Blueberry Extract


April 9, 2017

Dear Friends,

Cognitive decline, memory loss, and foggy thinking are on the rise and do not automatically accompany old age but affect all ages (Joseph, 2009).

Plant polyphenols and a healthy microbiome in the GI tract have shown to strongly support a healthy functioning nervous system, regenerate nerve tissue and protect against the onset of neuro-degenerative decline (Brewer et al., 2010; Burokas et al., 2015).

Therapeutic Food Protocol for Cognitive Support.

Food Science

A declining nervous system leads to the problematic onset of neurodegenerative diseases (Parkinson’s and Alzheimer’s).  Protecting against this decline, berry fruit polyphenols were examined, and in particular, blueberry extract anthocyanins for their multiplicity of actions that goes beyond the established antioxidant ability (Galli et al., 2002). The other possible mechanisms for the berry’s positive effects include: direct effects on signaling to enhance neuronal communication (Joseph et al., 2003), the ability to buffer against excess calcium (Joseph et al., 2004), enhancement of neuroprotective stress shock proteins (Galli et al., 2006), and reduction of stress signals such as nuclear factor B (NF-B) (Goyarzu et al., 2004).  Additionally, the anthocyanins contained in blueberries have been shown to enter the brain, and their concentrations were correlated with cognitive performance (Andres-Lacueva et al., 2005).

The brain-gut axis is a bidirectional communication system between the central nervous system (CNS) and the gastrointestinal tract. Regulation of the microbiota-brain-gut axis is essential for maintaining homeostasis, including that of the CNS. It is clear that the gut microbiota can be a key regulator of mood, cognition, pain, and obesity (Burokas et al., 2015; Borre et al., 2014).


  • Andres-Lacueva, C., Shukitt-Hale, B., Galli RL., Jauregui O., Lamuela-Reventos, RM., Joseph, J. (2005). Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci; 8:111-120.
  • Borre, Y.E., Moloney, R.D., Clarke, G., Dinana, T.G., Cryan, J.F. (2014). The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Adv Exp Med Biol, 817, 373-403.
  • Brewer, G.J., Torricelli, J.R., Lindsey, A.L., Kunz, E.Z., Neuman, A., Fisher, D.R., & Joseph, J.A. (2010). Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem, 21, 991-998.
  • Burokas, A., Moloney, RD., Dinan, TG., Cryan, JF. (2015). Microbiotia regulation of the Mammalian gut-brain axis. Adv Appl Microbiol; 91(1): 1-62.
  • Galli, R.L., Shukitt-Hale, B., Youdim, K.A.. Joseph, J.A. (2002). Fruit polyphenolics and brain aging:  nutritional interventions targeting age-related neuronal and behavioral deficits. Ann NY Acad Sci; 959: 128-32.
  • Galli,RL., Bielinski, DF., Szprengiel, A., Shukitt-Ale, B., Joseph, J. (2006). Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection.  Neurobiol Aging; 27:344-350.
  • Goyarzu, P., Malin, DH., Lau FC., Taglialatela, G. Moon, WD., Jennings, R., Moy, E., et al. (2004).  Blueberry supplemented diet: effects on object recognition memory and nuclear factor kappa B levels in aged rats. Nutr Neurosci: 7:75-83.
  • Joseph, J., Denisova, NA., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003).  Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 6:153-162.
  • Joseph, J., Fisher, D.R., Carey, AN. (2004). Fruit extracts antagonize Abeta- or DA- induced deficits in Ca2++ flux in M1-transfect COS-7 cells. J Alzheimers Dis; 6:403;discussion 443-9.
  • Joseph, J., Cole, G., Head, E., Ingram, D. (2009). Nutrition, brain aging, and neurodegeneration. J Neurosci; 29(41): 12795-801.
  • Joseph, J.A., Denisova, N.A., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003). Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci, 6, 153-162.

Sincerely yours,


We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Have you tune into the Rocky Mountain Institute.  Their vision is a world thriving, verdant and secure, for all, for ever.  Their mission is to drive the efficient and restorative use of resources.

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Dear Friends

Recent clincial research has demonstrated that berry fruits can prevent age-related neurodegenerative diseases and improve motor and cognitive functions.

Regular flavonoid rich fruit intake is associated with delayed Parkinson’s disease, Alzheimer’s disease, ischemic diseases and aging effects (Subash, 2014).

Therapeutic Food recipe to support motor and cognitive function:

Food Science

The berry fruits are not only powerful broad spectrum antioxidants, but also are hormetic by nature (hormone like), capable of modulating metabolic and signaling pathways involved in inflammantory reactions, cell survival, neurotransmission and enhancing neuroplasticity.

Blueberry Extract contains pure anthocyanin extract from Vaccinium corymbosum– a  North American blueberry cultivar with an exceptionally broad spectrum of anthocyanins.  It takes us 80 pounds of blueberries to get one pound of this precious and very potent extract.

Blueberries are rich in phytochemicals such as anthocyanin, chlorogenic acid, catechin, quercetin, kaempferol, and tannins.  Chlorogenic acid for example crosses the blood-brain barrier and through hydrolysis converts to caffeic acid, the most potent of all antioxidants for neutralizings the fires of oxidations in the brain.

Phyto Power contains three species of wildcrafted Alaskan Rosehips (the whole fruit and seeds), four species of wildcrafted dandelions (aerial parts 90% w/w, roots 10% w/w and flower), and four species of wildcrafted blueberry (fruit >95% w/w and leave and stems < 5% w/w).

Cerebral deposition of amyloid B-peptide in the brain is an invariant feature of Alzheimer’s Disease.  A consistent protective effect of polyphenols consumption on AD has been documented by epidemiological studies (Ono, 2003).  The polyphenolics involved where myricetin, morin, quercetin, kaempferol, catechin and epicatechins—all which are the high actives in Phyto Power‘s rose hips, blueberries, and dandelion.

Akiyama et al. (2000) looked at how inflammation fits into the overall framework of AD pathology and determined that virtually all the cytokines and chemokines that have been studied in AD including IL-1beta, IL-6, TNF-alpha, IL-8, COX-2, etc. are up-regulated in AD; and that AD patients should significantly benefit from anti-inflammatory treatment.

Read more on AD and Phyto Power support by clicking on the link above.

High ORAC Synbiotic contains 20 billion of probiotic (L. acidophilus, B.longum) plus blueberry extract, grape and grape seed extract, raspberry and raspberry seed extract, cranberry, strawberry, prune, tart cherry and wild bilberry extract plus 250mg inulin.

The gut has been called the second brain for a good reason.  With a population of 100 million nerves in the enteric nervous system, there is more neuronal tissue in the gut than in the spinal cord.  The digestive tract is the Port of Entry into our body via the food we put into our mouth. The gut has 100 trillion luminal microbes, and hence, it is the frontline of our body’s communication with the outside world.  The commensal gut microbiota influences systemic immune response, with recent research showing a causive effect on various neural tissues. Much literature is now focused on the connection between microbiota and pain and cognition, illnesses such as MS, Guillain-Barre Syndrome, neurodevelopmental and behavioral disorders, and Alzheimer’s disease (Catanzaro, et al., 2015). High ORAC Synbiotic supports the health of microbiota. Read more by clicking on the link above.


  • Akiyama et al. (2000). Inflammation and Alzheimer’s disease. Neurobiol Aging; 21(3): 383-421.
  • Carey et al. (2014). Blueberry supplementation improves memory in middle-aged mice fed a high-fat diet. J Agric Food Chem; 62: 3972-3978.
  • Catanzaro et al. (2015). The gut microbiota and its correlations with the central nervous system disorders. Panminerva Med; 57(3): 127-43.
  • Ono et al. (2003). Potent Anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer’s isease. J Neurochem; 87: 172-181
  • Stratheam et al. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson’s diseases. Brian Res; 1555: 60-77.
  • Subash et al. (2014). Neuroprotective effects of berry fruits on neurodegenerative diseases.  Neural Regeneration Research; 9(16): 1557-1566.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Maintaining a good relationship with Mother Nature is crucial to our health, and our very survival as we are all inextricably tied together.  I love the Global Oneness Project as it invites us back into a healthy relationship with her.  Just click on any of their amazing and enlightened videos and essays.


Fatty Liver

February 9, 2016

Dear Friends

Nonalcoholic fatty liver disease (NAFLD), defined by excessive lipid accumulation in the liver, is the hepatic manifestation of insulin resistance and the metabolic syndrome. Due to the epidemics of obesity, NAFLD is rapidly becoming the leading cause of altered liver enzymes in Western countries (Blachier et al., 2004).   A fatty liver may lead to a fatty pancreas which leads to diabetes (Lichtenstein, Schwab., 2000).

Valenti et al. (2013) explain how steatosis (fatty liver) may be associated with oxidative hepatocellular damage, inflammation, and activation of fibrogenesis, defining nonalcoholic steatohepatitis (NASH).  And, NASH is potentially a progressive liver disease leading to cirrhosis and hepatocellular carcinoma.

Therapeutic Foods support for Nonalcoholic Fatty Liver Disease:
Fatty Liver Protocol 3

  • Blueberry Extract– one daily
  • Phyto Power– two daily
  • Cruciferous Sprouts Complex– two daily
  • Original Synbiotic– one tsp. daily

Food Science:

Anthocyanins decrease hepatic lipid accumulation and counteract oxidative stress and hepatic inflammation (Valenti, 2013; Zhu  et al., 2012; Guo et al., 2011).

Blueberry Extract contains pure anthocyanin extract from Vaccinium corymbosum– a North American blueberry cultivar with an exception broad spectrum of anthocyanins.  It takes us 80 pounds of blueberries to get one pound of this precious extract.

Phyto Power contains four species of wild-crafted Alaskan blueberries (the whole berry), with an exceptionally high concentration of anthocyanins. Plus, it contains the flavonoids of three species of whole wild-crafted rose hips (including seeds) and four species of wild-crafted Alaskan dandelion (including roots, leaves and flowers).  The roots increase liver bile flow.

Dietary supplementation with broccoli sprout extract containing sulforaphane precursor glucoraphanin is likely to be highly effective in improving liver function through reduction of oxidative stress (Kikuchi, 2015).

Cruciferous Sprouts Complex contains broccoli sprouts, daikon radish sprouts, red radish sprouts, water cress sprouts, kale sprouts, mustard sprouts and cabbage sprouts; all together containing high levels of not only glucosinolates, but also high levels of myrosinase (from red radish), the enzymes necessary for high production of sulforaphanes.

The effects of probiotics and prebiotics have proven to be beneficial in NAFLD (Iacono, 2010; Yadav, 2007).

The Original Synbiotic contains 5 pedigreed strains of L. acidophilus, L. rhamnosus, L. plantarum, S. thermophilus and B. longum, plus inulin derived from organic chicory root.

Inulin is very bifidogenic, enhancing the growth of Lactobacillus as well.  These good bacterial produce copious amounts of butyrate upon the fermentation of inulin which facilitate the tightening of gut epithelial cell junctions—reducing leaky gut syndrome.  Delzenne and Kok (1999) demonstrated that FOS, modifying the gene expression of lipogenic enzymes, reduced the de novo liver fatty acid synthesis.

Lactobacillus acidophilus reduced liver oxidative stress and improved insulin resistance (Yadav et al., 2007).  Lactobacillus plantarum reduced liver  and serum cholesterol and triglycerides (Wang et al., 2009).  Lactobacillus rhamnosus reduced hepatic steatosis (Lee 2006).


  • Blachier et al. (2004). The burden of liver disease in Europe: a review of available epidemiological data. Journal of Hepatology; 58(3): 593-608.
  • Browning et al. (2004). Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology; 40(6): 1387-1395.
  • Delzenne NM, Kok NN. (1999). Biochemical basis of oligofructose3-induced hypolipidemia in animal models. J Nutr; 129: 1467S-1470S.
  • Guo et al. (2011). Anthocyanin inhibits high glucose-induced hepatic mtGRAT1 activation and prevents fatty acid synthesis through PKC. Journal of Lipid Research;52(5): 908-922.
  • Iacono et al. (2010). Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms. JNB; 22(8): 699-711.
  • Johnson-Henry et al. (2008). Lactobacillus rhamnosus strain GG prevents enterohemorrhagic Escherichia coli 0157:H7- Induced changes in epithelial barrier function. Infect Immun; 76:1340-1348.
  • Kikuchi et al. (2015). Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World J Gastroenterol; 21(43): 12457-12467.
  • Lee et al. (2006). Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochim Biophys Acta; 1761: 736-744.
  • Lichtenstein AH, Schwab US. (2000). Relationship of dietary fat to glucose metabolism. Atherosclerosis; 150(2): 227-243.
  • Valenti et al. (2013). Dietary Anthocyanins as Nutritional Therapy for Non alcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity; Volume 2013:Article ID 145421.
  • Vendrame et al. (2013a). Wild Blueberry (Vaccinium angustifolium)-enriched diet improves dyslipidaemia and modulates the expression of genes related to lipid metabolism in obese Zucker rats. British Journal of Nutrition; 111(2): 194-200.
  • Wang et al. (2009). Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet. Appl Microbiol Biotechnol; 84: 341-347.
  • Yadav et al. (2007). Antidiabetic effect of probiotic dahl containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition; 23: 62-68.
  • Zhu et al. (2012). The anthocyanin cyaniding-3-O-beta-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: involvement of a cAMP-PKA-dependent signaling pathway. Free Radical Biology and Medicine; 52(2): 314-327.


Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health.  Please  use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Michael Gregor in his educational series shows how saturated fat in the diet causes insulin resistance which leads to fatty muscles leading to fatty liver leading to fatty pancreas leading to diabetes: What Causes Insulin Resistance? and Diabetes as a Disease of Fat Toxicity.

Dear Friends,

Do you  know that blueberries are a rich source of fiber? As a matter of fact, bifidobacterium love blueberries and grow well when they’re fed a mixure of the berries.

A repeated-measure, crossover dietary intervention on human volunteers was designed to study the effect of a six week consumption of a low bush blueberry (Vaccinium angustifolium) drink, versus a placebo drink, in modulating the intestinal microbiota.

The results obtained suggest that regular consumption of blueberries can possibly modulate the composition of the intestinal microbiota. The Bifidobacteria appeared to be selectively favored suggesting an important role for the fiber present in low bush blueberries.

Joseph et al. 2007. Fruit polyphenols and their effects on neuronal signaling and behavior in senescence.  Ann NY Acd Sci; 1100:470-85.

Vendrame et al. 2011. Six-week consumption of a wild blueberry powder drink increases Bifidobacteria in the human gut. J. Agric Food Chem; 59(24):12815-20.

Sincerely yours,

Seann Bardell

Clinical Note:

Our Phyto Power contains the 4 species of blueberry, 3 species of rosehip and 4 species of dandelion all from the wilds of Alaskan.  They are wild-crafted (picked in the wild),  and are exceptionally loaded with polyphenols and fiber.

But the berries do more: As we look for ways to reduce age-related decline in neuronal function, or explore methods to retard or reverse the age-related neuronal deficits, we find that the regular consumption of polyphenolics in high active fruits continues to rise to the top of the list. Blueberries are still thought of as one of the very best. The Blueberry Extract along with the Phyto Power is a winning combination.

Take two capsule daily of the Phyto Power.  This is equivalent of eating six of the rosehip (seeds and all), a small hand full of the blueberries, and a small cup of dandelion salad.

Add one capsule of the Blueberry Extract for a boost. This is equivalent of eating a cup plus of blueberries.

Green Facts

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“I would like to enter a dialogue with all people about our common home.”  So begins the encyclical delivered to the world last week from Pope Francis.
It was so beautiful.  He spared no words, and here you have the link to the whole talk in its title:  Revolution needed to combat climate change.

Dear Friends,

Many scientists posit that the common cause behind modern society’s major chronic degenerative diseases is inflammation. That’s the bad new.

The good news is:  Research consistently shows that certain foods help to down regulate inflammation—foods such as blueberry extract, and phytonutrients such as those contained in our Phyto Power. (Vendrame, 2013)

Let’s look at cancer as an example.  In the 2008 paper, Cancer is a preventable disease that requires major lifestyle changes, the researchers state that:

“Inflammation is the link between the agents/factors that cause cancer and the agents that prevent it.”

For starters they make the point that only 5-10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90-95% have their roots in the environment and lifestyle.

Evidence indicates that 25-30% are due to tobacco, 30-35% are linked to diet, 15-20% are due to infections, and the remainging percentage are due to other factors like radiation, physical activity and environmental pollution.

When we talk about inflammatory markers we are looking at cytokines such as TNF alpha, IL-6 and chemokines, enzymes such as COX-2, LOX-5 and MMP-9, etc.  And the authors make the strong point that all of these inflammatory gene products have been shown to be regulated by Nuclear Factor Kappa B (NF-kB).  And, NF-kB activation is a component found in most types of cancers.

Anand et al. 2008. Cancer is a Preventable Disease that Requires Major Lifestyle Changes. Pharm Res., 25(9), 2097-2116.

How might Therapeutic Foods be agents that downregulate these various inflammatory messagers and help to prevent cancer?

Sincerely yours,

Seann Bardell

Clinical Note:

BioImmersion’s Blueberry Extract supplement contains 60 capsules with 500mg per capsule of pure blueberry extract and nothing else.  There are no excipients of any kind.  The capsule is a vegetarian capsule made from cellulose and water.  Take one capsule per day.

Our Phyto Power contains wildcrafted blueberries, rosehips (with their seeds) and dandelions (roots, leaves and flowers) rich in a broad spectrum of anti-inflammatory compounds—flavonoids and polyphenols.  Take one to two a day.

The Last Quiz Answer:

Leopards are one powerful big cat.  So strong that it often hauls its kills into the branches of trees.  They are also strong swimmers, comfortable in the water.  They weigh up to 176 lbs and from head to body over 6 ft with a 4 ft tail extending beyond that.  Black leopards, which appear to be almost solid in color because their spots are hard to distinguish, are commonly called black panthers.  They are really black leopards.  They are such a magnificent creature.  (National Geographic)



Green Facts

How Whales Change The ClimateLast week we looked at how Elephants are eco-farmers of the Africa jungles. This week you will see in the amazing video above how whales are definately the eco warrior of the deep.

They are actually responsible for reducing COs levels from the atmophere.  As they increase the plankton levels throughout the seas—the base of the whole ocean food chain.