Weight Loss Support

Weight-Less

September 22, 2017

Dear Friends                                                                                                                                                      WL Low Cropped Jpeg

Recent research has shown the link between chronic hyperglycemia, oxidative stress, and weight gain. Hyperglycemia puts our body into a state of oxidative stress, which leads to many pathologies such as diabetes mellitus, obesity, cancer, and cardiovascular diseases (Domingueti et al., 2016).

Ingredients of Weight-Less per capsule

  • 7-Keto DHEA- 25mg (helps to burn fat)
  • 2 Brown Seaweed extracts- 200mg (help to lower and prevent high blood sugar levels, offers a strong anti-inflammatory, and supports weight loss)

Take 1 – 2 capsules of Weight-less one-half hour before meals, especially important before your carbohydrate (or meat) laden meals.* (See Green Facts on meat and diabetes)

Food Science

The ingredients in Weight-less have been shown to reduce both the states of hyperglycemia and oxidative stress. The Kelp and Bladderwrack polyphenol extracts (phlorotannins) offer organic-certified bioactive ingredients that (1) act on amylase and glucosidase enzymes to optimize post-meal blood glucose and insulin responses and (2) demonstrate that they have a high total antioxidant activity as verified by the Total ORAC 6.0 assay.

The phenols in the kelp and bladderwrack have superior antioxidant activity – a neutralizing effect – on the primary free radical superoxide anion. Superoxide  anion is known as the “mother of  free radicals” because  it also can become a hydroxyl ROS, a nitrogen RNS and a hydrogen peroxide ROS.

Thus, Weight-Less helps prevent post-meal hyperglycemia and has a direct scavenging action on excess free radical generation.  The key is not to totally neutralize all free radical activity but to bring about a healthy redox homeostasis.

References:

  • Domingueti, C. P., Dusse, L. M. S. A., das Graças Carvalho, M., de Sousa, L. P., Gomes, K. B., & Fernandes, A. P. (2016). Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. Journal of diabetes and its complications, 30(4), 738-745.
  • Hulsmans, M., & Holvoet, P. (2010). The vicious circle between oxidative stress and inflammation in atherosclerosis. Journal of cellular and molecular medicine, 14(1‐2), 70-78.
  • InterAct Consortium. (2013). Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study. Diabetologia, 56(1), 47-59
  • Gutowski, M., & Kowalczyk, S. (2013). A study of free radical chemistry: their role and pathophysiological significance. Acta Biochimica Polonica, 60(1), 1-16.
  • Valko, M., Rhodes, C., Moncol, J., Izakovic, M. M., & Mazur, M. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions, 160(1), 1-40.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3High meat intake is also shown in research to generate oxidatative stress and hyperglacemia. We will discuss this in another email but meanwhile, see Dr. Greger’s informative video on Why is meat a risk factor for diabetes?
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Lose Weight

August 2, 2017

Dear Friends                                                                                                                                                                                                            Beta Glucan Photo jpeg 2

Over a billion people in the industrialized world are overweight or obese.  The rising tide of obesity leads to a constellation of disease conditions, from diabetes and heart disease to cancer and non-alcoholic liver disease (WHO, Fact Sheet Update, 2016).

The Beta Glucan High Potency Synbiotic promotes a healthy weight loss due to the gluten free oat beta glucan.*

Chang, H.C., Huang, C.N., Yeh, D.M. … Wang, C.J et al. (2013) conclude in their study entitled, Oat prevents Obesity and Abdominal Fat Distribution, and improves Liver Function in Humans, that consumption of oat reduced obesity, abdominal fat, and improved lipid profiles and liver functions. Taken as a daily supplement, oat could act as an adjuvant therapy for metabolic disorders.

Chang et al. (2013) performed a clinical trial to confirm the effect of oat. Subjects with BMI ≧27 and aged 18–65, were randomly divided into a control (n = 18) and an oat-treated (n = 16) group, taking a placebo or beta glucan-containing oat cereal, respectively, for 12 weeks. The data showed that consumption of oat reduced body weight, BMI, body fat and the waist-to-hip ratio. The researchers showed that profiles of hepatic function, including AST, but especially ALT, were useful resources to help in the evaluation of the liver, since both showed decrements in patients with oat consumption.

Our high potency Original probiotics, along with the B-Glucans, Beetroot, and Inulin provide not only weight-management benefits, but also strong support for heart, liver, GI tract and energy support (see references below).*

*These statements have not been evaluated by the Food & Drug Administration. This products is not intended to diagnose, treat, cure or prevent any disease. The information and citations of research are for informational purposes only. Please be sure to consult your health care provider before taking this or any other product.

References:

  • Cani, P.D., Bibiloni, R., Knauf, C., waget, A., Neyrinck, A.M., Delzenne, N.M., Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice. Diabetes, 57, 1470-8. DOI:10.2337/db07-1403
  • Cani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D. … Burelini, R. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56, 1761-72. DOI:10.2337/db06-1491
  • Chang, H.C., Huang, C.N., Yeh, D.M., Wang, S.J., Peng, C.H., & Wang, C.J. (2013). Oat prevents obesity and abdominal fat distribution, and improves liver function in human. Plant Foods Hum Nutr, 68(1), 18-23. DOI:10.1007/s11130-013-0336-2
  • Delzenne, N.M., Neyrinck, A.M., Cani, P.D. (2011). Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact, 10 Suppl 1, S10. DOI: 10.1186/1475-2859-10-S1-S10
  • Maki, .KC., Beiseigel, J.M., Jonnalagadda, S.S., Gugger, C.K., Reeves, M.S., Farmer, M.V., Kaden, V.N., Rains, T.M. (2010). Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods. J Am Diet Assoc, 110(2), 205–214.
  • Peng, C.H., Chang, H.C., Yang, M.Y., Huang, C.N., Wang, S.J., Wang, C.J. (2012). Oat attenuate non-alcoholic fatty liver and obesity via inhibiting lipogenesis in high fat-fed rat. J Funct Foods, http://dx.doi.org/10.1016/j.jff.2012.08.003
  • Sáez-Lara, M.J., Robles-Sanchez, C., Ruiz-Ojeda, F.J., Plaza-Diaz, J., Gil, A. (2016). Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials. Int J Mol Sci, 17(6). DOI:10.3390/ijms1706


Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Vermonters are seeing the light!  Green Mountain Power is trying to turn homes, neighborhoods and towns into virtual power plants, to wean them off the electric power grid into total energy self-sufficiency.  A good investment of our time, energy and money?  Think if you had invested in Exxon or Amazon way back when.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Cani (2007, 2007a, 2008, 2009) demonstrated in their research that adding to the diet soluble fibers such as inulin (such as the inulin oligofructose chains found in the Original Synbiotic, the Beta Glucan Synbiotic and the No. 7 Systemic Booster) stimulates the growth of Bifidobacteria sp., which caused a reduction in gut permeability, thereby reducing the levels of LPS systemically, and resulted in weight loss and reduced metabolic disorders.

Leaky Gut Cascade 2

High-fat diets increases insulin resistance (IR) and the risk of developing metabolic diseases such as obesity and diabetes.

Cani et al. (2007), Metabolic Endotoxemia Initiates Obesity and Insulin Resistance, describe their search for an inflammatory factor causative for the onset of insulin resistance, obesity, and diabetes. They identified bacterial lipopolysaccharide (LPS) as a major triggering factor.

In various research studies (using a rat research model), Cani et al. found that normal endotoxemia increased or decreased during the fed or fasted state, respectively. A 4-week high-fat diet chronically increased plasma LPS concentration two to three times, a threshold that they defined as metabolic endotoxemia.  The immune system reacts vigorously to LPS in the plasma creating chronic inflammation and causing insulin resistance.

The consequence of insulin resistance will favor hyperinsulinemia and excessive hepatic and adipose tissue lipid storage.  And, adipose tissue presents increased expression and content of pro-inflammatory cytokines such as TNF-a, IL-1 (3,4) and Il-6 (4).

Importantly, a high-fat diet for 4 weeks resulted in significant modulation of dominant bacterial populations within the intestinal microbiota. Shifting to a higher percentage of gram-negative bacteria over gram-positive bacteria.  In particular they found a lowering of the gram-positive Bifidobacterial levels, which cause an increased opening within the tight junctions, allowing for more LPS from the gram-negative bacteria to pass into the plasma.

Cani et al. (2007a) found that adding inulin to the high-fat feed of the research animals, increased the Bifido levels in their colon, which tightened the junctions and reduced the LPS systemic levels.

Their conclusion:  Bifidobacterium spp. significantly and positively correlated with improved glucose tolerance, glucose-induced insulin secretion and normalised inflammatory tone (decreased endotoxaemia, plasma and adipose tissue proinflammatory cytokines).

Food Science: Risk-Reduction of Metabolic Disease

Select from any one of the following Synbiotic products.  They also can be alternated from dose to dose.

  • Original Synbiotic– one tsp. daily
  • Beta Glucan High Potency Synbiotic– one tbl. daily
  • No. 7 Systemic Booster– one tsp. daily

All of these formulas contain ample amounts of organic chicory root derived inulin and the probiotic bacteria Bifido longum found in the research of Cani et al. to facilitate the reduction of entoxemia, and thereby reducing a contributing factor in obesity and diabetes.

Bibliography:

  • Cani et al. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut; 58(8): 1091-1103
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Cani et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes; 56:1761-72.
  • Cani et al. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia; 50: 2374-83.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

  • Which country in the world has the highest percentage of obese citizens?
  • The Kingdom of Tonga with 68.7% obesity, and over 30% diabetes.  Their daily diet, an exceedingly high fatty corn beef, along with high starch sweet potatoes.  For snacks the Tongans love to frequently munch on lamb flap which contain 50% fat.  See Matoto et al. (2014). Burden and spectrum of disease in people with diabetes in Tonga. Public Health Action; 4: S44-S49.

 

Dear Friends

New studies show that Chlorella help us to reduce body fat percentage, improve fat and glucose metabolism, decrease weight, and reduce the risk factors involved with Metabolic Disease.

Therapeutic Food Protocol: Organic Chlorella

Food Science

Mizoguchi et al. (2008) in their research, Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease, demonstrated that Chlorella intake, in 17 subjects with high risk factors for lifestyle-related disease (obesity, diabetes or hyperlipidemia) and 17 healthy subjects, results in noticeable reductions in body fat percentage, total blood serum cholesterol, and fasting blood glucose levels.

Their research confirmed that Chlorella intake brings about improvements in both fat metabolism and glucose metabolism.  The expression of genes involved in the insulin signaling pathway were also affected by Chlorella vulgaris intake, especially those related to glucose uptake in tissue, providing support for the observation that Chlorella lowers blood glucose levels.

Vecina et al. (2014), Chlorella modulate insulin signaling pathway and prevents high-fat diet induces insulin resistance in mice, research goal was to evaluate the prophylactic effect Chlorella vulgaris on body weight, lipid profile, blood glucose and insulin signaling in liver, skeletal muscle and adipose tissue of diet-induced obese mice.

Their conclusion was that C. vulgaris supplementation (Chlorella) could be considered as an adjunctive therapy to decrease weight and improve glycemic status and reducing hs-CRP as well as improving liver function in patients with NAFLD.

Add Inulin fiber and Bifidobacteria to the protocol:

Food Science:

Cani and associates (2008) found that bacterial lipopolysaccharide (LPS) levels set the tone of insulin sensitivity and the onset of obesity and diabetes.  An increased gut permeability allowed for the passage of LPS through the gut wall into the systemic circulation.  Thus, lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.

Cani (2007, 2007a, 2008, 2009) demonstrated in their research that adding to the diet soluble fibers such as inulin (containing oligofructose chains found in the Original Synbiotic) stimulates the growth of Bifidobacteria sp., which caused a reduction in gut permeability, thereby reducing the levels of LPS systemically, and resulted in weight loss and reduced metabolic disorders.

Leaky Gut Cascade 2

Bibliography:

  • Vecina et al. (2014). Chlorella modulate insulin signaling pathway and prevents high-fat diet–induced insulin resistance in mice. Life Sci; 95(1): 45-52.
  • Mizoguchi et al. (2008). Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease.  J Med Food; 11(3): 395-404.
  • Cani et al. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut; 58(8): 1091-1103
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Cani et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes; 56:1761-72.
  • Cani et al. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia; 50: 2374-83.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3If the fructose in sugar and high fructose corn syrup has been considered alcohol without the buzz in terms of the potential to inflict liver damage, what about the source of natural fructose, fruit?  See Dr. Michael Greger’s informative Video:   If Fructose is Bad, What About Fruit?

 

Dear Friends

What is the correlation between processed foods, endotoxemia, and weight gain?

Cani and associates (2008) found that bacterial lipopolysaccharide (LPS) levels set the tone of insulin sensitivity and the onset of obesity and diabetes. An increased gut permeability allowed for the passage of LPS through the gut wall into the systemic circulation.  Thus, lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.

LPS are large molecules that are found in the outer membrane of Gram-negative bacteria, and elicit strong immune responses in animals.

I’ll discuss a handy protocol below based on some exciting fiber and probiotic research.

The following diagram from Cani (2008)graphically spells out the chain of events.

Leaky Gut Cascade

 Food Science

“This graph shows that changes in the gut microbiota controls endotoximia, inflammation, and associated disorders by a mechanism that increases intestinal permeability” (Cani, 2008).

Cani (2007, 2007a, 2008, 2009) demonstrated in their research that adding to the diet soluble fibers such as inulin (containing oligofructose chains) stimulates the growth of Bifidobacteria sp. which caused a reduction in gut permeability, thereby reducing the levels of LPS systemically, and resulted in weight loss and reduced metabolic disorders.

A Therapeutic Food protocol for adding bifidobacteria and fiber (inulin) for the reduction and prevention of Obesity and Diabetes:

Pick one of these excellent sources for daily dosaging.

Direction:  Pick from any of these three products of probiotics, which contain large amounts of bifidobacteria and inulin.

Bibliography

  • Cani et al. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut; 58(8): 1091-1103.
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-81.
  • Cani et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes; 56:1761-72.
  • Cani et al. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia; 50: 2374-83.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Which country in the world has the highest percentage of obese citizens?
The Kingdom of Tonga with 68.7% obesity, and over 30% diabetes.  Their daily diet, an exceedingly high fatty corn beef, along with high starch sweet potatoes.  For snacks the Tongans love to frequently munch on lamb flap which contain 50% fat.  See Matoto et al. (2014). Burden and spectrum of disease in people with diabetes in Tonga. Public Health Action; 4: S44-S49.