 cells. The different concentrations of blueberry juice and varying treatment times resulted in distinct influences on the invasion, migration, proliferation, cell cycle and apoptosis in the HEPG2 cells. The higher the concentration of blueberry the better were the results.

Note:  HEPG2 is an immortalized cell line consisting of human liver carcinoma cells derived from the tissue of a 15 year old caucasion male who had a well differentiated hepatocellular carcinoma.

Blueberry Extract is the most powerful blueberry extract on the market, our 100% North American blueberry (Vaccinium corymbosum) provides a comprehensive profile of anthocyanins.

The Blueberry Extract is expensive: It takes 80 pounds of blueberries to get one pound of the pure purple extract. One capsule of this extract is equivalent to a cup and a quarter of whole blueberries.

  • Blueberry Extract- 1 capsule daily

To promote blueberry cancer support:  15% off on Blueberry Extract in June.

Like hepatocellular carcinoma, triple negative breast cancer has a high mortality rate.  See the research article below in Green Facts on blueberry’s positive results against this cancer.

References:

  • Zhan, W., Liao, X., Yu, L., Tian, T., Liu, X., Liu, J., … & Yang, Q. (2016). Effects of blueberries on migration, invasion, proliferation, the cell cycle and apoptosis in hepatocellular carcinoma cells. Biomedical reports, 5(5), 579-584.
    https://www.spandidos-publications.com/10.3892/br.2016.774

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Adams, L. S., Phung, S., Yee, N., Seeram, N. P., Li, L., & Chen, S. (2010). Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer research, 70(9), 3594-3605.

This study investigated the chemopreventive activity of blueberry extract in triple-negative breast cancer cell lines in vitroand in vivo.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

How can we best protect our brain from dementia?

Barbara Shukit-Hale’s (2012) research, Blueberries and neuronal aging, clearly demonstrates the power of blueberry and particularly blueberry extract in protecting and even reversing cognitive decline.  Good news for all of us!

Blueberry Extract is the most powerful blueberry extract on the market, our 100% North American blueberry (Vaccinium corymbosum) provides a comprehensive profile of anthocyanins.

Scientists describe blueberries as agents of neuro-regeneration. Research studies show that blueberry and blueberry extract offer a potent and effective brain food to support cognition, memory, and the general health of our nervous system.

The Blueberry Extract is expensive: It takes 80 pounds of blueberries to get one pound of the pure purple extract. One capsule of this extract is equivalent to a cup and a quarter of whole blueberries.

  • Blueberry Extract- 1 capsule daily

Blueberry protects by lowering oxidative stress and inflammation or directly by altering the signaling involved in neuronal communication, calcium buffering ability, neuroprotective stress shock proteins, plasticity and stress signaling pathways. (Shukitt-Hale, 2012)

Click the link below, under References, for Shukit-Hale’s paper.  It will give you hope.  Order a bottle for yourself and religiously take in a capsule daily.  That will give you a 60 day trial.  Notice how your brain functions particularly after the steady dosing.

To promote brain health:  15% off on Blueberry Extract in June.

The brain is responsible for conscious control of movement, and alterations in motor function may include decreases in balance, muscle strength and coordination, while memory deficits are seen on cognitive tasks that require the use of special learning and memory. (Shukitt-Hale, 2012)

One capsule of Blueberry Extract offers a steady dose of the needed amount per the research.

References:

  • Shukitt-Hale, B. (2012). Blueberries and neuronal aging. Gerontology, 58, 518-523. DOI: 10.1159/000341101

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA: Blueberry supplementation improves memory in older adults. J Agric Food Chem 2010;58:3996–4000.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

Senescence is the technical word for aging. It is the condition or process of deterioration with age- a loss of a cell’s power of division and growth. The question is, What does healthy ageing look like?

We certainly can see unhealthy ageing all around us- people ridden with chronic degenerative diseases.  Ageing is among the greatest known risk factors for most human diseases: of the roughly 150,000 people who die each day across the globe, about two thirds die from age-related causes (Dillin et al., 2014).

blueberry X 4So, what methods can be used today to support healthy ageing?  An ageing where our bodies may be slowing down but where our bodily systems are still functioning well.  How for example can we keep our brain sharp, even to the very end of our life?

Research suggests that the polyphenolic compounds found in fruits, such as blueberries, may exert protection against Alzheimer’s or Parkinson’s diseases; that they do indeed provide benefits for cognitive health, protection, and restoration (Joseph et al., 2007).

Spencer’s (2010) research, Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain, explores the potential inhibitory or stimulatory actions of flavonoids within three sytems:  The first, through their interactions with important neuronal and glial signaling cascades in the brain; second, through an ability to improve peripheral and cerebral blood flow and trigger angiogenesis and neurogenensis in the hippocampus; third, by their capacity to directly react with and scavenge neurotoxic species and pro-inflammatory agents produced in the brain as a result of both normal and abnormal brain senenscence.

Blueberry Extract is the most powerful blueberry extract on the market, our 100% North American blueberry (Vaccinium corymbosum) provides a comprehensive profile of anthocyanins.  Scientists describe blueberries as agents of neuro-regeneration. Research studies show that blueberry and blueberry extract offer a potent and effective brain food to support cognition, memory, and the general health of our nervous system.

  • Blueberry Extract- 1 capsule daily

Phyto Power Photo 10Phyto Power is formulated to support DNA and cellular integrity. A wildcrafted wonder from remote, pure, and fertile regions of Alaska, Phyto Power is filled with biologically high actives, creating a phenolic powerhouse. Blueberries, rose hip, and dandelion are shown in research to help maintain cellular integrity, suppressing or interfering with oncogenic transformation, bolstering antioxidant and anti-inflammatory defenses, and contributing significant re-generative health benefits.

  • Phyto Power- 2 capsules daily

References:

  • Dillin, A., Gottschling, D. E., & Nyström, T. (2014). The good and the bad of being connected: the integrons of aging. Current opinion in cell biology, 26, 107-112.
  • Joseph, J.A., Shukitt-Hale, B., & Lau, F.C. (2007). Fruit polyphenols and their effects on neuronal signaling and behavior in senescence . Ann NY Acd Sci, 1100, 470-85. DOI: 10.1196/annals.1395.052
  • Spencer, J. P. (2010). Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. Proceedings of the Nutrition Society, 69(2), 244-260 https://doi.org/10.1017/S0029665110000054

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

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The Food Revolution Summit 2018(April 26 to May 6) is over but you can still tap into the wonderful information and all the great presenters.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

Cognitive decline, including Alzheimer’s, dementia, and other neurological diseases are linked with old age, yet we see these brain/nerve issues in both young and old.

There is a large body of scientific evidence regarding blueberry and blueberry extract’s benefits for cognitive health, protection, and restoration. See Food Science and References below and visit Blueberry Extract and Phyto Power research tab on the product page.

blueberry X 4
Blueberry Extract is the most powerful blueberry extract on the market, our 100% North American blueberry (Vaccinium corymbosum) provides a comprehensive profile of anthocyanins.  Scientists describe blueberries as agents of neuro-regeneration. Research studies show that blueberry and blueberry extract offer a potent and effective brain food to support cognition, memory, and the general health of our nervous system.

  • Blueberry Extract- 1 capsule daily

Phyto Power Photo 10Phyto Power is formulated to support DNA and cellular integrity. A wildcrafted wonder from remote, pure, and fertile regions of Alaska, Phyto Power is filled with biologically high actives, creating a phenolic powerhouse. Blueberries, rose hip, and dandelion are shown in research to help maintain cellular integrity, suppressing or interfering with oncogenic transformation, bolstering antioxidant and anti-inflammatory defenses, and contributing significant re-generative health benefits.

  • Phyto Power- 2 capsules daily

Food Science:

Esteemed research scientists demonstrate that blueberries and blueberry extract reverse and prevent brain aging (Shukitt-Hale et al., 2008; 2007), improve memory and motor skills  (Carey et al., 2014; Malin et al., 2011; Brewer et al., 2010), repair neuronal tissue and function (Joseph et al., 2003; Miller et al., 2012), and serve as a potent anti-aging food (Joseph et al., 1999; 2009; Shukitt-Hale et al., 2015; 2012).

References:

  • Shukitt-Hale, B., Lau, F.C., Joseph, J.A. (2008). Berry fruit supplementation and the aging brain. Journal of Agricultural and Food Chemistry, 56, 636–641.
  • Shukitt-Hale, B., Carey, A.N., Jenkins, D., Rabin, B.M., Joseph, J.A. (2007). Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging, 28, 1187-1194. DOI: 10.1016/j.neurobiolaging.2006.05.031
  • Carey, A.N., Gomes, S.M., & Shukitt-Hale, B. (2014). Blueberry supplementation improves memory in middle-aged mice fed a high-fat diet.J Agric Food Chem, 62, 3972-3978. DOI: 10.1021/jf404565s
  • Malin, D.H., Lee, D.R., Goyarzum P., Chang, Y.H., Ennis, L.J., Beckett, E., Shukitt-Hale, B., Joseph, J.A. (2011). Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats.Nutrition, 27, 338-342. DOI: 10.1016/j.nut.2010.05.001  
  • Brewer, G.J., Torricelli, J.R., Lindsey, A.L., Kunz, E.Z., Neuman, A., Fisher, D.R., & Joseph, J.A. (2010). Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem, 21, 991-998. DOI: 10.1016/j.jnutbio.2009.08.005
  • Joseph, J.A., Denisova, N.A., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003). Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci, 6 (3), 153-162. DOI:10.1080/1028415031000111282
  • Joseph, J.A., Shukitt-Hale, B., & Lau, F.C. (2007). Fruit polyphenols and their effects on neuronal signaling and behavior in senescence . Ann NY Acd Sci, 1100, 470-85. DOI: 10.1196/annals.1395.052
  • Miller, M.G., Shukitt-Hale, B. (2012). Berry fruit enhances beneficial signaling in the brain. J. Agric. Food Chem,60(23), 5709–5715. DOI: 10.1021/jf2036033
  • Joseph, J.A., Shukitt-Hale, B., Denisova, N.A., Bielinski, D., Martin, A., McEwen, J.J., & Bickford, P.C. (1999). Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci, 19(18), 8114-21. . Article
  • Joseph, J., Cole, G., Head, E., Ingram, D. (2009). Nutrition, brain aging, and neurodegeneration. J. Neurosci.29(41), 12795–12801. DOI:10.1523/JNEUROSCI.3520-09.2009
  • Shukitt-Hale, B., Bielinski, D. F., Lau, F. C., Willis, L. M., Carey, A. N., & Joseph, J. A. (2015). The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. British Journal of Nutrition, 114(10), 1542-154.
  • Shukitt-Hale, B. (2012). Blueberries and neuronal aging. Gerontology, 58, 518-523. DOI: 10.1159/000341101DOI:10.1021/jf072505f

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The Food Revolution Summit 2018(April 26 to May 6) is over but you can still tap into the wonderful information and all the great presenters.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends
High ORAC Photo
High ORAC Synbiotic is back in and what a powerful formula it is.

With a potent mix of polyphenols and two pedigreed strains of colonizing Bifido and Lacto species.

  • The CFU per capsule of L. acidophilus and B. longum (50:50 mix) is over 25 billion.
  • 3000 ORAC value per capsule with grape seed extract, wild blueberry, quercetin, resveratrol, wild bilberry, cranberry, tart cherry, prune, raspberry and strawberry.
  • The organic chicory root inulin is 100mg.

We understand how upsetting back orders can be. One of our absolute commitments to you is creating the highest and most potent therapeutic foods, probiotics, and nutraceuticals. But to do so, at times, we have to reject batches of the raw materials. Plants and foods are unpredictable, with different moisture levels, potency, and consistency. The typical practice is to simply keep these batches and get a reduction in price to help profit margins. But this practice is not part of our sourcing, formulating, and manufacturing.

The BioImmersion’s products are truly special, and one of a kind in the supplement industry for multiple reasons. We make small batches of each product often to ensure therapeutic potency.  Our sourcing of raw materials is strict and thorough; plants are grown to produce very high actives.  We encapsulate without excipients, which means there are no flowing agents, fillers, or additives. We are currently the only company that fills every plant-based (vegan) capsule with only high active, powerful ingredients.  Our collaborating partners are holistic minded scientists, doctors,  farmers, and manufacturing experts — a network of thoughtful professionals who care greatly about your health.

It is very difficult, expensive, and time consuming to produce such fresh, pure, and powerful products in small batches. Please know that we have you in mind when we produce each and every batch of our products. Call us for suggestions on what to use as different foods and probiotics are multi-dimensional and can easily preform the same tasks.

To your health!

References

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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We believe that alive, potent foods is real medicine. Consuming mostly a whole food, plant-base, organic diet is the medicine of the future for all humanity to truly thrive.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved