Inflammatory Support

Dear Friends

A leaky gut leads to chronic inflammation within our body (liu, li, & Neu, 2005).  And, chronic inflammation is causative for a whole host of non-communicable diseases—autoimmune disease, metabolic syndrome, obesity, diabetes, CVD, cancer, neurological disease and more (Goldsmith, 2014).

What factors lead to the prevention or treatment of Leaky Gut Syndrome?

Our diets greatly influence the make up of our GI tract microbiome.  Research data show that eating the right foods to supply plenty fiber and polyphenols on a regular basis creates a healthy balance of human friendly bacteria within our gastrointestinal system, leading to the tighteninng of the intestinal cellular junctions and the elimination of a leaky gut (Claussen, 2012).

To aid in the consistent intake of fiber, probiotics, and polyphenols:


Food Science

Health-promoting effects of the microflora may include immunostimulation, improved digestion and absorption, vitamin synthesis, inhibition of the growth of potential pathogens and lowering of gas distension.  Detrimental effects are carcinogen production, intestinal putrefaction, toxin production, diarrhoea/constipation and intestinal infections (Saulnier, 2009).

Stool microbiota of individuals with different types of habitual diets (e.g., vegetarians or vegans versus omnivores or from geopraphically distinct areas) have been charactertized.  It has become evident that the diet has a dominatn role on the stool microbiota and that the diet-driven changes in it occur with days to weeks (Simoes, 2013).

The data indicate that the frailest older people tend to harbour similar intestinal microbial communities.  The study also suggests that this shift in their gut microbiome is driven by a diet high in fat and lacking in fibre, and that a decline in our microbial community underlies ill health as we grow old (Wu, 2011; Claussen, 2012; Simoes, 2013.).

Bibliography

  • Claesson MJ, Jeffery IB, Conde S, Power SE, O’Conner EM, Cusack S, Harris HM … et al. (2012). Gut microbiota composition correlates with diet and health in the elderly. Nature; 9,488(7410). 178-84.
  • Goldsmith Jr, Sartor RB. (2014). The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications. J Gastroenterol, 49(5): 785-98.
  • Liu, Z., Li, N., & Neu, J. (2005). Tight junctions, leaky intestines, and pediatric diseases. Acta Paediatr, 94(4), 386-93.
  • Maukonen J, Saarela M. (2015). Human Gut microbiota:  Does diet matter? Proc Nutr Soc; 74(1): 23-36.
  • Saulnier MD, Kolida S, Gibson GR. (2009). Microbiology of the human intestinal tract and approaches for its dietary modulation. Curr Pharm Des; 15(13): 1403-14.
  • Simoes CD, Maukonen J, Kaprio J, Rissanen A, Poetiainen KH, Saarela M. (2013). Habitual dietary intake is associated with stool microbiota composition in monzygotic twins. J Nutr; 143(4): 417-23.
  • Tuohy KM, Gougolias C, Shen Q, Fava F, Ramnani P. (2009). Studying the human gut microbiota in the trans-omics era–focus on metagenomics and metabonomics. Curr Pham Des 15(13): 1415-27.
  • Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA … et al. (2011).  Linking long-term dietary patterns with gut microbial enterotypes. Science; 334(6052): 105-8.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3David Granet MD and Rob Knight PhD converse regarding the Microbiome. Some points by Knight:  Avoid fries and certain carbohydrates; but not all for fibers both soluble and insoluble are very important for microbiome health.  Also eat a rainbow of colored vegetables and fermented foods.
 

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Dear Friends

Chronic tissue inflammation goes hand-in-hand for people suffering from obesity and diabetes.  The inflammatory cytokine Tumor Necrosis Factor Alpha (TNF-a) is elevated in the plasma and adipose tissue of these individuals.  TNF-a induces the expression of inflammatory genes such as IL-6, IL-1B, IL-8 and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8 and MCP-1.  Hence, chronic inflammation.

Chuang et al, 2010 research aim was to examine the extent to which quercetin and resveratrol prevent inflammation or insulin resistance in primary cultures of human adipocytes.  What they found was that quercitin is equally or more effective than resveratrol in attenuating TNF-a mediated inflammation and insulin resistance in fat cells.

(more…)

The Missing Fiber

December 29, 2015

Dear Friends

As dietary fiber goes up the risk of Metabolic Syndrome goes down!

The greater our dietary fiber intake is, the more we reduce the risk for Type 2 Diabetes, cardiovascular disease, certain cancers, weight gain, obesity and diverticular disease as well as constipation (Grooms, 2013).

The average American intake is about ½ of what it should be with the guidelines for dietary fiber from the American Heart Association and the Institute of Medicine being at 30g/day (King, 2013).

Two BioImmersion Therapeutic Foods help to increase your dietary fiber:

Beta Glucan High Potency Synbiotic and Energy Sustain.  See Clinical Notes.

References:

  • King et al. (2012). Trends in dietary fiber intake in the United States, 1999-2008. J Acad Nutr Diet;112(5):642-8.
  • Grooms et al. (2013). Dietary Fiber Intake and Cardiometabolic Risk among US Adults: NHANES 1999-2010. Am J Med;126(12):1059-1067.
Yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health.  Please  use our products under the advisement of your doctor.

Clinical NotesBG and ES 4

Here’s to our health:

Take one heaping tablespoons of the Beta Glucan daily and two–three heaping tablespoons of the Energy Sustain at least three times a week. Combine the two and make a smoothie as a meal replacement.  With this kind of dosing you will be adding around 10 grams of fiber.  And other wonderful life enhancing
nutrients (see the links above and below).

To make a great smoothie, add to the Beta Glucan and Energy Sustain some fresh fruit, protein powder, and flax seed. We can easily get to 20 grams with the added fiber.

Green Facts:

Globe_Home 3Here is your free online Permaculture Design Course with World-Class Sustainability Teachers.  Perhaps in 2016 we can all get involved in some way with Permaculture.

 

Dear Friends,

Chronic inflammation is a key risk factor to the growing degenerative diseases we are facing today.

The No. 7 Systemic Booster is a foundational product that potentiates many protocols as it is designed to support multiple systems in our body’s ability to overcome chronic inflammation.  Think of the foods, fiber, and probiotics in the No 7 as a communication switchboard that directs the different items in your protocols toward their therapeutic goal. That is the power of foods acting epigenetically (Han. 2007).

No.7 2Research on the effects of foods and probiotics found in the No 7 is exciting.

Liopis (2009) research demonstrated L. casei’s abilitiy to downregulate inflammatory signals (TNF-alpha, IFN-gamma, IL-2, IL-6, IL-8, and CXCL 1) in Crohn’s disease mucosa. The researchers conclusion was that live L. casei can counteract the proinflammatory effects of E. coli on CD inflamed mucosa.

Ford (2014) meta-analysis on the efficacy of prebiotics, probiotic and synbiotics in IBS and CIC (the mean number of stools per week) found that probiotic had beneficial effects on global IBS, abdominal pain, bloating and flatulence.  Their conclusion: probiotics are effective treatments for IBS. Their degrees of effectiveness depending on the species and strains.

The No. 7’s bacteria strains and the supernatant were chosen by our Bulgarian scientists for their effectiveness supporting the inhibition of Clostridial species, as overgrowth of Clostridia is found to create a serious GI tract inflammatory problem (Kounev 2007).  The inulin, berries and fruit provides the prebiotic for the inflammatory reducing-strain of acidophillis, casei and longum.  Inulin is very bifidogenic.

Fruit and berry polyphenols provide a myriad anti-inflammatory actions.  They perform as anti-oxidants, anti-inflammatories, anti-microbials, they protect against the diseases of aging.  They are also hormetic, that is they behave like hormones, epigenetically activating endogenous defense systems (Han. 2007).

Lapshina (2015) demonstrated that the flavonoids in cranberry prevent toxic rat liver mitochondrial damage in vivo and scavenge free radicals in vitro.  They scavenged nitric oxide radicals, superoxide anion radicals, and hydroxyl radicals.  Novotny (2015) showed that cranberry juice consumption lowers markers of cardiometabolic risk including CRP.

Colombo’s (2013) research demonstrated the anti-inflammatory activity of pomegranate in the gastrointestinal tract.  Pomegranate is shown to help with gastritis.

Howatson et al. (2009) determined the efficacy of a tart cherry juice in aiding recovery and reducing muscle damage, inflammation and oxidative stress.  The cherry juice appears to provide a viable means to aid recovery following strenous exercise by increasing total antioxidative capacity, reducing inflammation, lipid peroxidation and so aiding in the recovery of muscle function.  There is much anecdotal evidence for tart cherry reducing the pain of arthritis.

Regarding the nutriceutical contribution within the No. 7, the Fructo Borate Complex contributes to inflammatory reduction by a variety of mechnisms.  Boron downregulates over zealous immune cells for unloading their oxidative bursts into inflamed joints.  Boron also decreases blood levels of CRP and increases blood levels of Vitamin D3. We also add extra Vitamin D3 to No. 7 at 400 IU per tsp (Scorei et al., 2011).

Barley Sprout Nucleotides lower the blood sugar levels for hyperglycemics.  Reducing blood sugar levels also reduces blood LDL levels, and lower LDLs reduces the risk for oxidized LDL, a very dangerous inflammatory inducing free radical.

Lee et al (2015) investigated the effect of L-carnitine supplementation on inflammation markers in patients with CAD.  CRP,IL-6, and TNF- alpha were all significantly lowered.  They suggested the use of L-carnitine supplementation to reduce inflammation in CAD.

L- Carnosine is an exciting anti-aging molecule, much has been said and researched about it.  In short, carnosine works as an antioxidant to prevent the formation of oxidized sugars, also called Advanced Glycosylation End-products or AGEs. The less AGEs in your body the younger your body feels (Asif et al., 2000).

References:

  • Liopis et al. (2009). Lactobacillus casei downregulates commensals’ inflammatory signals in Crohn’s diseases mucosa. inflamm Bowel Dis;15(2):275-83.
  • Ford et al. (2014). Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol;109(10):1547-61.
  • Han et al. (2007). Dietary Polyphenols and their Biological Significance. Int J Mo Sci; 8(9):950-988.
  • Lapshina et al. (2015). Cranberry flavonoids prevent toxic rat liver mitochondrial damage in vivo and scavenge free radicals in vitro. Cell Miochem Funct;33(4):202-210.
  • Novotny et al. (2015). Cranberry juice consumption lowers markers of cardiometabliolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults. J Nutr;145(6):1185-93.
  • Colombo et al. (2013). A review on the Anti-Inlfammatory Activity of Pomegranate in the Gastrointestinal tract. Evidence-based Complementary and Alternative Medicine;Article ID 247145.
  • Howatson et al. (2009). Influence of tart cherry juice on indices of recovery following marathon. Scandinavian Journal of Med & Sci in Sports;20(6):843-852.
  • Scorei et al. (2011). A double-blind, Placebo-Controlled Polot Study to Evaluate the Effect of Calcium Fructoborate on Systemic Inflammation and Dyslipidemia Markers for Middle-Aged People with Ordinary Osteoarthritis. Biol Trace Elem Res;144:253-263.
  • Lee et al. (2008). Vitamin Deficiency: An important, Common, and Easiiy Treatable Cardiovascual Risk Factor? J Am Coll Cardiol;52(24):1949-1956.
  • Lee et al. (2015). Antiinflammatory effects of L-canitine supplementation (1000 mg/d) in coronary artery disease patients. Nutrition;31(3):475-9.
  • Asif et al. (2000). An Advanced Glycation Endproduct cross-link breaker can reverse age-related increases in myocardial stiffness. Proc Natl Acad Sci USA; 97(6):2809-2813.

Yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health.  Please  use our products under the advisement of your doctor.

Clinical Notes

The No. 7 Systemic Booster is meant to be taken on a regular basic as not only your gastrointestinal probiotic/prebiotic supplement but as your multiple for all of the body’s systems—as a anti-inflammatory, healthy aging product.

The suggested dose is one teaspoon daily.

No. 7 contains:  probiotics (L. acidophilus, L. casei, B. longum), supernatant (inactive probiotic cells populations of L. bulgaricus, S. thermophilus and their metabolites), whole organic pineapple, organic tart cherry, organic cranberry and extract, organic pomegranate and extract, Fructo Borate Complex, barley sprout nucleotides, inulin (derived from organic chicory root), L-Carnitine, L-Carnosine, Vitamin D-3 and folic acid.

The Bulgarian probiotics and their Supernatant are exceptional contributors within the army of synbiotic organisms in the gut microbiome towards the reduction of GI tract inflammation.

Green Facts:

Globe_Home 3Is not investment into new energy a smart investment, the right investment?  Even before December arrived, 2015 had proven a record breaking year for corporate purchasing of large scale wind and solar energy.