Original Synbiotic

Foundational Probiotics

September 5, 2017

Dear Friends

Original copy


What makes the BioImmersion probiotics so effective?

The Original Synbiotic Formula offers foundational bacterial organisms with a long history. These species were originally  researched by Metchnikoff, have a rich scientific historicity behind them, used as fermenting agents in different societies, and are now packaged in our Original Synbiotic formula.

No wonder we call them pedigreed strains—they have been shown for centuries to bring health building benefits to the human body.  The Original Synbiotic provides a powerful symbiotic combination of Lactobacillus acidophilus (ATCC 4356), Streptococcus thermophilus (ATCC 19258), Lactobacillus plantarum (ATCC 8014), Lactobacillus rhamnosus (ATCC 7469) and Bifidobacterium longum (ATCC 15707).

This is a comprehensive everyday formula to be used by the whole family.  It combines the five pedigreed human strains of lactic acid bacteria along with the prebiotic soluble fiber inulin, derived from organic chicory root.  The formula is dairy free, soy free, kosher, non GMO, and gluten free.*

Food Science

Syngai et al. (2016), Probiotic- the versatile functional food ingredient, summarize the potential health benefits derived from probiotics along with the versatility of their applications for human health as well as animal well-being.

Ilie Metchnikoff (Zoologist and Nobel Laureate who identified, named and researched probiotic bacteria) believed that consumption of the fermenting Lactobacillus positively influenced the microflora of the gut, decreasing the toxic microbial activity of the pathogenic bacterial population (Figueroa-Gonzalez et al. 2011; Sharma et al. 2012).

Syngai et al. (2016)  identiy the multiple modes of action by which probiotics can influence our health— (1) Enhancement of epithelial barrier function; (2) Increasing adhesion to intestinal epithelial cells; (3) Competitive exclusion of pathogenic microorganisms; (4) Production of antiomicrobial peptides; (5) Modulation of the immune system. And more.

Intestinal barrier function is maintained by several interrelated systems including mucus secretion, chloride and water secretion, and binding together of epithelial cells at their apical junctions by tight junction proteins (Ng et al., 2009).  Streptococcus thermophilus and Lactobacillus acidophilus have been found to limit chloride and water secretion which reversed the E. coli– induced chloride secretion by epithelial cells (Brown, 2011).  L. acidophilus and S. thermophilus individually or collectively maintain or stablilize other cytoskeleton structures like actin, AO-1, and occludin when disrupted by pathogenic bacteria (Ng et al. 2009).

Integral to the gut barrier defense is mucus, composed of mucins (MUC 2 and MUC 3), which are secreted from the goblet cells. Mucin polymerization provides the structural foundation of the mucus, granting protection from pathogens, enzymes, toxins, dehydration and abrasion. Lactobacillus plantarum and Lactobacillus rhamnosus have been shown to up-regulate production of intestinal mucins (MUC 2 and MUC 3), which subvert the adherence of the enteropathogenic bacterium Escherichia coli to intestinal epithelial cells, consequently preventing pathogenic bacterial translocation (Hardy et al. 2013).

References:

Brown, M. (2011). Modes of action of probiotics: recent developments. Journal of animal and Veterinary Advances, 10(14), 1895-1900.

Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.

Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.

Metchnikoff, I.I. (1907). The Prolongation of Life: Optimistic Studies. Springer Publishing Company.

Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.

Sharma SK, Joshi VK, Sharma S. Probiotics: concepts and applications in food. In: Joshi VK, Singh RS, editors. Food biotechnology: principles and practices. India: IK International Publishing House Pvt

Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of food science and technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.Green Facts:

Globe_Home 3 At Slow Food Nation’s July 2017 Conference Alice Waters presented her vision for School Lunch as an Academic Subject— click here to see and hear her most illuminating talk— a program that if implemented would transform our US food system into one that heals as apposed to what we are now all experiencing.
 

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Dear Friends

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the United States and dietary habits account for a large percentage of the risk for developing CRC (Pitsouni et al., 2009)

Can probiotic supplementation help in the prevention of colorectal cancer?

Azcarate-Peril et al. (2011), The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer, examined the peer reviewed medical literature and conclude that probiotics help protect against the development of colorectal cancer.  In their article, New scientific paradigms for probiotics and prebiotics, Reid et al. (2003) come to the same conclusion.

Additionally, Liu et al. (2011), in their randomized clinical trial on L. plantarum, L. acidophilus, and B. longum, concluded that probiotic treatment on barrier function and postoperative infectious complications in colorectal cancer surgery demonstrated beneficial results.

Therapeutic Food Probiotics to support CRC: according to the research, take 6 days before surgery, and 10 days after surgery (Liu et al., 2011).

Both the Original and Supernatant are formulated with probiotics shown in research to confer beneficial results.

Click on any of the links above to learn more about the probiotic bacteria within each of the formulas.

References

  • Azcarate-Peril, M.A., Sikes, M., Bruno-Barcena, J.M. (2011). The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? Am J Physiol Gastrointest Liver Physiol, 301, G401-G424. doi:10.1152/ajpgi.00110.2011.
  • Liu, Z., Qin, H., Yang, Z., Xia, Y., Liu, W., Yang, J., Jiang, Y., Zhang, H., Wang, Y., Zheng, Q. (2011). Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery – a double-blind study. Aliment Pharmacol Ther, 33: 50–63, 2011.
  • Pitsouni, E., Alexiou, V., Saridakis, V., Peppas, G., Falagas, M.E. (2009). Does the use of probiotics/synbiotics prevent postoperative infections in patients undergoing abdominal surgery? A meta-analysis of randomized controlled trials. Eur J Clin Pharmacol65, 561–70. PubMed
  • Reid, G., Sanders, M.E., Gaskins, H.R., Gibson, G.R., Mercenier, A., Rastall, R., Roberfroid, M., Rowland, I., Cherbut, C., Klaenhammer, T.R. (2003). New scientific paradigms for probiotics and prebiotics. J Clin Gastroenterol, 37, 105–118.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Watch the new trailer An Inconvenient Sequel: Truth to Power.    The sequel to An Inconvenient Truth.  In theatres July 28, 2017.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Cox and fellow researchers concluded in their paper, Lactobacillus casei Abundance is Associated with Profound Shifts in the Infant Gut Microbiome, that supplementing infants with Lactobacillus casei rhamnosus is positively associated with the promotion of a stable, even, and functionally redundant infant gastrointestinal community; and the reduced risk of atopy and asthma later in life (Cox et al., 2010).

Cox et al. (2010) hypothesize that Lactobacillus casei subsp. Rhamnosus  promote a clustering (a consortium of bugs that work well together) of known probiotic species within the infant gut that are more resistant to perturbation and outgrowth of pathogens (See Food Science below).

A randomized, controlled, double-blind study of 159 newborns, found that early feeding of Lactobacillus casei decrease the rate of atopic dermatitis at age two by 50% (Kalliomaki et al., 2001) and that this protective effect was sustained past infancy (Kalliomaki et al., 2003).

Colonization of the infant gut microorganisms over the first year of life is crucial for development of a balanced immune response; and, early alterations in the gastrointestinal microbiota of neonates has been linked with subsequent development of asthma and atopy in older children (Cox et al., 2010).

Therapeutic Food Protocol for the Neonate LactORN Bottle 2

  • LactORN– 1/8th of a tsp twice a week (one way is to offer LactORN on your fingertip).

Comment:  LactORN contains Lactobacillius casei rhamnosus. LactOrn is blended with inulin derived from organic chicory root, functioning as an important prebiotic fiber.  It has a naturally sweet taste that babies and adults love.

Others of our synbiotic formulas, that have proven to be powerful probiotic formulas for children, are the Original Synbiotic, the Beta Glucan Synbiotic, and the Supernatant Synbiotic.  Click on their links to see their ingredients.  They all contain L. casei rhamnosus plus other good bugs that L. casei promotes a clustering for a healthy and stronger microbiome.

Food Science

Cox et al.’s (2010)  research question centered upon whether the demonstrable positive effects of L. casei rhamnosus was the result of a species-specific increase in relative abundance that accounts for its protective benefits, or, if there is a global effect on the complex GI microbial consortium.  In other words, is it the L. casei rhamnosus all by itself that is doing the disease-reducing work? Or, is it the presence of L. casei that somehow promotes the growth of other good probiotic organisms, and all together as a consortium (cluster) they protect and enhence the baby’s microbiome. They concluded it was the later, it takes a village to raise a baby!

Analysis of the phylogenetic (physical form/identity) differences characteristic of samples with high L. casei rhamnosus revealed a large number of taxa (families of organism) increased in relative abundance in these communities.  These included a number of known beneficial species belonging to the Lactobacillaceae and Bifidobacteriaceae.  Community phylogenetic metrics demonstrated that the promoted taxa were strongly phylogenetically related; and, suggests functional redundancy with GI communities that possess L. casei rhamnosus in high abundance.

In summary the Cox et al. L. casei rhamnosus study demonstrates that high abundance of this probiotic organism is associated with a dramatic change in GI microbial community composition in infants, impacting the relative abundance of a large number of taxa that can be beneficial in reducing the risk of allergy and atopy later in life.

References

  • Cox, M.J., Huang, Y.J., Huang Y.J., Fujimura, K.E., Liu, J.T., McKean, M., Boushey, H.A., Segal, M.R., Brodie, E.L., Cabana, M.D., Lynch, S.V. (2010). Lactobacillus casei Abundance Is Associated with Profound Shifts in the Infant Gut Microbiome. PLOS| one; Tenth Anniversary. Full paper.
  • Kalliomaki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P. et al (2001). Probiotic in primary prevention of atopic disease: a randomized placebo-controlled trial. Lancet; 357: 1076-1079.
  • Kalliomaki, M., Salminen, S., Poussa, T., Arvilommi, H., Isolauri, E. (2003). Probiotics and prevention of atopic disease: 4-year follow-up of a randomized placebo-controlled trial. Lancet; 361: 1869-18

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Watch the new trailer An Inconvenient Sequel: Truth to Power.    The sequel to An Inconvenient Truth.  In theatres July 28, 2017.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Neuro-regeneration

April 9, 2017

Dear Friends,

Cognitive decline, memory loss, and foggy thinking are on the rise and do not automatically accompany old age but affect all ages (Joseph, 2009).

Plant polyphenols and a healthy microbiome in the GI tract have shown to strongly support a healthy functioning nervous system, regenerate nerve tissue and protect against the onset of neuro-degenerative decline (Brewer et al., 2010; Burokas et al., 2015).

Therapeutic Food Protocol for Cognitive Support.

Food Science

A declining nervous system leads to the problematic onset of neurodegenerative diseases (Parkinson’s and Alzheimer’s).  Protecting against this decline, berry fruit polyphenols were examined, and in particular, blueberry extract anthocyanins for their multiplicity of actions that goes beyond the established antioxidant ability (Galli et al., 2002). The other possible mechanisms for the berry’s positive effects include: direct effects on signaling to enhance neuronal communication (Joseph et al., 2003), the ability to buffer against excess calcium (Joseph et al., 2004), enhancement of neuroprotective stress shock proteins (Galli et al., 2006), and reduction of stress signals such as nuclear factor B (NF-B) (Goyarzu et al., 2004).  Additionally, the anthocyanins contained in blueberries have been shown to enter the brain, and their concentrations were correlated with cognitive performance (Andres-Lacueva et al., 2005).

The brain-gut axis is a bidirectional communication system between the central nervous system (CNS) and the gastrointestinal tract. Regulation of the microbiota-brain-gut axis is essential for maintaining homeostasis, including that of the CNS. It is clear that the gut microbiota can be a key regulator of mood, cognition, pain, and obesity (Burokas et al., 2015; Borre et al., 2014).

Bibliography

  • Andres-Lacueva, C., Shukitt-Hale, B., Galli RL., Jauregui O., Lamuela-Reventos, RM., Joseph, J. (2005). Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci; 8:111-120.
  • Borre, Y.E., Moloney, R.D., Clarke, G., Dinana, T.G., Cryan, J.F. (2014). The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Adv Exp Med Biol, 817, 373-403.
  • Brewer, G.J., Torricelli, J.R., Lindsey, A.L., Kunz, E.Z., Neuman, A., Fisher, D.R., & Joseph, J.A. (2010). Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem, 21, 991-998.
  • Burokas, A., Moloney, RD., Dinan, TG., Cryan, JF. (2015). Microbiotia regulation of the Mammalian gut-brain axis. Adv Appl Microbiol; 91(1): 1-62.
  • Galli, R.L., Shukitt-Hale, B., Youdim, K.A.. Joseph, J.A. (2002). Fruit polyphenolics and brain aging:  nutritional interventions targeting age-related neuronal and behavioral deficits. Ann NY Acad Sci; 959: 128-32.
  • Galli,RL., Bielinski, DF., Szprengiel, A., Shukitt-Ale, B., Joseph, J. (2006). Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection.  Neurobiol Aging; 27:344-350.
  • Goyarzu, P., Malin, DH., Lau FC., Taglialatela, G. Moon, WD., Jennings, R., Moy, E., et al. (2004).  Blueberry supplemented diet: effects on object recognition memory and nuclear factor kappa B levels in aged rats. Nutr Neurosci: 7:75-83.
  • Joseph, J., Denisova, NA., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003).  Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 6:153-162.
  • Joseph, J., Fisher, D.R., Carey, AN. (2004). Fruit extracts antagonize Abeta- or DA- induced deficits in Ca2++ flux in M1-transfect COS-7 cells. J Alzheimers Dis; 6:403;discussion 443-9.
  • Joseph, J., Cole, G., Head, E., Ingram, D. (2009). Nutrition, brain aging, and neurodegeneration. J Neurosci; 29(41): 12795-801.
  • Joseph, J.A., Denisova, N.A., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003). Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci, 6, 153-162.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Well, in just 12 days from today it’s the Hawaii Doc Talks Convention!, but who’s counting.

On Friday March 3rd we will host the breakfast in Maui and teach on a topic that gets right to the heart of the matter regarding food as medicine:  The Intelligence and Power of Therapeutic Food Supplements: Science, Research, and Protocol.

Click on the above link to the see our learning objectives for the doctors.  The third objective is: Discover the next generation probiotics — infection fighting Supernatant metabolites and immune boosting microRNA.

Remember, if you can’t join us this time around, I would be more than happy to meet you via the zoom meeting format online.  Just let me know and we’ll set it up.

The two photos below present our synbiotic formulas.  The top one highlighting our new LactORN Synbiotic and the photo below seven more probiotic offerings.

LactORNs

Understanding our microbiome is without a question one of the hottest topics in medicine. Hippocrates, 2400 years ago, said that all disease begins in the gut.  In a recent speech Dr. Francis Collins, past director of the Human Microbiome Project, and present director of the NIH said,

We are a chimera-like creatire whose healthy metabolic and physiologic functioning is governed by not only our 10 trillion human cells and their 22,000 genes but also by our human microbiome community that co-habitate our bodies, all 100 trillion of them with their 2 to 8 million genes—most of them bacteria living in our GI tract. (2015, Supercharging Science for the Superorganism)

grp_2

“An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.”  (HMP Home page).

The microbiome must be taken into account regarding metabolic diseases (Metabolic Syndrome, Obesity, Diabetes, Heart Disease), gastrointestinal disease (IBS, IBD), and neuroligical health.

Yours truly,

Seann Bardell CEO
BioImmersion Inc.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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  • Dr. Francis Collins, the Director of the NIH recently said “The time of the importance of the microbiome and human health has arrived.  Our gut microbiome is of central importance for our immune system health, our neural-transmitter health, our GI tract health, and our metabolic health.