Inflammatory Support

Dear Friends

What is the connection between the microbiome and heart heatlh? The microbiome’s metabolites are emerging as the deciding influence for good or bad health. We will dive into this topic in the next couple of weeks (check green facts below).

BG photoAs Dr. JoAnn Manson, professor of medicine at Harvard Medical School and chief of preventive medicine at Brigham and Women’s Hospital says in Healthy gut, Healthy Heart(2018):

There’s a complex interplay between the microbes in our intestines and most of the systems in our bodies, including the vascular, nervous, endocrine, and immune systems.  All of these relationships are highly relevant to cardiovascular health.

What we eat plays a major role in the composition of our gut microbiota.  And we’re learning more about how the substances gut microbes churn out (called metabolites) influence our risk for many chronic diseases, including diabetes, heart disease, and cancer.

The Beta Glucan High Potency Synbiotic: Cardio-Metabolic Support is a great product for seeding the gut with good pedigreed bacteria and prebiotic fibers that strongly support the integrity of the GI tract membrane, support the reduction of GI tract inflammation, support the strengthening and balancing of the immune system.

Probiotics are found in research to positively effect heart health (Kassaian et al., 2017; Sáez-Lara et al., 2016; DiRienzo, 2014; Delzenne et al., 2011; Saini et al., 2010), with many researchers positing the connection between heart and gut health (Serino et al., 2014; Huang et al., 2013).*

Oats and oat beta glucan have enjoyed a rich cultural historicity and extensive research on heart health (Andersson & Hellstrand, 2012).  Oats and oat beta glucan are found to reduce serum LDL cholesterol (Ho et al., 2016; Zhu et al., 2015; Whitehead et al., 2014; Wolever et al., 2010), improve liver function (Chang et al., 2013), and promote bowel regularity (Clemens, 2012; Mobley et al., 2014).*

Red beetroot offer a rich source of phyto-nutrients, including ascorbic acid (vitamin C), carotenoids, phenolic acids, and flavonoids. Beets provide a source of dietary nitrate, shown in research to have important implication for heart health (Kapil et al., 2014). Beet’s nutrients are shown to prevent oxidation of LDLs, lower triglycerides, and balances blood pressure (Clifford et al., 2015; Eggenbeen et al., 2016; Hobbs et al., 2013).*

Inulin from organic chicory root supplies food for the probiotic organisms. Probiotic organisms need fiber to grow and multiply. See Slavin (2013) on fiber as prebiotics, and Dehghan et al. (2013) on inulin and cardiovascular support.*  Together with probiotic, inulin is also found in research to help tighten cell junctions, which is thought to aid against leaky gut syndrome (Cani et al., 2007, 2007a, 2008, 2009).*

The Beta Glucan was formulated to nourish both heart and gut into health.*

Bibliography:

  • Kassaian, N., Aminorroaya, A., Feizi, A., Jafari, P., Amini, M. (2017). The effects of probiotic and synbiotic supplementation on metabolic syndrome indices in adults at risk of type 2 diabetes: study protocol for a randomized controlled trial. Trial, 18(1), 148. DOI: 10.1186/s13063-017-1885-8
  • Sáez-Lara, M.J., Robles-Sanchez, C., Ruiz-Ojeda, F.J., Plaza-Diaz, J., Gil, A.(2016). Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials. Int J Mol Sci, 17(6).DOI: 10.3390/ijms17060928
  • DiRienzo D.B. (2014). Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets. Nutr Rev, 72(1), 18-29. DOI: 10.1111/nure.12084
  • Delzenne, N.M., Neyrinck, A.M., Cani, P.D.(2011). Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact, 10 Suppl 1, S10. DOI: 10.1186/1475-2859-10-S1-S10
  • Saini, R., Saini, S., & Sharma, S. (2010). Potential of probiotics in controlling cardiovascular diseases. J.Cardiovasc Dis Res,1(4), 213-214. DOI: 10.4103/0975-3583.74267
  • Serino, M., Blasco-Baque, V., Nicolas, S., & Burcelin, R. (2014). Far from the Eyes, Close to the Heart: Dysbiosis of Gut Microbiota and Cardiovasuclar Consequences. Curr Cardiol Rep, 16(11), 540. DOI: 10.1007/s11886-014-0540-1
  • Huang, Y., Wang, X., Wang, J., Wu, F., Sui, Y., Yang, L., Wang, Z. (2013). Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. J Dairy Sci, 96(5), 2746-53.DOI: 10.3168/jds.2012-6123
  • Anderson, K.E., & Hellstrand, P. (2012). Dietary oats and modulation of atherogenic pathways. Mol Nutr Food Res, 56(7), 1003-13. DOI: 10.1002/mnfr.201100706
  • Ho, H.V., Sievenpiper, J.L., Zurbau, A., Blanco Mejia, S., Jovanovski, E., Au-Yeung, F… Vuksan, V. (2016). The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials. Br J Nutr. 116(8):1369-1382. DOI: 10.1017/S000711451600341X
  • Zhu, X., Sun, X., Wang, M., Zhang, C., Cao, Y., Mo, G., Liang, J., Zhu, S. (2015).Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects. Nutr Metab Cardiovasc Dis, 25(8), 714-23.DOI: 10.1016/j.numecd.2015.04.008
  • Whitehead A, Beck EJ, Tosh S, Wolever TM. (2014). Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 100(6), 1413-21.DOI: 10.3945/ajcn.114.086108


Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

Healthy Gut, Healthy Heart:  How the trillions of bacteria in your intestinal tract play a role in your cardiovascular health.

Metabolomics—the study of metabolites—is an emerging scientific discipline of great importance for bettering our understanding of the connection of our GI tract microbiome and the health of our body. More on this topic next week.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

Reduce blood sugar levels with polyphenols!

Americans have a serious problem with chronic hyperglycemia.

Untreated hyperglycemia can cause long-term complications. These include:

  • Cardiovascular disease
  • Nerve damage (neuropathy)
  • Kidney damage (diabetic nephropathy) or kidney failure
  • Damage to the blood vessels of the retina (diabetic retinopathy), potentially leading to blindness
  • Clouding of the normally clear lens of your eye (cataract)
  • Feet problems caused by damaged nerves or poor blood flow that can lead to serious infections, and in some severe cases, amputation
  • Bone and joint problems
  • Skin problems, including bacterial infections, fungal infections and non-healing wounds
  • Teeth and gum infections

What are its causes?  There are multiple, and some may surprise you.

The diet for many Americans contains an overwhelming amount of carbohydrates, with a high proportion coming from added sugars.  To give you an idea, the annual added sugar intake has been reported to range from over 50 lb (median value) in the Dutch population to 142 lb in Americans (Wells & Buzby, 2008).

This means that almost every meal is followed by hyperglycemic conditions.  Recent studies indicate that hyperglycemia induces overproduction of Superoxide Anion (O2-) by the mitochondrial electron transport chain (Node & Inoue, 2009).  O2- is known as a primary free radical, because it converts either spontaneously or through enzymatic assistance into H2O2, peroxynitrite or hydroxyl radical (Gutowski & Kowalczyk, 2014).

Intervention aiming to reduce postprandial hyperglycemia are thus believed to benefit health through prevention of oxidative stress from glucose-overloaded mitochondria.

No. 4 Systemic Booster: Weight-less accomplishes this in two ways: WL Photo 2

  • It contains a powerful mix of wild crafted brown seaweed extracts of Ascophyllum nodosum (kelp) and Fucus vesiculosus (bladderwrack) along with 7-Keto DHEA.
  • These phlorotannin extracts are a class of polyphenols found exclusively in brown seaweed that act on amylase and glucosidase enzymes to optimize post-meal blood glucose and insulin responses.
  • Brown seaweed phlorotannins have a high Total ORAC and the extracts in Weight-less showed the highest antioxidant potency against superoxide anion of all antioxidants tested.
  • Dosage:  take one capsule 20 minutes before your meals.

Since post-meal glycemic fluctuations lead to oxidative stress, these results suggest that Weight-less could have a superior action against free radicals by preventing post-meal hyperglycemia as well as having a direct scavenging action.

References

  • Gutowski, M., & Kowalczyk, S. (2013). A study of free radical chemistry: their role and pathophysiological significance. Acta Biochimica Polonica, 60(1).
  • Node, K., & Inoue, T. (2009). Postprandial hyperglycemia as an etiological factor in vascular failure. Cardiovascular Diabetology, 8(1), 23.
  • Roy, M. C., Anguenot, R., Fillion, C., Beaulieu, M., Bérubé, J., & Richard, D. (2011). Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo. Food research international, 44(9), 3026-3029.
  • Wells, H. F., & Buzby, J. C. (2008). Dietary assessment of major trends in US food consumption, 1970-2005. Washington: US Department of Agriculture, Economic Research Service.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

In our next Forward Thinking newsletter we will look at how fat causes insulin resistance and therefore hyperglycemia.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Phenols and Oncogenes

February 19, 2018

Dear Friends

Phyto Power:  Supports DNA and cellular integrity during oncogenic treatment due to
its potent antioxidant, anti-inflammatory, and antimicrobial properties.Phyto Power Photo 3

Food Science
  • DNA & Cellular Integrity: Blueberries, rose hip, and dandelion are shown in research to help maintain cellular integrity, suppressing or interfering with oncogenic transformation, bolstering antioxidant and anti-inflammatory defenses, and contributing significant re-generative health benefits to the brain and nervous system (Jedrejek et al., 2017; Jiménez et al., 2016; Skrovankova et al., 2015; Joseph et al., 2014; Liu et al., 2013; Andersson et al., 2012; Chatterjee et al., 2011; Adams et al., 2010).*
  • Anti-Inflammation: García-Lafuente et al. (2009) conclude that flavonoids from berries and plants behave as anti-inflammatory agents in our body. Blueberries are rich with anthocyanins and a wide variety of phytochemicals that have been shown to effect neuro-regeneration in the brain (Albarracin et al., 2012).*
  • Energy & Weight-Loss: Dandelion is shown to have a great antioxidant activity (Hu et al., 2003), exhibiting diverse biological activities that promote energy, weight loss, and reduced risk of metabolic syndrome (Jedrejek et al., 2017; González-Castejón et al., 2012; Jeon et al., 2008). The Rose hip has a rich phytochemical profile known for its antioxidant protection (Widen et al., 2012), supporting weight loss with a potential mechanism that decreases abdominal visceral fat (Nagatomo et al., 2015).*

Added Suggestion: Combine with the Original Synbiotic to bolster immune support. Add also the greenest food, Organic Chlorella, to support detox mechanism and immunity.

References

  • Adams, L.S., Phung, S. Yee, N., Sheeram, N.P., Li, L., & Chen, S. (2010).Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, 70(9), 3594-605.DOI: 10.1158/0008-5472.CAN-09-3565
  • Albarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J….Barreto, G.E. (2012). Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci, 15, 1-9. DOI: 10.1179/1476830511Y.0000000028
  • Andersson, U., Berger, K., Hogberg, A., Landin-Olsson, M., & Holm, C. (2012). Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr, 66, 585-590. DOI: 10.1038/ejcn.2011.203
  • Chatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., & Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evid Based Complement Alternat Med, 129045.DOI: 10.1155/2011/129045
  • Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI: 10.3402/ijch.v72i0.21188
  • García-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M.A., & Martínez, J.A. (2009). Flavonoids as antiinflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res, 58, 537-552. DOI: 10.1007/s00011-009-0037-3
  • Hu, C., & Kitts, D.D. (2003). Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro. Journal of Agricultural and Food Chemistry, 51, (1), 301-310.DOI: 10.1021/jf0258858
  • Jeon, H.J., Kang, H. J., JungH.J. Kant, Y.S., Lim, C.J., Kim, Y.M., & Park, E.H. (2008). Anti-inflammatory activity of Taraxacum officinale. Journal of Ethnopharmacology, 115 (1), 82-88. DOI: 10.1016/j.jep.2007.09.006
  • Jeyabalan, J., Aqil, F., Munagala, R., Annamalai, L., Vadhanam, M.V., Gupta, R.C. (2014). Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer.J. Agric. Food Chem, 62, 3963-3971. DOI: 10.1021/jf403734j
  • Jiménez, S., Gascón, S., Luquin, A., Laguna, M., Ancin-Azpilicueta, C., Rodríguez-Yoldi, M.J. (2016). Rosa canina Extracts Have Antiproliferative and Antioxidant Effects on Caco-2 Human Colon Cancer. PLoS One, 11(7), e0159136. https://doi.org/10.1371/journal.pone.0159136
  • Joseph, S.V., Edirisinghe, I., & Burton-Freeman, B.M. (2014). Berries: anti-inflammatory effects in humans. J Agric Food Chem, 7; 62(18), 3886-903. DOI:10.1021/jf4044056
  • Liu, W., Lu, X., He, G., Gao, X., Xu, M., Zhang, J… Luo, C. (2013). Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Int Mol Sci, 14(11), 21447-62. DOI: 10.3390/ijms141121447
  • Nagatomo, A., Nishida, N., Fukuhara, I., Noro, A., Kozai, Y., Sato, H., & Matsuura, Y. (2015). Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial. Diabetes Metab Syndr Obes, 8, 147-156.DOI: 10.2147/DMSO.S78623
  • Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., Sochor, J.(2015). Bioactive Compounds and Antioxidant Activity in Different Types of Berries.Int J Mol Sci, 16(10), 24673-706. doi: 10.3390/ijms161024673
  • Widen, C., Ekholm, A., Coleman, M.D., Renvert, S., Rumpunen, K. (2012). Erythrocyte antioxidant protection of rose hips (Rosa spp.) Oxid Med Cell Longev, 621579. http://dx.doi.org/10.1155/2012/621579 .

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Phyto Power is indeed powerful. In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.*
 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends
HO Front Low Rez
Berry phenolics selectively inhibit the growth of intestinal pathogens.

Such is the title of Puupponen‐Pimiä et al.’s (2005) research on berry phenolics.  The purpose of the their study was to determine the effects of berries and berry phenolics on selected pathogenic gastrointestinal bacteria and to identify single phenolic compounds possessing antimicrobial activity.

Phenolic’s antimicrobial activity has gained importance as phenolic berry extracts inhibit the growth of selected Gram-negative intestinal bacteria and are not active against Gram-positive beneficial probiotic lactic acid bacteria (Puupponen-Pimiä et al. 2001).

The study includes a selection of Scandanavian berries whose collective polyphenolic content is similiar to what is present in the offering in our High ORAC Synbiotic.

The outcome of the study showed that Staphlococcus, E coli, Salmonella were inhibited, while lactic acid bacteria such as L. rhamnosus was not effected.  This is particularly important because the increased incidence of antibiotic resistant strains of the above pathogens.  Staph. aureus, the most dangerous of drug resistant pathogens was well inhibited by this collection (Puupponen‐Pimiä, 2005).

BioImmersion’s High ORAC Synbiotic powerfully mixes polyphenols with Lactobacillus and Bifidobacterium species.

Per capsule: A minimum of 25 billion CFU (Colony Forming Units) of probiotics and a high ORAC (Oxygen Radical Absorbent Capacity) score of 3000 from the berry phenolics.  The extracts include blueberry, bilberry and grape seed extracts along with other whole berries, quercetin and resveratrol.

High ORAC final 2

References

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The modulation of the gut microbiome composition by alteration of food habits has potentialities in health improvement or even disease prevention.

Polyphenols are extensively metabolized by gut bacteria into a complex series of end-products that support a significant effect on the functional ecology of symbiotic partners that can affect the host physiology.

Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research, 11(10), 4781-4790. http://pubs.acs.org/doi/abs/10.1021/pr300581s.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends
HO Front Low Rez
Recent studies show that dietary polyphenols support the growth of good bacteria in the gut while inhibiting pathogenic bacteria.

Dueñas et al.’s (2015) study entitled, A survey of modulation of gut microbiota by dietary polyphenols, showed that dietary polyphenols contribute to the maintenance of intestinal health by preserving the gut microbial balance through the stimulation of beneficial bacteria (i.e., Lactobacilli and Bifidobacteria) and the inhibition of pathogenic bacteria, exerting prebiotic-like effects.

One of the many beneficial effects attributed to dietary polphenols is due to phenolic metabolites formed in the gastrointestinal tract through the interaction with good lactic acid bacteria. The outcome is the formation of more good bacteria and the inhibition of various pathogenic bacteria and yeast.

BioImmersion’s High ORAC Synbiotic powerfully mixes polyphenols with Lactobacillus and Bifidobacterium species. Per capsule: A minimum a 25 billion probiotics and a high ORAC score of 3000.


High ORAC final 2

References

  • Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015). Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition54(3), 325-341. https://link.springer.com/article/10.1007/s00394-015-0852-y
  • Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., … & Bartolomé, B. (2015). A survey of modulation of gut microbiota by dietary polyphenols. BioMed research international2015. https://www.hindawi.com/journals/bmri/2015/850902/
  • Gupta, A., Dwivedi, M., Mahdi, A. A., Gowda, G. N., Khetrapal, C. L., & Bhandari, M. (2012). Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin. Urological research, 40(2), 143-150. https://link.springer.com/article/10.1007/s00240-011-0398-2
  • Heinonen, M. (2007). Antioxidant activity and antimicrobial effect of berry phenolics–a Finnish perspective. Molecular nutrition & food research, 51(6), 684-691. http://onlinelibrary.wiley.com/doi/10.1002/mnfr.200700006/full
  • Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research, 11(10), 4781-4790. http://pubs.acs.org/doi/abs/10.1021/pr300581s
  • Nohynek, L. J., Alakomi, H. L., Kähkönen, M. P., Heinonen, M., Helander, I. M., Oksman-Caldentey, K. M., & Puupponen-Pimiä, R. H. (2006). Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens. Nutrition and cancer, 54(1), 18-32.
  • Puupponen‐Pimiä, R., Nohynek, L., Hartmann‐Schmidlin, S., Kähkönen, M., Heinonen, M., Määttä‐Riihinen, K., & Oksman‐Caldentey, K. M. (2005). Berry phenolics selectively inhibit the growth of intestinal pathogens. Journal of applied microbiology, 98(4), 991-1000.
    http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2672.2005.02547.x/full

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The modulation of the gut microbiome composition by alteration of food habits has potentialities in health improvement or even disease prevention.

Polyphenols are extensively metabolized by gut bacteria into a complex series of end-products that support a significant effect on the functional ecology of symbiotic partners that can affect the host physiology.

Moco, S., Martin, F. P. J., & Rezzi, S. (2012). Metabolomics view on gut microbiome modulation by polyphenol-rich foods. Journal of proteome research, 11(10), 4781-4790. http://pubs.acs.org/doi/abs/10.1021/pr300581s.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved