Blueberry Extract

Dear Friends

Atherosclerosis Cardiovascular Disease (ACD), or clogged arteries, is the leading cause of death in the world. Hypercholesterolemia, or high cholesterol levels in the blood, is one of the  major causative factor (Barquer et al., 2015) .  Hence, statins are among the top selling drugs.

High use of statins, however, comes with possible serious side effects.  Stroher et al. (2015) tested the possible advantages of combining lower doses of statins with a Blueberry Extract, or using Blueberry Extract on its own.  Her research group found that dosing hypercholesterolemic rats with a combination of Zocor (also called SIM) and Blueberry Extract (BE) brought better results. However, using Blueberry Extract alone also brought good results.

Thirty-six hypercholesterolemic rats were divided into six groups of six animals each, with  14 days of the following supplementation regime for each group: (1) Control (only got the high-fat diet), (2) Fat diet + SIM 10mg/kg, (3) Fat diet + BE  25mg/kg, (4) Fat diet + BE 50mg/kg, (5) Fat diet + BE 25mg/kg + SIM, (6) Fat diet + BE 50mg/kg + SIM.  Many beneficial results were found as is presented in bar graphs below.

This graph shows, after histological section, the thickness measurements of the aorta of hypercholesterolemic rats after treatment.  Notice here that groups 3-6 got better results. But the interesting part about this measurement is that group 4 got only 50mg of blueberry extract and has similar result to group 6 which got SIM drug and blueberry extract, 50mg.

Aorta thickness

To see the multitude of other bar graphs from their paper, graphically illustrating the various benefits derived from adding the Blueberry Extract, click the Stroher link in the References below.

After 14 days of supplementation with blueberry extract the levels of total cholesterol, LDLs, and triglycerides were decrease in hypercholesterolemic rats.  Histopathological analysis, analyzing the tissues after death, showed significant decrease of aortic lesions.  Oxidative parameters showed significant reductions in oxidative damage to lipids and proteins and an increase in activities of endogenous antioxidant enzymes such as catalase, superoxide dismutase and glutathione peroxidase.

In conclusion, Stroher et al. (2015) state that Blueberry Extract supplementation was able to protect against weight gain, improve the lipid profile, reduce the high levels of total cholesterol, LDL and triglycerides and showed an anti-atherogenic effect in these rats.  The Blueberry Extract also showed improved oxidative parameters, showing a decrease is oxidation of lipids and proteins.  They concluded that as nutraceutical blueberry extract may have great potential as people prefer natural therapies.

Therapeutic Food Blueberry Extract is a powerhouse not only for brain function but for heart health as well.  Recommended dose is 1-2 capsules daily- with 500mg of pure blueberry extract in each capsule. We also suggest 1-2 tablespoons of Beta Glucan Synbiotic for lowering LDL cholesterol, and a primarily whole food, plant-based diet which is shown in research to combat heart disease.

References:

  • Barquera, S., Pedroza-Tobías, A., Medina, C., Hernández-Barrera, L., Bibbins-Domingo, K., Lozano, R., & Moran, A. E. (2015). Global overview of the epidemiology of atherosclerotic cardiovascular disease. Archives of medical research, 46(5), 328-338.
  • Serino, A., & Salazar, G. (2019). Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease. Nutrients,11(1), 53.
  • Stroher, D. J., Piccoli, J. D. C. E., da Costa Güllich, A. A., Pilar, B. C., Coelho, R. P., Bruno, J. B., … & Manfredini, V. (2015). 14 Days of supplementation with blueberry extract shows anti-atherogenic properties and improves oxidative parameters in hypercholesterolemic rats model. Int J Food Sci Nutr, 66(5), 559-68.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Our diet is a major factor for heart health. We suggest eating a primarily whole food, plant-based diet, with organic meat, dairy, and eggs serving as condiments every so often. (Serino & Salazar, 2019).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Alzheimer’s has moved up to the number three cause of death in the United States just under cancer and heart disease (NIH- National Institute of Aging, 2019).

Julien et al. (2009) compared the concentration of SIRT1 in the brains of AD patients and controls. In the first group of 19 patients and 22 controls,  a significant reduction of SIRT1 in the parietal cortex of AD patients was found.  Further analyses in a second cohort of 36 subjects confirmed that cortical SIRT1 was decreased in AD but not in individuals with mild cognitive impairments.  A significant relationship between SIRT1 levels and global cognition scores proximate to death was also found. Collectively, their results indicate that loss of SIRT1 is closely associated with the accumulation of amyloid-beta and tau in the cerebral cortex of persons with AD.  Furthermore, autopsies of Alzheimer’s victims reveal that loss of sirtuin enzyme activity is closely associated with the accumulation of the plaques and tangles.

Plants (fruits, berries, veggies, and greens) contain key phytonutrients, namely polyphenols. In research, an increasing number of polyphenols are being found to turn on a family of our anti-aging genes called sirtuins.  Sirtuins, particularly SIRT1 expression, is shown to reduce and eliminate amyloid-B and tangles, two protein derangements that are symptomatic of Alzheimer’s.   High heat cooked meats and fats create a molecule called advanced glycation end products (AGEs) which when present in the blood turn off the sirtuin gene expression, thereby turning off the expression of these anti-aging genes (Julien et al., 2009).

The Therapeutic Food Supplements  boost our body with key plant polyphenols that turn on the sirtuins.  Each of the four products is designed to supply ample amounts of phytonutrients and in particular polyphenols such as resveratrol, quercetin, and catechins to  enhance brain function.

For preventing cognitive decline and beginning stages of dementia, add to your protocol the High ORAC Synbiotic  with standardized high levels of  resveratrol and quercetin.

For a progressive decline and Alzheimer’s, add to the High ORAC a more robust protocol of powerful polyphenols to regenerate neurons in the brain:

References:

  • Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017). Sirtuins, a promising target in slowing down the ageing process. Biogerontology,18(4), 447-476.
  • Julien, C., Tremblay, C., Emond, V., Lebbadi, M., Salem Jr, N., Bennett, D. A., & Calon, F. (2009). Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. Journal of Neuropathology & Experimental Neurology, 68(1), 48-58.
  • Uribarri, Jaime, Sandra Woodruff, Susan Goodman, Weijing Cai, Xue Chen, Renata Pyzik, Angie Yong, Gary E. Striker, and Helen Vlassara. (2010). “Advanced glycation end products in foods and a practical guide to their reduction in the diet.” Journal of the American Dietetic Association110, no. 6: 911-916.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Our diet is a major factor in whether we succumb to Alzheimers or not.  Eating primarily a whole-foods plant-based diet with meat and fat being more like a condiment puts the odds highly in one’s favor on not becoming its victim (Uribarri et al., 2010).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Parkinson’s is a neurological disease characterized by mitochondrial dysfunction and oxidative stress in the dopaminergic neurons of the mid brain, causing them to die, resulting in motor dysfunction.

Parkinson’s (PD) has been positively associated with two groups of pesticides, those that impair mitochondrial function and those that increase oxidative stress.  Two such pesticides are paraquat, which causes oxidative stress, and rotenone, which inhibits mitochondrial complex I, both induce loss of nigral dopaminergic neurons and behavioral changes associated with human PD.

Epidemiological findings suggest that the consumption of berries rich in anthocyanins and proanthocyanidins may reduce PD risk.  Strathearn et al. (2014) demonstrated powerful protective effects of blueberry extract in protecting the neurons from the oxidative damage of the pesticides.  In their study, they investigated whether extracts rich in anthocyanins, proanthocyanidins, or other polyphenols, suppress the neurotoxic effects of rotenone in a primary cell culture model of PD.

Extracts rich in anthocyanins and proanthocyanidins exhibited greater neuroprotective activity than extracts rich in other polyphenols, and a number of individual anthocyanins interfered with rotenone neurotoxicity.  The blueberry and grape seed extracts rescued rotenone-induced defects in mitochondrial respiration in a dopaminergic cell line.

Dr. Mary Ann Lila, one of the study’s team of scientists, and the director of North Carolina State University’s Plants for Human Health Institute stated:

Blueberries have both of these natural chemicals (anthocyanins and proanthocyanidins) in high concentrations, so they pack a more powerful, one-two punch.  They can have synergistic benefits that surpass many other fruits when it comes to protection against brain cell death, which in turn may reduce the risk of contracting Parkinson’s.(Moore, 2014)

A cup a day is a good routine for health, according to Lila, and it provides abundant amounts of vitamins A and C, fiber, manganese and phytonutrients, which have antioxidant and anti-inflammatory properties.  Blueberries are also a “brain food”, and have been shown to increase powers of concentration and slow cognitive degeneration.

Our  Blueberry Extract (1 capsule) has a cup and a quarter of blueberries, while the Phyto Power (2 capsules) has 200mg of four species of wild harvested blueberries plus 400 mg of rosehips with their powerful collection of flavonoids including proanthocyanidins.

We will focus on these cognitive benefits in our next Forward Thinking.

References

Moore, J. (2014). Blueberries reduce risk of Parkinson’s, boost brain function finds new study. Plants for human health institute, NC State. Article

Strathearn, K. E., Yousef, G. G., Grace, M. H., Roy, S. L., Tambe, M. A., Ferruzzi, M. G., … & Rochet, J. C. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson׳ s disease. Brain research, 1555, 60-77. Article

Tanner, C. M., Kamel, F., Ross, G. W., Hoppin, J. A., Goldman, S. M., Korell, M., … & Comyns, K. (2011). Rotenone, paraquat, and Parkinson’s disease. Environmental health perspectives, 119(6), 866-872. Article

Best,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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It is estimated that one million people suffer from Parkinson’s in the U.S., and although the disease itself is not fatal, complications arising from it can be, and the CDC states that these co-morbidities result in it being the 14th leading cause of death in the country (National Parkinson Foundation).

 

©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

When we talk about the function of the the brain, blueberry consumption should be front and center, for much research has shown that blueberry, and blueberry extract in particular, can not only protect us from cognitive decline but help reverse the effects of senescense.

blueberry X 4Scientific research indicates that a cup or two of blueberry every day will improve cognitive performance, improve our athletic abilities (balance, strength, and endurance), and even elevate our mood (Miller et al., 2018; Schrager et al., 2015; Khalid et al., 2017).  Research also emphasizes that the quantity of blueberries matter: one cup a day is good but 2 cups a day may be even better (Miller & Shukitt-Hale,  2012).  These health improvements are not just limited to the elderly but to all ages.  Research has shown that children can greatly benefit too (Whyte, 2016; Khalid, 2017).

The BioImmersion Blueberry Extract is a very serious product.  The cognitive, mood enhancing, and athletic benefits emanate from the blueberry pigment; and that is what is extracted from the North American blueberry we have chosen for the Blueberry Extract.  Each capsule contains 500mg of this precious extract, equivalent to one and a quarter cups of blueberries.  In fact,  it takes 80 lbs. of blueberries to get 1 lb. of this extract!

Recommended dose:  one capsule daily.

References:

  • Whyte, A. R., Schafer, G., & Williams, C. M. (2016). Cognitive effects following acute wild blueberry supplementation in 7-to 10-year-old children. European journal of nutrition, 55(6), 2151-2162.
  • Miller, M. G., Hamilton, D. A., Joseph, J. A., & Shukitt-Hale, B. (2018). Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. European journal of nutrition, 57(3), 1169-1180.
  • Schrager, M. A., Hilton, J., Gould, R., & Kelly, V. E. (2015). Effects of blueberry supplementation on measures of functional mobility in older adults. Applied Physiology, Nutrition, and Metabolism, 40(6), 543-549.
  • Khalid, S., Barfoot, K. L., May, G., Lamport, D. J., Reynolds, S. A., & Williams, C. M. (2017). Effects of acute blueberry flavonoids on mood in children and young adults. Nutrients, 9(2), 158.
  • Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: the PANAS scales. Journal of personality and social psychology, 54(6), 1063.
  • Miller, M. G., & Shukitt-Hale, B. (2012). Berry fruit enhances beneficial signaling in the brain. Journal of agricultural and food chemistry, 60(23), 5709-5715.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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One of the world’s great organization for learning how to work with nature is the Biomimicry Institute.  Check them out:  Global Design Challenge.  They are truly one of the bright rays of hope for bonding with Mother Nature and learning from her 3 billion years of life experience on Earth .

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Blueberry and Cancer

June 25, 2018

Dear Friends

Blueberries have shown protective effects against liver and breast cancers.

Liver cancer was the fourth most common cause of mortality worldwide.  In China, greater than 90% of patients with primary liver cancer have hepatocellular carcinoma (HCC), which was the second-leading cause of cancer-associated mortality, influencing individuals of all ages.

The global overall survival of HCC patients remained particularly poor.  The majority of the poor prognoses were associated with recurrence and metastasis following treatment, including curative resection.

Zhan, W., et al. (2016) study investigate the effects of blueberry consumption on the migration, invasion, proliferation, cell cycle, and apoptosis in human hepatocellular carcinoma cells in order to provide clinical treatment and prevention strategies for liver cancer therapeutic agents.

In the present study, the blueberry components were not detected and the important components were not extracted from the fresh blueberries. However, fresh blueberry juice was fed to the rats and the serum was collected. The serum from the blueberry-fed rats was used for co-culturing with HEPG2 cells, and the proliferation, invasion, migration, cell cycle and apoptosis in HEPG2 cells was detected following culture with serums taken from rats fed with different concentrations of blueberry juice. The results indicated that the blueberry juice exerted significant antitumor and therapeutic effects on HEPG2 cells. The different concentrations of blueberry juice and varying treatment times resulted in distinct influences on the invasion, migration, proliferation, cell cycle and apoptosis in the HEPG2 cells. The higher the concentration of blueberry the better were the results.

Note:  HEPG2 is an immortalized cell line consisting of human liver carcinoma cells derived from the tissue of a 15 year old caucasion male who had a well differentiated hepatocellular carcinoma.

Blueberry Extract is the most powerful blueberry extract on the market, our 100% North American blueberry (Vaccinium corymbosum) provides a comprehensive profile of anthocyanins.

The Blueberry Extract is expensive: It takes 80 pounds of blueberries to get one pound of the pure purple extract. One capsule of this extract is equivalent to a cup and a quarter of whole blueberries.

  • Blueberry Extract- 1 capsule daily

To promote blueberry cancer support:  15% off on Blueberry Extract in June.

Like hepatocellular carcinoma, triple negative breast cancer has a high mortality rate.  See the research article below in Green Facts on blueberry’s positive results against this cancer.

References:

  • Zhan, W., Liao, X., Yu, L., Tian, T., Liu, X., Liu, J., … & Yang, Q. (2016). Effects of blueberries on migration, invasion, proliferation, the cell cycle and apoptosis in hepatocellular carcinoma cells. Biomedical reports, 5(5), 579-584.
    https://www.spandidos-publications.com/10.3892/br.2016.774

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Adams, L. S., Phung, S., Yee, N., Seeram, N. P., Li, L., & Chen, S. (2010). Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer research, 70(9), 3594-3605.

This study investigated the chemopreventive activity of blueberry extract in triple-negative breast cancer cell lines in vitroand in vivo.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved