Metabolic Syndrome Support

Dear Doctor

Let’s face it, we are not eating enough fiber. Recent published reviews continue to highlight the connection between eating enough fiber, especially from plants, to lower cholesterol and improve heart health.

Statins are prescribed to lower cholesterol, however, there are side-effects that are not tolerable.

Two review from the USA and the UK summarize our need to increase fiber, especially the kind that lowers cholesterol, like beta glucan.

In the USA, Dr. Ghada Soliman, an associate professor of Nutrition in the Department of Environmental, Occupational and Geospatial Health Sciences, concludes her review of the literature that higher intake of fiber can in fact lower the need for statins. Some people may need statins but in much lower dosage.

Here are other fiber functions in the article by Ghada A. Soliman:

Dietary fiber has several protective effects against chronic diseases, including cardiovascular disease, diabetes, metabolic syndrome, inflammatory bowel syndrome, diverticular disease, obesity, and colorectal cancer in the age-adjusted analysis [77,78,79,80,81,82,83,84]. For example, insoluble fiber binds to and adsorbs carcinogens, mutagens, and toxins, and therefore, prevents their harmful effects to the body, by preventing the toxins absorption and targeting them for elimination [83,85,86]. Other fiber properties include delayed colonic transit time, prolonged post-meal satiety and satiation, and induction of cholecystokinin satiety hormone [87,88]. The Academy of Nutrition and Dietetics position on fiber intake is to increase consumption of whole grains, fruits and vegetables, nuts and legumes, and that dietary fiber is associated with risk reduction of type 2 diabetes, cardiovascular disease, and select cancer types [89].

In the UK, Dr Charlotte Elizabeth Evans, an associate professor in nutritional epidemiology and public health nutrition, speaks highly of high fiber intake and the positive association between fiber and health benefits such as cardio-vascular health (2019).

Dietary fibre and cardiovascular health: a review of current evidence and policy

Charlotte Elizabeth Louise Evans:

Dietary fibre comprises many different, mainly plant-based, compounds that are not fully digested in the human gut. Insoluble fibres include cellulose, hemi-celluloses and lignin and soluble fibres include pectins, β-glucan and hydro-colloids. In the UK, the daily recommended amount has increased to 30 g but only 13 % of men and 4 % of women meet this recommendation. Currently the mean intake for adults is 21 g for men and 17 g for women. There is a wealth of epidemiological evidence based on systematic reviews of trials and cohorts to support the higher fibre recommendation. This includes evidence of reductions in the risk for CVD (both heart disease and stroke) and lower risk of type 2 diabetes, lower blood pressure, lower LDL-cholesterol, as well as some cancers. Beneficial effects of fibre operate via a diverse range of mechanisms throughout the digestive system including the mouth, stomach and small and large intestine; some of which are still not completely understood. The updated recommendation for fibre is a long way from a typical British diet and requires several daily portions of fruit and vegetables and wholegrain foods. Improving dietary fibre intakes will require a variety of actions and policies from stakeholders; however, there is currently more of a focus on reducing sugar than increasing fibre. In order to increase the number of adults meeting the fibre recommendation, social marketing and labeling of high-fibre foods are warranted as well as reformulation and wider availability of wholegrain versions of popular foods. 

References

  • Evans, C. E. L. (2019). Dietary fibre and cardiovascular health: a review of current evidence and policy. Proceedings of the Nutrition Society, 1-7.Article
  • Soliman, G. A. (2019). Dietary Fiber, Atherosclerosis, and Cardiovascular Disease. Nutrients11(5), 1155. Article

Beta Glucan Synbiotic: High Potency Cardiovascular and Metabolic Support provides these highly beneficial beta glucan and other important dietary fibers from beetroot and inulin from chicory root along with key pedigreed probiotic bacteria.

BG F

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Transformation to healthy diets by 2050 will require substantial dietary shifts.  Global consumption of fruits, vegetables, nuts and legumes will have to double, and consumption of foods such as red meat and sugar will have to be reduced by more than 50%. A diet rich in plant-based foods and with fewer animal source foods confers both improved health and environmental benefits.  (Walter Willett MD, Harvard T.H. Chan School of Public Health, 2019)

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Anderson et al.  (2011) demonstrated the powerful anti-obesity effects of rose hip in their research entitled, Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program.

Two different parts of the 2011 research provided a window into rose hip’s weight lowering power.

In Study A, labeled the preventative study, 20 mice were divided into two groups, the control group and the rose hip fed group. Both groups were fed the high-fat diet during the 20 week trial but  the rose hip group showed a markedly lower body weight gain compared to the control group: 7.1 grams vs. 17.1 grams.

In Study B, labeled the intervention study, 10 mice were divided into two groups, the control group and the rose hip fed group. Both groups were fed the same low-fat diet during their 10 week trial but the control group kept gaining body weight while the rose hip group immediately started to lose weight. By at the end of the study, the difference in the body weight of the two groups was pronounced with the rose hip group average weight being 28.6 grams and the control being 38.5 grams.


Rose Hip Obesity Graph

Anderson et al. (2011) summarized that high doses of rose hip are capable of both preventing and reversing the increase in body weight.  Another dramatic beneficial aspect of rose hip supplementation:  Hepatic lipids were reduced by >50%  following the rose hip intake as a result of down-regulation of the hepatic lipogenic program. The researchers theorized that this may represent a major mechanism underlying the improvement in insulin sensitivity and glucose tolerance.  Finally, they concluded that their results show great promise for the use of more moderate doses of rose hip to improve glucose tolerance and lower body weight in humans.

Phyto Power is a polyphenolic powerhouse comprised of several species of wildcrafted Rose hips, Blueberries, and Dandelions, harvested in the wilds of Alaska at the peak of their phytonutrient potential.

Recommended dose:  2 capsules daily

References:

  • Andersson, U., Henriksson, E., Strom, K., Alenfall, J., Goransson, O., Holm, C. (2011). Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program. Am J Physiol Endocrinol Metab, 300, E111–121.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Type 2 diabetes is strongly associated with obesity; 90% of all patients with type 2 diabetes are overweight or obese.  Both type 2 diabetes (T2D) and obesity are also strongly associated with nonalcoholic fatty liver disease (NAFLD), the most common liver disease worldwide.  More than 70% of subjects with T2D and/or obesity are affected with NAFLD (Anderson et al., 2011).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Longevity research teaches us that when we turn to a whole food plant-based diet, with less meat, dairy, and eggs (and refined, processed foods), we lower inflammation in every cell of our body. As we have discussed in our recent emails on the longevity field of study, inflammation is the root causative factor for most all of our chronic diseases.

Breakfast is a major meal, and hence our notoriously delicious breakfast drink that indeed lowers inflammation with a host of major nutrients that deeply nourish and energize your body. And the breakfast drink does so much more: it lubricates the bowels with fiber and polyphenols, lower cholesterol to benefits the heart, supports the liver, kidneys, immune system, brain, aids in blood sugar regulation, and fortifies bones and joints. It is an amazingly healthy drink.

Here is BioImmersion’s famous morning drink: a breakfast meal all by itself.

In a blender add: (for one person)

  • Be Regular:  Optimal Bowel Health-  1 heaping tbls.
  • Add Flax seed 1 tbls.
  • Bee Pollen- 1 tsp.
  • Fresh or frozen berries (depending on the season)- 1 cup
  • Banana or other fruit like melon, papaya, mango
  • Organic Apple juice, or pineapple, berry, or a juice of your choice- 1 cup.
  • Filtered water- 1 to 2 cups.

 

Dohrea Famous Drink

 

Further notes on Be Regular, Beta Glucan and No. 7 Systemic Booster

Be Regular

Be Regular is a gluten free, global blend of indigenous organic seeds, originating in ancient cultures from all around the world. The five organic seeds provide gentle yet effective fiber for everyday regularity.  One scoop of Be Regular offers over 7 grams of fiber towards your 25 to 35 grams a day.

We have formulated Be Regular with organic seeds from:  Amaranth, Buckwheat, Chia, Millet and Quinoa.  These seeds are ancient! They have been with us for thousands of years and globally used as foundational foods. Rich in both soluble and insoluble fibers, they contain essential nutrients such as amino acids, vitamins, minerals, complex carbohydrates with an overall low glycemic index.  Besides being organic and gluten free these seed are vegan, kosher, non GMO,

Beta Glucan

Beta Glucan is a great product for seeding the gut with good pedigreed bacteria, Supernatant and ORNs (microRNAs), along with prebiotic fibers that strongly support the integrity of the GI tract membrane, support the reduction of GI tract inflammation, support the strengthening and balancing of the immune system.

One heaping tablespoon provides 65 billion strong probiotic organisms, and our famous beta glucans with red beet root to lower cholesterol and support liver function, open and relax blood vessels, and energize the body. The beta glucans also are shown to support  prevention of variety of cancers.

No. 7 Systemic Booster

The No 7 contains:  Potent Phytonutrients– Organic berries, fruits, hardy vegetables, and green leafy vegetables: strawberry, raspberry, blueberry, tart cherry, elderberry, cranberry, apple extract, pineapple, beet, broccoli florets, kale leaves, spinach leaves. BioImmersion Super Blend: ProbioticsBifidobacterium longum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus, and Steptococcus thermophilus. Supernatant– probiotic metabolites, and ORNs. PrebioticsInulin from Chicory Root along with Fibers- from organic veggies, greens, fruits, and berries. VitalNutriceuticals– Fructo Borate, Vitamin B12, Vitamin D3, Folate, and Chromium.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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David Granet MD and Rob Knight PhD converse regarding the Microbiome. Some points by Knight:  Avoid fries and certain carbohydrates; but not all for fibers both soluble and insoluble are very important for microbiome health.  Also eat a rainbow of colored vegetables and fermented foods.

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Cellular Senescence means that cells cannot divide due to multiple reasons,  with inflammation posing as one of the greatest. Cellular Senescence hastens the development of chronic diseases like cardiovascular, diabetes, Alzheimer’s, dementias, cancer, immune and kidney dysfunction, IBD, and osteoarthritis among many others.

Current research has shown that certain plant polyphenols (i.e. quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential  for reducing and preventing senescence, which reduces the risk for developing chronic disease, and even reverses the onset of chronic illnesses and geriatric syndrome.  Research is now focused on the utilization of senolytic molecules in therapies.

The No. 7 Systemic Booster: the New Longevity contains both of these powerful phenolic flavonoids, quercetin and fisetin, within its high-active fruits and vegetables.  Daily dosing at 1 tsp supports the body’s ability to to fight against chronic disease.  (See Further Notes below)

 

No 7 Photo_2 copy

 

Further notes on cellular senescence: 

Chronic low-grade inflammation (LGI) in the body is an etiological factor in chronic disease and it is also a causative force in cells going into senescence.  Cellular senescence is characterized as a state where cells: (1) lose their ability to divide and renew their healthy functionality; (2) become resistant to apoptosis (cell death); and  (3) increase their production of reactive oxygen species (ROS), and secret into their external environment pro-inflammatory cytokines, bradykines, prostenoids, miRNAs, damage-associated molecular pattern proteins (DAMPs), and other pro-inflammatory mediators, chemokines that attract immune cells.  In other words, these cells create more inflammation; more collateral damage that can lead to pathology.  This condition is called a senescence-associated secretory phenotype (SASP).

Senescent cells have been identified at sites of pathology in multiple diseases.  They accumulate in adipose tissue in diabetes and with age-related metabolic dysfunction, osteoarthritic joints, the aorta in vascular hypo-reactivity and atherosclerosis and the lung in idiopathic pulmonary fibrosis.  Transplantation of small numbers senescent cells around the knee joint can cause osteoarthritis (Zhu, Y., et al. 2015).

Therefore, the discovery of strong senolytic molecules  present in certain vegetables and fruits that  are able to delay, prevent, or alleviate a number of chronic  diseases is very exciting. The No. 7 Systemic Booster: the New Longevity is a great starting point to reduce inflammation and deeply nourish our cells with the nutrients they need to function healthily.

References:

  • Kirkland, J. L., & Tchkonia, T. (2017). Cellular senescence: a translational perspective. EBioMedicine, 21, 21-28.
  • Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., … & Kirkland, J. L. (2017). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging (Albany NY), 9(3), 955.
  • Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., … & O’Hara, S. P. (2015). The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging cell, 14(4), 644-658.

To your health,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Our findings here give support for the speculation that these agents [senolytics] may one day be used for treating cardiovascular disease, frailty, loss of resilience, including delayed recovery or dysfunction after chemotherapy or radiation, neurodegenerative disorders, osteoporosis, osteoarthritis, other bone and joint disorders, and adverse phenotypes related to chronologic aging.  Theoretically, other conditions such as diabetes and metabolic disorders, visual impairment, chronic lung disease, liver disease, renal and genitourinary dysfunction, skin disorders, and cancers could be alleviated with senolytics (Zhu,Y. et al., 2017).

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©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Doctor

The proprietary mix of plant minerals and apple extract in our new product ENERGY was used in a double blind research by Joy et al. (2016). The research demonstrated that the mix increases energy and enhances performance during exercise. The mix also helped relax sore muscles from over exercising. We suggest one capsule a day or when you need extra energy.

ENERGY

The Research

Twenty-five healthy, resistance-trained, male subjects completed this double-blind study.  All subjects were prohibited from using any supplements not provided in the study except for a multivitamin or protein powder food substitute, which they were not permitted to use within 2 hours before or after resistance training sessions.

Each subject was required to be capable of lifting 1.5 times their bodyweight in the squat and deadlift and 1 times bodyweight in the bench press.  At baseline, the placebo group (PLA) was able to squat 1.71, bench press 1.45, and dead lift 2.17 times their bodyweight; and the treatment (TRT) was able to squat 1.66, bench press 1.31, and deadlift 1.93 times their bodyweight.

Subjects were randomly assigned to either the PLA or TRT groups.  The TRT got 1 serving of 150mg of the proprietary blend of Energy, which is one capsule. And, the PLA group got the placebo.  The single capsule dose was given 45 minute prior to training on training days or at a similar time of day on rest days.

The resistance training program, weeks 1-8, consisted of one muscle hypertrophy-oriented workout, one power-oriented workout, and one strength-oriented workout featuring cycle ergometer Wingates following strength training.

The back squat, bench press, and deadlift exercises were performed on each day along with several other multi- and single-joint exercises.  Participants rested 48-72 hours between each training day.  During the overreach phase (weeks 9 and 10), participants performed high volume workouts on Monday through Thursday with a strength-oriented workout or performance testing conducted on Friday for weeks 9 and 10, respectively.

The taper phase (weeks 11 and 12) consisted of one power day on Mondays then strength and power days on both Wednesdays and Fridays performed at low volume for back squat, bench press, and deadlift only.

The Results

Energy appeared to beneficially augment strength and power adaptations to resistance training and attenuate power loss during overreaching (over exercising).  Squat and deadlift IRM both increased to a greater degree in TRT than in PLA,  Peak power in the vertical jump seemed to increase as a result of training and supplementation, and vertical jump peak power and peak velocity did not decline following overreaching.  Strength endurance was preserved during overreaching in TRT compared to PLA. The proprietary blend of ancient peat and apple extracts may be better suited to resist performance decrements, as a decline in performance was only observed in the PLA group in the present study

Reference

Joy, J. M., Vogel, R. M., Moon, J. R., Falcone, P. H., Mosman, M. M., Pietrzkowski, Z., … & Kim, M. P. (2016). Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men. BMC complementary and alternative medicine, 16(1), 224. https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1222-x

Sincerely yours,

Seann

Green Facts:

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Dr. Dohrea Bardell’s new book, Living Well – Dying Well (2018, chapter 8), has plenty of advice on increasing energy and stamina. The foundation is a whole food, plant-based diet that keeps our bodies protected and energized.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved