What works for sepsis?

September 27, 2017

Dear Friends                                                                                                                                                   SN Front Low Rez copy

Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction. It is especially common in the elderly and is likely to increase substantially as the U.S. population ages (Angus et al., 2001).

The health benefits of probiotics and synbiotics are well established in healthy adults, but what of their role in preventing postoperative sepsis?  This is the question that Arumugam, Lau, and Chamberlain sought an answer for in their 2016 meta-analysis which assessed the impact of probiotics and synbiotics on the incidence of postoperative sepsis in gastrointestinal surgical patients.

As the title of their study indicates— “Probiotics and synbiotics decrease postoperative sepsis in elective gastrointestinal surgical patients:  a meta-analysis” — their answer is affirmative.

A comprehensive literature search of all published randomized control trials (RCTs) was conducted with 15 RCTs meeting their selecting criteria in which 1201 patients were involved (192 receiving probiotics, 413 receiving synbiotics, and 596 receiving placebo) and analyzed.

Overall, probiotics and synbiotic uses significantly reduced the risk of developing postoperative sepsis by 38%.  Their conclusion was that probiotic/synbiotic supplementation is a valuable adjunct in the care of patients undergoing GI surgery.

The Supernatant Synbiotic contains:  15.75 billion cfu/cap of certified strains of Traditional Bulgarian pedigreed probiotics. They are B. longum, L. casei, L. acidophilus, L. bulgaricus (multi-strain) and S. thermophilus (multi-strain) along with Supernatant (inactive probiotic cell populations of L. bulgaricus and S. thermophilus and their metabolites) plus inulin (derived from organic chicory root fiber).

Suggested supplementation: 1-2 capsules daily.
LactORN LRez jpeg 3
The LactORN contains:  the probiotic Lactobacillus casei grown in a way to retain its natural oligoribonucleotides (ORNs). Plus it contains the prebiotic inulin derived from organic chicory root.  Think of it as your immune boosting tool. Across animal species, the LactORN has been shown to support immune system competencies to prevent infections caused by viruses and bacteria. It also helps the body to protect itself from toxins.  Plus it helps to keep the adaptive immune system from overreacting into septic shock (Marshall, 2007).

Suggested supplementation: 1 level tsp per week (dissolve in mouth).


  • Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001). Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine, 29(7), 1303-1310.
  • Arumugam, S., Lau, C. S., & Chamberlain, R. S. (2016). Probiotics and synbiotics decrease postoperative sepsis in elective gastrointestinal surgical patients: a meta-analysis. Journal of Gastrointestinal Surgery, 20(6), 1123-1131.
  • Marshall W. (2007). Oligoribonucleotides alert the immune system of animals to the imminence of microbial infections. US patent 7,189,834 B2

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3At BioImmersion, we created the Therapeutic Food Supplement line with a new medical framework in mind: the power and intelligence of food. Our Therapeutic Foods are indeed potent food supplements that behave intelligenly in the body – repairing, healing, protecting and preventing.

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Cox and fellow researchers concluded in their paper, Lactobacillus casei Abundance is Associated with Profound Shifts in the Infant Gut Microbiome, that supplementing infants with Lactobacillus casei rhamnosus is positively associated with the promotion of a stable, even, and functionally redundant infant gastrointestinal community; and the reduced risk of atopy and asthma later in life (Cox et al., 2010).

Cox et al. (2010) hypothesize that Lactobacillus casei subsp. Rhamnosus  promote a clustering (a consortium of bugs that work well together) of known probiotic species within the infant gut that are more resistant to perturbation and outgrowth of pathogens (See Food Science below).

A randomized, controlled, double-blind study of 159 newborns, found that early feeding of Lactobacillus casei decrease the rate of atopic dermatitis at age two by 50% (Kalliomaki et al., 2001) and that this protective effect was sustained past infancy (Kalliomaki et al., 2003).

Colonization of the infant gut microorganisms over the first year of life is crucial for development of a balanced immune response; and, early alterations in the gastrointestinal microbiota of neonates has been linked with subsequent development of asthma and atopy in older children (Cox et al., 2010).

Therapeutic Food Protocol for the Neonate LactORN Bottle 2

  • LactORN– 1/8th of a tsp twice a week (one way is to offer LactORN on your fingertip).

Comment:  LactORN contains Lactobacillius casei rhamnosus. LactOrn is blended with inulin derived from organic chicory root, functioning as an important prebiotic fiber.  It has a naturally sweet taste that babies and adults love.

Others of our synbiotic formulas, that have proven to be powerful probiotic formulas for children, are the Original Synbiotic, the Beta Glucan Synbiotic, and the Supernatant Synbiotic.  Click on their links to see their ingredients.  They all contain L. casei rhamnosus plus other good bugs that L. casei promotes a clustering for a healthy and stronger microbiome.

Food Science

Cox et al.’s (2010)  research question centered upon whether the demonstrable positive effects of L. casei rhamnosus was the result of a species-specific increase in relative abundance that accounts for its protective benefits, or, if there is a global effect on the complex GI microbial consortium.  In other words, is it the L. casei rhamnosus all by itself that is doing the disease-reducing work? Or, is it the presence of L. casei that somehow promotes the growth of other good probiotic organisms, and all together as a consortium (cluster) they protect and enhence the baby’s microbiome. They concluded it was the later, it takes a village to raise a baby!

Analysis of the phylogenetic (physical form/identity) differences characteristic of samples with high L. casei rhamnosus revealed a large number of taxa (families of organism) increased in relative abundance in these communities.  These included a number of known beneficial species belonging to the Lactobacillaceae and Bifidobacteriaceae.  Community phylogenetic metrics demonstrated that the promoted taxa were strongly phylogenetically related; and, suggests functional redundancy with GI communities that possess L. casei rhamnosus in high abundance.

In summary the Cox et al. L. casei rhamnosus study demonstrates that high abundance of this probiotic organism is associated with a dramatic change in GI microbial community composition in infants, impacting the relative abundance of a large number of taxa that can be beneficial in reducing the risk of allergy and atopy later in life.


  • Cox, M.J., Huang, Y.J., Huang Y.J., Fujimura, K.E., Liu, J.T., McKean, M., Boushey, H.A., Segal, M.R., Brodie, E.L., Cabana, M.D., Lynch, S.V. (2010). Lactobacillus casei Abundance Is Associated with Profound Shifts in the Infant Gut Microbiome. PLOS| one; Tenth Anniversary. Full paper.
  • Kalliomaki, M., Salminen, S., Arvilommi, H., Kero, P., Koskinen, P. et al (2001). Probiotic in primary prevention of atopic disease: a randomized placebo-controlled trial. Lancet; 357: 1076-1079.
  • Kalliomaki, M., Salminen, S., Poussa, T., Arvilommi, H., Isolauri, E. (2003). Probiotics and prevention of atopic disease: 4-year follow-up of a randomized placebo-controlled trial. Lancet; 361: 1869-18

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Watch the new trailer An Inconvenient Sequel: Truth to Power.    The sequel to An Inconvenient Truth.  In theatres July 28, 2017.

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Well, in just 12 days from today it’s the Hawaii Doc Talks Convention!, but who’s counting.

On Friday March 3rd we will host the breakfast in Maui and teach on a topic that gets right to the heart of the matter regarding food as medicine:  The Intelligence and Power of Therapeutic Food Supplements: Science, Research, and Protocol.

Click on the above link to the see our learning objectives for the doctors.  The third objective is: Discover the next generation probiotics — infection fighting Supernatant metabolites and immune boosting microRNA.

Remember, if you can’t join us this time around, I would be more than happy to meet you via the zoom meeting format online.  Just let me know and we’ll set it up.

The two photos below present our synbiotic formulas.  The top one highlighting our new LactORN Synbiotic and the photo below seven more probiotic offerings.


Understanding our microbiome is without a question one of the hottest topics in medicine. Hippocrates, 2400 years ago, said that all disease begins in the gut.  In a recent speech Dr. Francis Collins, past director of the Human Microbiome Project, and present director of the NIH said,

We are a chimera-like creatire whose healthy metabolic and physiologic functioning is governed by not only our 10 trillion human cells and their 22,000 genes but also by our human microbiome community that co-habitate our bodies, all 100 trillion of them with their 2 to 8 million genes—most of them bacteria living in our GI tract. (2015, Supercharging Science for the Superorganism)


“An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.”  (HMP Home page).

The microbiome must be taken into account regarding metabolic diseases (Metabolic Syndrome, Obesity, Diabetes, Heart Disease), gastrointestinal disease (IBS, IBD), and neuroligical health.

Yours truly,

Seann Bardell CEO
BioImmersion Inc.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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  • Dr. Francis Collins, the Director of the NIH recently said “The time of the importance of the microbiome and human health has arrived.  Our gut microbiome is of central importance for our immune system health, our neural-transmitter health, our GI tract health, and our metabolic health.

Tired of Your Colds & Flu?

January 23, 2017

Dear Friends

We are in the midst of the season for colds and flu, and added stress certainly does not help the situation, or does it?

Suzanne Segerstrom and Gregory Miller (2004), Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry, examined more than 300 empirical articles describing a relationship between psychological stress and parameters of the immune system in human participants.

Segerstrom and Miller found that acute stressors (lasting minutes) were associated with potentially adaptive up-regulation of some parameters of natural immunity and down-regulation of some functions of specific immunity.  But chronic stressors on the other hand were associated with suppression of both cellular and humoral measures (see also Priyandarshini & Aich, 2012).

Chronic stress compromises our immune system putting us at risk to bacterial and viral infections; where as an acute momentary stressor can enhance/prime the innate immune system to more apply protect us from invading bacteria and viruses.  The trick is knowing how to prime our immune system successfully.

Do you have a tough time getting rid of your sore throat, cold, or flu?  Three BioImmersion products support the more robust functioning of our immune system to nip a cold. The garlic and No7 are famous for kicking out nasty sore throats and colds, while the LactORN alerts our immune system into action.

Recipe for Immune System support against colds and flu

  • LactORN- 1tsp. daily (held into the mouth until it dissolves). This paradigm shifter product kicks the fast acting (innate) immune system into gear!
  • No. 7 Systemic Booster- 1 tsp. daily (mix in a glass of water).
  • Organic Garlic- 1-2 capsules. For sore throats, open the capsules into a cup of water (or your mix with No7) and stir, let sit for one minutes and drink.

Both the LactORN and the No.7 Systemic Booster contain ingredients that challenge our immune system—namely, the oligoribonucleotides (ORNs) and the supernatant broth (whole dead-cells of probiotics, vitamins & minerals, enzymes, bacteriocin, ORNs, and more), respectively.  No.7 and LactORN also contain strong probiotic organisms that actually fight against pathogens. Garlic, especially when it is sourced with high allicin potential and manufactured correctly to preserve its high actives is known to offer a wonderful broad spectrum antimicrobial.  Hard on many pathogens but minimally so on good lactic acid bacteria in our probiotic mix, garlic is a perfect agent against colds and flu.

Food Science

Segerstrom and Miller (2004) divided stressors into 6 categories: Acute time-limited, Brief naturalistic, Event sequence, Chronic, Distant, and Life event.  Each type has a different effect on our immune system ability to defend us from colds and flus.

The Acute time-limited stressor category falls within the fight-or flight responses, an encounter more common to our ancestors.  Fighting and/or fleeing carries the risk of injury and subsequent entry of infectious agents into the bloodstream or skin.  Any wound in the skin is likely to contain pathogens that could multiply and cause infections (Williams & Leaper, 1998).  Stress-induced changes in the immune system that could accelerate wound repair and help prevent infections from taking hold would therefore be adaptive and selected along with other physiological changes that increased evolutionary fitness.

Cells involved in natural immunity do not provide defense against any particular pathogen; rather, they are all-purpose cells that can attack a number of different pathogens and do so in a relatively short time frame (minutes to hours) when challenged.


  • Priyandarshini S, Aich P. (2012). Effects of Psychological Stress on Innate Immunity and Metabolism in humans:  A Systematic Analysis.
  • Segerstrom SC, Miller GE. (2004). Psychological Stress and the Human Immune System:  A Meta-Analytic study of 30 Years of inquiry. Psychol Bull; 130(3): 601-630.
  • Williams, N. A., & Leaper, D. J. (1998). Infection. In D. J. Leaper & K. G. Harding (Eds.), Wounds: Biology and management (pp. 71– 87). New York: Oxford University Press.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.
Green Facts:

Globe_Home 3How can we deliver nutrition in a way that nourishes both planet and people?  See Janine Benyus, Dec 1, 2016 key note talk, Biomimicry as a Cooperative Inquiry, on nature-inspired breakthroughs in agriculture.

Dear Friends

For support against Traveler’s Diarrhea, and other pathogenic maladies that one can be exposed to and catch while traveling, a good garlic supplement, as well as along a potent probiotic can be your best friend.

Therapeutic Food recipes for Healthy Travels: 

Organic Garlic: 1 to 2 capsules daily
Supernatant Synbiotic: 1 capsule daily
LactORN: 1 level tsp. twice a week