Cran. Pom. Synbiotic

Dear Friends

What is the new longevity? Aging and chronic illness are often linked in research to inflammation from environmental toxins, pathogens, lack of exercise, too much sugar and fat in the diet, and lack of sleep. In short – ongoing stress that diminishes our body’s supply of stem cells. And, once our stem cells are used up, we deplete our ability to regenerate and heal.

Our new No. 7 Systemic Booster rejuvinates multiple systems in our body by reducing inflammation in the gut and body, so we do not use up our own stem cells to reduce inflammation, and keep us healthy.

Let’s have a look:

No. 7 Systemic Booster:  The New Longevity

  • The new longevity: In research, aging is linked to a variety of chronic illnesses that occur due to a continual inflammatory state in the body, which accelerates stem cells’ deterioration and ultimately lessens our ability to regenerate. 
  • The No 7 combination of Polyphenols (from high active berries, fruit, veggies, and greens), Fibers, Prebiotic, B12, Fructo Borate, Folate, Chromium, and the new blend of naturally occurring whole Probiotics with their Supernatant and ORNs (the Probiotic Super Blend) offer potent calming nutrients, protection and rejuvination.
  • The No 7 boosts many systems in the body: the Immune, GI Tract, Urogenital, Osteo-skeletal, Cardiovascular, Brain and Neurological, Detoxification, Metabolic, Digestive, and Energy.

No7_ 8.15.18

As you can see, the No. 7 taken on a regular basis provides a base of strength to build upon.  For example, its Probiotic Super Blend protects your GI tract with pedigreed strains of strong lactic acid bacteria, building a healthy eco-system within the GI tract microbiome that reduces inflammation in the gut.

The probiotic count (CFU) of the No. 7  is 15 billion per teaspoon.  To add more probiotic count to your daily dose, simply add one capsue of the new Supernatant Synbiotic which provides a CFU of 20 billion per capsule.  The Supernatant Synbiotic is, in fact, the Probiotic Super Blend itself.

No. 7 provides intense antioxidant, anti-inflammatory, and anti-microbial properties, all are agents of the longevity enducing power of organic plant polyphenols.  For more plant power,  add one capsule daily of the new High ORAC Synbiotic with a Total ORAC score of 40,000.  Plus it also has 20 billion CFU of the Probiotic Super Blend.

For UTI issues, add to your daily tsp dose of No. 7 one capsule of the new Cranberry Pomegranate Synbiotic, which will provide high active cranberry and pomegranate extracts plus 20 billion CFU of the Probiotic Super Blend.

A healthy plant based diet, along with good probiotic organisms and concentrated supplements of plant polyphenols all are critical for our daily health and longevity, reducing the risk of chronic degenerative disease now and later in our life.

References:

  • Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research11(10), 4781-4790.http://pubs.acs.org/doi/abs/10.1021/pr300581s.
  • Possemiers, S., Bolca, S., Verstraete, W., & Heyerick, A. (2011). The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals. Fitoterapia82(1), 53-66. https://www.sciencedirect.com/science/article/pii/S0367326X10001899?via%3Dihub
  • Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015). Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition54(3), 325-341. https://link.springer.com/article/10.1007/s00394-015-0852-y
  • Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F., & Loguercio, C. (2007). Chronic inflammation and oxidative stress in human carcinogenesis. International Journal of Cancer, 121(11), 2381-2386.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.cts under the advisement of your doctor.

Green Facts:

Globe_Home 3

One of the world’s great organization for learning how to work with nature is the Biomimicry Institute.  Check them out:  Global Design Challenge.  They are truly one of the bright rays of hope for bonding with Mother Nature and learning from her 3 billion years of life experience on Earth .condition and its down stream consequences.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

Our Cranberry Pomegranate Synbiotic embodies a high potency and powerful ability for all sorts of bladder and UTI issues. But the combination of supernatant with ORNs, probiotics, cranberries, and pomegranates do so much more!

NEW CP Jpeg Short 4

The phytonutrients are more concentrated, standardize to 6% quinic acid for the cranberry and 40% punicalagins for the pomegranate extract.

There are now five different organisms of probiotics in the formula. We grow them as whole organisms with their supernatant and ORNs.  We selected organisms that have a natural antimicrobial abilities against hospital generated infections.

The supernatant component of the product is much more comprehensive, dramatically enhancing its benefits.  It has our typical famous metabolites of the Lactobacillus bulgaricus and Streptococcus thermophilus plus the metabolites of our added three more organisms, five all together! Supernatant contains the food fermentation by-products (metabolites) that include lactic acids, amino acids, folates, bacterocins, biosurfactants and various beneficial enzymes such as bile salts hydrolase and lactase.  And of course, the supernatant also has the ORNs (oligoribnucleotides- their shorter chains of microRNAs), which prime the immune system and activate the rapid growth of these powerful probiotic organisms.

The prebiotic per capsule is 100mg of organic chicory root inulin (the total amount of ingredients per capsule is 500mg). Since our probiotics wake up much more rapidly due to complete sets of ORNs, they need food to grow.

In research, these ingredients show a reduction, not only, to the risk of UTI associated conditions but for both colon and breast cancers as well.

  • Vaginal eubiosis- Vaginal eubiosis is characterised by beneficial lactobacillus-dominated microbiota. In contrast, vaginal dysbiosis (e.g. bacterial vaginosis, BV), characterized by an overgrowth of multiple anaerobes, is associated with an increased risk of adverse urogenital and reproductive health outcomes.  The Lactobaccilus sp. in our Cranberry Pomegranate Synbiotic are strong lactic acid producers.
  • Biosurfactants- The role of Lactobacillusspecies in the female urogenital tract as a barrier to infection is of considerable interest.  These organisms are believed to contribute to the control of vaginal microbiota by competing with other micro-organisms for adherence to epithelial cells and by producing biosurfactants (Rodrigues, L. et al., 2006).  The good probiotics in this formula have demonstrated the ability to produce mucins as biosurfactants against bacterial, fungal and viral pathogens.
  • Cancer Protection Support- Ou, J et al. (2012) in their paper, Association between low colonic short-chain fatty acids and high bile acid in high colon cancer risk populations, proposed that the influence of diet on colon cancer risk is mediated by the microbiota.  Their results suggested that the higher risk of colon cancer in Americans may be partly explained by their high-fat and high-protein, low complex carbohydrate diet, which produces colonic residues that promote microbes such as Clostridia and E. coli to produce potentially carcinogenic secondary bile acids and less antineoplastic SCFAs.  Our collection of good bacteria in this formula are SCFA producers and secondary bile acids reducers as you can see with one of their metabolites being the enzyme bile salts hydrolase.  These good bugs also put out bacterocins agains Clostridiaand E. coli.
  • Breast Cancer- Costarelli, V., and Sanders, T.A.B. (2002) found that the mean plasma secondary bile salt derivative DCA concentration were 52% higher in patients  with breast cancer compared with controls.  Reducing gut levels of DCA will reduce plasma levels.  Thereby, reducing this risk factor.
  • Colon Cancer- AJouz, H., Mukherjui, D., and Shamseddine, A. in their 2014 research paper stated that bile acids going into the intestines stimulate growth in the colon of Clostridia which convert primary to secondary bile acids, and secondary bile acids that were shown to be carcinogenic.   Hence the important of our good bugs that produce bacterocins to reduce Clostridial populations.
  • Animal Fat-Rich Diets- There is increasing evidence (Barrasa, J.I. et al. 2013) that the continous exposure to certain hydrophobic bile acids, due to a fat-rich diet may induce oxidative DNA damage that, in turn, may lead to colorectal carcinogenesis.

References

  • Tachedjian, G., Aldunate, M., Bradshaw, C. S., & Cone, R. A. (2017). The role of lactic acid production by probiotic Lactobacillus species in vaginal health. Research in microbiology, 168(9-10), 782-792. https://www.sciencedirect.com/science/article/pii/S0923250817300839?via%3Dihub
  • Rodrigues, L., Banat, I. M., Teixeira, J., & Oliveira, R. (2006). Biosurfactants: potential applications in medicine. Journal of Antimicrobial Chemotherapy, 57(4), 609-618. https://academic.oup.com/jac/article/57/4/609/669417
  • Ou, J., DeLany, J. P., Zhang, M., Sharma, S., & O’Keefe, S. J. (2012). Association between low colonic short-chain fatty acids and high bile acids in high colon cancer risk populations. Nutrition and cancer, 64(1), 34-40.
  • Costarelli, V., & Sanders, T. A. B. (2002). Plasma deoxycholic acid concentration is elevated in postmenopausal women with newly diagnosed breast cancer. European journal of clinical nutrition, 56(9), 925.  https://www.nature.com/articles/1601396
  • Ajouz, H., Mukherji, D., & Shamseddine, A. (2014). Secondary bile acids: an underrecognized cause of colon cancer. World journal of surgical oncology, 12(1), 164.
  • Barrasa, J. I., Olmo, N., Lizarbe, M. A., & Turnay, J. (2013). Bile acids in the colon, from healthy to cytotoxic molecules. Toxicology in Vitro, 27(2), 964-977.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Cranberry consumption has shown prophylactic effects against urinary tract infections (UTI).  Anti-adhesive activity of cranberry phenolic compounds and their microbial-drived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures

González de Llano, D., Esteban-Fernández, A., Sánchez-Patán, F., Martínlvarez, P. J., Moreno-Arribas, M., & Bartolomé, B. (2015). Anti-adhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures. International journal of molecular sciences, 16(6), 12119-12130.

In the study sited below data indicated that both pomegranate aril and peel extracts have an effective antimicrobial activity, as evidenced by the inhibitory effect on the bacterial growth of two important human pathogens, including Staphylococcus aureus and Escherichia coli.

Pagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., & Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831. DOI: 10.1016/j.foodchem.2015.06.028

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Powerful UTI Care

July 31, 2018

Dear Friends

Cranberry Pomegranate Synbiotic is back!  And it is more powerful with a broad specturm anti-microbial ability.

NEW CP Jpeg Short 4

The raw materials are the same, but more powerful, and with supernatant from each of the probiotics plus their individual ORNs.

We standardized the Cranberry concentrate at 6%.  The 6% is refers to its amount of quinic acid, key for UTI issues.  The pomegranate is standardized at 40% with its punicalagins, offering more intensive anti-microibal, anti-oxidants, and cancer support. The probiotics work synergistically with the extracts, breaking them down into shorter phenolic molecules, which means they are bio-available to do their various tasks.

We have five probiotics now, with  newly added  L. bulgaricus and S. thermophilus.  The supernatant contains the metabolites of  L. bulgaricus and S. thermophilus, L. casei, L. acidophilus, and B. longum, including their ORNs (oligoribonucleotides).

Our new blend of naturally occurring whole probiotic organisms is grown to fully retain their oligoribonucleotides (ORNs) and mixed with their metabolites from their culture supernatant. The cultures are now able to grow faster without any delay (the term in microbiology is ‘lag-time’), and because of that they are more effective and generate a healthier microbiome balance.

This new Cranberry Pomegranate Synbiotic combines the power of our Supernatant Synbiotic and the LactORN Synbiotic products. With the polyphenol concentrates, the formula is truly a powerhouse for UTI care.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Cranberry consumption has shown prophylactic effects against urinary tract infections (UTI).  Anti-adhesive activity of cranberry phenolic compounds and their microbial-drived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures

González de Llano, D., Esteban-Fernández, A., Sánchez-Patán, F., Martínlvarez, P. J., Moreno-Arribas, M., & Bartolomé, B. (2015). Anti-adhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures. International journal of molecular sciences, 16(6), 12119-12130.

In the study sited below data indicated that both pomegranate aril and peel extracts have an effective antimicrobial activity, as evidenced by the inhibitory effect on the bacterial growth of two important human pathogens, including Staphylococcus aureus and Escherichia coli.

Pagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., & Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831. DOI: 10.1016/j.foodchem.2015.06.028

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends
CPLow copy 3

Urinary tract infection (UTI) is one of the most common bacterial infections (Foxman, 2014), often caused by Gram-negative bacteria, enterobacteriaceae (Bader, Loeb & Brooks, 2017), and more specifically within this large bacterial family, the familiar Escherichia coli (Jensen et al., 2017).

In recent years, more women suffer from chronic UTIs due to the climbing rise of antibiotic resistant bacteria. As a natural alternative or a supportive adjunct treatment with antibiotics, the Cranberry Pomegranate Synbiotic Formula offers well-researched phyto nutrients, probiotics, prebiotics, and D- mannose. Studies and clinical trials find cranberries (Bader et al., 2017; Jensen et al., 2017; de Llano et al., 2015), Pomegranates (Pagliarulo et al., 2016; Heber, 2011; Duman et al., 2009), along with probiotics, prebiotics, and D- mannose (Spaulding et al., 2017; 2017a; Domenici et al., 2016), to offer effective management and support for UTI.*

Historically, cranberries and cranberry juice have long been used to alleviate urinary tract infections, with research linking the ability of cranberries’ proanthocyanidins (Krueger et al., 2013) to inhibit adhesion of E. coli bacteria (Neto, 2007). As early as 1933, research by Fellers et al. has shown cranberries to positively effect urinary health. Cowan’s (1999) seminal work on plant products as antimicrobial agents, which includes cranberries, has been cited in approximately 7,500 research articles. Studies on cranberries show not only an alternative to antibiotic but also as a daily supplement for a steady prevention of UTIs.*

Recent studies continue to observe and explain cranberries’ excellent antimicrobial properties, especially the phenol elements and mechanism that are beneficial for the management and prevention of UTI (Jensen et al., 2017; Rodríguez-Pérez et al., 2017; Baranowska & Bartoszek, 2016; Sagdic et al, 2006; Lee, 2000). As stated above, proanthocyanidins in cranberries are found to prevent the adherence of Escherichia coli to uroepithelial cells in the urinary tract (Sun et al., 2015; Rowley, 2012; Burger et al., 2000), and disrupt hard to treat biofilm-mediated infections caused by Pseudomonas aeruginosa (Ulrey et al., 2014).*

Cranberries also pack other antimicrobial, antioxidant and anti-inflammatory benefits. With their powerful anti-adhesion properties, cranberries are found to inhibit growth of Helicobacter Pylori (Shmuely et al., 2007; Zhang et al., 2005; Burger et al., 2002), suppress tumor cell proliferation and offer support during cancer treatment (Bshayee et al., 2016; Kresty et al., 2015), as well as lower markers of cardio-metabolic risk (Novotny et al., 2015), and enhance the GI’s microbiota (Blumberg et al., 2016). Cranberries are shown to be effective agents for health.*

Pomegranate has enjoyed an exalted status since ancient times, and no wonder (Parseh et al., 2012). Studies show pomegranates contain 124 different phyto-nutrients with curative and preventative qualities. The pomegranate fruit is actually considered a berry, or more accurately, each pomegranate contains 600 seeds, each surrounded by fleshy white to dark red pulp (Rahimi et al., 2012).*

With their potent polyphenolic flavonoids, pomegranates show higher concentrations of antioxidants than green tea (Noda et al., 2002; Nori-Okamoto et al., 2004), cranberries, apples, grapes, or pears (Hmid et al., 2017; Heber, 2011; Heber et al., 2006). The pomegranate’s high concentration of polyphenols wields an inhibitory effect on pathogenic Staphylococcus aureus and Escherichia coli, serving as natural antimicrobial agents (Pagliarulo et al., 2016; Naz et al., 2007; Voravuthikunchai et al., 2005). Other microbial organisms are shown to be sensitive to the pomegranate phenolic flavonoids. Nascimento et al. (2000) tested extracts from a variety of plants in search of a natural support against antibiotic resistant microorganisms and found the pomegranate to be especially effective against Pseudomonas aeruginosa. Machado et al. (2002) identified antimicrobial ellagitannin of the pomegranate to be valuable to treat methicillin-resistant Staphylococcus aureus (MRSA) strains.*

Similarly, the pomegranate’s antioxidants work as scavengers and metal chelators (Kulkarni et al., 2007). The antioxidant, antimalarial, and antimicrobial activities of the tannin-rich fractions, ellagitannins and phenolic acids from pomegranates offer excellent daily dietary food supplement to enhance the immune system (Reddy et al., 2007).*

Probiotics and Supernatant are important to the health of our urogenital system. The genus Lactobacillus has been studied for their promising preventative and/or treatment potential against UTIs (de Llano et al., 2017). Three strains of lactobacillus were tested for their capabilities to inhibit pathogenic adherence of E. coli, E. faecalis, and Staphylococcus epidermidis to T24 epithelial bladder cells. L. salivarious, L. acidophilus showed a significantly inhibited the adherence of pathogens (de Llano et al., 2017; see also Shim et al., 2016). Lactobacillus species were also studies with infants experiencing acute pyelonephritis [kidney infection], and found effective in the prevention of urinary tract infections (Lee et al., 2016).*

The “anti-infective activities” of lactobacillus strains are exhibiting a great promise as innovative anti-infectious agents (Liévin-Le Moal et al., 2014), and especially for recurrent UTIs (Manzoor et al., 2016).*

Depletion of vaginal Lactobacilli has also found in research to be linked with UTI risk, which suggests that repletion (re-colonization of Lactobacilli) might be beneficial (Syngai et al., 2016; Fontana et al., 2013; Maurya et al., 2014).*

Supernatant is the fermented medium created during the culturing process of probiotics. Supernatant is the fermented “soup” that contains important probiotic metabolites which is comprised of enzymes, peptides, proteins, vitamins, and other nutrients and factors, including antimicrobials such as bacitracins. Supernatant is shown in research to have powerful antimicrobial properties with the potential to block adhesion, invasion and translocation of E. coli, yet it is gentle enough to be used to ‘enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense’ (He et al., 2017). In fact, Lazar et al. (2009) in vitro study concluded that the soluble probiotic metabolites, or supernatant, might actually interfere with the beginning stages of adherence and colonization of selected E. coli. This means that the supernatant itself exudes protective effects (Lazar et al., 2009), as well as work synergistically with probiotics organism to stimulate the immune system against pathogenic invasion (Ditu et al., 2014).*

D-mannose has long shown an ability to support acute UTIs, inhibiting bacterial adhesion to the urothelium (Domenici et al., 2016; Kranjčec et al., 2014). Testing more sensitive populations, such as people with multiple sclerosis (MS) who suffer from recurrent UTIs, showed that D-mannose effected a reduction in the number of UTIs as well as reduction for the need of antibiotics (Panicker et al., 2016).*

Since 150 million people suffer from UTIs annually, using natural foods and nutriceutical agents to combat recurrence of UTI infections is advisable (Spaulding et al., 2017). The use of cranberries, pomegranates, probiotics, supernatant, and D-mannose form a potent synergistic effect that is shown in research to be very effective (Vicarotto, 2014).*

There are many more health functions that cranberries and pomegranates perform. For many years cranberries and pomegranates were studied to understand their anti-tumorigenic elements (e.g., Castonguay et al., 1997). More recent studies continue to reveal and explain the bioactivity of pomegranate (Panth et al., 2017; Bishayee et al., 2016; Faria & Calhau, 2011) and cranberries (Kresty et al., 2015; Hochman et al., 2008; Ferguson et al., 2006) as promising suppressants and inhibitors of different kinds of cancer cells (Weh et al., 2016; Liberty et al., 2009; Adams et al., 2006).*

And there is more: Research studies find pomegranate and cranberries phenolics to contribute to heart health (Taheri et al., 2017; Novotny et al., 2015; Aviram et al., 2008, 2002), to balance the gut microbiota (Blumberg et al., 2016), and to offer liver support (Bishayee et al., 2013, 2011). Check the Research Tab for more in depth studies.*

The Cranberry Pomegranate Synbiotic Formula is an excellent choice for UTIs. Cranberries, Pomegranates, Probiotics, supernatant, and D-mannose have all shown in research to provide a potent effect against UTIs. The combination of these ingredients offers a promising natural supplement to prevent and maintain a healthy balance of the urogenital system.

We suggest 2-4 capsules twice daily for UTI management, and 1-2 capsules daily for preventative support.


References:

Bader, M. S., Loeb, M., & Brooks, A. A. (2017). An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgraduate medicine, 129(2), 242-258. http://dx.doi.org/10.1080/00325481.2017.1246055

Baranowska, M., & Bartoszek, A. (2016). Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry. Postepy higieny i medycyny doswiadczalnej (Online), 70, 1460-1468. DOI: 10.5604/17322693.1227896

Bishayee, A., Mandal, A., Bhattacharyya, P., Bhatia, D. (2016). Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Nutr Cancer, 68(1), 120-30. DOI: 10.1080/01635581.2016.1115094

Blumberg, J.B., Basu, A., Krueger, C.G., Lila, M.A., Neto, C.C., Novotny, JA… Toner, C.D. (2016). Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015. Adv Nutr, 7(4), 759S-70S. DOI:10.3945/an.116.012583

Burger, O., Weiss, E., Sharon, N., Tabak, M., Neeman, I., Ofek, I. (2002). Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice. Crit Rev Food Sci Nutr, 42(3), 279-84. DOI: 10.1080/10408390209351916

Cowan, M. M. (1999). Plant products as antimicrobial agents. Clinical microbiology reviews, 12(4), 564-582. Abstract

de Llano, D. G., Arroyo, A., Cárdenas, N., Rodríguez, J. M., Moreno-Arribas, M., & Bartolomé, B. (2017). Strain-specific inhibition of the adherence of uropathogenic bacteria to bladder cells by probiotic Lactobacillus spp. Pathogens and Disease, 75(4). DOI:10.1093/femspd/ftx043

de Llano, D.G., Esteban-Fernández, A., Sánchez-Patán, F., Martínlvarez, P.J., Moreno-Arribas, M.V., Bartolomé, B. (2015). Anti-Adhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Escherichia coli in Bladder Epithelial Cell Cultures. Int J Mol Sci, 16(6), 12119-30. DOI:10.3390/ijms160612119

Ditu, L.M., Chifiriuc, M.C., Bezirtzoglou, E., Marutescu, L., Bleotu, C., Pelinescu, D., Mihaescu, G., Lazar, V. (2014). Immunomodulatory effect of non-viable components of probiotic culture stimulated with heat-inactivated Escherichia coli and Bacillus cereus on holoxenic mice. Microb Ecol Health Dis, 25. DOI:10.3402/mehd.v25.23239

Domenici, L., Monti, M., Bracchi, C., Giorgini, M., Colagiovanni, V., Muzii, L., & Panici, P. B. (2016). D-mannose: a promising support for acute urinary tract infections in women. A pilot study. Eur Rev Med Pharmacol Sci, 20(13), 2920-5. Article

Ermel, G., Georgeault, S., Inisan, C., Besnard, M. (2012). Inhibition of adhesion of uropathogenic Escherichia coli bacteria to uroepithelial cells by extracts from cranberry. J Med Food, 15(2):126-34. DOI: 10.1089/jmf.2010.0312

Fellers, C. R., Redmon, B. C., & Parrott, E. M. (1933). Effect of cranberries on urinary acidity and blood alkali reserve. Journal of Nutrition, 6, 455-463. Abstract

Fontana, L., Bermudez-Brito, M., Plaza-Diaz, J., Munoz-Quezada, S., & Gil, A. (2013). Sources, isolation, characterisation and evaluation of probiotics. British journal of nutrition, 109(S2), S35-S50. DOI:10.1017/S0007114512004011

Foxman B. (2014). Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden. Infect. Dis. Clin. North. Am. 28, 1–13. DOI:10.1016/j.idc.2013.09.003

He, X., Zeng, Q., Puthiyakunnon, S., Zeng, Z., Yang, W., Qiu, J… Cao H…(2017). Lactobacillus rhamnosus GG [ATCC 53103] supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense. Sci Rep, 7, 43305. DOI: 10.1038/srep43305

Heber, D. (2011). Pomegranate Ellagitannins. In I.F.F., Benzie, & S. Wachtel-Galor (Eds.), Herbal medicine: Biomolecular and clinical aspects. 2nd edition. Boca Raton, FL: CRC Press/Taylor & Francis. https://www.ncbi.nlm.nih.gov/books/NBK92772/

Heber, D., Schulman, R. N., & Seeram, N. P. (Eds.). (2006). Pomegranates: ancient roots to modern medicine. CRC press. Summary

Hmid, I., Elothmani, D., Hanine, H., Oukabli, A., & Mehinagic, E. (2017). Comparative study of phenolic compounds and their antioxidant attributes of eighteen pomegranate (Punica granatum L.) cultivars grown in Morocco. Arabian Journal of Chemistry, 10, S2675-S2684. https://doi.org/10.1016/j.arabjc.2013.10.011

Hochman, N., Houri-Haddad, Y., Koblinski, J., Wahl, L., Roniger, M., Bar-Sinai, A. …Hochman, J. (2008). Cranberry juice constituents impair lymphoma growth and augment the generation of antilymphoma antibodies in syngeneic mice. Nutr Cancer, 60, 511–7. DOI:10.1080/01635580801956493

Jensen, H.D., Carsten, S., Christensen, S.B., & Krogfelt, K.A. (2017). Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection. Front Microbiol, 8, 542. doi: 10.3389/fmicb.2017.00542

Kresty, L.A., Weh, K.M., Zeyzus-Johns, B., Perez, L.N., Howell, A.B. (2015). Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation. Oncotarget, 6, 33438–33455. DOI:10.18632/oncotarget.5586

Krueger, C. G., Reed, J. D., Feliciano, R. P., & Howell, A. B. (2013). Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health. Analytical and bioanalytical chemistry, 405(13), 4385-4395. DOI: 10.1007/s00216-013-6750-3

Kulkarni, A. P., Mahal, H. S., Kapoor, S., & Aradhya, S. M. (2007). In vitro studies on the binding, antioxidant, and cytotoxic actions of punicalagin. Journal of agricultural and food chemistry, 55(4), 1491-1500. DOI:10.1021/jf0626720

Lazar, V., Miyazaki, Y., Hanawa, T., Chifiriuc, M. C., Ditu, L. M., Marutescu, L., … & Kamiya, S. (2009). The influence of some probiotic supernatants on the growth and virulence features expression of several selected enteroaggregative E. coli clinical strains. Roum Arch Microbiol Immunol, 68(4), 207-214. Abstract

Lee, S. J., Cha, J., & Lee, J. W. (2016). Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts. World Journal of Pediatrics, 12(4), 425-429. DOI: 10.1007/s12519-016-0013-2

Lee, Y. L., Owens, J., Thrupp, L., & Cesario, T. C. (2000). Does cranberry juice have antibacterial activity?. Jama, 283(13), 1691-1691.

Liberty, A.M., Amoroso, J.W., Hart, P.E., Neto, C.C. (2009). Cranberry PACs and triterpenoids: anti-cancer activities in colon tumor cell lines. Proceedings of the Second International Symposium on Human Health Effects of Fruits and Vegetables. Acta Horticulturae, 841, 61–66. DOI: 10.17660/ActaHortic.2009.841.4

Liévin-Le Moal, V., & Servin, A. L. (2014). Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents. Clinical microbiology reviews, 27(2), 167-199. DOI: 10.1128/CMR.00080-13

Machado, T. D. B., Leal, I. C., Amaral, A. C. F., Santos, K., Silva, M. G. D., & Kuster, R. M. (2002). Antimicrobial ellagitannin of Punica granatum fruits. Journal of the Brazilian Chemical Society, 13(5), 606-610. Article

Manzoor, A., Ul-Haq, I., Baig, S., Qazi, J. I., & Seratlic, S. (2016). Efficacy of locally isolated lactic acid bacteria against antibiotic-resistant uropathogens. Jundishapur journal of microbiology, 9(1). DOI:10.5812/jjm.18952

Maurya, P., Mogra, R., & Bajpai, P. (2014). Probiotics: an approach towards health and disease. Trends in Biosciences, 7(20), 3107-3113. Abstract

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Novotny, J. A., Baer, D. J., Khoo, C., Gebauer, S. K., & Charron, C. S. (2015). Cranberry juice consumption lowers markers of cardiometabolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults. The Journal of nutrition, 145(6), 1185-1193. DOI:10.3945/jn.114.203190

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Article by Dohrea Bardell, PhD

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Extraintestinal pathogenic Escherichia coli is the most common cause of community-acquired and hospital-acquired extraintestinal infections.  Could poultry-meat be part of the problem?

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Well, in just 12 days from today it’s the Hawaii Doc Talks Convention!, but who’s counting.

On Friday March 3rd we will host the breakfast in Maui and teach on a topic that gets right to the heart of the matter regarding food as medicine:  The Intelligence and Power of Therapeutic Food Supplements: Science, Research, and Protocol.

Click on the above link to the see our learning objectives for the doctors.  The third objective is: Discover the next generation probiotics — infection fighting Supernatant metabolites and immune boosting microRNA.

Remember, if you can’t join us this time around, I would be more than happy to meet you via the zoom meeting format online.  Just let me know and we’ll set it up.

The two photos below present our synbiotic formulas.  The top one highlighting our new LactORN Synbiotic and the photo below seven more probiotic offerings.

LactORNs

Understanding our microbiome is without a question one of the hottest topics in medicine. Hippocrates, 2400 years ago, said that all disease begins in the gut.  In a recent speech Dr. Francis Collins, past director of the Human Microbiome Project, and present director of the NIH said,

We are a chimera-like creatire whose healthy metabolic and physiologic functioning is governed by not only our 10 trillion human cells and their 22,000 genes but also by our human microbiome community that co-habitate our bodies, all 100 trillion of them with their 2 to 8 million genes—most of them bacteria living in our GI tract. (2015, Supercharging Science for the Superorganism)

grp_2

“An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.”  (HMP Home page).

The microbiome must be taken into account regarding metabolic diseases (Metabolic Syndrome, Obesity, Diabetes, Heart Disease), gastrointestinal disease (IBS, IBD), and neuroligical health.

Yours truly,

Seann Bardell CEO
BioImmersion Inc.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

  • Dr. Francis Collins, the Director of the NIH recently said “The time of the importance of the microbiome and human health has arrived.  Our gut microbiome is of central importance for our immune system health, our neural-transmitter health, our GI tract health, and our metabolic health.