Healthy Aging Support

Phenols and Oncogenes

February 19, 2018

Dear Friends

Phyto Power:  Supports DNA and cellular integrity during oncogenic treatment due to
its potent antioxidant, anti-inflammatory, and antimicrobial properties.Phyto Power Photo 3

Food Science
  • DNA & Cellular Integrity: Blueberries, rose hip, and dandelion are shown in research to help maintain cellular integrity, suppressing or interfering with oncogenic transformation, bolstering antioxidant and anti-inflammatory defenses, and contributing significant re-generative health benefits to the brain and nervous system (Jedrejek et al., 2017; Jiménez et al., 2016; Skrovankova et al., 2015; Joseph et al., 2014; Liu et al., 2013; Andersson et al., 2012; Chatterjee et al., 2011; Adams et al., 2010).*
  • Anti-Inflammation: García-Lafuente et al. (2009) conclude that flavonoids from berries and plants behave as anti-inflammatory agents in our body. Blueberries are rich with anthocyanins and a wide variety of phytochemicals that have been shown to effect neuro-regeneration in the brain (Albarracin et al., 2012).*
  • Energy & Weight-Loss: Dandelion is shown to have a great antioxidant activity (Hu et al., 2003), exhibiting diverse biological activities that promote energy, weight loss, and reduced risk of metabolic syndrome (Jedrejek et al., 2017; González-Castejón et al., 2012; Jeon et al., 2008). The Rose hip has a rich phytochemical profile known for its antioxidant protection (Widen et al., 2012), supporting weight loss with a potential mechanism that decreases abdominal visceral fat (Nagatomo et al., 2015).*

Added Suggestion: Combine with the Original Synbiotic to bolster immune support. Add also the greenest food, Organic Chlorella, to support detox mechanism and immunity.

References

  • Adams, L.S., Phung, S. Yee, N., Sheeram, N.P., Li, L., & Chen, S. (2010).Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, 70(9), 3594-605.DOI: 10.1158/0008-5472.CAN-09-3565
  • Albarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J….Barreto, G.E. (2012). Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci, 15, 1-9. DOI: 10.1179/1476830511Y.0000000028
  • Andersson, U., Berger, K., Hogberg, A., Landin-Olsson, M., & Holm, C. (2012). Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr, 66, 585-590. DOI: 10.1038/ejcn.2011.203
  • Chatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., & Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evid Based Complement Alternat Med, 129045.DOI: 10.1155/2011/129045
  • Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI: 10.3402/ijch.v72i0.21188
  • García-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M.A., & Martínez, J.A. (2009). Flavonoids as antiinflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res, 58, 537-552. DOI: 10.1007/s00011-009-0037-3
  • Hu, C., & Kitts, D.D. (2003). Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro. Journal of Agricultural and Food Chemistry, 51, (1), 301-310.DOI: 10.1021/jf0258858
  • Jeon, H.J., Kang, H. J., JungH.J. Kant, Y.S., Lim, C.J., Kim, Y.M., & Park, E.H. (2008). Anti-inflammatory activity of Taraxacum officinale. Journal of Ethnopharmacology, 115 (1), 82-88. DOI: 10.1016/j.jep.2007.09.006
  • Jeyabalan, J., Aqil, F., Munagala, R., Annamalai, L., Vadhanam, M.V., Gupta, R.C. (2014). Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer.J. Agric. Food Chem, 62, 3963-3971. DOI: 10.1021/jf403734j
  • Jiménez, S., Gascón, S., Luquin, A., Laguna, M., Ancin-Azpilicueta, C., Rodríguez-Yoldi, M.J. (2016). Rosa canina Extracts Have Antiproliferative and Antioxidant Effects on Caco-2 Human Colon Cancer. PLoS One, 11(7), e0159136. https://doi.org/10.1371/journal.pone.0159136
  • Joseph, S.V., Edirisinghe, I., & Burton-Freeman, B.M. (2014). Berries: anti-inflammatory effects in humans. J Agric Food Chem, 7; 62(18), 3886-903. DOI:10.1021/jf4044056
  • Liu, W., Lu, X., He, G., Gao, X., Xu, M., Zhang, J… Luo, C. (2013). Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Int Mol Sci, 14(11), 21447-62. DOI: 10.3390/ijms141121447
  • Nagatomo, A., Nishida, N., Fukuhara, I., Noro, A., Kozai, Y., Sato, H., & Matsuura, Y. (2015). Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial. Diabetes Metab Syndr Obes, 8, 147-156.DOI: 10.2147/DMSO.S78623
  • Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., Sochor, J.(2015). Bioactive Compounds and Antioxidant Activity in Different Types of Berries.Int J Mol Sci, 16(10), 24673-706. doi: 10.3390/ijms161024673
  • Widen, C., Ekholm, A., Coleman, M.D., Renvert, S., Rumpunen, K. (2012). Erythrocyte antioxidant protection of rose hips (Rosa spp.) Oxid Med Cell Longev, 621579. http://dx.doi.org/10.1155/2012/621579 .

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Phyto Power is indeed powerful. In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.*
 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Plants Heal

February 13, 2018

Dear Friends

Plants heal. A plant based diet centered around vegetable, fruits, grains, legumes, nuts, and seeds is now being promoted by Kaiser Permanente (the largest of Americas health care providers), the WHO (The World Health Organization), and Harvard Medical School.
Noncommunicable diseases (chronic diseases) are on the rise. According to our Dr. Dohrea Bardell, statistics on “our aging population project” that 6 out of 10 people will live with 1 to 5 different chronic illnesses. But that is not all, chronic diseases also affect our younger (0-18) and working-age (from 18-64) populations.
Plant based diets (vegetarian and vegan) have shown in research to prevent and even reverse noncommunicable diseases (NCDs) such as Metabolic Syndrome, Obesity, Diabetes, Heart Disease, Cancer and additionally Arthritis, and Neurological Disorders. More on that will be published in the joint project with Dr. Judy Stevens-Long and Dr. Dohrea Bardell later this year.

The following four BioImmersion products provide the essence of what these dietary regimes must give your body to support your body attaining health in old age.

Garlic: 1 capsule each day. Garlic is shown to not only fight colds/flu but to support the body against a variety of cancers.
Cruciferous Sprouts– 2 capsules a day before bed to support the liver’s ability to detox (phase II detox). Cruciferous vegetables are touted as the best preventative foods against cancer.
Phyto Power– 1-2 capsules daily taken in the morning to provide the brain with the best food for better thinking, regeneration of nerves, and prevent aging brain. The potent polyphenols also protect against a variety of cancers (blueberries and rose hips), offer anti inflammatory properties, and liver support (dandelion).

Beta Gluten High Potency Synbiotic– one heaping tablespoon taken before breakfast or dinner. One of the most potent probiotic product with 65 billion strong probiotic organisms, and our famous beta glucans with red beet root to lower cholesterol and support liver function. The beta glucans also are shown to support  prevention of variety of cancers.

As you can see, we revere plants and their power to heal our bodies.

Cancer Support

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

 

Green Facts:

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Choosing a healthy diet: Research studies link the emerging global pattern of metabolic syndrome and weight gain to the prevalence of Westernized diet of daily meats, dairy, eggs, simple and processed carbohydrates, and too much sugar (Chai et al., 2017; Azadbakht & Esmaillzadeh, 2009; Lutsey et al., 2008). Although there are conflicting views on dietary guidelines, many scientists and health organizations agree that a focus on whole food plant-based diet is the healthiest guideline for metabolic syndrome and weight loss (Yokoyama et al., 2017; Satija et al., 2017; Kahleova et al., 2017; Hever et al., 2017; Turner et al., 2017; UN Report, 2016; Wang et al., 2015; Tilman & Clark, 2014; WHO/FAO, 2003).*

 

The Plates, Pyramids, Planet report, compiled in collaboration with the Food Climate Research Network (FCRN) at the University of Oxford, concludes that a plant-based diet has many advantages for health and the environment (UN Report, 2016).*

The type and nature of carbohydrates that improve our metabolic health (obesity, cardiovascular, and diabetes) are comprised of whole plants with fiber (Wright et al., 2017). Whereas low carbs diets with high fat content is shown to increase metabolic syndrome (Lamont et al., 2017; UN Report, 2016).*

A diet that is 80-90% whole food plant-based is highly recommeded by many health organizations and medical universities around the world.


 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends
Blueberry Extract
BioImmersion produces the most potent and pure polyphenolic and probiotic products in the market.

For example: the Blueberry Extract provides intense broad spectrum anthocyanins from the North American blueberry species, Vaccinium corymbosum.

We use 80 pounds of blueberries to create one pound of the purest extract. It is indeed powerful.

Esteemed research scientists demonstrate that blueberries and blueberry extract reverse and prevent brain aging (Shukitt-Hale et al., 2008; 2007), improve memory and motor skills (Carey et al., 2014; Malin et al., 2011; Brewer et al., 2010), repair neuronal tissue and function (Joseph et al., 2003; Miller et al., 2012), and serve as a potent anti-aging food (Joseph et al., 1999; 2009; Shukitt-Hale et al., 2015; 2012).*

Cognitive decline is becoming a reality for most Baby Boomers as we see our parents suffer with Alzheimer’s or dementia.  Also on the rise is Parkinson’s and other neurological diseases associated with aging … old age. But old age should not be associated with these diseases.

The good news is that there is a growing body of evidence regarding blueberry and specifically blueberry extract’s benefits for cognitive health, protection, and restoration. There is more than hope, there is scientific research to back it up!

We’ve captured much more of the research here in this link to our Blueberry Extract.  Click on the research tab and you’ll be able to access the abstracts and full studies or reviews.

Let’s do a costs/benefits analysis:

The retail price for our Blueberry Extract is $137.94.  There are 60 capsules in a bottle.  The recommended dose for most people is one capsule a day.  Therefore, the daily cost is $2.30, and you have a two month supply.  Is it worth the cost? Yes, the Blueberry Extract is a must do for brain health (read Green Facts for more fun).

References

  • Brewer, G.J., Torricelli, J.R., Lindsey, A.L., Kunz, E.Z., Neuman, A., Fisher, D.R., & Joseph, J.A. (2010). Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem, 21, 991-998. DOI: 10.1016/j.jnutbio.2009.08.005
  • Carey, A.N., Gomes, S.M., & Shukitt-Hale, B. (2014). Blueberry supplementation improves memory in middle-aged mice fed a high-fat diet. J Agric Food Chem, 62, 3972-3978. DOI: 10.1021/jf404565s
  • Joseph, J.A., Shukitt-Hale, B., Denisova, N.A., Bielinski, D., Martin, A., McEwen, J.J., & Bickford, P.C. (1999). Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci, 19(18), 8114-21. . Article
  • Joseph, J.A., Denisova, N.A., Arendash, G., Gordon, M., Diamond, D., Shukitt-Hale, B., Morgan, D. (2003). Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci, 6 (3), 153-162. DOI:10.1080/1028415031000111282
  • Joseph, J.A., Shukitt-Hale, B., & Lau, F.C. (2007). Fruit polyphenols and their effects on neuronal signaling and behavior in senescence . Ann NY Acd Sci, 1100, 470-85. DOI: 10.1196/annals.1395.052
  • Joseph, J., Cole, G., Head, E., Ingram, D. (2009). Nutrition, brain aging, and neurodegeneration. J. Neurosci. 29(41), 12795–12801. DOI:10.1523/JNEUROSCI.3520-09.2009
  • Malin, D.H., Lee, D.R., Goyarzum P., Chang, Y.H., Ennis, L.J., Beckett, E., Shukitt-Hale, B., Joseph, J.A. (2011). Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats. Nutrition, 27, 338-342. DOI: 10.1016/j.nut.2010.05.001  
  • Miller, M.G., Shukitt-Hale, B. (2012). Berry fruit enhances beneficial signaling in the brain. J. Agric. Food Chem, 60(23), 5709–5715. DOI: 10.1021/jf2036033
  • Shukitt-Hale, B., Carey, A.N., Jenkins, D., Rabin, B.M., Joseph, J.A. (2007). Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging, 28, 1187-1194. DOI: 10.1016/j.neurobiolaging.2006.05.031
  • Shukitt-Hale, B., Lau, F.C., Joseph, J.A. (2008). Berry fruit supplementation and the aging brain. Journal of Agricultural and Food Chemistry, 56, 636–641.
  • Shukitt-Hale, B. (2012). Blueberries and neuronal aging. Gerontology, 58, 518-523. DOI: 10.1159/000341101DOI:10.1021/jf072505f
  • Shukitt-Hale, B., Bielinski, D. F., Lau, F. C., Willis, L. M., Carey, A. N., & Joseph, J. A. (2015). The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. British Journal of Nutrition, 114(10), 1542-154.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Putting costs in perspective: It is a matter of priorities

When one goes to Starbucks or a great organic cafe for their favorite coffee (and many of us do it daily) like a double latte, is it worth the $3.50 or more?  Of course, it is.  No questions to ask here; and I’ll say no more.  Only that we need to think of one capsule of Blueberry Extract in this way.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Think better with blueberry

January 22, 2018

Dear Friends
Blueberry Extract
The CNS (the brain and spinal cord) is particulary vulnerable to oxidative stress, and this vulnerability increases during ageing (Joseph et al, 1998).  In fact as Dr. Joseph put it, “the brain becomes a hot bed of free radical activity in our old age.”

Shukitt-Hale et al. (2015) demonsrated in her research titled, The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing, the powerful cognitive effects by adding blueberry extract and strawberry extract to the diets of senile old rats.

The results showed that rats consuming the berry diets exhibited enhanced motor performance and improved cognition, specifically working memory. In addition, the rats supplemented with blueberry and strawberry diets showed increased hippocampal neurogenesis and expression of insulin-like growth factor 1.

What about research today on the bioavailability of blueberry polyphenols and their beneficial effect with human subjects?

Sandhu et al. (2017) explored the metabolic fate of blueberry anthocyanins after daily (90 days) supplementation of freeze-dried blueberry (equivalent of 1 cup of fresh blueberries).  Their conclusion was that blueberry anthocyanins are absorbed and extensively metablized resulting in the production of various phenolic acid derivatives and their conjugates, all together contributing to the bioavailability and beneficial effects associated with blueberry comsumption.

Miller et al. (2017) studied men and women between the ages of 60 and 75 years. Their findings showed that the group consuming the equivalent of one cup of blueberries daily for 90 days exhibited significantly fewer errors in a verbal learning test and increased mental flexibility on a task-switching test, relative to the placebo group.

BioImmersion powerhouses for polyphenolics supplementation for a healthy brain: 

References

  • Joseph, J. A., Denisova, N., Fisher, D., Shukitt-Hale, B., Bickford, P., Prior, R., & Cao, G. (1998). Age-related neurodegeneration and oxidative stress: putative nutritional intervention. Neurologic clinics, 16(3), 747-755.
  • Joseph, J. A., Denisova, N., Fisher, D., Shukitt‐Hale, B., Bickford, P., Prior, R., & Cao, G. (1998). Membrane and receptor modifications of oxidative stress vulnerability in aging: nutritional considerations. Annals of the New York Academy of Sciences, 854(1), 268-276.
  • Miller, M. G., Hamilton, D. A., Joseph, J. A., & Shukitt-Hale, B. (2017). Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. European Journal of Nutrition, 1-12.
  • Sandhu, A., Miller, M. G., Shukitt-Hale, B., Edirisinghe, I., & Burton-Freeman, B. (2017). Metabolic Fate of Blueberry Anthocyanins after Chronic Supplementation in Healthy Older Adults. The FASEB Journal, 31(1 Supplement), 646-20.
  • Shukitt-Hale, B., Bielinski, D. F., Lau, F. C., Willis, L. M., Carey, A. N., & Joseph, J. A. (2015). The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. British Journal of Nutrition, 114(10), 1542-154.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3
Five Habits to Heal the Heart of Democracy. 

The human heart is the first home of democracy. It is where we embrace our questions. Can we be equitable? Can we be generous? Can we listen with our whole beings ….

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Endotoxemia and Chlorella

December 14, 2017

Dear Friends

Chlorella HZ 2

Chlorella and inulin reduce endotoxemia and protect the intestinal mucosa barrier.

What is an endotoxin, and what causes endotoxemia? How does chlorella reduce endotoxemia, and how does inulin produce a healthy microbiome?  Let’s take a look at a few studies.

An endotoxin is often used synonymously with LPS.  Lipopolysaccharides (LPSs) are the major components of the outer membrane of Gram-negative bacteria. Rietschel et al. found in 1994 that LPSs induce strong inflammatory responses from the immune systems of all animals.

Liver Diseases are associated with leaky gut syndrome, which allows for the passage LPS molecules into the systemic circulation, causing chronic inflammation, and a condition called endotoxemia. A large enough load of LPSs in the systemic circulations can cause septic shock.

In fact, severe sepsis is a common and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction. It is especially common in the elderly and is likely to increase substantially as the U.S. population ages (Angus et al., 2001)

Bedirli et al. (2009) investigated the role of different microalgae (Chlorella sp. and Spirulina sp.) extracts in intestinal barrier function and oxidative stress in experimentally jaundice rats.

The main outcomes measured were endotoxin concentrations in plasma [e.g. LPS levels], evidence of bacterial translocation in mesenteric lymph nodes and liver oxidative stress, and histology.

Their findings: A Chlorella sp. supplemented diet significantly demonstrated protective effects on the intestinal mucosa barrier in obstructive jaundice, and reduced intestinal translocation of bacteria and endotoxin.  Spirulina had no significant effect.

Original copyCani et al. (2008) found that a high animal fat diet changes the GI tract microbiome into a population of increasing numbers of Gram-negative bacteria, which raises the level of LPS endotoxins within the gut lumen and allows their passing through the GI tract membrane into the plasma.

The research team concluded that the plasma concentration of lipopolysaccharides (LPS) controls the inflammatory tone of the body.  This means that high concentrations of LPS set the stage for endotoxemia, resulting in metabolic diseases (obesity, diabetes, CVD) and cancer.

They further demonstrated in the study that increased fibers in the diet, such as inulin, increase the populations of Bifidobacterial sp. and Lactobacillus sp. which reduce both the load of Gram-negative bacteria and the permeability of the gastrointestinal membrane.

Our Suggestion: Take 4 to 8 tablets of Organic Chlorella daily.
Take 1 tsp. of Original Synbiotic daily.
References:

  • Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001). Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine, 29(7), 1303-1310.
  • Bedirli, A., Kerem, M., Ofluoglu, E., Salman, B., Katircioglu, H., Bedirli, N., … & Pasaoglu, H. (2009). Administration of Chlorella sp. microalgae reduces endotoxemia, intestinal oxidative stress and bacterial translocation in experimental biliary obstruction. Clinical nutrition, 28(6), 674-678.
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Rietschel, E. T., Kirikae, T., Schade, F. U., Mamat, U., Schmidt, G., Loppnow, H., … & Di Padova, F. (1994). Bacterial endotoxin: molecular relationships of structure to activity and function. The FASEB Journal, 8(2), 217-225.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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What kind of world do you want to wake up to 30 years from now?
The Biomimicry Institute aspires to a world where what we make is inspired by, and connected to, the natural world.  This means cities are resilient, emission targets are achieved, and industrial processes create healthy air, water, and soil.  It also means all species are thriving because our human designs restore the planet as nature’s desgns do.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved