Original Synbiotic

Endotoxemia and Chlorella

December 14, 2017

Dear Friends

Chlorella HZ 2

Chlorella and inulin reduce endotoxemia and protect the intestinal mucosa barrier.

What is an endotoxin, and what causes endotoxemia? How does chlorella reduce endotoxemia, and how does inulin produce a healthy microbiome?  Let’s take a look at a few studies.

An endotoxin is often used synonymously with LPS.  Lipopolysaccharides (LPSs) are the major components of the outer membrane of Gram-negative bacteria. Rietschel et al. found in 1994 that LPSs induce strong inflammatory responses from the immune systems of all animals.

Liver Diseases are associated with leaky gut syndrome, which allows for the passage LPS molecules into the systemic circulation, causing chronic inflammation, and a condition called endotoxemia. A large enough load of LPSs in the systemic circulations can cause septic shock.

In fact, severe sepsis is a common and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction. It is especially common in the elderly and is likely to increase substantially as the U.S. population ages (Angus et al., 2001)

Bedirli et al. (2009) investigated the role of different microalgae (Chlorella sp. and Spirulina sp.) extracts in intestinal barrier function and oxidative stress in experimentally jaundice rats.

The main outcomes measured were endotoxin concentrations in plasma [e.g. LPS levels], evidence of bacterial translocation in mesenteric lymph nodes and liver oxidative stress, and histology.

Their findings: A Chlorella sp. supplemented diet significantly demonstrated protective effects on the intestinal mucosa barrier in obstructive jaundice, and reduced intestinal translocation of bacteria and endotoxin.  Spirulina had no significant effect.

Original copyCani et al. (2008) found that a high animal fat diet changes the GI tract microbiome into a population of increasing numbers of Gram-negative bacteria, which raises the level of LPS endotoxins within the gut lumen and allows their passing through the GI tract membrane into the plasma.

The research team concluded that the plasma concentration of lipopolysaccharides (LPS) controls the inflammatory tone of the body.  This means that high concentrations of LPS set the stage for endotoxemia, resulting in metabolic diseases (obesity, diabetes, CVD) and cancer.

They further demonstrated in the study that increased fibers in the diet, such as inulin, increase the populations of Bifidobacterial sp. and Lactobacillus sp. which reduce both the load of Gram-negative bacteria and the permeability of the gastrointestinal membrane.

Our Suggestion: Take 4 to 8 tablets of Organic Chlorella daily.
Take 1 tsp. of Original Synbiotic daily.
References:

  • Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001). Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine, 29(7), 1303-1310.
  • Bedirli, A., Kerem, M., Ofluoglu, E., Salman, B., Katircioglu, H., Bedirli, N., … & Pasaoglu, H. (2009). Administration of Chlorella sp. microalgae reduces endotoxemia, intestinal oxidative stress and bacterial translocation in experimental biliary obstruction. Clinical nutrition, 28(6), 674-678.
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Rietschel, E. T., Kirikae, T., Schade, F. U., Mamat, U., Schmidt, G., Loppnow, H., … & Di Padova, F. (1994). Bacterial endotoxin: molecular relationships of structure to activity and function. The FASEB Journal, 8(2), 217-225.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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What kind of world do you want to wake up to 30 years from now?
The Biomimicry Institute aspires to a world where what we make is inspired by, and connected to, the natural world.  This means cities are resilient, emission targets are achieved, and industrial processes create healthy air, water, and soil.  It also means all species are thriving because our human designs restore the planet as nature’s desgns do.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

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The Original Synbiotic is a daily probiotic for the whole family.

The Original probiotics are researched pedigreed strains of lactic acid bacteria that support the development of a healthy GI tract microbiome.

A healthy gut microbiome is dependent on strong and proven probiotics, such as the Original strains. The Original Synbiotic provides a powerful symbiotic combination of Lactobacillus acidophilus (ATCC 4356), Streptococcus thermophilus (ATCC 19258), Lactobacillus plantarum (ATCC 8014), Lactobacillus rhamnosus (ATCC 7469) and Bifidobacterium longum (ATCC 15707).

Our chosen probiotics are foundational ATCC strains shown in research to work together with human cells to perform many functions in the body. For example, these probiotic strains help the digestive system, support and balance the immune system, and enhance our nervous system by producing neurotransmitters. They reinforce the GI barrier function to protect us from xenobiotics and pathogens, even binding heavy metals. Moreover, they neutralize carcinogens such as those caused by heterocyclic amines found in blackened meat and elements such as nitrosamines in sausage. By acidifying the epithelial membrane, they enable the absorption of minerals such as calcium and magnesium more readily. And lastly, our chosen strains also support the important task of daily regularity (Syngia et al., 2016; Hardy et al., 2013; Figueroa‐González et al., 2011; Ng et al., 2009).

The Original Synbiotic suggested daily dose: one tsp daily.

Of the many beneficial functions needed to be performed by our probiotic friends, colonizing the GI tract membrane and thereby protecting from our body from pathogens and xenobiotics, is very important. Check out these studies on colonization (Toscano et al., 2017; Underwood et al., 2015; Panigrahi et al., 2008; De Champs et al., 2003; Sarem- Damerdji et al., 1995).

See the Original Synbiotic Monograph.

References:

  • De Champs, C., Maroncle, N., Balestrino, Damien., Rich, C., Forestier, C. (2003). Persistence of Colonization of Intestinal Mucosa by A Probiotic Strain, Lactobacillus casei subsp rhamnosus Lcr35, after Oran Consumption. J Com Microbiol; 41(3): 1270-1273.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150315/
  • Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.
  • Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.
  • Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.
  • Panigrahi, P., Pradhan, L., Mohapatra, S.S., Misra, P.R., Johnson, J.A., Chaudhry, R., Taylor, S., Hanse, N.I., Gewolb, I.H. (2008). Long-term colonization of a Lactobacillus plantarum synbiotic preparation in the neonatal gut. J Pediatr Gastroenterol Nutr; 47(1):45-53. https://www.ncbi.nlm.nih.gov/pubmed/18607268
  • Sarem-Damerdji, L., Sarem, F., Marchal, L., Micolas, J.P. (1995). In vitro colonization ability of human colon mucosa by exogenous Lactobacillus strains. FEMS Microbiology Letters; 131(2):133-137. https://academic.oup.com/femsle/article-abstract/131/2/133/524865/In-vitro-colonization-ability-of-human-colon?redirectedFrom=PDF
  • Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of food science and technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0
  • Toscano, M., De Grandi, R., Stronati, L., De Vecchi, E., & Drago, L. (2017). Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study. World journal of gastroenterology, 23(15), 2696.
  • Underwood, M. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2015). Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatric research, 77, 229.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350908/

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3In today’s world the level of assault on our bodies from pollution, pathogens, and stress is so high that we need powerful food supplements.  Our bodies, after all, know exactly what and how to utilize food for therapeutic purposes.

At BioImmersion, we created the Therapeutic Food Supplement line with a new medical framework in mind: the power and intelligence of food. Our Therapeutic Foods are indeed potent food supplements that behave intelligenly in the body – repairing, healing, protecting and preventing.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Foundational Probiotics

September 5, 2017

Dear Friends

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What makes the BioImmersion probiotics so effective?

The Original Synbiotic Formula offers foundational bacterial organisms with a long history. These species were originally  researched by Metchnikoff, have a rich scientific historicity behind them, used as fermenting agents in different societies, and are now packaged in our Original Synbiotic formula.

No wonder we call them pedigreed strains—they have been shown for centuries to bring health building benefits to the human body.  The Original Synbiotic provides a powerful symbiotic combination of Lactobacillus acidophilus (ATCC 4356), Streptococcus thermophilus (ATCC 19258), Lactobacillus plantarum (ATCC 8014), Lactobacillus rhamnosus (ATCC 7469) and Bifidobacterium longum (ATCC 15707).

This is a comprehensive everyday formula to be used by the whole family.  It combines the five pedigreed human strains of lactic acid bacteria along with the prebiotic soluble fiber inulin, derived from organic chicory root.  The formula is dairy free, soy free, kosher, non GMO, and gluten free.*

Food Science

Syngai et al. (2016), Probiotic- the versatile functional food ingredient, summarize the potential health benefits derived from probiotics along with the versatility of their applications for human health as well as animal well-being.

Ilie Metchnikoff (Zoologist and Nobel Laureate who identified, named and researched probiotic bacteria) believed that consumption of the fermenting Lactobacillus positively influenced the microflora of the gut, decreasing the toxic microbial activity of the pathogenic bacterial population (Figueroa-Gonzalez et al. 2011; Sharma et al. 2012).

Syngai et al. (2016)  identiy the multiple modes of action by which probiotics can influence our health— (1) Enhancement of epithelial barrier function; (2) Increasing adhesion to intestinal epithelial cells; (3) Competitive exclusion of pathogenic microorganisms; (4) Production of antiomicrobial peptides; (5) Modulation of the immune system. And more.

Intestinal barrier function is maintained by several interrelated systems including mucus secretion, chloride and water secretion, and binding together of epithelial cells at their apical junctions by tight junction proteins (Ng et al., 2009).  Streptococcus thermophilus and Lactobacillus acidophilus have been found to limit chloride and water secretion which reversed the E. coli– induced chloride secretion by epithelial cells (Brown, 2011).  L. acidophilus and S. thermophilus individually or collectively maintain or stablilize other cytoskeleton structures like actin, AO-1, and occludin when disrupted by pathogenic bacteria (Ng et al. 2009).

Integral to the gut barrier defense is mucus, composed of mucins (MUC 2 and MUC 3), which are secreted from the goblet cells. Mucin polymerization provides the structural foundation of the mucus, granting protection from pathogens, enzymes, toxins, dehydration and abrasion. Lactobacillus plantarum and Lactobacillus rhamnosus have been shown to up-regulate production of intestinal mucins (MUC 2 and MUC 3), which subvert the adherence of the enteropathogenic bacterium Escherichia coli to intestinal epithelial cells, consequently preventing pathogenic bacterial translocation (Hardy et al. 2013).

References:

Brown, M. (2011). Modes of action of probiotics: recent developments. Journal of animal and Veterinary Advances, 10(14), 1895-1900.

Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.

Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.

Metchnikoff, I.I. (1907). The Prolongation of Life: Optimistic Studies. Springer Publishing Company.

Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.

Sharma SK, Joshi VK, Sharma S. Probiotics: concepts and applications in food. In: Joshi VK, Singh RS, editors. Food biotechnology: principles and practices. India: IK International Publishing House Pvt

Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of food science and technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.Green Facts:

Globe_Home 3 At Slow Food Nation’s July 2017 Conference Alice Waters presented her vision for School Lunch as an Academic Subject— click here to see and hear her most illuminating talk— a program that if implemented would transform our US food system into one that heals as apposed to what we are now all experiencing.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the United States and dietary habits account for a large percentage of the risk for developing CRC (Pitsouni et al., 2009)

Can probiotic supplementation help in the prevention of colorectal cancer?

Azcarate-Peril et al. (2011), The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer, examined the peer reviewed medical literature and conclude that probiotics help protect against the development of colorectal cancer.  In their article, New scientific paradigms for probiotics and prebiotics, Reid et al. (2003) come to the same conclusion.

Additionally, Liu et al. (2011), in their randomized clinical trial on L. plantarum, L. acidophilus, and B. longum, concluded that probiotic treatment on barrier function and postoperative infectious complications in colorectal cancer surgery demonstrated beneficial results.

Therapeutic Food Probiotics to support CRC: according to the research, take 6 days before surgery, and 10 days after surgery (Liu et al., 2011).

Both the Original and Supernatant are formulated with probiotics shown in research to confer beneficial results.

Click on any of the links above to learn more about the probiotic bacteria within each of the formulas.

References

  • Azcarate-Peril, M.A., Sikes, M., Bruno-Barcena, J.M. (2011). The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? Am J Physiol Gastrointest Liver Physiol, 301, G401-G424. doi:10.1152/ajpgi.00110.2011.
  • Liu, Z., Qin, H., Yang, Z., Xia, Y., Liu, W., Yang, J., Jiang, Y., Zhang, H., Wang, Y., Zheng, Q. (2011). Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery – a double-blind study. Aliment Pharmacol Ther, 33: 50–63, 2011.
  • Pitsouni, E., Alexiou, V., Saridakis, V., Peppas, G., Falagas, M.E. (2009). Does the use of probiotics/synbiotics prevent postoperative infections in patients undergoing abdominal surgery? A meta-analysis of randomized controlled trials. Eur J Clin Pharmacol65, 561–70. PubMed
  • Reid, G., Sanders, M.E., Gaskins, H.R., Gibson, G.R., Mercenier, A., Rastall, R., Roberfroid, M., Rowland, I., Cherbut, C., Klaenhammer, T.R. (2003). New scientific paradigms for probiotics and prebiotics. J Clin Gastroenterol, 37, 105–118.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Watch the new trailer An Inconvenient Sequel: Truth to Power.    The sequel to An Inconvenient Truth.  In theatres July 28, 2017.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Cox and fellow researchers concluded in their paper, Lactobacillus casei Abundance is Associated with Profound Shifts in the Infant Gut Microbiome, that supplementing infants with Lactobacillus casei rhamnosus is positively associated with the promotion of a stable, even, and functionally redundant infant gastrointestinal community; and the reduced risk of atopy and asthma later in life (Cox et al., 2010).

Cox et al. (2010) hypothesize that Lactobacillus casei subsp. Rhamnosus  promote a clustering (a consortium of bugs that work well together) of known probiotic species within the infant gut that are more resistant to perturbation and outgrowth of pathogens (See Food Science below).

A randomized, controlled, double-blind study of 159 newborns, found that early feeding of Lactobacillus casei decrease the rate of atopic dermatitis at age two by 50% (Kalliomaki et al., 2001) and that this protective effect was sustained past infancy (Kalliomaki et al., 2003).

Colonization of the infant gut microorganisms over the first year of life is crucial for development of a balanced immune response; and, early alterations in the gastrointestinal microbiota of neonates has been linked with subsequent development of asthma and atopy in older children (Cox et al., 2010).

Therapeutic Food Protocol for the Neonate LactORN Bottle 2

  • LactORN– 1/8th of a tsp twice a week (one way is to offer LactORN on your fingertip).

Comment:  LactORN contains Lactobacillius casei rhamnosus. LactOrn is blended with inulin derived from organic chicory root, functioning as an important prebiotic fiber.  It has a naturally sweet taste that babies and adults love.

Others of our synbiotic formulas, that have proven to be powerful probiotic formulas for children, are the Original Synbiotic, the Beta Glucan Synbiotic, and the Supernatant Synbiotic.  Click on their links to see their ingredients.  They all contain L. casei rhamnosus plus other good bugs that L. casei promotes a clustering for a healthy and stronger microbiome.

Food Science

Cox et al.’s (2010)  research question centered upon whether the demonstrable positive effects of L. casei rhamnosus was the result of a species-specific increase in relative abundance that accounts for its protective benefits, or, if there is a global effect on the complex GI microbial consortium.  In other words, is it the L. casei rhamnosus all by itself that is doing the disease-reducing work? Or, is it the presence of L. casei that somehow promotes the growth of other good probiotic organisms, and all together as a consortium (cluster) they protect and enhence the baby’s microbiome. They concluded it was the later, it takes a village to raise a baby!

Analysis of the phylogenetic (physical form/identity) differences characteristic of samples with high L. casei rhamnosus revealed a large number of taxa (families of organism) increased in relative abundance in these communities.  These included a number of known beneficial species belonging to the Lactobacillaceae and Bifidobacteriaceae.  Community phylogenetic metrics demonstrated that the promoted taxa were strongly phylogenetically related; and, suggests functional redundancy with GI communities that possess L. casei rhamnosus in high abundance.

In summary the Cox et al. L. casei rhamnosus study demonstrates that high abundance of this probiotic organism is associated with a dramatic change in GI microbial community composition in infants, impacting the relative abundance of a large number of taxa that can be beneficial in reducing the risk of allergy and atopy later in life.

References

  • Cox, M.J., Huang, Y.J., Huang Y.J., Fujimura, K.E., Liu, J.T., McKean, M., Boushey, H.A., Segal, M.R., Brodie, E.L., Cabana, M.D., Lynch, S.V. (2010). Lactobacillus casei Abundance Is Associated with Profound Shifts in the Infant Gut Microbiome. PLOS| one; Tenth Anniversary. Full paper.
  • Kalliomaki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P. et al (2001). Probiotic in primary prevention of atopic disease: a randomized placebo-controlled trial. Lancet; 357: 1076-1079.
  • Kalliomaki, M., Salminen, S., Poussa, T., Arvilommi, H., Isolauri, E. (2003). Probiotics and prevention of atopic disease: 4-year follow-up of a randomized placebo-controlled trial. Lancet; 361: 1869-18

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3
Watch the new trailer An Inconvenient Sequel: Truth to Power.    The sequel to An Inconvenient Truth.  In theatres July 28, 2017.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved