Metabolic Support

Weight-Less

September 22, 2017

Dear Friends                                                                                                                                                      WL Low Cropped Jpeg

Recent research has shown the link between chronic hyperglycemia, oxidative stress, and weight gain. Hyperglycemia puts our body into a state of oxidative stress, which leads to many pathologies such as diabetes mellitus, obesity, cancer, and cardiovascular diseases (Domingueti et al., 2016).

Ingredients of Weight-Less per capsule

  • 7-Keto DHEA- 25mg (helps to burn fat)
  • 2 Brown Seaweed extracts- 200mg (help to lower and prevent high blood sugar levels, offers a strong anti-inflammatory, and supports weight loss)

Take 1 – 2 capsules of Weight-less one-half hour before meals, especially important before your carbohydrate (or meat) laden meals.* (See Green Facts on meat and diabetes)

Food Science

The ingredients in Weight-less have been shown to reduce both the states of hyperglycemia and oxidative stress. The Kelp and Bladderwrack polyphenol extracts (phlorotannins) offer organic-certified bioactive ingredients that (1) act on amylase and glucosidase enzymes to optimize post-meal blood glucose and insulin responses and (2) demonstrate that they have a high total antioxidant activity as verified by the Total ORAC 6.0 assay.

The phenols in the kelp and bladderwrack have superior antioxidant activity – a neutralizing effect – on the primary free radical superoxide anion. Superoxide  anion is known as the “mother of  free radicals” because  it also can become a hydroxyl ROS, a nitrogen RNS and a hydrogen peroxide ROS.

Thus, Weight-Less helps prevent post-meal hyperglycemia and has a direct scavenging action on excess free radical generation.  The key is not to totally neutralize all free radical activity but to bring about a healthy redox homeostasis.

References:

  • Domingueti, C. P., Dusse, L. M. S. A., das Graças Carvalho, M., de Sousa, L. P., Gomes, K. B., & Fernandes, A. P. (2016). Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. Journal of diabetes and its complications, 30(4), 738-745.
  • Hulsmans, M., & Holvoet, P. (2010). The vicious circle between oxidative stress and inflammation in atherosclerosis. Journal of cellular and molecular medicine, 14(1‐2), 70-78.
  • InterAct Consortium. (2013). Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study. Diabetologia, 56(1), 47-59
  • Gutowski, M., & Kowalczyk, S. (2013). A study of free radical chemistry: their role and pathophysiological significance. Acta Biochimica Polonica, 60(1), 1-16.
  • Valko, M., Rhodes, C., Moncol, J., Izakovic, M. M., & Mazur, M. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions, 160(1), 1-40.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3High meat intake is also shown in research to generate oxidatative stress and hyperglacemia. We will discuss this in another email but meanwhile, see Dr. Greger’s informative video on Why is meat a risk factor for diabetes?
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends
Phyto Power High Rez
Stull’s (2016) review, Blueberries’ Impact on Insulin Resistance and Glucose Intolerance, highlighted a multitude of in vivo and in vitro studies that demonstrated another of blueberries important attributes — the anti-diabetic effects of blueberries and berry extracts in insulin-resistant rodent, human, and cell culture models.

The scientific evidence in support of the anti-diabetic health benefits of blueberries and blueberry extract is encouraging. Epidemiological studies reported that consumption of foods rich in anthocyanins, especially from blueberries, were associated with a lower risk of type 2 diabetes (T2DM) and of peripheral insulin resistance.

Prediabetes is a condition in which blood glucose levels are higher than normal, but not high enough to be classified as T2DM.  Although the prediabetes stage is when corrective actions need to be implemented to prevent the possible development of T2DM, many studies find blueberries to have an anti-diabetic effect. See the references below.

Dinstel et al. (2013) found the blueberries in Alaska to have the highest anthocyanins content. See Green Facts below. Our Phyto Power utilizes Alaskan blueberries’ potent levels of plant phenols.

Phyto Power is comprised of several species of wildcrafted blueberries, Rose hip, and Dandelion, including their leaves, stems, roots, and flowers. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan Natives have used these power-filled berries and plants for their daily nourishment as well as ceremonial and medicinal purposes

Learn how to use Phyto Power in our research and description tabs.

References:

  • Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI: 10.3402/ijch.v72i0.21188
  • Haffner, S.M. (1996). The insulin resistance syndrome revisited. Diabetes Care,19:275-277. doi: 10.2337/diacare.19.3.275.
  • Jennings, A., Welch, A. A., Spector, T., Macgregor, A., & Cassidy, A. (2014). Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. The Journal of nutrition, 144(2), 202-208.
  • Muraki, I., Imamura, F., Manson, J. E., Hu, F. B., Willett, W. C., van Dam, R. M., & Sun, Q. (2013). Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies. Bmj, 347, f5001.
  • Stull, A. J. (2016). Blueberries’ Impact on Insulin Resistance and Glucose Intolerance. Antioxidants, 5(4), 44. doi:  10.3390/antiox5040044
  • Wedick N.M., Pan A., Cassidy A., Rimm E.B., Sampson L., Rosner B., Willett W., Hu F.B., Sun Q., van Dam R.M. (2012). Dietary flavonoid intakes and risk of type 2 diabetes in US men and women.  Am. J. Clin. Nutr, 95:925–933. doi: 10.3945/ajcn.111.028894.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.*
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends
Phyto Power High Rez
Phyto Power is comprised of several species of wildcrafted blueberries, Rose hip, and Dandelion, including their leaves, stems, roots, and flowers. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan Natives have used these power-filled berries and plants for their daily nourishment as well as ceremonial and medicinal purposes.

  • Three species of Rosehip, wildcrafted, whole fruit and seeds (100% w/w), refractory dried, three Rosa species, 200mg per capsule.
  • Four species of Dandelion, wildcrafted, aerial parts (90% w/w), root (10% w/w) with flower, refractory dried, four Taraxacum species, 200mg per capsule.
  • Four species of Blueberry, wildcrafted, fruit (>90% w/w), leaves and stem (<5% w/w), refractory dried, four Vaccinium species, 100mg per capsule.

Food Science

Alaskan wildcrafted berries and plants supply ample antioxidants, anti-inflammatory, and anti-microbial factors (Grace et al., 2014; Youself et al., 2013).

Phyto Power is indeed powerful. In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.

The Alaskan red Rose hip fruit and seeds, blue-purple Blueberries with twigs and leaves, and the Dandelion’s green leaves, stems, roots and yellow flowers are filled with potent phytonutrients. These vibrant and nutritious phytochemicals protect and enhance the health of both plants and humans (Joseph, Nadeau, & Underwood, 2003). James Duke’s (2000) substantial USDA phytochemical database illustrates the mechanism of the world of plants in the support and maintenance of our health (p. 2).

Scientific evidence links the lack of sufficient nutrients and colorful phytochemicals in our daily diets to the rise of chronic inflammation, one of the causes of metabolic syndrome, which includes cardiovascular, type 2 diabetes, as well as various cancers (Joseph, 2003; Ridker et al., 2000, 2003; Kristo et al., 2016, Ovadje et al., 2016, respectively). For this reason, García-Lafuente et al. (2009) conclude that flavonoids from berries and plants behave as anti-inflammatory agents in our body, calling for more research on the implication of these effects as protection against cancer and cardiovascular issues.

The effect of Blueberries, Rose hip, and Dandelion on Metabolic Syndrome’s risk markers is well documented and researched (Choi et al., 2010; Basu et al., 2012). For example, Andersson et al. (2011) demonstrated in a randomized, double-blind, crossover study* with 31 obese individuals that daily consumption of rose hip (drink) significantly decreased plasma cholesterol and systolic blood pressure, effectting the risk markers of type 2 diabetes and cardiovascular disease. In 2012, Andersson et al. conducted a study with lean and obese mice that were fed high-fat diet and a dietary supplement of rose hip powder. The supplement of rose hip prevented and reversed the increase in body weight. Andersson et al. (2012) concluded that rose hip supports the prevention of diabetic state in the mouse and that downregulation of the hepatic lipogenic program is one of the mechanisms underlying this antidiabetic effect.

Choi et al.’s (2010) demonstrated that supplementing rabbits that are fed with high cholesterol diets with dandelion leaf and root positively changed plasma antioxidant enzyme activities and lipid profiles, offering “hypolipidemic and antioxidant effects.”

These research findings are not new amongst scientists. Johnson et al. (1994) discovered that plants and their biologically active constituents contribute protective and anti-carcinogenic effects (Table 1, p. 193). These ‘dietary phytoprotectants’ in foods (p. 194) have continually shown in research to impart an important anti-inflammatory effect (Vendrame et al., 2015; Joseph et al., 2014), act as powerful anti-oxidants (Jedrejek et al., 2017; Skrovankova et al., 2015), and offer protection and inhibition of certain cancers (Zhan et al., 2016; Yang & Li, 2015; Li et al., 2009; Seeram, 2008; Sigstedt et al., 2008).

Although the exact mechanisms and reasons (the why) of these promising effects are still in the process of discovery, the findings suggest a regular habit of dietary supplementation with these plants and berries.

Blueberries, Rose hip, and Dandelion demonstrate in research a potential effect on different cancers. For example, blueberries are shown to inhibit growth and metastatic potential (Adams et al., 2010; Liu et al., 2013), and manage gastrointestinal tract cancers (Bishayee et al., 2016). Rose hip has shown to effect human brain cell proliferation (Cagle et al., 2012) and offer antiproliferation effect on Caco-2 human colon cancer (Jiménez et al., 2016). Dandelion was found to induce apoptosis in drug-resistant human melanoma cells (Chatterjee et al., 2011; see also Jeon et al., 2008 and Hu et al., 2003 for further reading on dandelion).

The Rose hip has a rich phytochemical profile shown to also support many different mechanisms in the human body. For example, the red berry of Rose hip is known for its antioxidant protection (Widen et al., 2012), supporting weight loss by a possible mechanism of decreasing abdominal visceral fat (Nagatomo et al., 2015). Andersson et al. (2011) examined the Rose hip antidiabetic effect, as well as the effect of Rose hip on risk markers of type 2 diabetes and cardiovascular disease in obese persons (Andersson et al., 2012). Rose hip is also found to support the liver (Nagatomo et al., 2013; Sadeghi et al., 2016), and offer relief from joint pain (Christensen et al., 2008; Willich et al., 2010; Winther et al., 2005).

For further study of the Rosa canina see Chrubasik et al. for a systemic review and clinical efficacy of the Rose hip (2008; 2006, respectively).

Dandelion is shown to have a great antioxidant activity (Hu et al., 2003), exhibiting diverse biological activities that promote energy, weight loss, and reduced risk of metabolic syndrome (Jedrejek et al., 2017; González-Castejón et al., 2012; Jeon et al., 2008). Ovadje et al. (2016) conclude that dandelion root extract effects colorectal cancer proliferation which may occur through the activation of ‘multiple death signalling pathways,’ and a selective induction of apoptosis and autophagy in human pancreatic cancer cells (2012; 2012a). Signstedt (2008) found similar results with extract of Taraxacum officinale on the growth and invasion of breast and prostate cancer cells, while Yang et al. (2015) demonstrated that Dandelion extract protects human skin fibroblasts from uvb damage.

For further study of the Taraxacum (Dandelion), see Schütz, Carle, & Schieber (2006) for a systemic review on its phytochemical and pharmacological profile.

Blueberries are rich with anthocyanins and a wide variety of phytochemicals that have been shown to effect neuro-generation (Albarracin et al., 2012). Studies are showing that a neuro-generative effect also occurs with Parkinson (Chao et al., 2012; Gao et al., 2012; Strathearn et al., 2014). Blueberries regenerate neuronal aging (Shukitt-Hale, 2012), and support memory (Krikorian et al., 2010). For more on nerve regeneration, see the Research tab of Blueberry Extract.

A daily consumption of blueberries is shown to support a lower blood pressure and arterial stiffness (Johnson et al., 2015), increase natural killer cell counts (McAnulty et al., 2014), down-regulate hepatic lipogentic program (Andersson et al., 2011), and impact insulin resistance and glucose intolerance (Stull, 2016). Zhan et al. (2016) discovered the importance of blueberries on the migration, invasion, proliferation of hepatocellular carcinoma cells. Yang et al. has shown in 2001 the inhibition of carcinogenesis by dietary polyphenolic compounds.

These impressive findings support dietary supplementation with berries as a healthy approach to various Metabolic Syndrome concerns, including cancer (Vendrame et al., 2015; Seeram, N.P., 2008; Seeram et al., 2006, respectively).

The hormetic mechanism of phyto-nutrients is an exciting area of research. Scientists have discovered that small amounts of phytochemicals offer much more than nutrients. Phytochemicals offer a hormetic mechanism; a stimulation of many pathways in our body that prevents, repairs, or reverses aging and disease (Lee et al., 2014; Davinelli et al., 2012). The concept of hormesis is defined as an adoptive response of cells and organism to low dosages of phytochemicals. This adoptive response stimulates a beneficial effect in the body (Mattson, 2008, 2008a). Calabrese et al. conducted many studies on hormetic phytochemicals and vitagenes in aging and longevity, including the effect of antioxidants such as polyphenols on neuro-generation (2012, 2011, 2009). The vitagene network of genes involved in the process of repair and maintenance is thought of as the longevity assurance processes (Rattan, 2004, 1998).

Phyto Power as a dietary supplement offers a regular serving of several species of Blueberries, Rose hip, and Dandelion, including the leaves, stems, flower, and root.

See the Research tab for additional bibliography to further understand the research, findings, application and use of Blueberries, Rose hip, and Dandelion. Visit Resources on the tool bar to find helpful protocols (Library) and summaries (News).

*Double blind, crossover study: in a double blind study A study the participants and those in contract with them (assistants) are blind to the details of the study. A crossover is when at one point in the study the participants switch from taking an active substance (such as rose hip in the Andersson study) to a placebo or vice versa.

References:

Adams, L.S., Phung, S. Yee, N., Sheeram, N.P., Li, L., & Chen, S. (2010). Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, 70(9), 3594-605. DOI: 10.1158/0008-5472.CAN-09-3565

Albarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J….Barreto, G.E. (2012). Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci, 15, 1–9. DOI:10.1179/1476830511Y.0000000028

Andersson, U., Berger, K., Hogberg, A., Landin-Olsson, M., & Holm, C. (2012). Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr, 66, 585–590. DOI:10.1038/ejcn.2011.203

Andersson, U., Henriksson, E., Strom, K., Alenfall, J., Goransson, O., Holm, C. (2011). Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program. Am J Physiol Endocrinol Metab, 300, E111–121. DOI:10.1152/ajpendo.00268.2010

Basu, A., &  Lyons,  T.J. (2012). Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives. J Agric Food Chem, 60: 5687-92. DOI:10.1021/jf203488k

Bishayee, A., Haskell, Y., Do, C., Siveen, K.S., Mohandas, N., Sethi, & G., Stoner, G.D. (2016). Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence. Crit Rev Food Sci Nutr, 56(10), 1753-75. DOI: 10.1080/10408398.2014.982243

Cagle, P., Idassi, O., Carpenter, J., Minor, R., Goktepe, I., & Martin, P. (2012). Effect of Rosehip (Rosa canina) extracts on human brain tumor cell proliferation and apoptosis. Journal of Cancer Therapy, 3(5), 13. . DOI:10.4236/jct.2012.35069

Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Iavicoli, I., Di Paola, R., Koverech, A. … Calabrese, E.J. (2012). Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta, 1822(5), 753-83. DOI:10.1016/j.bbadis.2011.11.002

Calabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarell,i E., Calabrese, E.J. (2011). Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. Mol Aspects Med, 32(4-6):279-304. DOI:10.1016/j.mam.2011.10.007

Calabrese, V., Cornelius, C., Mancuso, C., Barone, E., Calafato, S., Bates, T., Rizzarelli, E., Kostova, A.T. (2009). Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases. Front Biosci, 14, 376-397. Abstract

Chao, J., Leung, Y., Wang, M., & Chang, R.C. (2012). Nutraceuticals and their preventive or potential therapeutic value in Parkinson’s disease. Nutr Rev, 70, 373–86. DOI:10.1111/j.1753-4887.2012.00484.x.

Chatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., & Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evid Based Complement Alternat Med, 129045. DOI:10.1155/2011/129045

Choi, U.K., Lee, O.H., Yim, J.H., Ch,o C.W., Rhee, Y.K., Lim, S.I., & Kim, Y.C. (2010). Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits. Int Mol Sci, 11(1), 67-78. doi:10.3390/ijms11010067.

Christensen, R., Bartels, E.M., Altman, R.D., Astrup, A., Bliddal, H. (2008). Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?–a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage, 16, 965–972. DOI:10.1016/j.joca.2008.03.001

Chrubasik, C., Roufogalis, B.D. Muller-Lander, U., & Chrubasik, S. (2008). A systematic review on the Rosa canina effect and efficacy profiles. Phytother Res, 22(6), 725-33. DOI:10.1002/ptr.2400

Chrubasik, C., Duke, R.K., Chrubasik, S. (2006). The evidence for clinical efficacy of rose hip and seed: a systematic review. Phytother Res, 20(1), 1-3. DOI:10.1002/ptr.1729

Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI:
10.3402/ijch.v72i0.21188

Davinelli, S., Willcox, D.C., & Scapagnini, G. (2012). Extending healthy aging: nutrient sensitive pathway and centenarian population. Immun Ageing, 9, 9. DOI:10.1186/1742-4933-9-9.

Gao, X., Cassidy, A., Schwarzschild, M.A., Rimm, E.B., & Ascherio, A. (2012). Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology, 78, 1138–45. doi:  10.1212/WNL.0b013e31824f7fc4

García-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M.A., & Martínez, J.A. (2009). Flavonoids as antiinflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res, 58, 537–552. DOI:10.1007/s00011-009-0037-3

Gonzalez-Castejon, M., Visioli, F., & Rodriguez-Casado, A. (2012). Diverse biological activities of dandelion. Nutr Rev, 70(9), 534-47. DOI:10.1111/j.1753-4887.2012.00509.x

Grace, M.H., Esposito D., Dunlap K.L., & Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries. J Agric Food Chem, 62(18), 4007-17. doi:10.1021/jf403810y.

Hu, C.,  & Kitts, D.D. (2003). Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro. Journal of Agricultural and Food Chemistry, 51, (1), 301–310. DOI:10.1021/jf0258858

Duke, J. (2000). The green pharmacy herbal handbook. Emmaus, PA: Rodale Inc.

Jedrejek, D., Kontek, B., Lis, B., Stochmal, A., Olas, B. (2017). Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe. Chem Biol Interact, 262, 29-37. DOI: 10.1016/j.cbi.2016.12.003

Jeon, H.J., Kang, H. J., JungH.J. Kant, Y.S., Lim, C.J., Kim, Y.M., & Park, E.H. (2008). Anti-inflammatory activity of Taraxacum officinale. Journal of Ethnopharmacology, 115 (1), 82–88. DOI:10.1016/j.jep.2007.09.006

Jiménez, S., Gascón, S., Luquin, A., Laguna, M., Ancin-Azpilicueta, C., Rodríguez-Yoldi, M.J. (2016). Rosa canina Extracts Have Antiproliferative and Antioxidant Effects on Caco-2 Human Colon Cancer. PLoS One, 11(7), e0159136. https://doi.org/10.1371/journal.pone.0159136

Johnson, I.T., Williamson, G., & Musk, S.R.R. (1994). Anticarcinogenic factors in plant foods: A new class of nutrients? Nutr Res Rev,7, 175–204. DOI:10.1079/NRR19940011

Johnson, S.A., Figueroa, A., Navae, N. Wong, A., Ralfon, R., Ormsbee, L.T…. Arjmandi, B.H. (2015). Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. J. Acad Nutr Diet, 115(3), 369-77. DOI:10.1016/j.jand.2014.11.001

Joseph, S.V., Edirisinghe, I., & Burton-Freeman, B.M. (2014). Berries: anti-inflammatory effects in humans. J Agric Food Chem, 7; 62(18), 3886-903. DOI:10.1021/jf4044056

Joseph, J., Nadeau, D., & Underwood, A. (2003). The color code: A revolutionary eating plan for optimum health. New York, NY: The Philip Lief Group, Inc. Book

Kristo, A.S., Klimis-Zacas, D., Sikalidis, A.K. (2016). Protective Role of Dietary Berries in Cancer. Antioxidants (Basel), 5(4), 37. doi:10.3390/antiox5040037

Krikorian, R., Shidler, M.D., Nash, T.A., Kalt, W., Vingvist-tymchuk, M.R., Shukitt-Hale, B., Joseph, J.A. (2010).  Blueberry supplementation improves memory in older adults. J. Agric Food Chem, 58, 3996-4000. DOI:10.1021/jf9029332

Lee, J., Jo, D.G., Park, D., Chung, H.Y., Mattson, M.P. (2014). Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.
Pharmacol Rev, 66(3), 815-68. DOI:10.1124/pr.113.007757

Li, L., Adams, L.S., Chen, S., Killan, C., Ahmed, A., & Seeram, N.P. (2009). Eugenia jambolana Lam. [purple berries] berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. J Agric Food Chem, 57(3), 826-31. DOI:10.1021/jf803407q

Liu, W., Lu, X., He, G., Gao, X., Xu, M., Zhang, J… Luo, C. (2013). Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Int Mol Sci, 14(11), 21447-62. DOI:10.3390/ijms141121447

