Original Synbiotic

Neuro-regeneration

April 9, 2017

Dear Friends,

Cognitive decline, memory loss, and foggy thinking are on the rise and do not automatically accompany old age but affect all ages (Joseph, 2009).

Plant polyphenols and a healthy microbiome in the GI tract have shown to strongly support a healthy functioning nervous system, regenerate nerve tissue and protect against the onset of neuro-degenerative decline (Brewer et al., 2010; Burokas et al., 2015).

Therapeutic Food Protocol for Cognitive Support.

Food Science

A declining nervous system leads to the problematic onset of neurodegenerative diseases (Parkinson’s and Alzheimer’s).  Protecting against this decline, berry fruit polyphenols were examined, and in particular, blueberry extract anthocyanins for their multiplicity of actions that goes beyond the established antioxidant ability (Galli et al., 2002). The other possible mechanisms for the berry’s positive effects include: direct effects on signaling to enhance neuronal communication (Joseph et al., 2003), the ability to buffer against excess calcium (Joseph et al., 2004), enhancement of neuroprotective stress shock proteins (Galli et al., 2006), and reduction of stress signals such as nuclear factor B (NF-B) (Goyarzu et al., 2004).  Additionally, the anthocyanins contained in blueberries have been shown to enter the brain, and their concentrations were correlated with cognitive performance (Andres-Lacueva et al., 2005).

The brain-gut axis is a bidirectional communication system between the central nervous system (CNS) and the gastrointestinal tract. Regulation of the microbiota-brain-gut axis is essential for maintaining homeostasis, including that of the CNS. It is clear that the gut microbiota can be a key regulator of mood, cognition, pain, and obesity (Burokas et al., 2015; Borre et al., 2014).

Bibliography

  • Andres-Lacueva, C., Shukitt-Hale, B., Galli RL., Jauregui O., Lamuela-Reventos, RM., Joseph, J. (2005). Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci; 8:111-120.
  • Borre, Y.E., Moloney, R.D., Clarke, G., Dinana, T.G., Cryan, J.F. (2014). The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Adv Exp Med Biol, 817, 373-403.
  • Brewer, G.J., Torricelli, J.R., Lindsey, A.L., Kunz, E.Z., Neuman, A., Fisher, D.R., & Joseph, J.A. (2010). Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem, 21, 991-998.
  • Burokas, A., Moloney, RD., Dinan, TG., Cryan, JF. (2015). Microbiotia regulation of the Mammalian gut-brain axis. Adv Appl Microbiol; 91(1): 1-62.
  • Galli, R.L., Shukitt-Hale, B., Youdim, K.A.. Joseph, J.A. (2002). Fruit polyphenolics and brain aging:  nutritional interventions targeting age-related neuronal and behavioral deficits. Ann NY Acad Sci; 959: 128-32.
  • Galli,RL., Bielinski, DF., Szprengiel, A., Shukitt-Ale, B., Joseph, J. (2006). Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection.  Neurobiol Aging; 27:344-350.
  • Goyarzu, P., Malin, DH., Lau FC., Taglialatela, G. Moon, WD., Jennings, R., Moy, E., et al. (2004).  Blueberry supplemented diet: effects on object recognition memory and nuclear factor kappa B levels in aged rats. Nutr Neurosci: 7:75-83.
  • Joseph, J., Denisova, NA., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003).  Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 6:153-162.
  • Joseph, J., Fisher, D.R., Carey, AN. (2004). Fruit extracts antagonize Abeta- or DA- induced deficits in Ca2++ flux in M1-transfect COS-7 cells. J Alzheimers Dis; 6:403;discussion 443-9.
  • Joseph, J., Cole, G., Head, E., Ingram, D. (2009). Nutrition, brain aging, and neurodegeneration. J Neurosci; 29(41): 12795-801.
  • Joseph, J.A., Denisova, N.A., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003). Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci, 6, 153-162.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Have you tune into the Rocky Mountain Institute.  Their vision is a world thriving, verdant and secure, for all, for ever.  Their mission is to drive the efficient and restorative use of resources.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Well, in just 12 days from today it’s the Hawaii Doc Talks Convention!, but who’s counting.

On Friday March 3rd we will host the breakfast in Maui and teach on a topic that gets right to the heart of the matter regarding food as medicine:  The Intelligence and Power of Therapeutic Food Supplements: Science, Research, and Protocol.

Click on the above link to the see our learning objectives for the doctors.  The third objective is: Discover the next generation probiotics — infection fighting Supernatant metabolites and immune boosting microRNA.

Remember, if you can’t join us this time around, I would be more than happy to meet you via the zoom meeting format online.  Just let me know and we’ll set it up.

The two photos below present our synbiotic formulas.  The top one highlighting our new LactORN Synbiotic and the photo below seven more probiotic offerings.

LactORNs

Understanding our microbiome is without a question one of the hottest topics in medicine. Hippocrates, 2400 years ago, said that all disease begins in the gut.  In a recent speech Dr. Francis Collins, past director of the Human Microbiome Project, and present director of the NIH said,

We are a chimera-like creatire whose healthy metabolic and physiologic functioning is governed by not only our 10 trillion human cells and their 22,000 genes but also by our human microbiome community that co-habitate our bodies, all 100 trillion of them with their 2 to 8 million genes—most of them bacteria living in our GI tract. (2015, Supercharging Science for the Superorganism)

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“An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.”  (HMP Home page).

The microbiome must be taken into account regarding metabolic diseases (Metabolic Syndrome, Obesity, Diabetes, Heart Disease), gastrointestinal disease (IBS, IBD), and neuroligical health.

Yours truly,

Seann Bardell CEO
BioImmersion Inc.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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  • Dr. Francis Collins, the Director of the NIH recently said “The time of the importance of the microbiome and human health has arrived.  Our gut microbiome is of central importance for our immune system health, our neural-transmitter health, our GI tract health, and our metabolic health.

Dear Friends

For support against Traveler’s Diarrhea, and other pathogenic maladies that one can be exposed to and catch while traveling, a good garlic supplement, as well as along a potent probiotic can be your best friend.

Therapeutic Food recipes for Healthy Travels: 

Organic Garlic: 1 to 2 capsules daily
Supernatant Synbiotic: 1 capsule daily
LactORN: 1 level tsp. twice a week

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garlic

Dear Friends

An old and natural practice to treat vaginal yeast infections is the vaginal douche using a good collection of lactic acid bacteria, such as the Lactobacillus species found within our Original Synbiotic formula, along with a clove of freshly reacted garlic in warmish water. The following protocol makes this an easy process:

We’ve seen in our April 24th Forward Thinking and earlier in the April 12th newsletter that according to current research certain Lactobacillus species taken orally with garlic can be a very effective protocol for treating both vaginosis and candidiasis respectively.  Click on their links to see these references.

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Candidiasis Support

April 12, 2016

Dear Friends

Did you know that nosocomal infections of multiply resistant pathogens kill more patients each year than breast cancer and HIV combined?  The war on pathogens with antibiotics is not a war that we are winning.  Picking a fight with natural selection is not a smart thing to do (Read, 2012).

The human gut contains a vast ecosystem of microorganisms, a flora that must be ecologically managed well by us, in order to be truly healthy.  The overuse and misuse of antibiotics in medicine, the practice of giving cattle low growth promoting doses of antibiotics has created grave gastrointestinal problems.  There are better ways to manage the ecosystem within our gut and control the overgrowth of pathogens, without antibiotics.

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