High ORAC

Dear Friends
HO Front Low Rez
Recent studies show that dietary polyphenols support the growth of good bacteria in the gut while inhibiting pathogenic bacteria.

Dueñas et al.’s (2015) study entitled, A survey of modulation of gut microbiota by dietary polyphenols, showed that dietary polyphenols contribute to the maintenance of intestinal health by preserving the gut microbial balance through the stimulation of beneficial bacteria (i.e., Lactobacilli and Bifidobacteria) and the inhibition of pathogenic bacteria, exerting prebiotic-like effects.

One of the many beneficial effects attributed to dietary polphenols is due to phenolic metabolites formed in the gastrointestinal tract through the interaction with good lactic acid bacteria. The outcome is the formation of more good bacteria and the inhibition of various pathogenic bacteria and yeast.

BioImmersion’s High ORAC Synbiotic powerfully mixes polyphenols with Lactobacillus and Bifidobacterium species. Per capsule: A minimum a 25 billion probiotics and a high ORAC score of 3000.


High ORAC final 2

References

  • Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015). Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition54(3), 325-341. https://link.springer.com/article/10.1007/s00394-015-0852-y
  • Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., … & Bartolomé, B. (2015). A survey of modulation of gut microbiota by dietary polyphenols. BioMed research international2015. https://www.hindawi.com/journals/bmri/2015/850902/
  • Gupta, A., Dwivedi, M., Mahdi, A. A., Gowda, G. N., Khetrapal, C. L., & Bhandari, M. (2012). Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin. Urological research, 40(2), 143-150. https://link.springer.com/article/10.1007/s00240-011-0398-2
  • Heinonen, M. (2007). Antioxidant activity and antimicrobial effect of berry phenolics–a Finnish perspective. Molecular nutrition & food research, 51(6), 684-691. http://onlinelibrary.wiley.com/doi/10.1002/mnfr.200700006/full
  • Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research, 11(10), 4781-4790. http://pubs.acs.org/doi/abs/10.1021/pr300581s
  • Nohynek, L. J., Alakomi, H. L., Kähkönen, M. P., Heinonen, M., Helander, I. M., Oksman-Caldentey, K. M., & Puupponen-Pimiä, R. H. (2006). Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens. Nutrition and cancer, 54(1), 18-32.
  • Puupponen‐Pimiä, R., Nohynek, L., Hartmann‐Schmidlin, S., Kähkönen, M., Heinonen, M., Määttä‐Riihinen, K., & Oksman‐Caldentey, K. M. (2005). Berry phenolics selectively inhibit the growth of intestinal pathogens. Journal of applied microbiology, 98(4), 991-1000.
    http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2672.2005.02547.x/full

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The modulation of the gut microbiome composition by alteration of food habits has potentialities in health improvement or even disease prevention.

Polyphenols are extensively metabolized by gut bacteria into a complex series of end-products that support a significant effect on the functional ecology of symbiotic partners that can affect the host physiology.

Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research, 11(10), 4781-4790. http://pubs.acs.org/doi/abs/10.1021/pr300581s.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Think better with blueberry

January 22, 2018

Dear Friends

blueberry X 4The CNS (the brain and spinal cord) is particulary vulnerable to oxidative stress, and this vulnerability increases during ageing (Joseph et al, 1998).  In fact as Dr. Joseph put it, “the brain becomes a hot bed of free radical activity in our old age.”

Shukitt-Hale et al. (2015) demonsrated in her research titled, The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing, the powerful cognitive effects by adding blueberry extract and strawberry extract to the diets of senile old rats.

The results showed that rats consuming the berry diets exhibited enhanced motor performance and improved cognition, specifically working memory. In addition, the rats supplemented with blueberry and strawberry diets showed increased hippocampal neurogenesis and expression of insulin-like growth factor 1.

What about research today on the bioavailability of blueberry polyphenols and their beneficial effect with human subjects?

Sandhu et al. (2017) explored the metabolic fate of blueberry anthocyanins after daily (90 days) supplementation of freeze-dried blueberry (equivalent of 1 cup of fresh blueberries).  Their conclusion was that blueberry anthocyanins are absorbed and extensively metablized resulting in the production of various phenolic acid derivatives and their conjugates, all together contributing to the bioavailability and beneficial effects associated with blueberry comsumption.

Miller et al. (2017) studied men and women between the ages of 60 and 75 years. Their findings showed that the group consuming the equivalent of one cup of blueberries daily for 90 days exhibited significantly fewer errors in a verbal learning test and increased mental flexibility on a task-switching test, relative to the placebo group.

BioImmersion powerhouses for polyphenolics supplementation for a healthy brain: 

References

  • Joseph, J. A., Denisova, N., Fisher, D., Shukitt-Hale, B., Bickford, P., Prior, R., & Cao, G. (1998). Age-related neurodegeneration and oxidative stress: putative nutritional intervention. Neurologic clinics, 16(3), 747-755.
  • Joseph, J. A., Denisova, N., Fisher, D., Shukitt‐Hale, B., Bickford, P., Prior, R., & Cao, G. (1998). Membrane and receptor modifications of oxidative stress vulnerability in aging: nutritional considerations. Annals of the New York Academy of Sciences, 854(1), 268-276.
  • Miller, M. G., Hamilton, D. A., Joseph, J. A., & Shukitt-Hale, B. (2017). Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. European Journal of Nutrition, 1-12.
  • Sandhu, A., Miller, M. G., Shukitt-Hale, B., Edirisinghe, I., & Burton-Freeman, B. (2017). Metabolic Fate of Blueberry Anthocyanins after Chronic Supplementation in Healthy Older Adults. The FASEB Journal, 31(1 Supplement), 646-20.
  • Shukitt-Hale, B., Bielinski, D. F., Lau, F. C., Willis, L. M., Carey, A. N., & Joseph, J. A. (2015). The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. British Journal of Nutrition, 114(10), 1542-154.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Five Habits to Heal the Heart of Democracy.The human heart is the first home of democracy. It is where we embrace our questions. Can we be equitable? Can we be generous? Can we listen with our whole beings ….

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

The New High ORAC Synbiotic

September 18, 2017

Dear Friends
HO Front Low Rez
We are very excited to present to you our High ORAC Synbiotic.  It’s back with an enhanced formula and a new look—a beautiful new label.

What’s new?

A higher probiotics count:  We’ve increased the CFUs (Colony Forming Units) to 25 billion per capsule.

More berries and extracts: We have added Quercetin, Resveratrol, and Strawberry.

Higher ORAC value:  The berry mixture provides 3000 ORAC (Oxygen Radical Absorbent Capacity)!

Let’s look at the new proprietary blend per capsule:

  • L. acidophilus & B. longum– 250mg
  • Grape Seed Extract, Wild Blueberry, Quercetin, Resveratrol, Wild Bliberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry & Inulin- 250mg.

Please notice that underneather the High ORAC Synbiotic name on the label it say:  “Post Antibiotic Care”.  (See Food Science and the References below for the scientific  conversation on this topic.)

Food Science:

The problem with antibiotics is that along with killing off the bad bacteria, antibiotics also kill the good gut bacteria — the protective bacteria such as Lactobaccilus and Bifidobacteria.  For many years researchers have warned us that antibiotics destroy the protective layer of good bacteria on our gut membrane, resulting in chronic inflammation (Barbut,f. & Petit, J.C., 2001; Bergogne-Berezin, E., 2000).

Both the Bifidobacteria longum and the Lactobacillus acidophilus strains are used in the High ORAC Synbiotic Formula to re-colonize and protect the GI membrane after antibiotic therapy. Bifidobacteria longum and Lactobacillus acidophilus colonize the GI tract membrane, thereby blocking out the pathogens; and also kill pathogenic microorganisms by producing antimicrobial peptides (bacterocins) against them (Hickson et al., 2007; Syngai et al., 2016).

The large offering of berry polyphenols, organic acids, and other phytochemicals offer a powerful antimicrobial and anti-inflammatory support (Grace et al., 2014; Nohynek et al., 2006) . Along with the inulin (a soluble fiber derived from organic chicory root), berries are also a great prebiotic for these good lactic acid bacteria (Puupponen-Pimia et al., 2005; Vendrame et al., 2011). (See the links to the references below for scientific support.)

References:

  • Barbut, F., & Petit, J. C. (2001). Epidemiology of Clostridium difficile‐associated infections. Clinical Microbiology and Infection, 7(8), 405-410.
  • Bergogne-Berezin, E. (2000). Treatment and prevention of antibiotic associated diarrhea. International journal of antimicrobial agents, 16(4), 521-526.
  • Cardona, F., Andrés-Lacueva, C., Tulipani, S., Tinahones, F. J., & Queipo-Ortuño, M. I. (2013). Benefits of polyphenols on gut microbiota and implications in human health. The Journal of nutritional biochemistry, 24(8), 1415-1422. http://www.sciencedirect.com/science/article/pii/S0955286313000946
  • Cremonini FI, Di Caro SI, Nista EC, Bartolozzi F, Capelli GI, Gasbarrini G, Gasbarrini AN. (2002). Meta‐analysis: the effect of probiotic administration on antibiotic‐associated diarrhoea. Alimentary pharmacology & therapeutics, 16(8), 1461-1467.
  • Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.
  • Grace, M.H., Esposito D., Dunlap K.L., & Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries. J Agric Food Chem, 62(18), 4007-17. doi: 10.1021/jf403810y.
  • Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.
  • Haslam, E., Lilley, T. H., Warminski, E., Liao, H., Cai, Y., Martin, R., … & Luck, G. (1992). Polyphenol complexation: a study in molecular recognition. ACS Publications.
  • Hattori, M., Kusumoto, I. T., Namba, T., Ishigami, T., & Hara, Y. (1990). Effect of tea polyphenols on glucan synthesis by glucosyltransferase from Streptococcus mutans. Chemical and Pharmaceutical Bulletin, 38(3), 717-720.
  • Joseph, S.V., Edirisinghe, I., & Burton-Freeman, B.M. (2014). Berries: anti-inflammatory effects in humans. J Agric Food Chem, 7; 62(18), 3886-903. DOI:10.1021/jf4044056
  • Kemperman, R.A., Bolca, S., Roger, L.C., Vaughan, E.E. (2010). Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities
    Microbiology, 156 (11), pp. 3224-3231
  • Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.
  • Nohynek, L. J., Alakomi, H. L., Kähkönen, M. P., Heinonen, M., Helander, I. M., Oksman-Caldentey, K. M., & Puupponen-Pimiä, R. H. (2006). Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens. Nutrition and cancer, 54(1), 18-32.
  • Puupponen-Pimiä, R., Nohynek, L., Hartman-Schmidlin, S., Kähkönen, M. Heinonen, M., Mata-Riihinen, K. et al.(2005). Berry phenolics selectively inhibit the growth of intestinal pathogens.  J. Appl Microbiol, 98, pp. 991-1000
  • Sirk, T. W., Friedman, M., & Brown, E. F. (2011). Molecular binding of black tea theaflavins to biological membranes: relationship to bioactivities. Journal of agricultural and food chemistry, 59(8), 3780-3787.
  • Sirk, T. W., Brown, E. F., Friedman, M., & Sum, A. K. (2009). Molecular binding of catechins to biomembranes: relationship to biological activity. Journal of agricultural and food chemistry, 57(15), 6720-6728.
  • Stapleton, P. D., Shah, S., Ehlert, K., Hara, Y., & Taylor, P. W. (2007). The β-lactam-resistance modifier (−)-epicatechin gallate alters the architecture of the cell wall of Staphylococcus aureus. Microbiology, 153(7), 2093-2103.
  • Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of Food Science and Technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0
  • Vendrame, S., & Klimis-Zacas, D. (2015). Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades. Nutr Rev, 73(6), 348-58. DOI:10.1093/nutrit/nuu066.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Bacteria in an average human body number ten times more than human cells, for a total of about 1000 more genes than are present in the human genome.  An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.   Check out NIH’s the Human Microbiome Projects 2017 website.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Osteoporosis on the Rise: What’s missing?

10 million Americans have osteoporosis; and the numbers are predicted to reach 14 million by 2020 (Burge, 2007).

What is missing in our diets and supplementation to have such an increase in the number of people suffering with osteoporosis?

Many studies show that it is our lack of adequate intake of polyphenols from fruits and vegetables, green teas, and some seeds. Berry polyphenols are found to reduce the risk of age related bone loss.

In fact, Hubert et al. (2014) find a positive association of high berry intake and higher bone mass. The researchers recommend the addition of berries to supplement our daily diet.

Their meta-analysis study, Dietary Polyphenols, Berries, and Age Related Bone Loss: A Review Based on Human, Animal and Cell Studies, evaluated human and animal studies and found strong associations between polyphenol intake, reduced fracture risk, increased bone formation markers, and increased BMD (Hubert et al., 2014). For similar studies, see also Welsh, 2012; Hardcastel, 2011; Hooshmand, 2011; Langsetmo, 2011; Arjmandi, 2010; Burge, 2007; Garrett, 1990.

A protocol for added phenols and boron:

Food Science

Strengthen your phenol dietary intake with our High ORAC Synbiotic Formula. The High ORAC includes a collection of berries and fruits with their extracts. High ORAC contains two strong probiotic organisms which in research are shown to tighten the cell junctions in the gut, reducing gut generated chronic inflammation (Ulluwishewa et al., 2011). Chronic inflammation is shown to cause an increase in osteoclast activity resulting in the de-mineralization of the bone (Weitzmann, 2013; Garrett et al., 1990).

Add Fructo Borate Complex to the phenolic and probiotic rich High ORAC to create a highly effective protocol. The Fructo Borate contains carbohydrate bound boron as found in nature. It is highly absorbable and instrumental in enhanving the re-mineralization of the bone (Miljkovic et al., 2004).

Bibliography

  • Arjmandi, B.H.; Johnson, C.D.; Campbell, S.C.; Hooshmand, S.; Chai, S.C.; Akhter, M.P. (2010). Combining fructooligosaccharide and dried plum has the greatest effect on restoring bone mineral density among select functional foods and bioactive compounds. J. Med. Food; 13: 312–319.
  • Burge, R.; Dawson-Hughes, B.; Solomon, D.H.; Wong, J.B.; King, A.; Tosteson, A. (2007). Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J. Bone Miner. Res.22: 465–475.
  • Garrett, I.R.; Boyce, B.F.; Oreffo, R.O.; Bonewald, L.; Poser, J.; Mundy, G.R. (1990). Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivoJ. Clin. Investig; 85: 632–639.
  • Hardcastle, A.C.; Aucott, L.; Reid, D.M.; Macdonald, H.M. (2011). Associations between dietary flavonoid intakes and bone health in a Scottish population. J. Bone Miner. Res: 26: 941–947.
  • Hooshmand, S.; Chai, S.C.; Saadat, R.L.; Payton, M.E.; Brummel-Smith, K.; Arjmandi, B.H. (2011). Comparative effects of dried plum and dried apple on bone in postmenopausal women. Br. J. Nutr; 106: 923–930
  • Hubert, P.A.; Lee, G.L.; Lee, S.K.; Chun, O.K. (2014). Dietary Polyphenols, Berries, and Age-related Bone loss:  A review Based on Human, Animal, and Cell Studies. Antioxidants; 3(1): 144-158.
  • Langsetmo, L.; Hanley, D.A.; Prior, J.C.; Barr, S.I.; Anastassiades, T.; Towheed, T.; Goltzman, D.; Morin, S.; Poliquin, S.; Kreiger, N. (2011). Dietary patterns and incident low-trauma fractures in postmenopausal women and men aged ≥50 y: A population-based cohort study. Am. J. Clin. Nutr; 93: 192–199.
  • Miljkovic D.; Miljkovic N.; McCary M.F. (2004). Up-regulatory impact of boron on Vitamin D function—does it reflect inhibition of 24-hydroxylase?; Medical Hypteses; 63: 1054-1056.
  • New, S.A.; Robins, S.P.; Campbell, M.K.; Martin, J.C.; Garton, M.J.; Bolton-Smith, C.; Grubb, D.A.; Lee, S.J.; Reid, D.M. (2000) Dietary influences on bone mass and bone metabolism: Further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr; 71, 142–151.
  • Ulluwishewa, D; Anderson, R.C.; McNabb W.C.; Moughan, P.J.; Wells, J.M.; Roy, N.C. (2011). Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components. J Nutr; 141(5): 769-776.
  • Weitzmann, M.N. (2013). The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis. Scientifica; 2013: 29 pages.
  • Welch, A.; MacGregor, A.; Jennings, A.; Fairweather-Tait, S.; Spector, T.; Cassidy, A. (2012). Habitual flavonoid intakes are positively associated with bone mineral density in women. J. Bone Miner. Res; 27: 1872–1878.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Take a quick look and click on this inspiring and beautiful video.  In West Oakland where liquor stores have replaced markets, The Peoples Grocery is creating a healthy alternative, offering access to organic produce.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Well, in just 12 days from today it’s the Hawaii Doc Talks Convention!, but who’s counting.

On Friday March 3rd we will host the breakfast in Maui and teach on a topic that gets right to the heart of the matter regarding food as medicine:  The Intelligence and Power of Therapeutic Food Supplements: Science, Research, and Protocol.

Click on the above link to the see our learning objectives for the doctors.  The third objective is: Discover the next generation probiotics — infection fighting Supernatant metabolites and immune boosting microRNA.

Remember, if you can’t join us this time around, I would be more than happy to meet you via the zoom meeting format online.  Just let me know and we’ll set it up.

The two photos below present our synbiotic formulas.  The top one highlighting our new LactORN Synbiotic and the photo below seven more probiotic offerings.

LactORNs

Understanding our microbiome is without a question one of the hottest topics in medicine. Hippocrates, 2400 years ago, said that all disease begins in the gut.  In a recent speech Dr. Francis Collins, past director of the Human Microbiome Project, and present director of the NIH said,

We are a chimera-like creatire whose healthy metabolic and physiologic functioning is governed by not only our 10 trillion human cells and their 22,000 genes but also by our human microbiome community that co-habitate our bodies, all 100 trillion of them with their 2 to 8 million genes—most of them bacteria living in our GI tract. (2015, Supercharging Science for the Superorganism)

grp_2

“An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.”  (HMP Home page).

The microbiome must be taken into account regarding metabolic diseases (Metabolic Syndrome, Obesity, Diabetes, Heart Disease), gastrointestinal disease (IBS, IBD), and neuroligical health.

Yours truly,

Seann Bardell CEO
BioImmersion Inc.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

  • Dr. Francis Collins, the Director of the NIH recently said “The time of the importance of the microbiome and human health has arrived.  Our gut microbiome is of central importance for our immune system health, our neural-transmitter health, our GI tract health, and our metabolic health.