Mattson, M.P. (2008). Hormesis defined. Ageing Res Rev, 7(1), 1-7. doi:  10.1016/j.arr.2007.08.007

Mattson M.P. (2008). Dietary factors, hormesis and health. Ageing Res Rev, 7(1), 43-48. doi:  10.1016/j.arr.2007.08.004

McAnulty, L.S., Collier, S.R., Landram, M.J., Whittaker, D.S., Isaacs, S.E., Klemka, J.M…  McAnulty, S.R. (2014). Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females. Nutr Res, 34(7), 577-84. DOI:10.1016/j.nutres.2014.07.002

Nagatomo, A., Nishida, N., Fukuhara, I., Noro, A., Kozai, Y., Sato, H., & Matsuura, Y. (2015). Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial. Diabetes Metab Syndr Obes, 8, 147–156. DOI:10.2147/DMSO.S78623

Nagatomo, A., Nishida, N., Matsuura, Y., & Shibata, N. (2013). Rosehip Extract Inhibits Lipid Accumulation in White Adipose Tissue by Suppressing the Expression of Peroxisome Proliferator-activated Receptor Gamma. Prev Nutr Food Sci, 18, 85–91. doi:  10.3746/pnf.2013.18.2.085

Ovadje, P., Ammar, S., Guerrero, J.A., Arnason, J.T., Pandey, S. (2016). Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. Oncotarget, 7(45):73080-73100. DOI:
10.18632/oncotarget.11485

Ovadje, P., Chochkeh, M., Akbari-Asl, P., Hamm, C., Pandey, S. (2012). Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells. Pancreas, 41(7), 1039-47. DOI: 10.1097/MPA.0b013e31824b22a2

Ovadje, P., Hamm, C., Pandey, S. (2012a). Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells.
PLoS One, 7(2), e30604. doi:  10.1371/journal.pone.0030604

Rattan SI. (2008). Hormesis in aging. Ageing Res Rev, 7(1), 63-78. DOI:
10.1016/j.arr.2007.03.002

Rattan, S.I. (1998). The nature of gerontogenes and vitagenes: Antiaging effects of repeated heat shock on human fibroblasts. Annals of the New York Academy of Sciences, 854, 54-60. doi:10.1111/j.1749-6632.1998.tb09891.

Ridker, P.M., Buring, J.E., Cook, N.R., & Rifai, N. (2003). C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation, 107(3), 391-7. DOI:org/10.1161/01.CIR.0000055014.62083.05

Ridker, P.M., Hennekens, C.H., Buring, J.E., & Rifai, N. (2000). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med, 342(12), 836-43. DOI:10.1056/NEJM200003233421202

Sadeghi, H., Hosseinzadeh, S., Akbartabar Touri, M., Ghavamzadeh, M., Jafari Barmak, M., Sayahi, M., & Sadeghi, H. (2016). Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat. Avicenna J Phytomed, 6(2), 181-8. DOI: 10.22038/ajp.2016.5481

Schütz, K, Reinhold, C., & Schieber, A. (2006). Taraxacum—A review on its phytochemical and pharmacological profile. J Ethnopharmacol, 107, 313–323. DOI: 10.1016/j.jep.2006.07.021
Seeram N.P. (2008). Berry fruits for cancer prevention: current status and future prospects. J Agric Food Chem; 56(3): 630-5. DOI:10.1021/jf072504n

Seeram, N.P., Adam, L.S., Zhang, Y., Lee, R., Sand, D., Scheuller, H.S., & Heber, D. (2006). Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem, 54(25), 9329-39. DOI:10.1021/jf061750g

Shukitt-Hale, B. (2012).  Blueberries and neuronal aging. Gerontology, 58, 518-523. DOI:10.1159/000341101

Sigstedt, S.C., Hooten, C.J., Callewaert, M.C., Jenkins, A.R., Romero, A.E., Pullin, M.J…. Steelant, W.F. (2008). Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. Int J Oncol. 32(5), 1085-90. https://doi.org/10.3892/ijo.32.5.1085

Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., Sochor, J.(2015). Bioactive Compounds and Antioxidant Activity in Different Types of Berries. Int J Mol Sci, 16(10), 24673-706. doi:10.3390/ijms161024673

Strathearn, K.E., Youself, G.G., Grace, M.H., Roy S.L., Tambe, M.A., Ferruzzi, M.G., Wu, Q.L., … Rochet, J.C. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson’s disease. Brain Research, 1555(25), 60-77. DOI:10.1016/j.brainres.2014.01.047

Vendrame, S., & Klimis-Zacas, D. (2015). Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades. Nutr Rev, 73(6), 348-58. DOI:10.1093/nutrit/nuu066.

Widen, C., Ekholm, A., Coleman, M.D., Renvert, S., Rumpunen, K. (2012). Erythrocyte antioxidant protection of rose hips (Rosa spp.) Oxid Med Cell Longev, 621579. http://dx.doi.org/10.1155/2012/621579

Willich, S.N., Rossnagel, K., Roll, S., Wagner, A., Mune, O., Erlendson, J…Winther, K. (2010). Rose hip herbal remedy in patients with rheumatoid arthritis – a randomised controlled trial. Phytomedicine, 17(2), 87-93. DOI:10.1016/j.phymed.2009.09.003

Winther, K., Apel, K., & Thamsborg, G. (2005). A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol, 34(4), 302-8. DOI:10.1080/03009740510018624

Yang, Y.,  & Li, S. (2015). Dandelion extracts protect human skin fibroblasts from UVB damage and cellular senescence. Oxid Med Cell Longev, 619560. http://dx.doi.org/10.1155/2015/619560

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Article by Dohrea Bardell, PhD.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.Green Facts:

Globe_Home 3Understanding the concept of hormesis and its relationship to plant phytonutrients opens the door to a whole new medical paradigm for reducing chronic oxidative stress.  Chronic oxidative stress increases cancer, metabolic and neurodegenerative disease risk.

See Callbrese et al. (2010) illuminating paper on this most important concept:

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Hi Everybody

I am back from my June hiatus on Forward Thinking Newsletter production, and excited to be sharing with you all again.  There is so much important stuff for us all to talk about regarding “food as medicine”.

This is after all the theme of the BioImmersion Therapeutic Food Supplements.  First of all, we must consider the wisdom of our 3 billion year old mother of all teachers- Mother Nature (see Janine Benjus below in Green Facts).

When we think about food, the food chain comes to mind, and this cyclic reality begins with the autotrophs (green plants). What comes to mind here is BioImmersion’s Organic Chlorella, our Phyto Power (wild-crafted berries from Alaska), our Cruciferous Sprouts, our Garlic, and our Blueberry Extract.  We offer the hormetic power of plant phytochemicals to heal.

But a prior to the food chain comes the raw material of earth from which our bodies are ultimately made- the inorganic elements (the minerals).  And, here we also have some very unique and powerful products- Ultra Minerals, Fructo Borate and BioOrganic Chromium.

For the purpose of your detailing and practical usage of, I will focus on the Ultra Minerals- Mesozoic Vegetate.  A true mineral multiple for us derived from DEEP TIME.

Back 65,000,000 years ago, in the late Dinosaur period, the earth had lush tropical forests teaming with all kinds of plant and animal life, and of course the earth’s living microbiome.   In fact,  by weight the microbiome is heavier than all of the higher plant’s and animal’s mass combined.

Then came the crash- THE FIFTH MASS EXTINCTION- and for many of the higher forms (around 75%) life must start over again, reemerging from the bacteria, slime, mold, and higher surviving phyla.  Now here is the interesting and exciting part, around the world there exists still today accessible deposits of the ancient rain forests, and it is from one of these massive deposits that we obtain our Mesozoic Vegetate.  From this vegetable matter we exact 72 plant derived minerals for our ULTRA MINERALS.

ultra_minerals 2

Using pure water, we are able to extract from the ancient peat (also referred to as “humic shale”) 72 different kinds of nano-sized, negatively charged minerals in a hydro-collodial solution.  This liquid we then drum dry into an absolutely pure mineral powder.

Colloidal minerals are negatively charged, hydrophilic, and nano-sized.  They form direct hydrogen bonds with water, and are therefore water-soluble and nearly 100% instantly absorbable with digestion.  If you open up a capsule in water, it immediately homogenizes in the water, and the minerals are absorbable when rubbed on the skin.

We have put 150mg of this pure negatively charged mineral powder into vegetarian capsules, 60 capsules to a bottle.  Dosages are 1 to 4 capsules a day.  Ultra Minerals is manufactured under GMP, Kosher, GRAS, and is without excipients of any kind.  Check out the Specification Sheet on these minerals in Ultra Minerals by clicking on the foregoing link, and then clicking on the Ingredient tab.  These are typical and not guaranteed values, as some natural variation in the source Mesozoic vegetate occurs from production lot to production lot.

Plant based minerals are naturally chelated through plant root uptake and digestion.  This is important to understand for we know that aluminum for example in its insoluble aluminum oxide or hydroxide form is toxic to our bodies, but in its soluble aluminum sulfate form is not.  All of the aluminum in this ancient vegetate is in the form of aluminum sulfate and has GRAS status by our FDA.

Healthy mineral rich soil, filled with an abundance of microbes, makes for healthy plants, and healthy plants makes for healthy animals.  The historicity of use of these ancient peet deposits by locals around the world in their farming and the benefits derived for their animals and for human energy, stamina and health is very exciting.  We are pleased to bring you this powerful Therapeutic Food supplement.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Biomimicry’s Janine Benyus, “The most important thing for us to do is to tune into nature’s solutions, for its organisms have figured out a way to do the amazing things they do while taking care of the place that’s going to take care of their offspring.  Learning about the natural world in one thing; learning from the natural world—that’s the switch.”
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Cani (2007, 2007a, 2008, 2009) demonstrated in their research that adding to the diet soluble fibers such as inulin (such as the inulin oligofructose chains found in the Original Synbiotic, the Beta Glucan Synbiotic and the No. 7 Systemic Booster) stimulates the growth of Bifidobacteria sp., which caused a reduction in gut permeability, thereby reducing the levels of LPS systemically, and resulted in weight loss and reduced metabolic disorders.

Leaky Gut Cascade 2

High-fat diets increases insulin resistance (IR) and the risk of developing metabolic diseases such as obesity and diabetes.

Cani et al. (2007), Metabolic Endotoxemia Initiates Obesity and Insulin Resistance, describe their search for an inflammatory factor causative for the onset of insulin resistance, obesity, and diabetes. They identified bacterial lipopolysaccharide (LPS) as a major triggering factor.

In various research studies (using a rat research model), Cani et al. found that normal endotoxemia increased or decreased during the fed or fasted state, respectively. A 4-week high-fat diet chronically increased plasma LPS concentration two to three times, a threshold that they defined as metabolic endotoxemia.  The immune system reacts vigorously to LPS in the plasma creating chronic inflammation and causing insulin resistance.

The consequence of insulin resistance will favor hyperinsulinemia and excessive hepatic and adipose tissue lipid storage.  And, adipose tissue presents increased expression and content of pro-inflammatory cytokines such as TNF-a, IL-1 (3,4) and Il-6 (4).

Importantly, a high-fat diet for 4 weeks resulted in significant modulation of dominant bacterial populations within the intestinal microbiota. Shifting to a higher percentage of gram-negative bacteria over gram-positive bacteria.  In particular they found a lowering of the gram-positive Bifidobacterial levels, which cause an increased opening within the tight junctions, allowing for more LPS from the gram-negative bacteria to pass into the plasma.

Cani et al. (2007a) found that adding inulin to the high-fat feed of the research animals, increased the Bifido levels in their colon, which tightened the junctions and reduced the LPS systemic levels.

Their conclusion:  Bifidobacterium spp. significantly and positively correlated with improved glucose tolerance, glucose-induced insulin secretion and normalised inflammatory tone (decreased endotoxaemia, plasma and adipose tissue proinflammatory cytokines).

Food Science: Risk-Reduction of Metabolic Disease

Select from any one of the following Synbiotic products.  They also can be alternated from dose to dose.

  • Original Synbiotic– one tsp. daily
  • Beta Glucan High Potency Synbiotic– one tbl. daily
  • No. 7 Systemic Booster– one tsp. daily

All of these formulas contain ample amounts of organic chicory root derived inulin and the probiotic bacteria Bifido longum found in the research of Cani et al. to facilitate the reduction of entoxemia, and thereby reducing a contributing factor in obesity and diabetes.

Bibliography:

  • Cani et al. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut; 58(8): 1091-1103
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Cani et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes; 56:1761-72.
  • Cani et al. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia; 50: 2374-83.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

  • Which country in the world has the highest percentage of obese citizens?
  • The Kingdom of Tonga with 68.7% obesity, and over 30% diabetes.  Their daily diet, an exceedingly high fatty corn beef, along with high starch sweet potatoes.  For snacks the Tongans love to frequently munch on lamb flap which contain 50% fat.  See Matoto et al. (2014). Burden and spectrum of disease in people with diabetes in Tonga. Public Health Action; 4: S44-S49.