Metabolic Support

Dear Friends
HO Front Low Rez
Recent studies show that dietary polyphenols support the growth of good bacteria in the gut while inhibiting pathogenic bacteria.

Dueñas et al.’s (2015) study entitled, A survey of modulation of gut microbiota by dietary polyphenols, showed that dietary polyphenols contribute to the maintenance of intestinal health by preserving the gut microbial balance through the stimulation of beneficial bacteria (i.e., Lactobacilli and Bifidobacteria) and the inhibition of pathogenic bacteria, exerting prebiotic-like effects.

One of the many beneficial effects attributed to dietary polphenols is due to phenolic metabolites formed in the gastrointestinal tract through the interaction with good lactic acid bacteria. The outcome is the formation of more good bacteria and the inhibition of various pathogenic bacteria and yeast.

BioImmersion’s High ORAC Synbiotic powerfully mixes polyphenols with Lactobacillus and Bifidobacterium species. Per capsule: A minimum a 25 billion probiotics and a high ORAC score of 3000.


High ORAC final 2

References

  • Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015). Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition54(3), 325-341. https://link.springer.com/article/10.1007/s00394-015-0852-y
  • Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., … & Bartolomé, B. (2015). A survey of modulation of gut microbiota by dietary polyphenols. BioMed research international2015. https://www.hindawi.com/journals/bmri/2015/850902/
  • Gupta, A., Dwivedi, M., Mahdi, A. A., Gowda, G. N., Khetrapal, C. L., & Bhandari, M. (2012). Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin. Urological research, 40(2), 143-150. https://link.springer.com/article/10.1007/s00240-011-0398-2
  • Heinonen, M. (2007). Antioxidant activity and antimicrobial effect of berry phenolics–a Finnish perspective. Molecular nutrition & food research, 51(6), 684-691. http://onlinelibrary.wiley.com/doi/10.1002/mnfr.200700006/full
  • Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research, 11(10), 4781-4790. http://pubs.acs.org/doi/abs/10.1021/pr300581s
  • Nohynek, L. J., Alakomi, H. L., Kähkönen, M. P., Heinonen, M., Helander, I. M., Oksman-Caldentey, K. M., & Puupponen-Pimiä, R. H. (2006). Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens. Nutrition and cancer, 54(1), 18-32.
  • Puupponen‐Pimiä, R., Nohynek, L., Hartmann‐Schmidlin, S., Kähkönen, M., Heinonen, M., Määttä‐Riihinen, K., & Oksman‐Caldentey, K. M. (2005). Berry phenolics selectively inhibit the growth of intestinal pathogens. Journal of applied microbiology, 98(4), 991-1000.
    http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2672.2005.02547.x/full

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The modulation of the gut microbiome composition by alteration of food habits has potentialities in health improvement or even disease prevention.

Polyphenols are extensively metabolized by gut bacteria into a complex series of end-products that support a significant effect on the functional ecology of symbiotic partners that can affect the host physiology.

Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research, 11(10), 4781-4790. http://pubs.acs.org/doi/abs/10.1021/pr300581s.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Endotoxemia and Chlorella

December 14, 2017

Dear Friends

Chlorella HZ 2

Chlorella and inulin reduce endotoxemia and protect the intestinal mucosa barrier.

What is an endotoxin, and what causes endotoxemia? How does chlorella reduce endotoxemia, and how does inulin produce a healthy microbiome?  Let’s take a look at a few studies.

An endotoxin is often used synonymously with LPS.  Lipopolysaccharides (LPSs) are the major components of the outer membrane of Gram-negative bacteria. Rietschel et al. found in 1994 that LPSs induce strong inflammatory responses from the immune systems of all animals.

Liver Diseases are associated with leaky gut syndrome, which allows for the passage LPS molecules into the systemic circulation, causing chronic inflammation, and a condition called endotoxemia. A large enough load of LPSs in the systemic circulations can cause septic shock.

In fact, severe sepsis is a common and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction. It is especially common in the elderly and is likely to increase substantially as the U.S. population ages (Angus et al., 2001)

Bedirli et al. (2009) investigated the role of different microalgae (Chlorella sp. and Spirulina sp.) extracts in intestinal barrier function and oxidative stress in experimentally jaundice rats.

The main outcomes measured were endotoxin concentrations in plasma [e.g. LPS levels], evidence of bacterial translocation in mesenteric lymph nodes and liver oxidative stress, and histology.

Their findings: A Chlorella sp. supplemented diet significantly demonstrated protective effects on the intestinal mucosa barrier in obstructive jaundice, and reduced intestinal translocation of bacteria and endotoxin.  Spirulina had no significant effect.

Original copyCani et al. (2008) found that a high animal fat diet changes the GI tract microbiome into a population of increasing numbers of Gram-negative bacteria, which raises the level of LPS endotoxins within the gut lumen and allows their passing through the GI tract membrane into the plasma.

The research team concluded that the plasma concentration of lipopolysaccharides (LPS) controls the inflammatory tone of the body.  This means that high concentrations of LPS set the stage for endotoxemia, resulting in metabolic diseases (obesity, diabetes, CVD) and cancer.

They further demonstrated in the study that increased fibers in the diet, such as inulin, increase the populations of Bifidobacterial sp. and Lactobacillus sp. which reduce both the load of Gram-negative bacteria and the permeability of the gastrointestinal membrane.

Our Suggestion: Take 4 to 8 tablets of Organic Chlorella daily.
Take 1 tsp. of Original Synbiotic daily.
References:

  • Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001). Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine, 29(7), 1303-1310.
  • Bedirli, A., Kerem, M., Ofluoglu, E., Salman, B., Katircioglu, H., Bedirli, N., … & Pasaoglu, H. (2009). Administration of Chlorella sp. microalgae reduces endotoxemia, intestinal oxidative stress and bacterial translocation in experimental biliary obstruction. Clinical nutrition, 28(6), 674-678.
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Rietschel, E. T., Kirikae, T., Schade, F. U., Mamat, U., Schmidt, G., Loppnow, H., … & Di Padova, F. (1994). Bacterial endotoxin: molecular relationships of structure to activity and function. The FASEB Journal, 8(2), 217-225.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3
What kind of world do you want to wake up to 30 years from now?
The Biomimicry Institute aspires to a world where what we make is inspired by, and connected to, the natural world.  This means cities are resilient, emission targets are achieved, and industrial processes create healthy air, water, and soil.  It also means all species are thriving because our human designs restore the planet as nature’s desgns do.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Chlorella for fatty liver

November 29, 2017

Dear Friends

Chlorella HZ 2

Can Chlorella supplementation help with Non-Alcoholic Fatty Liver Disease (NAFLD)?

Ebrahimi-Mameghani et al. (2016) sought to answer this question in their study entitled, Glucose homeostasis, insulin resistance and inflammatory biomarkers in patients with non-alcoholic fatty liver disease:  Beneficial effects of supplementation with microalgae Chlorella vulgaris: A double-blind placebo-controlled randomized clincial trail.

The authors researched the effects of C. vulgaris supplementation on glucose homeostasis, insulin resistance and inflammatory biomarkers in patients with NAFLD.

70 non-alcoholic fatty liver disease (NAFLD) patients confirmed by ultra-sonographic findings were randomly assigned into intervention group (four 300 mg tablets of C. vulgaris) or placebo group (four 300 mg tablets of placebos) for 8 weeks.

Anthropometric measurements, liver enzymes, fasting serum glucose (FSG), insulin, high sensitive C-reactive protein (hs-CRP), and tumor necrosis factor-alpha (TNF-a) were assessed and homeostatic model assessment (HOMA) score for insulin resistance was estimated before and after the intervention.

The results show the following:

  • Mean reduction in weight was significantly higher in C. vulgaris- treated group compared to placebo group.
  • Serum concentrations of liver enzymes, FSG and hs-CRP also significantly decreased.
  • Serum insulin concentration and HOMA score increased significantly only in C. vulgaris-treated group (insulin secretion was balanced).
  • Mean change in serum glucose and TNF-a levels were significant between the groups even after adjusting for the serum insulin and baseline values of variables.

The authors conclusion was that L. vulgaris supplementation could be considered as an adjunctive therapy to decrease weight and improve glycemic status and reducing hs-CRP as well as improving liver function in patients with NAFLD.

Take 3 tablets a day, 1500mg of Organic Chlorella, to meet the researched amounts of 1200mg a day.

References:

  • Ebrahimi-Mameghani, M., Sadeghi, Z., Farhangi, M. A., Vaghef-Mehrabany, E., & Aliashrafi, S. (2016). Glucose homeostasis, insulin resistance and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: Beneficial effects of supplementation with microalgae Chlorella vulgaris: A double-blind placebo-controlled randomized clinical trial. Clinical Nutrition; 36(4): 1001-1006.
  • Ebrahimi-Mameghani, M., Aliashrafi, S., Javadzadeh, Y., & AsghariJafarabadi, M. (2014). The effect of chlorella vulgaris supplementation on liver enzymes, serum glucose and lipid profile in patients with non-alcoholic fatty liver disease. Health Promotion Perspectives, 4(1), 107.
  • Care, D. (2007). Insulin sensitivity and insulin secretion determined by homeostasis model assessment (HOMA) and risk of diabetes in a multiethnic cohort of women: the women’s health initiative observational study. Diabetes Care, 30(7), 1747-1752.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Globe_Home 3One bottle of BioImmersions Organic Chlorella contains 120 tablets, with each tablet containing 500 mgs of pure organic chlorella.  Therefore, according to the above researched dose of 1200 mgs per day for NAFLD, the BioImmersion equivalent dose would be three tablets/d.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Chlorella for Fat Burning?

November 25, 2017

Dear Friends

Chlorella HZ 2
Chlorella is not often thought of as part of a weight loss protocol but with its powerful green nutrients, amino acids, vitamins, minerals and more, cholorella in fact can help with metabolic diseases such as obesity and diabetes.

Chlorella for fat burning?  Mizoguchi et al. (2008) concluded in their study, Nutrigenomic studies of effects of chlorella on subjects with high-risk factors for lifestyle-related disease, that chlorella intake resulted in noticeable reductions in body fat percentage, serum total cholesterol, and fasting blood glucose levels.

The researchers conducted Chlorella ingestion tests on 17 subjects with high risk factors for lifestyle-related diseases and 17 healthy subjects over a 16-week period including a 4-week post-observation period.

They utilized standard blood biochemical tests and also nutrigenomic analyses: analyzing gene expression profiles in whole blood cells in the peripheral blood before and after Chlorella intake.

Chlorella influences a myriad of metabolic pathways.  These included genes involved in fat metabolism and insulin signaling pathways.  There were clear variations in the expression profiles of genes directly related to uptake of glucose resulting from Chlorella intake, indicating that the activation of insulin signaling pathways could be the reason for the hypoglycemic effects of Chlorella.

The results of Mizoguchi et al. research as well as other studies (see below) showed that Chlorella intake brings about improvements in both fat and glucose metabolism.

References:

  • Grundy, S. M. (2004). Obesity, metabolic syndrome, and cardiovascular disease. The Journal of Clinical Endocrinology & Metabolism, 89(6), 2595-2600.
  • Mizoguchi et al. (2008). Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease.  J Med Food; 11(3): 395-404.
  • Vecina et al. (2014). Chlorella modulate insulin signaling pathway and prevents high-fat diet–induced insulin resistance in mice. Life Sci; 95(1): 45-52.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Using Chlorella as a daily dietary supplement facilitates many functions in the body that affect our metabolism. The suggested dosage is 4-6 tablets twice daily in order to duplicate the amounts used in the study.  However, much less amounts can be tried for achieving positive results, as you can see in the Forward Thinking Newsletter entitled Chlorella for Fatty Liver (Nov. 29, 2017).
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Care For Your Heart

November 14, 2017

Dear Friends                                                                                                                                                      

Metabolic Syndrome is considered the leading cause of Heart Disease, the number one killer in the United States.

Three of our Therapeutic Food Supplements are designed with intelligent ingredients that are shown in research to support and help reverse both heart disease and the different conditions associated with metabolic syndrome: Beta Glucan High Potency Synbiotic, Weight-less Systemic Booster, and Organic Chlorella.

  • Beta Glucan High Potency Synbiotic– 1 heaping tbl twice daily before two largest meals.
  • Weight-less:  NO. 4 Systemic Booster– 2 capsules one-half hour before meals. A must do before a high carb meal or snack.
  • Organic Chlorella– 4 tablets taken with meals.

Food Science

Metabolic Syndrome is a disorder affecting approximately one-quarter of the American population. It is in fact considered a worldwide epidemic (NIH: NHLBI, 2015).

The risk factors for Metabolic Syndrome are:  Abdominal obesity, Atherogenic dyslipidemia, Raised blood pressure, Insulin resistance, Pro-inflammatory state, and Pro-thrombotic state (McCullough 2011, Grundy 2004).
Beta Glucan HZ 3
The Beta Glucan High Potency Synbiotic contains powerful soluble and insoluble fibers and pedigreed strains of probiotics.

Multitude research articles strongly indicate that as dietary fiber goes up the risk of Metabolic Syndrome goes down (Grooms, 2013).

A healthy gut microbiome supports the maintenance of a healthy GI tract membrane barrier function.  Cani et al. (2008) found that bacterial lipopolysaccharide (LPS) levels set the tone of insulin sensitivity and the onset of obesity and diabetes.  An increased gut permeability allowed for the passage of LPS through the gut wall into the systemic circulation.  Thus, lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.

Cani et al. (2007, 2007a, 2008, 2009) demonstrated that adding soluble fibers to our daily diet, such as inulin and oat bran beta glucan (containing oligofructose chains found in the Beta Glucan Synbiotic), stimulates the growth of Bifidobacteria sp., which caused a reduction in gut permeability, thereby reducing the levels of LPS systemically, which initiates weight loss, and reduction of metabolic disorders.
WL Low Cropped Jpeg 2
Weight-less is a smart metabolic booster formula – the mix supports weight loss and effectively boosting energy levels.  Weight-less contains wild brown seaweed extracts from kelp and bladderwrack as well as 7-Keto DHEA.  Brown seaweeds are shown in research to lower the glycemic load of complex and simple carbohydrates for better insulin management, as well as offer a power-filled phenolic activity for antioxidant and anti-inflammation effect (Roy et al., 2011). The 7-Keto has been used for many years to turn on fat burning mechanism and offer an effective and safe way to lose weight (Bobyleva et al., 1997).

Together, Weight-less promotes a sustained energy level throughout the day as it modulates carbohydrate digestion and absorption for better weight management and metabolic health (Gabbia et al., 2017; Catarino et al., 2017).
Chlorella HZ
Organic Chlorella– New studies show that Chlorella supports reduction of body fat, improves fat and glucose metabolism, decrease weight, and reduce the risk factors involved with Metabolic Disease.

Mizoguchi et al. (2008) in their research, Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease, demonstrated that Chlorella intake, in 17 subjects with high risk factors for lifestyle-related disease (obesity, diabetes or hyperlipidemia) and 17 healthy subjects, results in noticeable reductions in body fat percentage, total blood serum cholesterol, and fasting blood glucose levels.

Their research confirmed that Chlorella intake brings about improvements in both fat metabolism and glucose metabolism.  The expression of genes involved in the insulin signaling pathway were also affected by Chlorella vulgaris intake, especially those related to glucose uptake in tissue, providing support for the observation that Chlorella lowers blood glucose levels.

Vecina et al.’s (2014), Chlorella modulates insulin signaling pathway and prevents high-fat-diet- induces insulin resistance in mice, research goal was to evaluate the prophylactic effect Chlorella vulgaris on body weight, lipid profile, blood glucose and insulin signaling in liver, skeletal muscle and adipose tissue of diet-induced obese mice.

Their conclusion was that C. vulgaris supplementation (Chlorella) could be considered as an adjunctive therapy to decrease weight and improve glycemic status and reducing hs-CRP as well as improving liver function in patients with NAFLD.

References:

  • Bobyleva, V., Bellei, M., Kneer, N., & Lardy, H. (1997). The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Archives of biochemistry and biophysics, 341(1), 122-128. https://doi.org/10.1006/abbi.1997.9955
  • Cani et al. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut; 58(8): 1091-1103
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
    Cani et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes; 56:1761-72.
  • Cani et al. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia; 50: 2374-83.
  • Catarino, M. D., Silva, A., & Cardoso, S. M. (2017). Fucaceae: A source of bioactive phlorotannins. International journal of molecular sciences, 18(6), 1327. Article
  • Gabbia, D., Dall’Acqua, S., Di Gangi, I. M., Bogialli, S., Caputi, V., Albertoni, L., … & De Martin, S. (2017). The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH. Marine drugs, 15(2), 41. DOI:10.3390/md15020041
  • Grooms et al. (2013). Dietary Fiber Intake and Cardiometablic Risk among US Adults: NHANES 1999-2010. Am J Med; 126(12): 1059-1067.
  • Grundy, S. M. (2004). Obesity, metabolic syndrome, and cardiovascular disease. The Journal of Clinical Endocrinology & Metabolism, 89(6), 2595-2600.
  • Mizoguchi et al. (2008). Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease.  J Med Food; 11(3): 395-404.
  • Roy, M. C., Anguenot, R., Fillion, C., Beaulieu, M., Bérubé, J., & Richard, D. (2011). Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo. Food research international, 44(9), 3026-3029. https://doi.org/10.1016/j.foodres.2011.07.023
  • Vecina et al. (2014). Chlorella modulate insulin signaling pathway and prevents high-fat diet–induced insulin resistance in mice. Life Sci; 95(1): 45-52.
  • Whaley-Connell, A., McCullough, P. A., & Sowers, J. R. (2011). The role of oxidative stress in the metabolic syndrome. Reviews in cardiovascular medicine, 12(1), 21-29.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.Green Facts:

Globe_Home 3Choosing a healthy diet: Research studies link the emerging global pattern of metabolic syndrome and weight gain to the prevalence of Westernized diet of daily meats, dairy, eggs, simple and processed carbohydrates, and too much sugar (Chai et al., 2017; Azadbakht & Esmaillzadeh, 2009; Lutsey et al., 2008). Although there are conflicting views on dietary guidelines, many scientists and health organizations agree that a focus on whole food plant-based diet is the healthiest guideline for metabolic syndrome and weight loss (Yokoyama et al., 2017; Satija et al., 2017; Kahleova et al., 2017; Hever et al., 2017; Turner et al., 2017; UN Report, 2016; Wang et al., 2015; Tilman & Clark, 2014; WHO/FAO, 2003).*

The Plates, Pyramids, Planet report, compiled in collaboration with the Food Climate Research Network (FCRN) at the University of Oxford, concludes that a plant-based diet has many advantages for health and the environment (UN Report, 2016).*

The type and nature of carbohydrates that improve our metabolic health (obesity, cardiovascular, and diabetes) are comprised of whole plants with fiber (Wright et al., 2017). Whereas low carbs diets with high fat content is shown to increase metabolic syndrome (Lamont et al., 2017; UN Report, 2016).*

A diet that is 80-90% whole food plant-based is highly recommeded by many health organizations and medical universities around the world.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved