Blueberry Extract

Fatty Liver

February 9, 2016

Dear Friends

Nonalcoholic fatty liver disease (NAFLD), defined by excessive lipid accumulation in the liver, is the hepatic manifestation of insulin resistance and the metabolic syndrome. Due to the epidemics of obesity, NAFLD is rapidly becoming the leading cause of altered liver enzymes in Western countries (Blachier et al., 2004).   A fatty liver may lead to a fatty pancreas which leads to diabetes (Lichtenstein, Schwab., 2000).

Valenti et al. (2013) explain how steatosis (fatty liver) may be associated with oxidative hepatocellular damage, inflammation, and activation of fibrogenesis, defining nonalcoholic steatohepatitis (NASH).  And, NASH is potentially a progressive liver disease leading to cirrhosis and hepatocellular carcinoma.

Therapeutic Foods support for Nonalcoholic Fatty Liver Disease:
Fatty Liver Protocol 3

  • Blueberry Extract– one daily
  • Phyto Power– two daily
  • Cruciferous Sprouts Complex– two daily
  • Original Synbiotic– one tsp. daily

Food Science:

Anthocyanins decrease hepatic lipid accumulation and counteract oxidative stress and hepatic inflammation (Valenti, 2013; Zhu  et al., 2012; Guo et al., 2011).

Blueberry Extract contains pure anthocyanin extract from Vaccinium corymbosum– a North American blueberry cultivar with an exception broad spectrum of anthocyanins.  It takes us 80 pounds of blueberries to get one pound of this precious extract.

Phyto Power contains four species of wild-crafted Alaskan blueberries (the whole berry), with an exceptionally high concentration of anthocyanins. Plus, it contains the flavonoids of three species of whole wild-crafted rose hips (including seeds) and four species of wild-crafted Alaskan dandelion (including roots, leaves and flowers).  The roots increase liver bile flow.

Dietary supplementation with broccoli sprout extract containing sulforaphane precursor glucoraphanin is likely to be highly effective in improving liver function through reduction of oxidative stress (Kikuchi, 2015).

Cruciferous Sprouts Complex contains broccoli sprouts, daikon radish sprouts, red radish sprouts, water cress sprouts, kale sprouts, mustard sprouts and cabbage sprouts; all together containing high levels of not only glucosinolates, but also high levels of myrosinase (from red radish), the enzymes necessary for high production of sulforaphanes.

The effects of probiotics and prebiotics have proven to be beneficial in NAFLD (Iacono, 2010; Yadav, 2007).

The Original Synbiotic contains 5 pedigreed strains of L. acidophilus, L. rhamnosus, L. plantarum, S. thermophilus and B. longum, plus inulin derived from organic chicory root.

Inulin is very bifidogenic, enhancing the growth of Lactobacillus as well.  These good bacterial produce copious amounts of butyrate upon the fermentation of inulin which facilitate the tightening of gut epithelial cell junctions—reducing leaky gut syndrome.  Delzenne and Kok (1999) demonstrated that FOS, modifying the gene expression of lipogenic enzymes, reduced the de novo liver fatty acid synthesis.

Lactobacillus acidophilus reduced liver oxidative stress and improved insulin resistance (Yadav et al., 2007).  Lactobacillus plantarum reduced liver  and serum cholesterol and triglycerides (Wang et al., 2009).  Lactobacillus rhamnosus reduced hepatic steatosis (Lee 2006).


  • Blachier et al. (2004). The burden of liver disease in Europe: a review of available epidemiological data. Journal of Hepatology; 58(3): 593-608.
  • Browning et al. (2004). Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology; 40(6): 1387-1395.
  • Delzenne NM, Kok NN. (1999). Biochemical basis of oligofructose3-induced hypolipidemia in animal models. J Nutr; 129: 1467S-1470S.
  • Guo et al. (2011). Anthocyanin inhibits high glucose-induced hepatic mtGRAT1 activation and prevents fatty acid synthesis through PKC. Journal of Lipid Research;52(5): 908-922.
  • Iacono et al. (2010). Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms. JNB; 22(8): 699-711.
  • Johnson-Henry et al. (2008). Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli 0157:H7- Induced changes in epithelial barrier function. Infect Immun; 76:1340-1348.
  • Kikuchi et al. (2015). Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World J Gastroenterol; 21(43): 12457-12467.
  • Lee et al. (2006). Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochim Biophys Acta; 1761: 736-744.
  • Lichtenstein AH, Schwab US. (2000). Relationship of dietary fat to glucose metabolism. Atherosclerosis; 150(2): 227-243.
  • Valenti et al. (2013). Dietary Anthocyanins as Nutritional Therapy for Non alcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity; Volume 2013:Article ID 145421.
  • Vendrame et al. (2013a). Wild Blueberry (Vaccinium angustifolium)-enriched diet improves dyslipidaemia and modulates the expression of genes related to lipid metabolism in obese Zucker rats. British Journal of Nutrition; 111(2): 194-200.
  • Wang et al. (2009). Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet. Appl Microbiol Biotechnol; 84: 341-347.
  • Yadav et al. (2007). Antidiabetic effect of probiotic dahl containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition; 23: 62-68.
  • Zhu et al. (2012). The anthocyanin cyaniding-3-O-beta-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: involvement of a cAMP-PKA-dependent signaling pathway. Free Radical Biology and Medicine; 52(2): 314-327.


Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health.  Please  use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Michael Gregor in his educational series shows how saturated fat in the diet causes insulin resistance which leads to fatty muscles leading to fatty liver leading to fatty pancreas leading to diabetes: What Causes Insulin Resistance? and Diabetes as a Disease of Fat Toxicity.

Dear Friends,

Do you  know that blueberries are a rich source of fiber? As a matter of fact, bifidobacterium love blueberries and grow well when they’re fed a mixure of the berries.

A repeated-measure, crossover dietary intervention on human volunteers was designed to study the effect of a six week consumption of a low bush blueberry (Vaccinium angustifolium) drink, versus a placebo drink, in modulating the intestinal microbiota.

The results obtained suggest that regular consumption of blueberries can possibly modulate the composition of the intestinal microbiota. The Bifidobacteria appeared to be selectively favored suggesting an important role for the fiber present in low bush blueberries.

Joseph et al. 2007. Fruit polyphenols and their effects on neuronal signaling and behavior in senescence.  Ann NY Acd Sci; 1100:470-85.

Vendrame et al. 2011. Six-week consumption of a wild blueberry powder drink increases Bifidobacteria in the human gut. J. Agric Food Chem; 59(24):12815-20.

Sincerely yours,

Seann Bardell

Clinical Note:

Our Phyto Power contains the 4 species of blueberry, 3 species of rosehip and 4 species of dandelion all from the wilds of Alaskan.  They are wild-crafted (picked in the wild),  and are exceptionally loaded with polyphenols and fiber.

But the berries do more: As we look for ways to reduce age-related decline in neuronal function, or explore methods to retard or reverse the age-related neuronal deficits, we find that the regular consumption of polyphenolics in high active fruits continues to rise to the top of the list. Blueberries are still thought of as one of the very best. The Blueberry Extract along with the Phyto Power is a winning combination.

Take two capsule daily of the Phyto Power.  This is equivalent of eating six of the rosehip (seeds and all), a small hand full of the blueberries, and a small cup of dandelion salad.

Add one capsule of the Blueberry Extract for a boost. This is equivalent of eating a cup plus of blueberries.

Green Facts

Globe_Home 3
“I would like to enter a dialogue with all people about our common home.”  So begins the encyclical delivered to the world last week from Pope Francis.
It was so beautiful.  He spared no words, and here you have the link to the whole talk in its title:  Revolution needed to combat climate change.

Dear Friends,

Many scientists posit that the common cause behind modern society’s major chronic degenerative diseases is inflammation. That’s the bad new.

The good news is:  Research consistently shows that certain foods help to down regulate inflammation—foods such as blueberry extract, and phytonutrients such as those contained in our Phyto Power. (Vendrame, 2013)

Let’s look at cancer as an example.  In the 2008 paper, Cancer is a preventable disease that requires major lifestyle changes, the researchers state that:

“Inflammation is the link between the agents/factors that cause cancer and the agents that prevent it.”

For starters they make the point that only 5-10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90-95% have their roots in the environment and lifestyle.

Evidence indicates that 25-30% are due to tobacco, 30-35% are linked to diet, 15-20% are due to infections, and the remainging percentage are due to other factors like radiation, physical activity and environmental pollution.

When we talk about inflammatory markers we are looking at cytokines such as TNF alpha, IL-6 and chemokines, enzymes such as COX-2, LOX-5 and MMP-9, etc.  And the authors make the strong point that all of these inflammatory gene products have been shown to be regulated by Nuclear Factor Kappa B (NF-kB).  And, NF-kB activation is a component found in most types of cancers.

Anand et al. 2008. Cancer is a Preventable Disease that Requires Major Lifestyle Changes. Pharm Res., 25(9), 2097-2116.

How might Therapeutic Foods be agents that downregulate these various inflammatory messagers and help to prevent cancer?

Sincerely yours,

Seann Bardell

Clinical Note:

BioImmersion’s Blueberry Extract supplement contains 60 capsules with 500mg per capsule of pure blueberry extract and nothing else.  There are no excipients of any kind.  The capsule is a vegetarian capsule made from cellulose and water.  Take one capsule per day.

Our Phyto Power contains wildcrafted blueberries, rosehips (with their seeds) and dandelions (roots, leaves and flowers) rich in a broad spectrum of anti-inflammatory compounds—flavonoids and polyphenols.  Take one to two a day.

The Last Quiz Answer:

Leopards are one powerful big cat.  So strong that it often hauls its kills into the branches of trees.  They are also strong swimmers, comfortable in the water.  They weigh up to 176 lbs and from head to body over 6 ft with a 4 ft tail extending beyond that.  Black leopards, which appear to be almost solid in color because their spots are hard to distinguish, are commonly called black panthers.  They are really black leopards.  They are such a magnificent creature.  (National Geographic)



Green Facts

How Whales Change The ClimateLast week we looked at how Elephants are eco-farmers of the Africa jungles. This week you will see in the amazing video above how whales are definately the eco warrior of the deep.

They are actually responsible for reducing COs levels from the atmophere.  As they increase the plankton levels throughout the seas—the base of the whole ocean food chain.

Dear Friends,

Blueberry extract is found to be one of the most effective fruits that protect human brain performance and reduce the risk of contracting Parkinson’s!

BioImmersion’s Blueberry extracts, is not only rich in anthocynanins and proanthocyanidins, but has the full spectrum of these important nutrients! Our new technology of extraction successfully captures all of these flavonoids that is in the whole blueberry. The extract is powerful and expensive. See how to benefit from the extract in the clinical notes.

Anthocynanis and Proanthocynidines were shown to alleviate neurodegeneration by stimulating cells mitochondria and thereby helping the cells to survive.  The study suggests that blueberries can contribute to prevention of the onset of neurodegeration, a hallmark of Parkinson’s.

Dr. Mary Ann Lia, blueberry researcher and director of North Carolina State University’s Plants for Human Health Institute, is part of the team of scientists, stated that “Blueberries have both of these natural chemicals, anthocyanins and proanthocyanidins, in high concentrations, so they pack a more powerful, one-two punch.  And, they can have synergistic benefits that surpass many other fruits when it comes to protection against brain cell death, which in turn may reduce the risk of contracting Parkinson’s.”

Strathearn et al. 2014. Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson’s disease. Brain Research, 1555(25), 60-77.

Sincerely yours,

Seann Bardell

Clinical Note:

Our new pure Blueberry Extract from the cultivar Vaccinium corymbosum offers an especially high yield of a broad spectrum of anthocyanins, and proanthocyanadins.  With our advanced extraction technology we are able to capture 100% of these important flavonoids from each berry.

Our suggested dose is to start with one capsule a day. Increase as needed and then go back to the smallest dosage for maintenance.



The Last Quiz Answer:

Are elephants the bees of the Ndok Forest?  These are.  These three amazing, rangy elephants are part of a family of jungle elephants emerging into a clearing deep in the heart of the Congo’s jungle wilderness.

The Congo, like the Amazon and the Great Boreal Forest of the Northern Woods are the lungs of the earth’s biosphere.  And, these elephants, like the bees, spread the seeds of plants, through their eating and pooping, to diversify plant species over wide areas of the jungle—planting trees, and greening our planet.

“Forest elephants at natural densities probably disperse more seeds than any other species or genus of vertebrates in African forests.”

Blake et al. 2009. Forest Elephants:  Tree Planters of the Congo, Biotropica, 10.1111/j.1744-7429.

Green Facts

CO 2 levels in atmosphere rising at dramatically faster rate, U.N. report warns!The very thing that is saving us from our demise— green plants and animals that help the plants and forests to grow are being systematically killed off.

Brain Food for 2015

December 30, 2014

Happy New Year Everyone!

Blueberries basket

Brain food!

Remember there’s 15% off all our products until January 7th, 2015.  Just use the coupon code HOLIDAY15 at checkout to apply our seasonal savings gift.

Why berries to protect our brains? Here is a great reason:

Berries are excellent foods for the brain.  Substances present in blueberries can both reduce oxidative stress and improve communication between brain cells.  

Blueberries, strawberries, and blackberries have all been shown to slow or reverse age-related cognitive decline in animal studies, and blueberries have now been tested for their effects on human memory (1). Older adults with mildly impaired memory were given wild blueberry juice as a supplement, and after as little as 12 weeks, measures of learning and memory had improved (2).  The antioxidants in cherries have also been shown to protect brain cells against oxidative stress, implying that eating cherries may help to prevent neurodegenerative diseases like dementia (3, 4).  In people with mild memory complaints, those who drank pomegranate juice daily performed better on memory task compared to placebo and displayed an increase in brain activation measured by functional MRI (5). (Fuhrman, 2014)


1. Shukitt-Hale B:  Blueberries and neuronal aging. Gerontology 2012;58:518-523.

2. Krikorian R, Shidler MD, Nash TA, et al:  Blueberry supplementation improves memory in older adults. J. Agric Food Chem 2010;58:3996-4000.

3.Kim DO, Heo HJ, Kim YJ, et al:  Sweet and sour cherry phenolics and their protective effects on neuronal cells. Journal of Agricultural and Food Chemistry 2005;53:9921-9927.

4. Raustadottir T, Davies SS, Stock AA, et al:  Tart cherry juice decreases oxidative stress in healthy older men and women. J Nutr 2009;139:1896-1900.

5. Bokkheimer SY, Renner BA, Ekstrom A, et al:  Pomegranate juice augments memory and FMRI acitivity in middle-aged and older adults with mild memory complaints.  Evid Based Complement Alternat Med 2013;2013:946-298.

Visit our Facebook page for the full Fuhrman article link (don’t forget to ‘Like’ the page to see more excellent articles!) 



The key to supporting good health: eat a variety of berries throughout the day to bring in the anti-oxidant and anti-inflammatory properties of these potent berries. Therapeutic Food supplements make this eloquently and powerfully possible. 

Clinical Notes:

Take the following daily for powerful brain protection and cognitive enhancement:

Blueberry Extract:  100% North American Blueberry flavonoid extract. Concentrated to supply the anti-inflammatory power of the blueberry’s broad spectrum of anthocyanins. Take one capsule daily in the morning around breakfast.

Phyto Power:  Wild-crafted Alaskan Blueberry (four species, whole fruit), wild-crafted Alaskan Rosehip (three species, whole fruit) and wild-crafted Alaskan Dandelion (four species, whole plant).  Take two capsules daily around lunch.

No. 7 Systemic Booster:  Contains organic pomegranate (whole fruit and extract), organic tart cherry (whole), organic cranberry (whole fruit and extract), organic pineapple (whole), organic soluble chicory fibers (inulin), 5 Bulgarian probiotic organisms, our famous supernatant, and a variety of supportive nutriceuticals.

Take one teaspoon daily around dinner time.

Blueberry Extract - Phyto Power - No 7 bottles

Part of the reason we suggest these around meal time is that the normal process of digestion creates free radicals itself, and when we have powerful fruit aboard, their damaging effects are minimized.



Environmental Working Group (EWG)

Many organizations are making their final push to raise funds before the year is out and EWG is one we believe is worthy of your attention to contribute to a healthier planet.

A persuasive e-mail written by the world-renowned activist Erin Brokovich says it the best:

EWG isn’t afraid to take on industry and their millions of lobbying dollars. EWG doesn’t shy away from the fight for clean water and toxics reform and giving powerful information directly to consumers.

What EWG does is hard, and it sure isn’t cheap. But we need EWG to be an independent advocate for us, and EWG depends on people just like you for nearly half of its funding.

You can make a year-end donation to EWG here.


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