Inflammatory Support

Think better with blueberry

January 22, 2018

Dear Friends

blueberry X 4The CNS (the brain and spinal cord) is particulary vulnerable to oxidative stress, and this vulnerability increases during ageing (Joseph et al, 1998).  In fact as Dr. Joseph put it, “the brain becomes a hot bed of free radical activity in our old age.”

Shukitt-Hale et al. (2015) demonsrated in her research titled, The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing, the powerful cognitive effects by adding blueberry extract and strawberry extract to the diets of senile old rats.

The results showed that rats consuming the berry diets exhibited enhanced motor performance and improved cognition, specifically working memory. In addition, the rats supplemented with blueberry and strawberry diets showed increased hippocampal neurogenesis and expression of insulin-like growth factor 1.

What about research today on the bioavailability of blueberry polyphenols and their beneficial effect with human subjects?

Sandhu et al. (2017) explored the metabolic fate of blueberry anthocyanins after daily (90 days) supplementation of freeze-dried blueberry (equivalent of 1 cup of fresh blueberries).  Their conclusion was that blueberry anthocyanins are absorbed and extensively metablized resulting in the production of various phenolic acid derivatives and their conjugates, all together contributing to the bioavailability and beneficial effects associated with blueberry comsumption.

Miller et al. (2017) studied men and women between the ages of 60 and 75 years. Their findings showed that the group consuming the equivalent of one cup of blueberries daily for 90 days exhibited significantly fewer errors in a verbal learning test and increased mental flexibility on a task-switching test, relative to the placebo group.

BioImmersion powerhouses for polyphenolics supplementation for a healthy brain: 

References

  • Joseph, J. A., Denisova, N., Fisher, D., Shukitt-Hale, B., Bickford, P., Prior, R., & Cao, G. (1998). Age-related neurodegeneration and oxidative stress: putative nutritional intervention. Neurologic clinics, 16(3), 747-755.
  • Joseph, J. A., Denisova, N., Fisher, D., Shukitt‐Hale, B., Bickford, P., Prior, R., & Cao, G. (1998). Membrane and receptor modifications of oxidative stress vulnerability in aging: nutritional considerations. Annals of the New York Academy of Sciences, 854(1), 268-276.
  • Miller, M. G., Hamilton, D. A., Joseph, J. A., & Shukitt-Hale, B. (2017). Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. European Journal of Nutrition, 1-12.
  • Sandhu, A., Miller, M. G., Shukitt-Hale, B., Edirisinghe, I., & Burton-Freeman, B. (2017). Metabolic Fate of Blueberry Anthocyanins after Chronic Supplementation in Healthy Older Adults. The FASEB Journal, 31(1 Supplement), 646-20.
  • Shukitt-Hale, B., Bielinski, D. F., Lau, F. C., Willis, L. M., Carey, A. N., & Joseph, J. A. (2015). The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. British Journal of Nutrition, 114(10), 1542-154.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3
Five Habits to Heal the Heart of Democracy.The human heart is the first home of democracy. It is where we embrace our questions. Can we be equitable? Can we be generous? Can we listen with our whole beings ….

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Endotoxemia and Chlorella

December 14, 2017

Dear Friends

Chlorella HZ 2

Chlorella and inulin reduce endotoxemia and protect the intestinal mucosa barrier.

What is an endotoxin, and what causes endotoxemia? How does chlorella reduce endotoxemia, and how does inulin produce a healthy microbiome?  Let’s take a look at a few studies.

An endotoxin is often used synonymously with LPS.  Lipopolysaccharides (LPSs) are the major components of the outer membrane of Gram-negative bacteria. Rietschel et al. found in 1994 that LPSs induce strong inflammatory responses from the immune systems of all animals.

Liver Diseases are associated with leaky gut syndrome, which allows for the passage LPS molecules into the systemic circulation, causing chronic inflammation, and a condition called endotoxemia. A large enough load of LPSs in the systemic circulations can cause septic shock.

In fact, severe sepsis is a common and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction. It is especially common in the elderly and is likely to increase substantially as the U.S. population ages (Angus et al., 2001)

Bedirli et al. (2009) investigated the role of different microalgae (Chlorella sp. and Spirulina sp.) extracts in intestinal barrier function and oxidative stress in experimentally jaundice rats.

The main outcomes measured were endotoxin concentrations in plasma [e.g. LPS levels], evidence of bacterial translocation in mesenteric lymph nodes and liver oxidative stress, and histology.

Their findings: A Chlorella sp. supplemented diet significantly demonstrated protective effects on the intestinal mucosa barrier in obstructive jaundice, and reduced intestinal translocation of bacteria and endotoxin.  Spirulina had no significant effect.

Original copyCani et al. (2008) found that a high animal fat diet changes the GI tract microbiome into a population of increasing numbers of Gram-negative bacteria, which raises the level of LPS endotoxins within the gut lumen and allows their passing through the GI tract membrane into the plasma.

The research team concluded that the plasma concentration of lipopolysaccharides (LPS) controls the inflammatory tone of the body.  This means that high concentrations of LPS set the stage for endotoxemia, resulting in metabolic diseases (obesity, diabetes, CVD) and cancer.

They further demonstrated in the study that increased fibers in the diet, such as inulin, increase the populations of Bifidobacterial sp. and Lactobacillus sp. which reduce both the load of Gram-negative bacteria and the permeability of the gastrointestinal membrane.

Our Suggestion: Take 4 to 8 tablets of Organic Chlorella daily.
Take 1 tsp. of Original Synbiotic daily.
References:

  • Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001). Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine, 29(7), 1303-1310.
  • Bedirli, A., Kerem, M., Ofluoglu, E., Salman, B., Katircioglu, H., Bedirli, N., … & Pasaoglu, H. (2009). Administration of Chlorella sp. microalgae reduces endotoxemia, intestinal oxidative stress and bacterial translocation in experimental biliary obstruction. Clinical nutrition, 28(6), 674-678.
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Rietschel, E. T., Kirikae, T., Schade, F. U., Mamat, U., Schmidt, G., Loppnow, H., … & Di Padova, F. (1994). Bacterial endotoxin: molecular relationships of structure to activity and function. The FASEB Journal, 8(2), 217-225.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3
What kind of world do you want to wake up to 30 years from now?
The Biomimicry Institute aspires to a world where what we make is inspired by, and connected to, the natural world.  This means cities are resilient, emission targets are achieved, and industrial processes create healthy air, water, and soil.  It also means all species are thriving because our human designs restore the planet as nature’s desgns do.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends                                                                                                                                                      WL Low Cropped Jpeg

Weight-Less is a smart formula for less weight and more energy.

Weight-Less is Wild Crafted (seaweeds), Organic (seaweeds), Vegan, Kosher, Non GMO, and Gluten Free. Take 1-2 capsules a half hour before meals.

Food Science

Marine algae, in particular, wild brown seaweed such as kelp and bladderwrack are shown to lower the glycemic load of complex and simple carbohydrates for better insulin management, as well as offer a power-filled phenolic activity for antioxidant and anti-inflammation effect (Roy et al., 2011). 7-Keto has been used for many years to turn on fat burning mechanism and offer an effective and safe way to lose weight (Bobyleva et al., 1997). Together, Weight-Less promotes a sustained energy level throughout the day as it modulates carbohydrate digestion and absorption for better weight management and metabolic health (Gabbia et al., 2017; Catarino et al., 2017).*

Weight management is essential to our health, yet difficult to achieve. Research has correlated excess body fat with metabolic syndrome, which includes high blood sugar, high blood pressure, high cholesterol and triglycerides. These metabolic syndrome factors are found to increase the risk for cardiovascular issues, obesity, diabetes, and cancer (American Heart Association, 2017; National Cancer Institute, 2017). In fact, metabolic syndrome is now a growing public health concern worldwide (Wright et al., 2017; Calton et al., 2014).*

Inflammation is also shown in research to link obesity and cardio–metabolic risks for obese and non-obese individuals (Phillips & Perry, 2013). Hence, a diet of whole plants rich in phenols is shown in research to offer anti-inflammatory benefits (Wright et al., 2017; McAnulty et al., 2014). Weight-Less is comprised of wildcrafted brown seaweeds shown in research to offer potent phenols with high total antioxidant potency, antidiabetic properties, and anti-inflammatory potential (Gabbia et al., 2017; Catarino et al., 2017; Pantidos et al., 2014; Bahar et al., 2012).*

Studies have linked low glycemic index to improved cardiovascular health, blood sugar control, weight control, and even skin health (McMillan-Price et al., 2006, Barclay et al., 2008, Hare-Bruun et al., 2006; Smith et al., 2007, respectively). For this reason, 250 mg of brown seaweed extracts of kelp and bladderwrack is used half an hour before meals to aid carbohydrate digestion and assimilation; shifting high glycemic index food to one typical of a low glycemic index food (Paradis et al., 2011; Roy et al., 2011; Bérubé et al., 2014). Studies find supplementing with brown seaweed before meals to help slow down the digestion of whole or simple carbs to significantly reduce blood glucose for overall glycemic control (Gabbia et al., 2017; Bérubé et al., 2014; Kim et al., 2014; Lamarche et al., 2010). Glycemic control supports a consistent metabolic health and weight management.*

7-Keto DHEA, or 7-oxo DHEA is named after the compound 3-acetyl-7-oxo dehydroepiandrosterone, a substance found naturally in the body that is metabolized from the hormone DHEA (Marwah et al., 2002). Studies have indicated that 7-Keto is stable (does not convert to testosterone or estrogens), safe and effective as part of a weight loss program (Lardy et al., 1995, Davidson et al., 2000; Humanetics Corps, 2005, respectively). In fact, 7-Keto has shown in studies to activate 3 thermogenic enzymes, known to help the body convert stored fat to energy (Zenk et al., 2007, 2004). But since levels of DHEA and 7-oxo decline in our body with age, supplementation with 7-Keto helps maintain healthy levels for weight management (Lardy et al., 1998; 1995).*

In the pre-clinical development (see Bobyleva et al., 1993), 7-Keto was found to behave similarly to the thyroid hormone which also activates the thermogenic enzymes in our body. 7-oxo DHEA showed similar ability to restore mitochondrial function (Bobyleva et al., 1997) and support weight loss by enhancing thermogenic enzyme activity.*

Clinical trials have been ongoing since 1999, in specific, two randomized, double-blinded, placebo-controlled (“RDBPC”) in 1999 and 2000 have shown that 7-keto significantly increased weight loss over a period of eight weeks compared to the placebo group (Zenk et al., 2002; see also Kaiman et al., 2000; Bobyleva et al., 1997).*

Thermogenesis is the creation of heat in the body; a form of energy that is produced when we eat and metabolize food. Kaiman et al. (2000; see also Zenk et al., 2002) conducted a RDBPC study of 30 healthy overweight adults for 8 weeks. The group taking the supplement of 7-Keto showed a significantly reduced body weight. The study included exercise (three times a week) and a reduced caloric diet for both placebo and 7-Keto groups. Zenk et al. (2004; 2007) similarly found that 7-Keto increased metabolism, which is shown in research to promote weight loss and support the management of weight overall. By up-regulating the activity of fat burning enzymes (the thermogenic effect), energy expenditure is increased, enhancing the process of weight loss (Gomez et al., 2002).*

Moreover, 7-oxo DHEA is also shown in research to enhance memory in young and old rats (Shi et al., 2000), immune modulation in older men (Hampl et al., 2000), and significantly enhance depressive symptoms and hypo-immunity of mice when induced by chronic mild stress (Liu et al., 2003).*

Weight-Less combines brown seaweed extracts of kelp and bladderwrack with 7-Keto to support weight loss. The formula enhances the body’s ability to burn fat more efficiently, create energy, and promote metabolic health. Together with a primarily whole food plant-based diet (see green facts below) and reasonable exercise, managing weight is healthy and even joyful. *

References:

  • American Heart Association. (2017). About metabolic syndrome. Article
  • Amine, E., Baba, N., Belhadj, M., Deurenbery-Yap, M., Djazayery, A., Forrester, T., … & Katan, M. (2002). Diet, nutrition and the prevention of chronic diseases: report of a Joint WHO/FAO Expert Consultation. World Health Organization. Diet, nutrition and the prevention of chronic diseases – World Health …
  • Azadbakht, L., & Esmaillzadeh, A. (2009). Red meat intake is associated with metabolic syndrome and the plasma C-reactive protein concentration in women. The Journal of nutrition, 139(2), 335-339. DOI:10.3945/jn.108.096297
  • Barclay, A. W., Petocz, P., McMillan-Price, J., Flood, V. M., Prvan, T., Mitchell, P., & Brand-Miller, J. C. (2008). Glycemic index, glycemic load, and chronic disease risk—a meta-analysis of observational studies. The American journal of clinical nutrition, 87(3), 627-637. Abstract
  • Bahar, B., O’Doherty, J. V., Hayes, M., & Sweeney, T. (2012). Extracts of brown seaweeds can attenuate the bacterial lipopolysaccharide-induced pro-inflammatory response in the porcine colon ex vivo. Journal of animal science, 90(Supplement_4), 46-48. Abstract
  • Bobyleva, V., Bellei, M., Kneer, N., & Lardy, H. (1997). The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Archives of biochemistry and biophysics, 341(1), 122-128. https://doi.org/10.1006/abbi.1997.9955
  • Calton, Emily K., Anthony P. James, Poonam K. Pannu, and Mario J. Soares. “Certain dietary patterns are beneficial for the metabolic syndrome: reviewing the evidence.” Nutrition Research 34, no. 7 (2014): 559-568. DOI:10.1016/j.nutres.2014.06.012
  • Catarino, M. D., Silva, A., & Cardoso, S. M. (2017). Fucaceae: A source of bioactive phlorotannins. International journal of molecular sciences, 18(6), 1327. Article
  • Chai, W., Morimoto, Y., Cooney, R. V., Franke, A. A., Shvetsov, Y. B., Le Marchand, L., … & Maskarinec, G. (2017). Dietary Red and Processed Meat Intake and Markers of Adiposity and Inflammation: The Multiethnic Cohort Study. Journal of the American College of Nutrition, 36(5), 378-385. DOI:10.1080/07315724.2017.1318317
  • Davidson, M., Marwah, A., Sawchuk, R. J., & Maki, K. (2000). Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clinical and investigative medicine, 23(5), 300. Abstract
  • Gabbia, D., Dall’Acqua, S., Di Gangi, I. M., Bogialli, S., Caputi, V., Albertoni, L., … & De Martin, S. (2017). The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH. Marine drugs, 15(2), 41. DOI:10.3390/md15020041
  • Gonzalez Fischer, C., & Garnett, T. (2016). Plates, pyramids, planet. Oxford, UK: Oxford University. Abstract
  • Gomez, F. E., Miyazaki, M., Kim, Y. C., Marwah, P., Lardy, H. A., Ntambi, J. M., & Fox, B. G. (2002). Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA. Biochemistry, 41(17), 5473-5482. Abstract
  • Hare-Bruun, H., Flint, A., & Heitmann, B. L. (2006). Glycemic index and glycemic load in relation to changes in body weight, body fat distribution, and body composition in adult Danes. The American journal of clinical nutrition, 84(4), 871-879. Abstract
  • Hampl, R., Lapcik, O., Hill, M., Klak, J., Kasal, A., Novacek, A., … & Starka, L. (2000). 7-Hydroxydehydroepiandrosterone-a natural antiglucocorticoid and a candidate for steroid replacement therapy?. Physiological Research, 49, S107-S112. Article
  • Hever, J., & Cronise, R. J. (2017). Plant-based nutrition for healthcare professionals: implementing diet as a primary modality in the prevention and treatment of chronic disease. Journal of Geriatric Cardiology: JGC, 14(5), 355. DOI:  10.11909/j.issn.1671-5411.2017.05.012
  • Humanetics Corporation (2005). 7 Keto Innovative Weight Loss. Retrieved from www.humaneticscorp.com.
  • Kahleova, H., Levin, S., & Barnard, N. (2017). Cardio-Metabolic Benefits of Plant-Based Diets. Nutrients, 9(8), 848. DOI:10.3390/nu9080848
  • Kaiman, D. S., Colker, C. M., Swain, M. A., Torina, G. C., & Shi, Q. (2000). A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current therapeutic research, 61(7), 435-442. https://doi.org/10.1016/S0011-393X(00)80026-0
  • Kim, K. T., Rioux, L. E., & Turgeon, S. L. (2014). Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum. Phytochemistry, 98, 27-33. https://doi.org/10.1016/j.phytochem.2013.12.003
  • Lamarche, B., Paradis, M. È., & Couture, P. (2010). Study of the acute impact of polyphenols from brown seaweeds on glucose control in healthy men and women. The FASEB Journal, 24(1 Supplement), 209-4. Abstract
  • Lamont, B. J., Waters, M. F., & Andrikopoulos, S. (2016). A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice. Nutrition & diabetes, 6(2), e194. DOI: 10.1038/nutd.2016.2
  • Lardy, H., Partridge, B., Kneer, N., & Wei, Y. (1995). Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. Proceedings of the National Academy of Sciences, 92(14), 6617-6619. Abstract
  • Lardy, H., Kneer, N., Wei, Y., Partridge, B., & Marwah, P. (1998). Ergosteroids II: biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids, 63(3), 158-165. https://doi.org/10.1016/S0039-128X(97)00159-1
  • Liu, Y. Y., Yang, N., Kong, L. N., & Zuo, P. P. (2003). Effects of 7-oxo-DHEA treatment on the immunoreactivity of BALB/c mice subjected to chronic mild stress. Yao xue xue bao= Acta pharmaceutica Sinica, 38(12), 881-884. Abstract
  • Lutsey, P. L., Steffen, L. M., & Stevens, J. (2008). Dietary intake and the development of the metabolic syndrome. The Atherosclerosis risk in communities study. Circulation, 117(6), 754-761. DOI:10.1161/CIRCULATIONAHA.107.71615
  • Marwah, A., Marwah, P., & Lardy, H. (2002). Ergosteroids: VI. Metabolism of dehydroepiandrosterone by rat liver in vitro: a liquid chromatographic–mass spectrometric study. Journal of Chromatography B, 767(2), 285-299. https://doi.org/10.1016/S1570-0232(01)00570-0
  • McAnulty, L.S., Collier, S.R., Landram, M.J., Whittaker, D.S., Isaacs, S.E., Klemka, J.M… McAnulty, S.R. (2014). Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females. Nutr Res, 34 (7), 577-84. DOI: 10.1016/j.nutres.2014.07.002
  • McMillan-Price, J., Petocz, P., Atkinson, F., O’Neill, K., Samman, S., Steinbeck, K., … & Brand-Miller, J. (2006). Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial. Archives of internal medicine, 166(14), 1466-1475. Article
  • Pantidos, N., Boath, A., Lund, V., Conner, S., & McDougall, G. J. (2014). Phenolic-rich extracts from the edible seaweed, ascophyllum nodosum, inhibit α-amylase and α-glucosidase: Potential anti-hyperglycemic effects. Journal of Functional Foods, 10, 201-209. https://doi.org/10.1016/j.jff.2014.06.018
  • Paradis, M. E., Couture, P., & Lamarche, B. (2011). A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women. Applied Physiology, Nutrition, and Metabolism, 36(6), 913-919. DOI:10.1139/h11-115
  • Phillips, C. M., & Perry, I. J. (2013). Does inflammation determine metabolic health status in obese and nonobese adults?. The Journal of Clinical Endocrinology & Metabolism, 98(10), E1610-E1619. https://doi.org/10.1210/jc.2013-2038
  • Roy, M. C., Anguenot, R., Fillion, C., Beaulieu, M., Bérubé, J., & Richard, D. (2011). Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo. Food research international, 44(9), 3026-3029. https://doi.org/10.1016/j.foodres.2011.07.023
  • Satija, A., Bhupathiraju, S. N., Spiegelman, D., Chiuve, S. E., Manson, J. E., Willett, W., … & Hu, F. B. (2017). Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults. Journal of the American College of Cardiology, 70(4), 411-422. https://doi.org/10.1016/j.jacc.2017.05.047
  • Shi, J., Schulze, S., & Lardy, H. A. (2000). The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice. Steroids, 65(3), 124-129. https://doi.org/10.1016/S0039-128X(99)00094-X
  • Smith, R. N., Mann, N. J., Braue, A., Mäkeläinen, H., & Varigos, G. A. (2007). A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial. The American journal of clinical nutrition, 86(1), 107-115. Abstract
  • Šulcová, J., Hill, M., Mašek, Z., Češka, R., Nováček, A., Hampl, R., & Starka, L. (2001). Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men. Physiol Res, 50, 9-18. Article
  • Tilman, D., & Clark, M. (2014). Global diets link environmental sustainability and human health. Nature, 515(7528), 518-522. Article
  • Turner, K. M., Keogh, J. B., Meikle, P. J., & Clifton, P. M. (2017). Changes in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks. Nutrients, 9(8). DOI:  10.3390/nu9080886
  • United Nation News Centre. (2016). UN study urges governments to develop guidelines that promote ‘win-win’ diets. Article
  • Wang, F., Zheng, J., Yang, B., Jiang, J., Fu, Y., & Li, D. (2015). Effects of vegetarian diets on blood lipids: a systematic review and meta‐analysis of randomized controlled trials. Journal of the American Heart Association, 4(10), e002408. DOI:10.1161/JAHA.115.002408
  • Wright, N., Wilson, L., Smith, M., Duncan, B., & McHugh, P. (2017). The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes. Nutrition & diabetes, 7(3), e256. DOI:10.1038/nutd.2017.3
  • Yokoyama, Y., Levin, S. M., & Barnard, N. D. (2017). Association between plant-based diets and plasma lipids: a systematic review and meta-analysis. Nutrition Reviews, 75(9), 683-698. https://doi.org/10.1093/nutrit/nux030
  • Zenk, J. L., Helmer, T. R., Kassen, L. J., & Kuskowski, M. A. (2002). The effect of 7-Keto Naturalean™ on weight loss: A randomized, double-blind, placebo-controlled trial. Current therapeutic research, 63(4), 263-272. https://doi.org/10.1016/S0011-393X(02)80031-5
  • Zenk, J. L., Helmer, T. R., & Kuskowski, M. A. (2004, March). The use of 3-acetyl-7-oxo-dehydroepiandrosterone for augmenting immune response in the elderly. In FASEB JOURNAL (Vol. 18, No. 5, pp. A794-A794). 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA: FEDERATION AMER SOC EXP BIOL.
  • Zenk, J. L., Frestedt, J. L., & Kuskowski, M. A. (2007). HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. The Journal of nutritional biochemistry, 18(9), 629-634. https://doi.org/10.1016/j.jnutbio.2006.11.008

Article by Dohrea Bardell PhD

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Choosing a healthy diet: Research studies link the emerging global pattern of metabolic syndrome and weight gain to the prevalence of Westernized diet of daily meats, dairy, eggs, simple and processed carbohydrates, and too much sugar (Chai et al., 2017; Azadbakht & Esmaillzadeh, 2009; Lutsey et al., 2008). Although there are conflicting views on dietary guidelines, many scientists and health organizations agree that a focus on whole food plant-based diet is the healthiest guideline for metabolic syndrome and weight loss (Yokoyama et al., 2017; Satija et al., 2017; Kahleova et al., 2017; Hever et al., 2017; Turner et al., 2017; UN Report, 2016; Wang et al., 2015; Tilman & Clark, 2014; WHO/FAO, 2003).*

The Plates, Pyramids, Planet report, compiled in collaboration with the Food Climate Research Network (FCRN) at the University of Oxford, concludes that a plant-based diet has many advantages for health and the environment (UN Report, 2016).*

The type and nature of carbohydrates that improve our metabolic health (obesity, cardiovascular, and diabetes) are comprised of whole plants with fiber (Wright et al., 2017). Whereas low carbs diets with high fat content is shown to increase metabolic syndrome (Lamont et al., 2017; UN Report, 2016).*

A diet that is 80-90% whole food plant-based is highly recommeded by many health organizations and medical universities around the world.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Original copy
The Original Synbiotic is a daily probiotic for the whole family.

The Original probiotics are researched pedigreed strains of lactic acid bacteria that support the development of a healthy GI tract microbiome.

A healthy gut microbiome is dependent on strong and proven probiotics, such as the Original strains. The Original Synbiotic provides a powerful symbiotic combination of Lactobacillus acidophilus (ATCC 4356), Streptococcus thermophilus (ATCC 19258), Lactobacillus plantarum (ATCC 8014), Lactobacillus rhamnosus (ATCC 7469) and Bifidobacterium longum (ATCC 15707).

Our chosen probiotics are foundational ATCC strains shown in research to work together with human cells to perform many functions in the body. For example, these probiotic strains help the digestive system, support and balance the immune system, and enhance our nervous system by producing neurotransmitters. They reinforce the GI barrier function to protect us from xenobiotics and pathogens, even binding heavy metals. Moreover, they neutralize carcinogens such as those caused by heterocyclic amines found in blackened meat and elements such as nitrosamines in sausage. By acidifying the epithelial membrane, they enable the absorption of minerals such as calcium and magnesium more readily. And lastly, our chosen strains also support the important task of daily regularity (Syngia et al., 2016; Hardy et al., 2013; Figueroa‐González et al., 2011; Ng et al., 2009).

The Original Synbiotic suggested daily dose: one tsp daily.

Of the many beneficial functions needed to be performed by our probiotic friends, colonizing the GI tract membrane and thereby protecting from our body from pathogens and xenobiotics, is very important. Check out these studies on colonization (Toscano et al., 2017; Underwood et al., 2015; Panigrahi et al., 2008; De Champs et al., 2003; Sarem- Damerdji et al., 1995).

See the Original Synbiotic Monograph.

References:

  • De Champs, C., Maroncle, N., Balestrino, Damien., Rich, C., Forestier, C. (2003). Persistence of Colonization of Intestinal Mucosa by A Probiotic Strain, Lactobacillus casei subsp rhamnosus Lcr35, after Oran Consumption. J Com Microbiol; 41(3): 1270-1273.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150315/
  • Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.
  • Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.
  • Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.
  • Panigrahi, P., Pradhan, L., Mohapatra, S.S., Misra, P.R., Johnson, J.A., Chaudhry, R., Taylor, S., Hanse, N.I., Gewolb, I.H. (2008). Long-term colonization of a Lactobacillus plantarum synbiotic preparation in the neonatal gut. J Pediatr Gastroenterol Nutr; 47(1):45-53. https://www.ncbi.nlm.nih.gov/pubmed/18607268
  • Sarem-Damerdji, L., Sarem, F., Marchal, L., Micolas, J.P. (1995). In vitro colonization ability of human colon mucosa by exogenous Lactobacillus strains. FEMS Microbiology Letters; 131(2):133-137. https://academic.oup.com/femsle/article-abstract/131/2/133/524865/In-vitro-colonization-ability-of-human-colon?redirectedFrom=PDF
  • Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of food science and technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0
  • Toscano, M., De Grandi, R., Stronati, L., De Vecchi, E., & Drago, L. (2017). Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study. World journal of gastroenterology, 23(15), 2696.
  • Underwood, M. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2015). Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatric research, 77, 229.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350908/

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3In today’s world the level of assault on our bodies from pollution, pathogens, and stress is so high that we need powerful food supplements.  Our bodies, after all, know exactly what and how to utilize food for therapeutic purposes.

At BioImmersion, we created the Therapeutic Food Supplement line with a new medical framework in mind: the power and intelligence of food. Our Therapeutic Foods are indeed potent food supplements that behave intelligenly in the body – repairing, healing, protecting and preventing.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Weight-Less

September 22, 2017

Dear Friends                                                                                                                                                      WL Low Cropped Jpeg

Recent research has shown the link between chronic hyperglycemia, oxidative stress, and weight gain. Hyperglycemia puts our body into a state of oxidative stress, which leads to many pathologies such as diabetes mellitus, obesity, cancer, and cardiovascular diseases (Domingueti et al., 2016).

Ingredients of Weight-Less per capsule

  • 7-Keto DHEA- 25mg (helps to burn fat)
  • 2 Brown Seaweed extracts- 200mg (help to lower and prevent high blood sugar levels, offers a strong anti-inflammatory, and supports weight loss)

Take 1 – 2 capsules of Weight-less one-half hour before meals, especially important before your carbohydrate (or meat) laden meals.* (See Green Facts on meat and diabetes)

Food Science

The ingredients in Weight-less have been shown to reduce both the states of hyperglycemia and oxidative stress. The Kelp and Bladderwrack polyphenol extracts (phlorotannins) offer organic-certified bioactive ingredients that (1) act on amylase and glucosidase enzymes to optimize post-meal blood glucose and insulin responses and (2) demonstrate that they have a high total antioxidant activity as verified by the Total ORAC 6.0 assay.

The phenols in the kelp and bladderwrack have superior antioxidant activity – a neutralizing effect – on the primary free radical superoxide anion. Superoxide  anion is known as the “mother of  free radicals” because  it also can become a hydroxyl ROS, a nitrogen RNS and a hydrogen peroxide ROS.

Thus, Weight-Less helps prevent post-meal hyperglycemia and has a direct scavenging action on excess free radical generation.  The key is not to totally neutralize all free radical activity but to bring about a healthy redox homeostasis.

References:

  • Domingueti, C. P., Dusse, L. M. S. A., das Graças Carvalho, M., de Sousa, L. P., Gomes, K. B., & Fernandes, A. P. (2016). Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. Journal of diabetes and its complications, 30(4), 738-745.
  • Hulsmans, M., & Holvoet, P. (2010). The vicious circle between oxidative stress and inflammation in atherosclerosis. Journal of cellular and molecular medicine, 14(1‐2), 70-78.
  • InterAct Consortium. (2013). Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study. Diabetologia, 56(1), 47-59
  • Gutowski, M., & Kowalczyk, S. (2013). A study of free radical chemistry: their role and pathophysiological significance. Acta Biochimica Polonica, 60(1), 1-16.
  • Valko, M., Rhodes, C., Moncol, J., Izakovic, M. M., & Mazur, M. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions, 160(1), 1-40.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3High meat intake is also shown in research to generate oxidatative stress and hyperglacemia. We will discuss this in another email but meanwhile, see Dr. Greger’s informative video on Why is meat a risk factor for diabetes?
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved