Inflammatory Support

Dear Friends

Our famous High ORAC Synbiotic is now 10 times more potent. What’s new?

HO PhotoFirst, we added our new advanced Probiotic Super Blend, naturally occuring whole probiotics with their Supernatant and ORNs (oligoribonucleotides). The five pedigreed lactic acid bacterial strains in our Supernatant Synbiotic are excellent as post antibiotic care.

We also added the supernatant of each of these five effective probiotics: The supernatant includes their healing metabolites, enzymes, vitamins, lactic acid, bacterocins, biosurfactants, bile salt hydrolase, and so much more.

The full-spectrum antioxidant activity component of High ORAC Synbiotic is a property of its new proprietary blend of fruit, berries and bioflavonoids.  A blend that successfully reduces the five major categories of free radicals- the hydroxyl, peroxyl, peroxynitrite, singlet oxygen, and superoxide anion.  It is standardized to a minimum total ORAC score of 40,000 umol Trolox equivalent (TE) per gram as measured by the ORAC 5.0 assay. That is 10 times more potent!

One capsule a day will do nicely.

Food Science

Studies are showing that dietary polyphenols contribute to the maintenance of intestinal health by preserving the gut microbial balance through the stimulation of the growth of beneficial bacteria such as Lactobacilli and Bifidobacteria while inhibiting that of pathogenic bacteria.

Dueñas et al.’s (2015) study, A survey of modulation of gut microbiota by dietary polyphenols, showed that the beneficial effects attributed to dietary polyphenols appear to be due more to phenolic metabolites formed in the gastrointestinal tract, mainly derived from the action of gut bacteria than to the original forms found in food.

This all occurs in the colon where the growth of good bacterial friends is enhanced by polyphenols while at the same time the beneficial attributes of the polyphenols are made possible by their reduction into shorter chain lengths by the enzymes of these good bacteria.  Making their antioxidant, antimicrobial, anti-inflammtory, healthy aging, cell signaling effects more bioavailable throughout the body.

Duda-Chodak et al. (2015) present possible pathways of polyphenol metabolism by intestinal bacteria and describe the diet-derived bioactive metabolites produced by gut microbiota, with a particular emphasis on polyphenols and their potential impact on human health.

We will talk much more about this in coming Forward Thinking newsletters.

References

Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., … & Bartolomé, B. (2015). A survey of modulation of gut microbiota by dietary polyphenols. BioMed research international2015. https://www.hindawi.com/journals/bmri/2015/850902/

Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015). Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition54(3), 325-341. https://link.springer.com/article/10.1007/s00394-015-0852-y

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The Game Changers  will introduce the world of elite athletes, special ops soldiers, visionary scientists, cultural icons and everyday heroes.  Each on a mission to create a seismic shift in the way we eat and live.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Our new ENERGY is here!

November 14, 2018

Dear Friends

We are very pleased to let you know that our new product, ENERGY– a combination of our plant Ultra Minerals plus the addition of apple extract – is here!

And, you are going to love it. Who doesn’t need more energy in their body today?  Energy provides clean, healthy energy that our body relies on to fuel all of its metabolic processes—ATP.

What is so exciting about Energy are the benefits shown in clinical human studies, by our collaborating scientists, using Energy’s exact ingredients and suggested doses.  Studies showed increases in strength, power, and stamina in adult atheletes, while in other trials with aged adults, a single treatment [of Energyat a serving of 150mg resulted in a significant increase of blood level of total ATP;  with no concomitant increase in blood ROS [free radicals] or serum lactate [lactic acid] and a reduction of total mTOR levels in blood under these experimental conditions (Reyes-Izquierdo et el., 2013).

ENERGY

Food Science

Joy et al.’s (2016) study, Ancient peat [ultra minerals] and apple extracts supplementation may improve strength and power adaptations in resistance trained men, aimed to determine the effects of a proprietary blend of ultra minerals derived from ancient peat and apple extracts on athletic performance. It was hypothesized that supplementation would improve strength and power over the duration of the training program as well as blunt a decrement in performance due to overreaching.

Overreaching is a training volume and/or intensity of exercise resulting in performance decrements.  In the state of overreaching, the adaptation capacity to training load is decreased.  In the state of overreaching one can not achieve optimal performance and is more susceptible to illness and injury.

Their conclusion was that the proprietary blend of plant ultra minerals and apple extracts (Energy) were capable of increasing lower body and total strength as well as lower body power output compared at an equal-volume, visually-identical placebo.  Moreover, the supplement was able to prevent performance decrements commonly associated with increased training volume and overreaching.

Suggested use: one capsule a day.

References

Reyes-Izquierdo, T., Nemzer, B., Argumedo, R., Shu, C., Huynh, L., & Pietrzkowski, Z. (2013). Effect of the dietary supplement ElevATP on blood ATP level: An acute pilot clinical study. J Aging Res Clin Practice, 2, 178-84.

Joy, J. M., Vogel, R. M., Moon, J. R., Falcone, P. H., Mosman, M. M., Pietrzkowski, Z., … & Kim, M. P. (2016). Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men. BMC complementary and alternative medicine, 16(1), 224.

Joy, J. M., Falcone, P. H., Vogel, R. M., Mosman, M. M., Kim, M. P., & Moon, J. R. (2015). Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men. Applied Physiology, Nutrition, and Metabolism, 40(11), 1171-1177.
Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The Game Changers  will introduce the world of elite athletes, special ops soldiers, visionary scientists, cultural icons and everyday heroes.  Each on a mission to create a seismic shift in the way we eat and live.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

What is the connection between the microbiome and heart heatlh? The microbiome’s metabolites are emerging as the deciding influence for good or bad health. We will dive into this topic in the next couple of weeks (check green facts below).

BG photoAs Dr. JoAnn Manson, professor of medicine at Harvard Medical School and chief of preventive medicine at Brigham and Women’s Hospital says in Healthy gut, Healthy Heart(2018):

There’s a complex interplay between the microbes in our intestines and most of the systems in our bodies, including the vascular, nervous, endocrine, and immune systems.  All of these relationships are highly relevant to cardiovascular health.

What we eat plays a major role in the composition of our gut microbiota.  And we’re learning more about how the substances gut microbes churn out (called metabolites) influence our risk for many chronic diseases, including diabetes, heart disease, and cancer.

The Beta Glucan High Potency Synbiotic: Cardio-Metabolic Support is a great product for seeding the gut with good pedigreed bacteria and prebiotic fibers that strongly support the integrity of the GI tract membrane, support the reduction of GI tract inflammation, support the strengthening and balancing of the immune system.

Probiotics are found in research to positively effect heart health (Kassaian et al., 2017; Sáez-Lara et al., 2016; DiRienzo, 2014; Delzenne et al., 2011; Saini et al., 2010), with many researchers positing the connection between heart and gut health (Serino et al., 2014; Huang et al., 2013).*

Oats and oat beta glucan have enjoyed a rich cultural historicity and extensive research on heart health (Andersson & Hellstrand, 2012).  Oats and oat beta glucan are found to reduce serum LDL cholesterol (Ho et al., 2016; Zhu et al., 2015; Whitehead et al., 2014; Wolever et al., 2010), improve liver function (Chang et al., 2013), and promote bowel regularity (Clemens, 2012; Mobley et al., 2014).*

Red beetroot offer a rich source of phyto-nutrients, including ascorbic acid (vitamin C), carotenoids, phenolic acids, and flavonoids. Beets provide a source of dietary nitrate, shown in research to have important implication for heart health (Kapil et al., 2014). Beet’s nutrients are shown to prevent oxidation of LDLs, lower triglycerides, and balances blood pressure (Clifford et al., 2015; Eggenbeen et al., 2016; Hobbs et al., 2013).*

Inulin from organic chicory root supplies food for the probiotic organisms. Probiotic organisms need fiber to grow and multiply. See Slavin (2013) on fiber as prebiotics, and Dehghan et al. (2013) on inulin and cardiovascular support.*  Together with probiotic, inulin is also found in research to help tighten cell junctions, which is thought to aid against leaky gut syndrome (Cani et al., 2007, 2007a, 2008, 2009).*

The Beta Glucan was formulated to nourish both heart and gut into health.*

Bibliography:

  • Kassaian, N., Aminorroaya, A., Feizi, A., Jafari, P., Amini, M. (2017). The effects of probiotic and synbiotic supplementation on metabolic syndrome indices in adults at risk of type 2 diabetes: study protocol for a randomized controlled trial. Trial, 18(1), 148. DOI: 10.1186/s13063-017-1885-8
  • Sáez-Lara, M.J., Robles-Sanchez, C., Ruiz-Ojeda, F.J., Plaza-Diaz, J., Gil, A.(2016). Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials. Int J Mol Sci, 17(6).DOI: 10.3390/ijms17060928
  • DiRienzo D.B. (2014). Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets. Nutr Rev, 72(1), 18-29. DOI: 10.1111/nure.12084
  • Delzenne, N.M., Neyrinck, A.M., Cani, P.D.(2011). Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact, 10 Suppl 1, S10. DOI: 10.1186/1475-2859-10-S1-S10
  • Saini, R., Saini, S., & Sharma, S. (2010). Potential of probiotics in controlling cardiovascular diseases. J.Cardiovasc Dis Res,1(4), 213-214. DOI: 10.4103/0975-3583.74267
  • Serino, M., Blasco-Baque, V., Nicolas, S., & Burcelin, R. (2014). Far from the Eyes, Close to the Heart: Dysbiosis of Gut Microbiota and Cardiovasuclar Consequences. Curr Cardiol Rep, 16(11), 540. DOI: 10.1007/s11886-014-0540-1
  • Huang, Y., Wang, X., Wang, J., Wu, F., Sui, Y., Yang, L., Wang, Z. (2013). Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. J Dairy Sci, 96(5), 2746-53.DOI: 10.3168/jds.2012-6123
  • Anderson, K.E., & Hellstrand, P. (2012). Dietary oats and modulation of atherogenic pathways. Mol Nutr Food Res, 56(7), 1003-13. DOI: 10.1002/mnfr.201100706
  • Ho, H.V., Sievenpiper, J.L., Zurbau, A., Blanco Mejia, S., Jovanovski, E., Au-Yeung, F… Vuksan, V. (2016). The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials. Br J Nutr. 116(8):1369-1382. DOI: 10.1017/S000711451600341X
  • Zhu, X., Sun, X., Wang, M., Zhang, C., Cao, Y., Mo, G., Liang, J., Zhu, S. (2015).Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects. Nutr Metab Cardiovasc Dis, 25(8), 714-23.DOI: 10.1016/j.numecd.2015.04.008
  • Whitehead A, Beck EJ, Tosh S, Wolever TM. (2014). Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 100(6), 1413-21.DOI: 10.3945/ajcn.114.086108


Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Healthy Gut, Healthy Heart:  How the trillions of bacteria in your intestinal tract play a role in your cardiovascular health.

Metabolomics—the study of metabolites—is an emerging scientific discipline of great importance for bettering our understanding of the connection of our GI tract microbiome and the health of our body. More on this topic next week.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

Reduce blood sugar levels with polyphenols!

Americans have a serious problem with chronic hyperglycemia.

Untreated hyperglycemia can cause long-term complications. These include:

  • Cardiovascular disease
  • Nerve damage (neuropathy)
  • Kidney damage (diabetic nephropathy) or kidney failure
  • Damage to the blood vessels of the retina (diabetic retinopathy), potentially leading to blindness
  • Clouding of the normally clear lens of your eye (cataract)
  • Feet problems caused by damaged nerves or poor blood flow that can lead to serious infections, and in some severe cases, amputation
  • Bone and joint problems
  • Skin problems, including bacterial infections, fungal infections and non-healing wounds
  • Teeth and gum infections

What are its causes?  There are multiple, and some may surprise you.

The diet for many Americans contains an overwhelming amount of carbohydrates, with a high proportion coming from added sugars.  To give you an idea, the annual added sugar intake has been reported to range from over 50 lb (median value) in the Dutch population to 142 lb in Americans (Wells & Buzby, 2008).

This means that almost every meal is followed by hyperglycemic conditions.  Recent studies indicate that hyperglycemia induces overproduction of Superoxide Anion (O2-) by the mitochondrial electron transport chain (Node & Inoue, 2009).  O2- is known as a primary free radical, because it converts either spontaneously or through enzymatic assistance into H2O2, peroxynitrite or hydroxyl radical (Gutowski & Kowalczyk, 2014).

Intervention aiming to reduce postprandial hyperglycemia are thus believed to benefit health through prevention of oxidative stress from glucose-overloaded mitochondria.

No. 4 Systemic Booster: Weight-less accomplishes this in two ways: WL Photo 2

  • It contains a powerful mix of wild crafted brown seaweed extracts of Ascophyllum nodosum (kelp) and Fucus vesiculosus (bladderwrack) along with 7-Keto DHEA.
  • These phlorotannin extracts are a class of polyphenols found exclusively in brown seaweed that act on amylase and glucosidase enzymes to optimize post-meal blood glucose and insulin responses.
  • Brown seaweed phlorotannins have a high Total ORAC and the extracts in Weight-less showed the highest antioxidant potency against superoxide anion of all antioxidants tested.
  • Dosage:  take one capsule 20 minutes before your meals.

Since post-meal glycemic fluctuations lead to oxidative stress, these results suggest that Weight-less could have a superior action against free radicals by preventing post-meal hyperglycemia as well as having a direct scavenging action.

References

  • Gutowski, M., & Kowalczyk, S. (2013). A study of free radical chemistry: their role and pathophysiological significance. Acta Biochimica Polonica, 60(1).
  • Node, K., & Inoue, T. (2009). Postprandial hyperglycemia as an etiological factor in vascular failure. Cardiovascular Diabetology, 8(1), 23.
  • Roy, M. C., Anguenot, R., Fillion, C., Beaulieu, M., Bérubé, J., & Richard, D. (2011). Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo. Food research international, 44(9), 3026-3029.
  • Wells, H. F., & Buzby, J. C. (2008). Dietary assessment of major trends in US food consumption, 1970-2005. Washington: US Department of Agriculture, Economic Research Service.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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In our next Forward Thinking newsletter we will look at how fat causes insulin resistance and therefore hyperglycemia.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Phenols and Oncogenes

February 19, 2018

Dear Friends

Phyto Power:  Supports DNA and cellular integrity during oncogenic treatment due to
its potent antioxidant, anti-inflammatory, and antimicrobial properties.Phyto Power Photo 3

Food Science
  • DNA & Cellular Integrity: Blueberries, rose hip, and dandelion are shown in research to help maintain cellular integrity, suppressing or interfering with oncogenic transformation, bolstering antioxidant and anti-inflammatory defenses, and contributing significant re-generative health benefits to the brain and nervous system (Jedrejek et al., 2017; Jiménez et al., 2016; Skrovankova et al., 2015; Joseph et al., 2014; Liu et al., 2013; Andersson et al., 2012; Chatterjee et al., 2011; Adams et al., 2010).*
  • Anti-Inflammation: García-Lafuente et al. (2009) conclude that flavonoids from berries and plants behave as anti-inflammatory agents in our body. Blueberries are rich with anthocyanins and a wide variety of phytochemicals that have been shown to effect neuro-regeneration in the brain (Albarracin et al., 2012).*
  • Energy & Weight-Loss: Dandelion is shown to have a great antioxidant activity (Hu et al., 2003), exhibiting diverse biological activities that promote energy, weight loss, and reduced risk of metabolic syndrome (Jedrejek et al., 2017; González-Castejón et al., 2012; Jeon et al., 2008). The Rose hip has a rich phytochemical profile known for its antioxidant protection (Widen et al., 2012), supporting weight loss with a potential mechanism that decreases abdominal visceral fat (Nagatomo et al., 2015).*

Added Suggestion: Combine with the Original Synbiotic to bolster immune support. Add also the greenest food, Organic Chlorella, to support detox mechanism and immunity.

References

  • Adams, L.S., Phung, S. Yee, N., Sheeram, N.P., Li, L., & Chen, S. (2010).Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, 70(9), 3594-605.DOI: 10.1158/0008-5472.CAN-09-3565
  • Albarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J….Barreto, G.E. (2012). Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci, 15, 1-9. DOI: 10.1179/1476830511Y.0000000028
  • Andersson, U., Berger, K., Hogberg, A., Landin-Olsson, M., & Holm, C. (2012). Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr, 66, 585-590. DOI: 10.1038/ejcn.2011.203
  • Chatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., & Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evid Based Complement Alternat Med, 129045.DOI: 10.1155/2011/129045
  • Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI: 10.3402/ijch.v72i0.21188
  • García-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M.A., & Martínez, J.A. (2009). Flavonoids as antiinflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res, 58, 537-552. DOI: 10.1007/s00011-009-0037-3
  • Hu, C., & Kitts, D.D. (2003). Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro. Journal of Agricultural and Food Chemistry, 51, (1), 301-310.DOI: 10.1021/jf0258858
  • Jeon, H.J., Kang, H. J., JungH.J. Kant, Y.S., Lim, C.J., Kim, Y.M., & Park, E.H. (2008). Anti-inflammatory activity of Taraxacum officinale. Journal of Ethnopharmacology, 115 (1), 82-88. DOI: 10.1016/j.jep.2007.09.006
  • Jeyabalan, J., Aqil, F., Munagala, R., Annamalai, L., Vadhanam, M.V., Gupta, R.C. (2014). Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer.J. Agric. Food Chem, 62, 3963-3971. DOI: 10.1021/jf403734j
  • Jiménez, S., Gascón, S., Luquin, A., Laguna, M., Ancin-Azpilicueta, C., Rodríguez-Yoldi, M.J. (2016). Rosa canina Extracts Have Antiproliferative and Antioxidant Effects on Caco-2 Human Colon Cancer. PLoS One, 11(7), e0159136. https://doi.org/10.1371/journal.pone.0159136
  • Joseph, S.V., Edirisinghe, I., & Burton-Freeman, B.M. (2014). Berries: anti-inflammatory effects in humans. J Agric Food Chem, 7; 62(18), 3886-903. DOI:10.1021/jf4044056
  • Liu, W., Lu, X., He, G., Gao, X., Xu, M., Zhang, J… Luo, C. (2013). Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Int Mol Sci, 14(11), 21447-62. DOI: 10.3390/ijms141121447
  • Nagatomo, A., Nishida, N., Fukuhara, I., Noro, A., Kozai, Y., Sato, H., & Matsuura, Y. (2015). Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial. Diabetes Metab Syndr Obes, 8, 147-156.DOI: 10.2147/DMSO.S78623
  • Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., Sochor, J.(2015). Bioactive Compounds and Antioxidant Activity in Different Types of Berries.Int J Mol Sci, 16(10), 24673-706. doi: 10.3390/ijms161024673
  • Widen, C., Ekholm, A., Coleman, M.D., Renvert, S., Rumpunen, K. (2012). Erythrocyte antioxidant protection of rose hips (Rosa spp.) Oxid Med Cell Longev, 621579. http://dx.doi.org/10.1155/2012/621579 .

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Phyto Power is indeed powerful. In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.*
 

©2005 – 2018 BioImmersion Inc. All Rights Reserved