Healthy Aging Support

Dear Friends

Parkinson’s is a neurological disease characterized by mitochondrial dysfunction and oxidative stress in the dopaminergic neurons of the mid brain, causing them to die, resulting in motor dysfunction.

Parkinson’s (PD) has been positively associated with two groups of pesticides, those that impair mitochondrial function and those that increase oxidative stress.  Two such pesticides are paraquat, which causes oxidative stress, and rotenone, which inhibits mitochondrial complex I, both induce loss of nigral dopaminergic neurons and behavioral changes associated with human PD.

Epidemiological findings suggest that the consumption of berries rich in anthocyanins and proanthocyanidins may reduce PD risk.  Strathearn et al. (2014) demonstrated powerful protective effects of blueberry extract in protecting the neurons from the oxidative damage of the pesticides.  In their study, they investigated whether extracts rich in anthocyanins, proanthocyanidins, or other polyphenols, suppress the neurotoxic effects of rotenone in a primary cell culture model of PD.

Extracts rich in anthocyanins and proanthocyanidins exhibited greater neuroprotective activity than extracts rich in other polyphenols, and a number of individual anthocyanins interfered with rotenone neurotoxicity.  The blueberry and grape seed extracts rescued rotenone-induced defects in mitochondrial respiration in a dopaminergic cell line.

Dr. Mary Ann Lila, one of the study’s team of scientists, and the director of North Carolina State University’s Plants for Human Health Institute stated:

Blueberries have both of these natural chemicals (anthocyanins and proanthocyanidins) in high concentrations, so they pack a more powerful, one-two punch.  They can have synergistic benefits that surpass many other fruits when it comes to protection against brain cell death, which in turn may reduce the risk of contracting Parkinson’s.(Moore, 2014)

A cup a day is a good routine for health, according to Lila, and it provides abundant amounts of vitamins A and C, fiber, manganese and phytonutrients, which have antioxidant and anti-inflammatory properties.  Blueberries are also a “brain food”, and have been shown to increase powers of concentration and slow cognitive degeneration.

Our  Blueberry Extract (1 capsule) has a cup and a quarter of blueberries, while the Phyto Power (2 capsules) has 200mg of four species of wild harvested blueberries plus 400 mg of rosehips with their powerful collection of flavonoids including proanthocyanidins.

We will focus on these cognitive benefits in our next Forward Thinking.

References

Moore, J. (2014). Blueberries reduce risk of Parkinson’s, boost brain function finds new study. Plants for human health institute, NC State. Article

Strathearn, K. E., Yousef, G. G., Grace, M. H., Roy, S. L., Tambe, M. A., Ferruzzi, M. G., … & Rochet, J. C. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson׳ s disease. Brain research, 1555, 60-77. Article

Tanner, C. M., Kamel, F., Ross, G. W., Hoppin, J. A., Goldman, S. M., Korell, M., … & Comyns, K. (2011). Rotenone, paraquat, and Parkinson’s disease. Environmental health perspectives, 119(6), 866-872. Article

Best,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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It is estimated that one million people suffer from Parkinson’s in the U.S., and although the disease itself is not fatal, complications arising from it can be, and the CDC states that these co-morbidities result in it being the 14th leading cause of death in the country (National Parkinson Foundation).

 

©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

Last week one of our doctors reported the following successful protocol for a new patient with a declining condition of Parkinson’s Disease (PD).  The patient could barely walk.

After analysis, the doctor added these three products:

After two months the patient is now walking 4 miles a day.  And was having increasingly long stretches where she was feeling very well.

Gao et al., (2012) found that daily intake of dietary flavonoids lowers the risk of developing Parkinson disease in a large cohort of 49,281 men and 80,336 women that were followed for 20-22 years.  In general, high amounts of flavonoids, such as anthocyanins, quercetin, epicatechin, and proanthocyanidins were found to be protective. People who eat less blueberries and strawberries are more likely to develop PD. During that time 438 men and 367 women developed Parkinson Disease. Other studies show that blueberry and strawberry extracts increase dopamine release alleviating oxidative stress and suppressing neuroinflammation (Balk et al., 2006).

A number of factors play into the risk reduction or even a turnaround into better health: researchers have known for a long time that more fiber and lower animal fats reduce the risk of PD (Renoudet et al, 2012). The combination of fiber, probiotics (to produce L-dopa), and polyphenols in the Beta Glucan and No 7 all play part in the healthy functioning of our nervous system.

Our protocols add the Phyto Power and Blueberry Extract for a powerful addition of polyphenols. We’ll discuss these two products in our next email.

References

Balk, E., Chung, M., Raman, G., Tatsioni, A., Chew, P., Ip, S., … & Lau, J. (2006). B vitamins and berries and age-related neurodegenerative disorders. Evid Rep Technol Assess (Full Rep), 134, 1-161.

Gao, X., Cassidy, A., Schwarzschild, M. A., Rimm, E. B., & Ascherio, A. (2012). Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology, 78(15), 1138-1145.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320056/

Renoudet, V. V., Costa-Mallen, P., & Hopkins, E. (2012). A diet low in animal fat and rich in N-hexacosanol and fisetin is effective in reducing symptoms of Parkinson’s disease. Journal of medicinal food, 15(8), 758-761.

Best,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The ultimate serious drink, the No 7 Longevity is bursting with a vital assortment of green leafy and hardy vegetables, fruits and berries concentrates, the BioImmersion Super Blend of naturally occurring whole probiotics with their supernatant and ORNS, fiber, and purposely selected nutriceuticals. The No 7 is defiantly powerful.*

 

©2005 – 2019 BioImmersion Inc. All Rights Reserved

Dear Friends

The scientific field of Longevity studies the forces that create chronic disease globally and the method that can reverse and prevent these illnesses.  We created potent formulas based on their studies and findings.

Immunosenescence and inflammageing are two key causative forces that are linked with the diseases of our time—metabolic syndrome, obesity, diabetes, heart disease, cancer, neurological disease, and other NCDs (Calder et al., 2017).

Franceschi (2014) has coined the term, Inflammageing:  As we age the concentration of pro inflammatory molecules increase in our blood stream—including acute phase proteins (CRP and serum amyloid A), cytokines (TNF-α, IL-1β, IL-6, IL-8), and adhesion molecules (sICAM-1 and sVCAM-1) amongst others.  The key to reversing chronic diseases and attaining a healthy life and longevity is to have plenty of anti-inflammatory molecules aboard and this can be attained through a specific diet and supplementation.

Immunosenescence:  One common characteristic of ageing is a decline in innate and acquired immune function, called immunosenescence, which increases ones susceptibility to infection.  The preserving of a healthy and strong immune system can be prolonged through a healthy anti-inflammatory food supplementation that turns on our endogenous antioxidant producing genes and networks; as well as to providing the kinds of fiberous and polyphenol rich foods that promote the development of a healthy, life- supporting gut microbiome.

BioImmersion’s Therapeutic Food Supplements are designed to mitigate micro-macro inflammation, the chronic low-grade inflammation (LGI) that is linked to our toughest chronic illnesses. Each formula is built with potent ingredients, concentrated foods that are highly researched as well as probiotics with their supernatant and ORNs (Holscher, 2017).

Call or email us to continue this conversation.

References:

Calder, P. C., Bosco, N., Bourdet-Sicard, R., Capuron, L., Delzenne, N., Doré, J., … & Visioli, F. (2017). Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing research reviews40, 95-119. Article

Franceschi, C., & Campisi, J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences69(Suppl_1), S4-S9. Article

Holscher, H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes8(2), 172-184. https://doi.org/10.1080/19490976.2017.1290756

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

 

Green Facts:

Globe_Home 3

The ultimate serious drink, the No 7 Longevity is bursting with a vital assortment of green leafy and hardy vegetables, fruits and berries concentrates, the BioImmersion Super Blend of naturally occurring whole probiotics with their supernatant and ORNS, fiber, and purposely selected nutriceuticals. The No 7 is defiantly powerful.*

 

©2005 – 2019 BioImmersion Inc. All Rights Reserved

The Chromium is here!

January 9, 2019

Dear Doctor

Our new Chromium has arrived!

The formula 9 times stronger, with 50mcg of elemental trivalent chromium per capsule (6mcg in the old chromium), and with high active beet root, standardized to 10,000ppm nitrate.

The new Chromium is also trivalent:  the ligand on each of the chromium ion ports is a molecule of nicotinic acid (in other words, niacin), in contrast to the nucleotide sugars from brewers’ yeast.

The supplemental facts on the label lists only the weight of the elemental chromium (50mcg), rather than the whole Chromium polynicotinate molecule, which is 500mcg.

The High Active Beet Root is also very powerful: it is standardized to offer a minimum of 10,000ppm plant nitrate. Our bodies convert plant nitrate into nitric oxide, an important nutrient that relaxes blood vessel muscles, opening up circulation. And of course, the high active beet root offers betalains, a unique polyphenolic molecule in beet root with very strong antioxidant, antimicrobial, and anti-inflammatory properties.

Chromium Label Jpeg

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

In this fascinating website you can watch the numbers of births and the number of deaths growth in real time.  See Current World Population.  With the increasing numbers of people reaching sennescense and the mounting pandemic of chronic degenerative diseases, we need a sea-change in how we feed ourselves, to one that brings healthy longevity.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Inflammation and Aging

January 2, 2019

Dear Friends,

Let’s continue our discussion on achieving longevity: What are the reason(s) behind the design of the No 7 New Longevity?

We defined longevity as a healthy state, free from  chronic illnesses.

The global numbers for chronic illnesses are alarming: chronic diseases are responsible for about 35 million deaths each year (United Nations, Ageing, 2017; Living Well, Dying Well, Chronic Illnesses, 2018, p. 119).

In the United States, 85% of people who are over 65 years of age suffer from one or two chronic illnesses, and nearly a quarter of children that are under 17 years old suffer one or more chronic conditions, with almost half of young to mature adults (18 to 64 years old) having one or more chronic illnesses (2018, Living Well, Dying Well, p. 120). That means that about a half of our population is constantly dealing with chronic conditions. On one hand, our life span has increased, but on the other hand, healthy longevity seems very far off the radar for people here and the world.

Did you realize that we actually have known that inflammation is a slowly debilitating killer since the late 1800s? Already in 1913, Dr. Arnold Lorand seminal work, Health and Longevity through Rational Diet, summarized the connection between inflammation and disease:

The majority of the diseases with which mankind is afflicted usually creep in through the accumulated effects of successive slight irritation, by the operation of apparently insignificant factors which are just sufficient to take part in some chemical reaction. (p. 115)

Calder et al. (2017) characterize aging as an increase in the concentration of inflammatory markers in the blood stream, a phenomenon that has been termed “inflammageing”(see Franceschi & Campisi, 2014; Franceschi et al., 2007; Franceschi et al., 2000).*

Key to longevity and anti-aging is the approach of calming inflammation, micro and macro inflammation, seen as the intrinsic biological aging clock (Luo et al., 2011). Along with inflammation, the ageing of the immune system, called immunosenescence, is an age-related decline of the immune system that leads to an increased frequency and severity of infectious diseases and certain cancers (Solana & Pawelec, 2004; Clements & Carding, 2016; Bauer & Fuente, 2014).

Immunosenescence is brought about by a continuous chronic antigenic (toxins inducing) immune response which then overloads the ability of the immune system to keep up with the demands for naïve cells, the component of cells that enable the body to fight off new, unrecognized infections or diseases (Candore et al., 2006; Calder et al., 2018).*

Once chronic inflammation is activated, it becomes a system-wide condition that leads to higher mortality rates from different illnesses (e.g., Bozzetto et al., 2018; AHA, 2017; Clements & Carding, 2016; Morrisette-Thomas et al., 2014). A study on 1018 Italian old persons demonstrated that higher levels of certain inflammation-related mediators such as IL- 6, IL-1ra ,TNA-a, TNF- a receptor II (TNFAR2) were associated with higher number of chronic illnesses, such as hypertension, diabetes, ischemic heart disease, stroke, cancer, Parkinson’s, hip fractures, joint diseases, anemia, kidney disease, and cognitive impairment (Fabbri et al., 2015).*

Longevity is a balanced state of pro- and anti-inflammatory mediators. By protecting the body against the harmful effects of inflammation with high levels of anti-inflammatory molecules, long-life with better health is attainable. For example, Le Couteur et al. (2016) explain the profound effects nutrition has on ageing and longevity, with animal studies showing longevity is achieved with a specific diet that is similar to the dietary traditions of the long-lived people on the island of Okinawa – a predominantly plant based diet.*

Many scientists have come to realize that health, longevity, and anti-aging are fundamentally dependent upon the correct nutritional strategy that facilitates and educates the body’s defense, repair, adaptation, and renewal functions (Calder et al., 2017; Mykytyn, 2005). *

In fact, scientific research insists upon the daily consumption of plant-based foods, probiotics and their fermented metabolites, plenty of fiber, and particular nutriceuticals to achieve and sustain longevity: the healthy systemic functions of the body (Seidelmann et al., 2018; Devi & Sekhar, 2018; Filosa et al, 2018; Donoiu et al., 2018; Iskar & Antonyak, 2018; Smith & Hsu, 2018; Holscher, 2017).*

The No7 Longevity is designed with what science considers the best nutritional molecules that support the body’s ability to to defend, repair, adapt and renew.

We will continue this conversation!

References

American Heart Association. (2017, March 09). Unhealthy diets linked to more than 400,000 cardiovascular deaths [AHA/ASA Newsroom]. Retrieved from Article

Bardell, D. (2018). Living with chronic illness: Better health through lifestyle medicine.  In Stevens-Long, J., Bardell, D., Living Well, Dying Well. Fielding University Press.

Bauer, M. E., & De la Fuente, M. (2014). Oxidative stress, inflammaging, and immunosenescence. In Inflammation, Advancing Age and Nutrition (pp. 39-47). https://doi.org/10.1016/B978-0-12-397803-5.00004-6

Bozzetto, L., Costabile, G., Della Pepa, G., Ciciola, P., Vetrani, C., Vitale, M., … & Annuzzi, G. (2018). Dietary fibre as a unifying remedy for the whole spectrum of obesity-associated cardiovascular risk. Nutrients10(7), 943. DOI:10.3390/nu10070943

Calder, P. C., Bosco, N., Bourdet-Sicard, R., Capuron, L., Delzenne, N., Doré, J., … & Visioli, F. (2017). Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing research reviews40, 95-119. Article

Candore, G., Colonna-Romano, G., Balistreri, C. R., Carlo, D. D., Grimaldi, M. P., Listì, F., … & Caruso, C. (2006). Biology of longevity: role of the innate immune system. Rejuvenation research9(1), 143-148. Abstract

Clements, S. J., & Carding, S. R. (2016). Can Nutritional Intervention Counteract Immunosenescence in the Elderly?. In Molecular Basis of Nutrition and Aging (pp. 375-391). https://doi.org/10.1016/B978-0-12-801816-3.00028-5

Donoiu, I., Militaru, C., Obleagă, O., Hunter, J. M., Neamţu, J., Biţă, A., … & Rogoveanu, O. C. (2018). Effects of Boron-Containing Compounds on Cardiovascular Disease Risk Factors–A Review. Journal of Trace Elements in Medicine and Biology. Abstract

Fabbri, E., An, Y., Zoli, M., Simonsick, E. M., Guralnik, J. M., Bandinelli, S., … & Ferrucci, L. (2014). Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkers. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences70(1), 63-70. https://doi.org/10.1093/gerona/glu127

Filosa, S., Di Meo, F., & Crispi, S. (2018). Polyphenols-gut microbiota interplay and brain neuromodulation. Neural regeneration research13(12), 2055. Article

Franceschi, C., & Campisi, J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences69(Suppl_1), S4-S9. Article

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., … & Cevenini, E. (2007). Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mechanisms of ageing and development128(1), 92-105. https://doi.org/10.1016/j.mad.2006.11.016

Franceschi, C., Bonafè, M., Valensin, S., Olivieri, F., De Luca, M., Ottaviani, E., & De Benedictis, G. (2000). Inflamm‐aging: an evolutionary perspective on immunosenescence. Annals of the New York Academy of Sciences908(1), 244-254. Abstract

Holscher, H. D. (2017). Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes8(2), 172-184. https://doi.org/10.1080/19490976.2017.1290756

Le Couteur, D. G., Solon-Biet, S., Wahl, D., Cogger, V. C., Willcox, B. J., Willcox, D. C., … & Simpson, S. J. (2016). New Horizons: Dietary protein, ageing and the Okinawan ratio. Age and ageing45(4), 443-447. Article

Lorand, A., (1013). Health and Longevity through a Rational Diet.

Luo, C., Urgard, E., Vooder, T., & Metspalu, A. (2011). The role of COX-2 and Nrf2/ARE in anti-inflammation and antioxidative stress: Aging and anti-aging. Medical hypotheses77(2), 174-178. https://doi.org/10.1016/j.mehy.2011.04.002

Morrisette-Thomas, V., Cohen, A. A., Fülöp, T., Riesco, É., Legault, V., Li, Q., … & Ferrucci, L. (2014). Inflamm-aging does not simply reflect increases in pro-inflammatory markers. Mechanisms of ageing and development139, 49-57. https://doi.org/10.1016/j.mad.2014.06.005

Mykytyn, C. E. (2006). Anti-aging medicine: A patient/practitioner movement to redefine aging. Social Science & Medicine62(3), 643-653. https://doi.org/10.1016/j.socscimed.2005.06.021

Seidelmann, S. B., Claggett, B., Cheng, S., Henglin, M., Shah, A., Steffen, L. M., … & Solomon, S. D. (2018). Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis. The Lancet Public Health3(9), e419-e428. Article

Solana R. & Pawelec, G. (2004). Immunosenescence. NeuroImmune Biology, 4, 9-21.

Untied Nations, Ageing (2017),  http://www.un.org/en/sections/issues-depth/ageing/ n

 

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

In this fascinating website you can watch the numbers of births and the number of deaths growth in real time.  See Current World Population.  With the increasing numbers of people reaching sennescense and the mounting pandemic of chronic degenerative diseases, we need a sea-change in how we feed ourselves, to one that brings healthy longevity.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved