Therapeutic Food Supplements

Dear Friends

GS Photo JPEGBroccoli sprouts provide an exceptionally rich source of sulforaphane – a potent inducer of enzymes that protect against chemical carcinogens.  In fact, three-day-old sprouts of broccoli contain 10-100 times higher levels of glucoraphanin (the glucosinolate of sulforaphane) than do the mature broccoli plants.  Broccoli sprouts are the richest natural source for sulforaphanes, and the BioImmersion organic broccoli sprouts selected for the Glucosinolate & Sulforaphane are at the 100 fold level.

Our Glucosinolate & Sulforaphane replaces the Cruciferous Sprout Complex as it supplies 6-8 times the potency of the most important phytochemical, sulforaphane.

Glucosinolate & Sulforaphane comes in two sizes: the 120 capsule size as shown to the right and is in stock now, and the 60 capsule size bottle that will be available in three weeks.  With a dose being 1-2 capsules a day, the larger bottle will give a 2-4 month supply.

Food Science

Broccoli sprouts are a rich source of glucosinolates and isothiocyanates, shown in research to induce phase 2 detoxication enzymes, boost antioxidant status, and protect animals against chemically induced cancer.  Glucosinolates are hydrolyzed by myrosinase (an enzyme found in plants and bowel microflora) to form isothiocyanates.  Glucosinolates are inert as phase 2 enzyme inducers and must be hydrolyzed (break-down) to generate the active isothiocyanates (Shapiro et al., 2001).

Sulforaphane (SFN) is a compound derived from cruciferous vegetables with numerous bioactivities (Su et al., 2018). In fact, Broccoli and especially broccoli sprouts, accumulate significant amounts of the phytonutrient glucoraphanin, which is metabolized in vivo to the biologically active sulforaphane (SFN).  The preponderance of evidence available from in vitro, animal and human studies supports the association of sulforaphane with phase II enzyme induction (James et al., 2012), moreover, SFN strongly displays both anticarcinogenic and anticancer activity by modulating ‘key signaling pathways and genes involved in the induction of apoptosis, cell cycle arrest, and inhibition of angiogenesis’ (Su et al., 2018; see also Peng et al., 2015; Zhang & Tang, 2007).

SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN (Peng et al., 2015).

Sulforaphane is found in research to have many different health benefits:  Alzheimer’s (Kim et al., 2013), Cardiovascular Disorders (Angeloni et al., 2009), Diabetes (Bahadoran et al., 2012), Asthma- upper airway congestion, (Riedl et al., 2009) and Detoxification in all cells, and in particular with Liver Phase II detoxification enhancement (Riedl et al., 2009).

Sulforaphane (SFN) has been demonstrated to be an effective chemopreventive agent for many years (Shapiro et al., 2001), with positive effects against different kinds of cancers, such as cervical (Chen et al., 2016; Abdull et al., 2013), breast (Peng et al., 2015; Li et al., 2010), bladder (Leone et al., 2017), renal cell carcinoma (Juengel et al., 2016), non-small-cell lung cancer (Wang et al., 2017), and colon and prostate cancers (Clarke et al., 2008; Abdull et al., 2013).

We will continue to examine the research on this important food in the next few weeks.

References

Abdull Razis, A. F., Konsue, N., & Ioannides, C. (2018). Isothiocyanates and Xenobiotic Detoxification. Molecular nutrition & food research62(18), 1700916.

Abdull, R., Ahmad, F., & Noor, N. M. (2013). Cruciferous vegetables: dietary phytochemicals for cancer prevention. Asian Pacific Journal of cancer prevention, 14(3), 1565-1570.

Angeloni, C., Leoncini, E., Malaguti, M., Angelini, S., Hrelia, P., & Hrelia, S. (2009). Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential. Journal of agricultural and food chemistry57(12), 5615-5622.

Bahadoran, Z., Tohidi, M., Nazeri, P., Mehran, M., Azizi, F., & Mirmiran, P. (2012). Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. International journal of food sciences and nutrition63(7), 767-771.

Cheng, Y. M., Tsai, C. C., & Hsu, Y. C. (2016). Sulforaphane, a dietary isothiocyanate, induces G2/M arrest in cervical cancer cells through cyclinB1 downregulation and GADD45β/CDC2 association. International journal of molecular sciences, 17(9), 1530.

Clarke, J. D., Dashwood, R. H., & Ho, E. (2008). Multi-targeted prevention of cancer by sulforaphane. Cancer letters, 269(2), 291-304.

Fahey, J. W., Zhang, Y., & Talalay, P. (1997). Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proceedings of the National Academy of Sciences, 94(19), 10367-10372.  http://www.pnas.org/content/94/19/10367

James, D., Devaraj, S., Bellur, P., Lakkanna, S., Vicini, J., & Boddupalli, S. (2012). Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition reviews70(11), 654-665.

Juengel, E., Maxeiner, S., Rutz, J., Justin, S., Roos, F., Khoder, W., … & Blaheta, R. A. (2016). Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro. Oncotarget, 7(51), 85208.

Kim, H. V., Kim, H. Y., Ehrlich, H. Y., Choi, S. Y., Kim, D. J., & Kim, Y. (2013). Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model. Amyloid20(1), 7-12.

Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H. F., Newman, B., … & Sun, D. (2010). Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clinical Cancer Research, 1078-0432.

Peng, X., Zhou, Y., Tian, H., Yang, G., Li, C., Geng, Y., … & Wu, W. (2015). Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells. Oncology reports34(3), 1565-1572.

Riedl, M. A., Saxon, A., & Diaz-Sanchez, D. (2009). Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clinical immunology130(3), 244-251.

Shapiro, T. A., Fahey, J. W., Wade, K. L., Stephenson, K. K., & Talalay, P. (2001). Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.Cancer Epidemiology and Prevention Biomarkers, 10(5), 501-508.  http://cebp.aacrjournals.org/content/10/5/501.long

Su, X., Jiang, X., Meng, L., Dong, X., Shen, Y., & Xin, Y. (2018). Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity2018.

Wang, D. X., Zou, Y. J., Zhuang, X. B., Chen, S. X., Lin, Y., Li, W. L., … & Lin, Z. Q. (2017). Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways. Acta Pharmacologica Sinica, 38(2), 241.

Zhang, Y., & Tang, L. (2007). Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta pharmacologica Sinica, 28(9), 1343-1354.


Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The Environmental Working Group is a most important organization to get to know.  Their mission is to empower people to live healthier lives in a healthier environment. With breakthrough research and education, they drive consumer choice and civic action.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

We are excited to announce our new and incredibly potent: organic broccoli cruciferous sprout. Our Glucosinolates & Sulforaphanes is a powerhouse, providing a four fold increase in the phase 2 enzymes inducing and cancer preventing molecules for which it is named.

G and S

Notice that the label above guarantees a Glucosinolate level of 15,000 ppm, a Glucoraphanin level of 10,000 ppm and a Sulforaphane potential of 4,000 ppm.  However, as you can see in the Certificate of Analysis below, the actual levels of these three most important ingredients are much higher, with the Glucosinolates at 21,359 ppm, the Glucoraphanins at 19,407 ppm, and the Sulforaphane yield at 8,733 ppm.  Our old beloved Cruciferous Sprouts product offered a 1500 ppm sulforaphane potential yield.

Organic Broc Sprout CofA

Recommended dose:  one to two capsules daily. Excellent before bed for liver detox.

Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer‐related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis.   Zhang and Tang (2007) review its discovery and development as a cancer chemopreventive agent.

The preponderance of evidence available from in vitro, animal, and human studies supports the association of sulforaphane with phase II enzyme inductions.  Broccoli sprouts are the richest source of glucoraphanin which is the direct precursor to sulforaphane.  Since broccoli sulforaphane is one of the most potent inducers of phase II enzymes, exploration into broccoli’s impact on other areas of human health, such as cardiovasucular health and upper airway immunity, has been suggested (James et al., 2012).

In Qidong, China, a region where exposures to food-and air-borne carcinogens has been considerable, clinical trials indicate that interventions with well characterized preparations of broccoli sprouts may enhance the detoxication of aflatoxins and air-borne toxins, which may in turn attenuate their associated health risks including cancer in exposed individuals (Kensler et al., 2012).

We will continue to discuss this powerhouse product in our next email.

References:

  • James, D., Devaraj, S., Bellur, P., Lakkanna, S., Vicini, J., & Boddupalli, S. (2012). Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition reviews, 70(11), 654-665.
  • Kensler, T. W., Egner, P. A., Agyeman, A. S., Visvanathan, K., Groopman, J. D., Chen, J. G., … & Talalay, P. (2012). Keap1–nrf2 signaling: a target for cancer prevention by sulforaphane. In Natural Products in Cancer Prevention and Therapy(pp. 163-177). Springer, Berlin, Heidelberg.
  • Zhang, Y., & Tang, L. (2007). Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta pharmacologica Sinica, 28(9), 1343-1354.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The Environmental Working Group is a most important organization to get to know.  Their mission is to empower people to live healthier lives in a healthier environment. With breakthrough research and education, they drive consumer choice and civic action.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

When we talk about the function of the the brain, blueberry consumption should be front and center, for much research has shown that blueberry, and blueberry extract in particular, can not only protect us from cognitive decline but help reverse the effects of senescense.

blueberry X 4Scientific research indicates that a cup or two of blueberry every day will improve cognitive performance, improve our athletic abilities (balance, strength, and endurance), and even elevate our mood (Miller et al., 2018; Schrager et al., 2015; Khalid et al., 2017).  Research also emphasizes that the quantity of blueberries matter: one cup a day is good but 2 cups a day may be even better (Miller & Shukitt-Hale,  2012).  These health improvements are not just limited to the elderly but to all ages.  Research has shown that children can greatly benefit too (Whyte, 2016; Khalid, 2017).

The BioImmersion Blueberry Extract is a very serious product.  The cognitive, mood enhancing, and athletic benefits emanate from the blueberry pigment; and that is what is extracted from the North American blueberry we have chosen for the Blueberry Extract.  Each capsule contains 500mg of this precious extract, equivalent to one and a quarter cups of blueberries.  In fact,  it takes 80 lbs. of blueberries to get 1 lb. of this extract!

Recommended dose:  one capsule daily.

References:

  • Whyte, A. R., Schafer, G., & Williams, C. M. (2016). Cognitive effects following acute wild blueberry supplementation in 7-to 10-year-old children. European journal of nutrition, 55(6), 2151-2162.
  • Miller, M. G., Hamilton, D. A., Joseph, J. A., & Shukitt-Hale, B. (2018). Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. European journal of nutrition, 57(3), 1169-1180.
  • Schrager, M. A., Hilton, J., Gould, R., & Kelly, V. E. (2015). Effects of blueberry supplementation on measures of functional mobility in older adults. Applied Physiology, Nutrition, and Metabolism, 40(6), 543-549.
  • Khalid, S., Barfoot, K. L., May, G., Lamport, D. J., Reynolds, S. A., & Williams, C. M. (2017). Effects of acute blueberry flavonoids on mood in children and young adults. Nutrients, 9(2), 158.
  • Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: the PANAS scales. Journal of personality and social psychology, 54(6), 1063.
  • Miller, M. G., & Shukitt-Hale, B. (2012). Berry fruit enhances beneficial signaling in the brain. Journal of agricultural and food chemistry, 60(23), 5709-5715.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

One of the world’s great organization for learning how to work with nature is the Biomimicry Institute.  Check them out:  Global Design Challenge.  They are truly one of the bright rays of hope for bonding with Mother Nature and learning from her 3 billion years of life experience on Earth .

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

What is the new longevity? Aging and chronic illness are often linked in research to inflammation from environmental toxins, pathogens, lack of exercise, too much sugar and fat in the diet, and lack of sleep. In short – ongoing stress that diminishes our body’s supply of stem cells. And, once our stem cells are used up, we deplete our ability to regenerate and heal.

Our new No. 7 Systemic Booster rejuvinates multiple systems in our body by reducing inflammation in the gut and body, so we do not use up our own stem cells to reduce inflammation, and keep us healthy.

Let’s have a look:

No. 7 Systemic Booster:  The New Longevity

  • The new longevity: In research, aging is linked to a variety of chronic illnesses that occur due to a continual inflammatory state in the body, which accelerates stem cells’ deterioration and ultimately lessens our ability to regenerate. 
  • The No 7 combination of Polyphenols (from high active berries, fruit, veggies, and greens), Fibers, Prebiotic, B12, Fructo Borate, Folate, Chromium, and the new blend of naturally occurring whole Probiotics with their Supernatant and ORNs (the Probiotic Super Blend) offer potent calming nutrients, protection and rejuvination.
  • The No 7 boosts many systems in the body: the Immune, GI Tract, Urogenital, Osteo-skeletal, Cardiovascular, Brain and Neurological, Detoxification, Metabolic, Digestive, and Energy.

No7_ 8.15.18

As you can see, the No. 7 taken on a regular basis provides a base of strength to build upon.  For example, its Probiotic Super Blend protects your GI tract with pedigreed strains of strong lactic acid bacteria, building a healthy eco-system within the GI tract microbiome that reduces inflammation in the gut.

The probiotic count (CFU) of the No. 7  is 15 billion per teaspoon.  To add more probiotic count to your daily dose, simply add one capsue of the new Supernatant Synbiotic which provides a CFU of 20 billion per capsule.  The Supernatant Synbiotic is, in fact, the Probiotic Super Blend itself.

No. 7 provides intense antioxidant, anti-inflammatory, and anti-microbial properties, all are agents of the longevity enducing power of organic plant polyphenols.  For more plant power,  add one capsule daily of the new High ORAC Synbiotic with a Total ORAC score of 40,000.  Plus it also has 20 billion CFU of the Probiotic Super Blend.

For UTI issues, add to your daily tsp dose of No. 7 one capsule of the new Cranberry Pomegranate Synbiotic, which will provide high active cranberry and pomegranate extracts plus 20 billion CFU of the Probiotic Super Blend.

A healthy plant based diet, along with good probiotic organisms and concentrated supplements of plant polyphenols all are critical for our daily health and longevity, reducing the risk of chronic degenerative disease now and later in our life.

References:

  • Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research11(10), 4781-4790.http://pubs.acs.org/doi/abs/10.1021/pr300581s.
  • Possemiers, S., Bolca, S., Verstraete, W., & Heyerick, A. (2011). The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals. Fitoterapia82(1), 53-66. https://www.sciencedirect.com/science/article/pii/S0367326X10001899?via%3Dihub
  • Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015). Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition54(3), 325-341. https://link.springer.com/article/10.1007/s00394-015-0852-y
  • Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F., & Loguercio, C. (2007). Chronic inflammation and oxidative stress in human carcinogenesis. International Journal of Cancer, 121(11), 2381-2386.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.cts under the advisement of your doctor.

Green Facts:

Globe_Home 3

One of the world’s great organization for learning how to work with nature is the Biomimicry Institute.  Check them out:  Global Design Challenge.  They are truly one of the bright rays of hope for bonding with Mother Nature and learning from her 3 billion years of life experience on Earth .condition and its down stream consequences.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

What’s new at BioImmersion?

September 18, 2018

Dear Friends

What’s new at BioImmersion?   Plenty!  And, we are very excited to share the good news this week.  First, we are almost done updating all the labels.  Thank you, Hovie Hawk, our amazing website and label art designer who we think has done a beautiful job! Secondly, we continually seek out and incorporate into our formulas more powerful plant materials and bio-available nutriceuticals. Our proprietary blends of naturally occuring, whole probiotics, complete with their supernatant and ORNs are better than ever. We have been working in the last two years with our scientists and researchers to advance and update our formulations according to the latest scientific findings.

As ususal, we are not trendy or commercial – we hold firm to scientific research and formulate accordingly.

Here is a glimpse of four advanced formulas.  I’ll expand on them in the coming weeks.

(1)  GLUCOSINOLATES & SULFORAPHANES:  Organic Broccoli Sprouts

  • This product advances the Cruciferous Sprout Complex, with six times  the potency of sulforaphane potential.
  • Glucosinolate is the precursor molecule to glucoraphanin which is the precursor to sulforaphanes.
  • Sulforaphes enhance detoxication of aflatoxins, the most dangerous of mold toxins, and air-borne pollutions, and is a major inducer of phanse 2 detoxication enzymes for liver detox.

G and S


(2)  ENERGY:  Plant Ultra Minerals with Apple Extract

  • Our proprietary blend of ancient plant minerals and apple extract has been clinically testedto increase ATP levels by enhancing mitochondrial ATP production.
  • Resistance training with healthy males saw increases in their strength and endurance while taking this product.
  • Supplementation with our Energyblend of ancient peat minerals and apple extract enhanced resistance training-induced skeletal muscle hypertrophy without affecting fat mass or blood chemistry of rhese healthy males.

ENERGY

 

(3)  No. 7 Systemic Booster:  The New Longevity

  • The new longevity: In research, aging is linked to a variety of chronic illnesses that occur due to a continual inflammatory state in the body, which accelerates stem cells’ deterioration and ultimately lessens our ability to regenerate. 
  • The No 7 combination of Polyphenols (from high active berries, fruit, veggies, and greens), Fibers, Prebiotic, B12, Fructo Borate, Folate, Chromium, and the new blend of naturally occurring whole Probiotics with their Supernatant and ORNs offer potent calming nutrients and rejuvination.
  • The No 7 boosts many systems in the body: the GI Tract, Urogenital, Osteo-skeletal, Cardiovascular, Brain and Neurological, Detoxification, Metabolic, Digestive, and Energy.

No7_ 8.15.18

 

(4)  High ORAC Synbiotic:  Post Antibiotic Care

  • The High ORAC is 10 times more potent with Total ORAC of 40,000ppm! The advanced formula’s Polyphenols re-energize our bodies by boosting nitric oxide levels in the blood; stimulate antioxidant activity while reducing ROS; improve cellular oxygen consumption.
  • The new naturally occuring whole probiotics with Supernatant and ORNs create a more acidic ph balance in the gut, allowing a better growth of good organisms while creating an antimircrobial effect that protects the GI tract membrane from opportinistic pathogen- e.g., Candida.
  • Since antibiotics often unbalance the microbiome (GI Tract) resulting in overgrowth of yeast in the gut and vagina, we have chosen plant extracts that have antimicrobial properties, and together with the probiotic, reduce pathogenic populations, calm the GI, and restore normal balance to the microbiome.

HOS _9.15.18

 

References:

  • Zhang, Y., Kensler, T. W., Cho, C. G., Posner, G. H., & Talalay, P. (1994). Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proceedings of the National Academy of Sciences, 91(8), 3147-3150.
  • Zhang, Y., & Tang, L. (2007). Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta pharmacologica Sinica, 28(9), 1343-1354.
  • Don James, Sridevi Devaraj, Prasad Bellur, Shantala Lakkanna, John Vicini and Sekhar Boddupalli, Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced‐glucoraphanin broccoli, Nutrition Reviews, 70, 11, (654-665), (2012).
  • Joy, J. M., Falcone, P. H., Vogel, R. M., Mosman, M. M., Kim, M. P., & Moon, J. R. (2015). Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men. Applied Physiology, Nutrition, and Metabolism, 40(11), 1171-1177.
  • Joy, J. M., Vogel, R. M., Moon, J. R., Falcone, P. H., Mosman, M. M., Pietrzkowski, Z., … & Kim, M. P. (2016). Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men. BMC complementary and alternative medicine, 16(1), 224.
  • Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research11(10), 4781-4790.http://pubs.acs.org/doi/abs/10.1021/pr300581s.
  • Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015). Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition54(3), 325-341. https://link.springer.com/article/10.1007/s00394-015-0852-y
  • Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F., & Loguercio, C. (2007). Chronic inflammation and oxidative stress in human carcinogenesis. International Journal of Cancer, 121(11), 2381-2386.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Federico et al. in their research paper, Federico, A., Morgillo, F., Tuccillo, C., Ciardiello, F., & Loguercio, C. (2007). Chronic inflammation and oxidative stress in human carcinogenesis.  International Journal of Cancer, 121(11), 2381-2386, state that a wide array of chronic inflammatory conditions predispose susceptible cells to neoplastic transformation.

Inflammatory condition occurs when the generation of free radicals and active inter-mediates in a system exceeds the system’s ability to neutralize and eliminate them.  Reactive intermediates of oxygen and nitrogen may directly oxidze DNA, or may interfere with DNA repair.

The above link takes you to this review which focuses on some of these intricate events by discussing the relationships occurring among oxidative/nitrosative/metabolic stress, inflammation and cancer.

You can see now when contemplating on the features and benefits of our products outlined above that they have major applications for this chronic inflammation condition and its down stream consequences.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved