Fructo Borate

Dear Friends

With great pleasure and joy we introduce BioImmersion’s medical director – George J Kessler, DO. His 2000 book, The Bone Density Diet: 6 weeks to a strong body and mind, has received great reviews.

In this newsletter,  Dr. Kessler writes about the Fructo Borate Complex as he has used it successfully in his practice for over nine years. Make sure to read Clincal Notes for Dr. Kessler’s suggested use of Fructo Borate.

Dr. George Kessler on boron and Fructo Borate:

Boron is a mineral that plants access from the soil.  It is contained in the cell membranes of every plant.  If the soil is of poor quality the plants grown in it will lack boron.  The Journal of the American College of Nutirition (Feb 2014) looked at dietary vitamin and mineral consumption in the United States from 2007 to 2010 and found large parts of the population did not get adequate levels of these nutrients from the foods they ate.  They recommended taking supplements to make up for these common deficiencies.

Boron in a natural food form such as fructoborate can be much more potent and much less toxic than synthetically manufactured boron supplements.  Boron from food sources can also be much more bioavailable than synthetic sources.

Although boron is considered a trace mineral, it has many important and necessary functions in the human body.  To paraphrase a July 5, 2014 article published in The Journal of Trace Element Medical Biology:

In human studies, boron is a bioactive element that beneficially affects bone growth and central nervous system function, alleviates arthritic symptoms, facilitates hormone action and is associated with a reduced risk of some types of cancer. In the medical book Breast Cancer- Current and Alternative Therapeutic Modalities (2011, chapter 5, 2.1 it is stated “A diet with low boron has been found to lead to a number of general health problems and to increase cancer risk. The most common symptoms of boron deficiency include arthritis, memory loss, osteoporosis, degenerative and soft tissue cartilage diseases, hormonal disequilibria and a drop in libido.

The chapter goes on to detail the information to support this quote. Keeping in mind the various and intertwined effects boron has on the entire human body, I will try to isolate some of the individual areas that boron is important in.

Bone Metabolism:

One of the most researched uses for boron is in its relationship to bone metabolism, how it affects calcium, magnesium, vitamin D metabolism and bone formation and loss.  It has been shown that boron has very important and useful effects on bone health and development.  The National Osteoporosis Foundation states that, “Millions of Americans—54 million to be exact—have low bone density or osteoporosis.  In fact, about one in two women and up to one in four men over the age of 50 will break a bone due to osteoporosis.”

While osteoporosis is a disease influenced by many factors, mineral composition of the bone is of utmost importance.  Boron helps both the uptake of calicum and magnesium into the bones and decreases the excretion of both through the kidney.  This is very helpful in both the treatment and prevention of kidney stones and in lowering parathyroid hormone levels in some patients.

Boron also decreases subacute inflammation, which is a factor in bone loss.  In Dec. 2013 The Biological Trace Element Research Journal printed an article stating that in human studies, boron protects the bones against inflammation disruption of the equilibrium between bone reabsorption and bone deposition.

This same journal printed an article in July 2001 showing that boron added to estrogen “significantly increased serum Ca, P, Mg and osteocalcin concentrations” resulting in increased bone growth.  Deficiencies of trace elements slows down the increase of childhood/adolescent bone mass and accelerates bone loss after menopause or in old age” Clinical Chemistry Laboratory Medicine Aug. 2013.


The American Journal of Biomedical Sciences Oct. 2011 published an article showing that plant based boron could, in 14 days, decrease the symptoms of osteoarthritis of the knee.  The article further found that taking boron also resulted in increased levels 1,25(OH)vitamin D.  Clinical intervention in Aug 2014 published an article that found the same relief of osteoarthritis symptoms in 14 days as found in the previous study.


Experimental and Toxicologic Pathology Jan 2012 found that boron played a protective role in lowering the genotoxic effects of heavy metals by its antioxidant capacity. Biological trace element Research April 2014 found that levels of boron in the 40 mg/L range could increase weight, organ indexes, and antioxidant capacities of spleen and improve the speen tissue structure.  There is a toxicity level of boron at over 640 mg/L.

Hormone Balancing:

Toxicology Ind. Health Jan. 2013 found boron decreased body weight, leptin, insulin and glucose levels and increased T3 (the thyroid hormone your cells actually use) and carnitine levels in plasma.

Biological Trace Element Reserch April 2013 published an article showing that “there was a significant relationship between age and qualitative values of body mass index for each subject.” This shows that there is a “reverse relationship between blood boron levels and body mass index in humans”.  This means that low boron levels are associated with increased weight and that high levels are associated with lower body weights.

The Indian Journal of Experimental Biology (March 2012) stated that the consumption of fatty acids, calcium, Vitamin D, and boron with physical activity increased levels of estradiol, testosterone and free testosterone. They also caused a strengthening and higher breaking point of bones.

The journal of Trace Elements in Medicine and Biology (Jan. 2011) stated that Boron possesses widespread properties in biochemistry and nutrition.  It further found that boron had significant biological effects on steroid hormones andinflammatory markers. Signficant decreases in sex hormone binding globulins, CRP, CRP-HS and TNF alpha levels.  Also found were increased levels of plasma free testosterone, dihydrotestosterone, cortisol and Vitamin D along with decreased levels of Estradiol. What this means is that not only can boron help to balance your hormones but can improve the cross talk between your various endocrine glands.


Oral resveritrol and boron supplementation showed a significant decrease in C-reactive protein, N-terminal prohormone of brain natriuretic peptide and an improvement in the quality of life of individuals in the study (Nutrition July 2012).

The Journal of Trace Elements in Medicine and Biology (April 2011) published an article showing that “added boron and copper had a significant effect on plasma high density lipoprotein  cholesterol fraction.”  And went on to state that “plasma lipid contents were also decreased by addition of copper and boron in the ration.”  What this means is that boron can affect blood cholesterol levels in good ways.

This was further found in the Journal of Diabetes (Mar. 2014) which stated that boron containing compounds could result in decreased hepatic and blood levels of lipids and that this may represent a novel approach for threating diseases with aberrant lipid homeostasis.

Anti Cancer Research:

Journal of Evidence-Based Complementary and Alternative Medicine (Oct 2011) found that boron could reduce cancer risk and had beneficial effects on oxidative stress, central nervous system function, hormone facilitation, immune response, arthritis, bone growth and inflammation.

Anti-Cancer Agents in Medicinal Chemistry (May 2010) found that consumption of “boron containing compounds resulted in significant decrease in the risk for prostate and cervical cancer, and decrease in lung cancer in smoking women.”  They also showed promising chemotherapeutic effects for specific forms of cancer.

Much more can be said about boron, i.e. its ability to down regulate the immun system, its antiaging effects, its lowering of CRP, but enough said for now.

George Kessler, DO


Clinical Notes:

To health practitioners:

Assuming that you are doing before and after tests, a typical dosage pattern would be to begin with one capsule of Fructo Borate Complex with breakfast and one with lunch for about 2 to 4 months.  After this trial period re-evaluate the lab tests, symptoms, etc to see the change in the parameters that you are following—bone formation and loss, pain, cholesterol levels, urinary excretion of calcium and/or magnesium, parathyroid hormoes, sex and stress and hormones etc. then adjust the dose accordingly.


The Last Quiz Answer:

This wild life photographer is getting a little love from a truly wild hyena who he has been filming for many months.

Hyenas are skilled hunters that will take down wildebeest or antelope.  They also kill and eat birds, lizards, snakes and insects.  They’ve got big bugs in Africa.  You can make a meal on the darn things.



Elephants may be extinct in the next 6 years if the current poaching rates continue. And, why all this poaching? For ivory bracelets, hair pins, pendants, chopsticks, trinkets and more. 35,000 were killed in 2013. Thirty Five Thousand. We are something else!

                   ©2005 – 2014 BioImmersion Inc. All Rights Reserved


Dear Friends

In our last email we highlighted the research on Fructo Borate’s ability to help reduce C-reactive protein (CRP) levels in the blood, and the potential positive effects  this lowering may have on the risk of developing cardiovascular disease (CVD).

This week we will share the initial 2011 pilot study research from Romania on Fructo Borate supplementation and the findings that it supports the prevention and reduction of osteoarthritis.

The study:  Romulus Scorei et al. Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Effect of  Calcium Fructoborate on Systemic Inflammation and Dyslipidemia Markers for Middle-Aged People with Primary Osteoarthritis, Bio Trace Elem Res., Dec 2011;144(1-3):253-263.  Romulus Scorei et al. sought to determine whether 15 days of dietary supplementation with calcium fructobotate could acutely modulate inflammatory and lipid blood markers in individuals with primary osteoarthritis.

Out of 116 initial subjects 60 completed the study as designed.   The aim was to compare the effects of fructo borate to placebo on subjects diagnosed with knee primary osteoarthritis.  The inflammatory biomarkers looked at were C-reactive protein, fibrinogen, and erythrocyte sedimentation rate.

The calcium fructo borate showed beneficial effect on the inflammatory markers for all groups subjected to the treatment.  This study suggests that short-term (2 weeks)fructo borate  supplementation in patients with osteoarthritis symptoms has a favorable prognosis.

Sincerely yours,

Seann Bardell


Clinical Notes:

For more information click here on the Fructo Borate Monograph.


The Last Quiz Answer:

This amazing primate is a Ring-tailed Lemur, “posture-child” for the Central Park Zoo.  We just got back from a week in New York City and my morning heavenly runs in Central Park, where I saw many ring-tail postures, inspiring me to show you this lemur.

Lemurs are found only on the island of Madagascar. Ring-tails live in  troups of 6 to 30 animals.  Both sexes live in a troop, but a dominant female presides over all.

Ring-tails lemurs, unlike the other four genuses of lemurs who spend most of their time in the trees, spend much of their time on the ground also.



When it comes to reducing greenhouse gasses and improving air quality Canadian cities are leading the way.  In fact, beautiful Vancouver BC just north of us is the real leader on Canadian urban climate initiatives.  It has the lowest greenhouse gas emissions of any major North American city.  Way to go Vancouver! Way to go Canada!!!

©2005 – 2014 BioImmersion Inc. All Rights Reserved


By Seann Bardell

Dear Friends

Fructo Borate Complex is a very exciting product: it naturally duplicates the molecular structure of boron as it is found of food—it is always found bound to carbohydrate.

In studies, by taking one to two capsules a day, Fructo Borate has been shown to help prevent and slow down osteoporosis, reduce the inflammation in osteoarthritis, and selectively increase steroid hormones in the blood—testosterone, DHEA and Vitamin D3   level.  It also decreases C-reactive protein levels.

But Fructo Borate does much more.

Let’s focus on cardiovascular disease and Fructo Borate’s ability to reduce CRP.

First of all CRP has been shown to be a very important marker for the potential of CVD.

Ridker P, et al. C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease In WomenN Engl J Med 2000; 342:836-843.

The researchers conducted a prospective control study among 28,263 apparently healthy postmenopausal women over a mean follow-up period of three years to assess the risk of cardiovascular events associated with base-line levels of markers of inflammation.  Of the 12 makers measure CRP was the strongest univariate predictor of the risk of cardiovascular events.

What is the evidence that Fructo Borate support reduction of C-reactive protein levels?

Militaru C, et al. Oral resveratrol and fructo borate supplementation in subjects with stable angina pectoris: Effects on lipid profiles, inflammation markers, and quality of life, Nutrition 2012, 1-6.

The objective of this study was to evaluate the effects of short-term (60-d) oral supplementation with fructo borate, resveratrol , and their combination with stable angina patients.  There was a significant decrease of high-sensitivity C-reactive protein in all groups.  This decrease was greater (39.7% at 60 d) in the Fructo Borate alone group, followed by the resveratrol plus fructo borate group (30.3% at 60 d).

As you can see the Fructo Borate by itself has demonstratable health benefits. Boron is critical for the proper functioning of many important metabolic pathways. The problem is the top soil in many areas of US is depleted in boron which means that the crops produced from such soil will be deplete in boron.  Supplementing with a boron supplement such as the Fructo Borate makes sense.

Sincerely yours,

Seann Bardell


Clinical Notes:

For preventive supplementation take 1 to 2 capsules a day.

For more information click here on the Fructo Borate Monograph.


The Last Quiz Answer:

The bill of the Toucan is around 7.5 inches long.  Both the males and the females have long bills.  It is much form functional for feeding than for fighting.  They eat insects, sometimes small birds, eggs or lizards.  The toucan live in small flocks of around six birds.  They are very popular pets and many are captured for that trade.



Half a Million Ask EPA to Reject Expanded Agricultural Use of Toxic Pesticide 2,4-D.

Over half a million people have submitted comments to the EPA asking the agency to reject Dow Chemical’s plan to see Enlist Duo herbicide for use on corn and soybeens genentically engineered to withstand 2,4-D.  The USDA has previously warned that approval of the herbicide and it corresponding GE (genetically engineered) crops would lead to a three to seven fold increase in agricultural use of 2,4-D, a toxic herbicide linked to Parkinson’s disease, non-Hodgkin’s lymphoma, and other health harms. (Center for Food Safety Press Release July 1st, 2014)

©2005 – 2014 BioImmersion Inc. All Rights Reserved


By Seann Bardell

The 9 to 13 Cure

February 26, 2014

Dear Friends

What used to be the mandate from the USDA of eating 5-A-Day of fruits and vegetable is now 9-13 A-Day! Read Liu RH. in his article Dietary bioactive compounds and their health implications. J Food Sc. 2013, Jun;78 Suppl 1:18-25., for the new dietary axiom!

The reality is clear: good food heals. But it is also a reality, says Liu, that the average American only consumes 3.6 servings of fruits and vegetables per day. So how do we go from here (average of 3.6 a day) to there (11 a day)???

That is where Therapeutic Foods come in! These foods are intelligent, powerful, and pure.

Their Functional Benefits–  Each of the plant based products are specifically created for their foundational, pointed and general health benefits that they provide our bodies, and taken together over time on a regular basic can produce a strong immune system, reduced inflammation, and much more! It is smart to build a good therapeutic foods foundation.

Their Powerful Contents–  Why is it that plant foods grown in the wilds of Alaska, the savannas of Africa or the jungles of Brazil, amongst many other places on our beautiful earth, have such a high pay-load of phytonutrients?

In harsh natural (organic) environments those plants that thrive are able to do so because of their high concentrations of phytochemicals that protect them from radiation (excessive sun) and pathogenic critters (virus, bacteria and larger).  These plant chemicals function as antioxidants, antimicrobials and anti-inflammatories.  The good news is that these powerful cellular protective phytochemical are the plants gifts to us.   The key is to eat a variety of powerful plants.

Our world today- provides intense challenges to our physical bodies health.  Chronic stress disables our immune systems, pathogens come to our neighborhoods from all corners of the earth (via international commerce, and human travel), and the ever-growing pollution of our planet is manifesting as a global chronic disease health crisis.  We must have a power diet to protect our bodies.  More than ever we need to power of plants to protect our bodies—we need powerful plants.

Lets go to Clinical Notes for a smart and powerful protocol. Give it a three month time to strengthen your body. For more specific issues, send an email or call us!
Sincerely yours,

Seann Bardell

Clinical Notes:

Upon rising drink 2 large glasses of water taking the following:

  • Organic Chorella- 4 tabs
  • Phyto Power- 2 caps
  • Wild Blueberry Extract- 1 cap (option for extra brain power)
  • Cruciferous Sprouts- 2 caps
  • Fructo Borate- 2 caps
  • Ultra Mineral- 2 caps
  • High ORAC Synbiotic Formula- 1 cap


The Last Quiz Answer:

The smallest of the antelope most commonly seen in South Africa’s Kruger National Park, steenbok show a marked preference for the open plains in the eastern region of the Park, formed on volcanic basalt. There is some sexual dimorphism, with only male steenbok having horns, and the females being slightly larger than the males.



“You have the right to know what’s in your food.  It seems so basic, yet thanks to more than 70 million of Big Foods lobbying dolllars we can’t trust food labels to tell us what we are really eating.”

“Japan, the EU, China and even Russia all have laws on the books that require companies to label foods with genetically engineered ingredients in them.”

The Environmental Working Group is doing something about this.



                ©2005 – 2012 BioImmersion Inc. All Rights Reserved

Dear Friends

A new book (Do you believe in Magic?  The Sense and Nonsense of Alternative Medicine) just came into the market 4 days ago, presenting a scathing attack on the nutriceutical industry and alternative medicine.  It is by Paul Offit whose is Chief of the Division of Infectious Diseases at the Childrens Hospital of Philadelphia.

Dr. Offit advises, “There is no such thing as alternative medicine.  There is only medicine that works and medicine that doesn’t.”  I don’t think we have a problem with that.  One might ask, how is mainstream medicine doing with chronic diseases?  How about let’s practicing integrative medicine taking the best practices from both worlds.

The reality is that over the last ten years there have been revolutionary discoveries of the role that specific phytonutrients have on physiology.  The power of certain food components to protect and heal our bodies is mounting.  There are thousands of clinical studies now available indicating their positive health benefit.  Just think about the exciting field of Nutrigenomics and the evidence based medical studies coming from their work at UC Davis.  Very powerful stuff.

That being said, I would like over the coming weeks to associate each of our Therapeutic Foods Products with various studies, for that in fact is how we built them.  Let’s start with our Fructo Borate Complex.

Militaru C. et al, Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris:  Effect on lipid profiles, inflammation markers, and quality of life, Nutrition, Vol. 29, Issue 1, pages 178- 183, January 2013.

Sincerely yours,
Seann Bardell

Clinical Note:

By clicking on the above study you will see that Fructo Borate was most effective over a 60 day period in reducing high-sensitivity C-reactive protein by 39.7%.  And that the resveratrol was most effective in reducing N-terminal prohormone of brain natriuretic peptide.  The 2 of them together were most effective in reducing angina.

In our earlier studies on Fructo Borate Complex which can be found in the BioImmersion Library.  Fructo Borate reduced osteroporosis swelling and pain in  over 70% of trail patients.  That is at the dosage level of 2 capsule per day.  It also protects against osteoporisis.  As far as steroid hormones go it increases blood levels of testosterone, DHEA and Vitamin D3.  It severe cases take 2 BID.

The Last Quiz Answer:
Two iguanas sharing a meal—a crab— or an example of synbiogenesis?  It is actually the later.  This photo was capture from the BBC documentary, the Galapagos. And, if you could see a few more frames you would realize that the crab is cleaning parasites from the iguana—essentially having dinner, while the iguanas are receiving facials.  Actions benefiting the survival of both species.  Here is an amazing and enriching interview with the founder of Synbiogenesis Lynn Margolin.

Tell Congress that Supplements are not drugs.

Nutritional Supplementations is under attack by Congress once again.  Here is an easy and effective way to take action: letter to Representatives