Healthy Aging Support

Dear Friends

Our famous High ORAC Synbiotic is now 10 times more potent. What’s new?

HO PhotoFirst, we added our new advanced Probiotic Super Blend, naturally occuring whole probiotics with their Supernatant and ORNs (oligoribonucleotides). The five pedigreed lactic acid bacterial strains in our Supernatant Synbiotic are excellent as post antibiotic care.

We also added the supernatant of each of these five effective probiotics: The supernatant includes their healing metabolites, enzymes, vitamins, lactic acid, bacterocins, biosurfactants, bile salt hydrolase, and so much more.

The full-spectrum antioxidant activity component of High ORAC Synbiotic is a property of its new proprietary blend of fruit, berries and bioflavonoids.  A blend that successfully reduces the five major categories of free radicals- the hydroxyl, peroxyl, peroxynitrite, singlet oxygen, and superoxide anion.  It is standardized to a minimum total ORAC score of 40,000 umol Trolox equivalent (TE) per gram as measured by the ORAC 5.0 assay. That is 10 times more potent!

One capsule a day will do nicely.

Food Science

Studies are showing that dietary polyphenols contribute to the maintenance of intestinal health by preserving the gut microbial balance through the stimulation of the growth of beneficial bacteria such as Lactobacilli and Bifidobacteria while inhibiting that of pathogenic bacteria.

Dueñas et al.’s (2015) study, A survey of modulation of gut microbiota by dietary polyphenols, showed that the beneficial effects attributed to dietary polyphenols appear to be due more to phenolic metabolites formed in the gastrointestinal tract, mainly derived from the action of gut bacteria than to the original forms found in food.

This all occurs in the colon where the growth of good bacterial friends is enhanced by polyphenols while at the same time the beneficial attributes of the polyphenols are made possible by their reduction into shorter chain lengths by the enzymes of these good bacteria.  Making their antioxidant, antimicrobial, anti-inflammtory, healthy aging, cell signaling effects more bioavailable throughout the body.

Duda-Chodak et al. (2015) present possible pathways of polyphenol metabolism by intestinal bacteria and describe the diet-derived bioactive metabolites produced by gut microbiota, with a particular emphasis on polyphenols and their potential impact on human health.

We will talk much more about this in coming Forward Thinking newsletters.

References

Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., … & Bartolomé, B. (2015). A survey of modulation of gut microbiota by dietary polyphenols. BioMed research international2015. https://www.hindawi.com/journals/bmri/2015/850902/

Duda-Chodak, A., Tarko, T., Satora, P., & Sroka, P. (2015). Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review. European journal of nutrition54(3), 325-341. https://link.springer.com/article/10.1007/s00394-015-0852-y

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The Game Changers  will introduce the world of elite athletes, special ops soldiers, visionary scientists, cultural icons and everyday heroes.  Each on a mission to create a seismic shift in the way we eat and live.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Our new ENERGY is here!

November 14, 2018

Dear Friends

We are very pleased to let you know that our new product, ENERGY– a combination of our plant Ultra Minerals plus the addition of apple extract – is here!

And, you are going to love it. Who doesn’t need more energy in their body today?  Energy provides clean, healthy energy that our body relies on to fuel all of its metabolic processes—ATP.

What is so exciting about Energy are the benefits shown in clinical human studies, by our collaborating scientists, using Energy’s exact ingredients and suggested doses.  Studies showed increases in strength, power, and stamina in adult atheletes, while in other trials with aged adults, a single treatment [of Energyat a serving of 150mg resulted in a significant increase of blood level of total ATP;  with no concomitant increase in blood ROS [free radicals] or serum lactate [lactic acid] and a reduction of total mTOR levels in blood under these experimental conditions (Reyes-Izquierdo et el., 2013).

ENERGY

Food Science

Joy et al.’s (2016) study, Ancient peat [ultra minerals] and apple extracts supplementation may improve strength and power adaptations in resistance trained men, aimed to determine the effects of a proprietary blend of ultra minerals derived from ancient peat and apple extracts on athletic performance. It was hypothesized that supplementation would improve strength and power over the duration of the training program as well as blunt a decrement in performance due to overreaching.

Overreaching is a training volume and/or intensity of exercise resulting in performance decrements.  In the state of overreaching, the adaptation capacity to training load is decreased.  In the state of overreaching one can not achieve optimal performance and is more susceptible to illness and injury.

Their conclusion was that the proprietary blend of plant ultra minerals and apple extracts (Energy) were capable of increasing lower body and total strength as well as lower body power output compared at an equal-volume, visually-identical placebo.  Moreover, the supplement was able to prevent performance decrements commonly associated with increased training volume and overreaching.

Suggested use: one capsule a day.

References

Reyes-Izquierdo, T., Nemzer, B., Argumedo, R., Shu, C., Huynh, L., & Pietrzkowski, Z. (2013). Effect of the dietary supplement ElevATP on blood ATP level: An acute pilot clinical study. J Aging Res Clin Practice, 2, 178-84.

Joy, J. M., Vogel, R. M., Moon, J. R., Falcone, P. H., Mosman, M. M., Pietrzkowski, Z., … & Kim, M. P. (2016). Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men. BMC complementary and alternative medicine, 16(1), 224.

Joy, J. M., Falcone, P. H., Vogel, R. M., Mosman, M. M., Kim, M. P., & Moon, J. R. (2015). Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men. Applied Physiology, Nutrition, and Metabolism, 40(11), 1171-1177.
Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The Game Changers  will introduce the world of elite athletes, special ops soldiers, visionary scientists, cultural icons and everyday heroes.  Each on a mission to create a seismic shift in the way we eat and live.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

GS Photo JPEGBroccoli sprouts provide an exceptionally rich source of sulforaphane – a potent inducer of enzymes that protect against chemical carcinogens.  In fact, three-day-old sprouts of broccoli contain 10-100 times higher levels of glucoraphanin (the glucosinolate of sulforaphane) than do the mature broccoli plants.  Broccoli sprouts are the richest natural source for sulforaphanes, and the BioImmersion organic broccoli sprouts selected for the Glucosinolate & Sulforaphane are at the 100 fold level.

Our Glucosinolate & Sulforaphane replaces the Cruciferous Sprout Complex as it supplies 6-8 times the potency of the most important phytochemical, sulforaphane.

Glucosinolate & Sulforaphane comes in two sizes: the 120 capsule size as shown to the right and is in stock now, and the 60 capsule size bottle that will be available in three weeks.  With a dose being 1-2 capsules a day, the larger bottle will give a 2-4 month supply.

Food Science

Broccoli sprouts are a rich source of glucosinolates and isothiocyanates, shown in research to induce phase 2 detoxication enzymes, boost antioxidant status, and protect animals against chemically induced cancer.  Glucosinolates are hydrolyzed by myrosinase (an enzyme found in plants and bowel microflora) to form isothiocyanates.  Glucosinolates are inert as phase 2 enzyme inducers and must be hydrolyzed (break-down) to generate the active isothiocyanates (Shapiro et al., 2001).

Sulforaphane (SFN) is a compound derived from cruciferous vegetables with numerous bioactivities (Su et al., 2018). In fact, Broccoli and especially broccoli sprouts, accumulate significant amounts of the phytonutrient glucoraphanin, which is metabolized in vivo to the biologically active sulforaphane (SFN).  The preponderance of evidence available from in vitro, animal and human studies supports the association of sulforaphane with phase II enzyme induction (James et al., 2012), moreover, SFN strongly displays both anticarcinogenic and anticancer activity by modulating ‘key signaling pathways and genes involved in the induction of apoptosis, cell cycle arrest, and inhibition of angiogenesis’ (Su et al., 2018; see also Peng et al., 2015; Zhang & Tang, 2007).

SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN (Peng et al., 2015).

Sulforaphane is found in research to have many different health benefits:  Alzheimer’s (Kim et al., 2013), Cardiovascular Disorders (Angeloni et al., 2009), Diabetes (Bahadoran et al., 2012), Asthma- upper airway congestion, (Riedl et al., 2009) and Detoxification in all cells, and in particular with Liver Phase II detoxification enhancement (Riedl et al., 2009).

Sulforaphane (SFN) has been demonstrated to be an effective chemopreventive agent for many years (Shapiro et al., 2001), with positive effects against different kinds of cancers, such as cervical (Chen et al., 2016; Abdull et al., 2013), breast (Peng et al., 2015; Li et al., 2010), bladder (Leone et al., 2017), renal cell carcinoma (Juengel et al., 2016), non-small-cell lung cancer (Wang et al., 2017), and colon and prostate cancers (Clarke et al., 2008; Abdull et al., 2013).

We will continue to examine the research on this important food in the next few weeks.

References

Abdull Razis, A. F., Konsue, N., & Ioannides, C. (2018). Isothiocyanates and Xenobiotic Detoxification. Molecular nutrition & food research62(18), 1700916.

Abdull, R., Ahmad, F., & Noor, N. M. (2013). Cruciferous vegetables: dietary phytochemicals for cancer prevention. Asian Pacific Journal of cancer prevention, 14(3), 1565-1570.

Angeloni, C., Leoncini, E., Malaguti, M., Angelini, S., Hrelia, P., & Hrelia, S. (2009). Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential. Journal of agricultural and food chemistry57(12), 5615-5622.

Bahadoran, Z., Tohidi, M., Nazeri, P., Mehran, M., Azizi, F., & Mirmiran, P. (2012). Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. International journal of food sciences and nutrition63(7), 767-771.

Cheng, Y. M., Tsai, C. C., & Hsu, Y. C. (2016). Sulforaphane, a dietary isothiocyanate, induces G2/M arrest in cervical cancer cells through cyclinB1 downregulation and GADD45β/CDC2 association. International journal of molecular sciences, 17(9), 1530.

Clarke, J. D., Dashwood, R. H., & Ho, E. (2008). Multi-targeted prevention of cancer by sulforaphane. Cancer letters, 269(2), 291-304.

Fahey, J. W., Zhang, Y., & Talalay, P. (1997). Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proceedings of the National Academy of Sciences, 94(19), 10367-10372.  http://www.pnas.org/content/94/19/10367

James, D., Devaraj, S., Bellur, P., Lakkanna, S., Vicini, J., & Boddupalli, S. (2012). Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition reviews70(11), 654-665.

Juengel, E., Maxeiner, S., Rutz, J., Justin, S., Roos, F., Khoder, W., … & Blaheta, R. A. (2016). Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro. Oncotarget, 7(51), 85208.

Kim, H. V., Kim, H. Y., Ehrlich, H. Y., Choi, S. Y., Kim, D. J., & Kim, Y. (2013). Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model. Amyloid20(1), 7-12.

Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H. F., Newman, B., … & Sun, D. (2010). Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clinical Cancer Research, 1078-0432.

Peng, X., Zhou, Y., Tian, H., Yang, G., Li, C., Geng, Y., … & Wu, W. (2015). Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells. Oncology reports34(3), 1565-1572.

Riedl, M. A., Saxon, A., & Diaz-Sanchez, D. (2009). Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clinical immunology130(3), 244-251.

Shapiro, T. A., Fahey, J. W., Wade, K. L., Stephenson, K. K., & Talalay, P. (2001). Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.Cancer Epidemiology and Prevention Biomarkers, 10(5), 501-508.  http://cebp.aacrjournals.org/content/10/5/501.long

Su, X., Jiang, X., Meng, L., Dong, X., Shen, Y., & Xin, Y. (2018). Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity2018.

Wang, D. X., Zou, Y. J., Zhuang, X. B., Chen, S. X., Lin, Y., Li, W. L., … & Lin, Z. Q. (2017). Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways. Acta Pharmacologica Sinica, 38(2), 241.

Zhang, Y., & Tang, L. (2007). Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta pharmacologica Sinica, 28(9), 1343-1354.


Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The Environmental Working Group is a most important organization to get to know.  Their mission is to empower people to live healthier lives in a healthier environment. With breakthrough research and education, they drive consumer choice and civic action.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

We are excited to announce our new and incredibly potent: organic broccoli cruciferous sprout. Our Glucosinolates & Sulforaphanes is a powerhouse, providing a four fold increase in the phase 2 enzymes inducing and cancer preventing molecules for which it is named.

G and S

Notice that the label above guarantees a Glucosinolate level of 15,000 ppm, a Glucoraphanin level of 10,000 ppm and a Sulforaphane potential of 4,000 ppm.  However, as you can see in the Certificate of Analysis below, the actual levels of these three most important ingredients are much higher, with the Glucosinolates at 21,359 ppm, the Glucoraphanins at 19,407 ppm, and the Sulforaphane yield at 8,733 ppm.  Our old beloved Cruciferous Sprouts product offered a 1500 ppm sulforaphane potential yield.

Organic Broc Sprout CofA

Recommended dose:  one to two capsules daily. Excellent before bed for liver detox.

Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer‐related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis.   Zhang and Tang (2007) review its discovery and development as a cancer chemopreventive agent.

The preponderance of evidence available from in vitro, animal, and human studies supports the association of sulforaphane with phase II enzyme inductions.  Broccoli sprouts are the richest source of glucoraphanin which is the direct precursor to sulforaphane.  Since broccoli sulforaphane is one of the most potent inducers of phase II enzymes, exploration into broccoli’s impact on other areas of human health, such as cardiovasucular health and upper airway immunity, has been suggested (James et al., 2012).

In Qidong, China, a region where exposures to food-and air-borne carcinogens has been considerable, clinical trials indicate that interventions with well characterized preparations of broccoli sprouts may enhance the detoxication of aflatoxins and air-borne toxins, which may in turn attenuate their associated health risks including cancer in exposed individuals (Kensler et al., 2012).

We will continue to discuss this powerhouse product in our next email.

References:

  • James, D., Devaraj, S., Bellur, P., Lakkanna, S., Vicini, J., & Boddupalli, S. (2012). Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition reviews, 70(11), 654-665.
  • Kensler, T. W., Egner, P. A., Agyeman, A. S., Visvanathan, K., Groopman, J. D., Chen, J. G., … & Talalay, P. (2012). Keap1–nrf2 signaling: a target for cancer prevention by sulforaphane. In Natural Products in Cancer Prevention and Therapy(pp. 163-177). Springer, Berlin, Heidelberg.
  • Zhang, Y., & Tang, L. (2007). Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta pharmacologica Sinica, 28(9), 1343-1354.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The Environmental Working Group is a most important organization to get to know.  Their mission is to empower people to live healthier lives in a healthier environment. With breakthrough research and education, they drive consumer choice and civic action.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

When we talk about the function of the the brain, blueberry consumption should be front and center, for much research has shown that blueberry, and blueberry extract in particular, can not only protect us from cognitive decline but help reverse the effects of senescense.

blueberry X 4Scientific research indicates that a cup or two of blueberry every day will improve cognitive performance, improve our athletic abilities (balance, strength, and endurance), and even elevate our mood (Miller et al., 2018; Schrager et al., 2015; Khalid et al., 2017).  Research also emphasizes that the quantity of blueberries matter: one cup a day is good but 2 cups a day may be even better (Miller & Shukitt-Hale,  2012).  These health improvements are not just limited to the elderly but to all ages.  Research has shown that children can greatly benefit too (Whyte, 2016; Khalid, 2017).

The BioImmersion Blueberry Extract is a very serious product.  The cognitive, mood enhancing, and athletic benefits emanate from the blueberry pigment; and that is what is extracted from the North American blueberry we have chosen for the Blueberry Extract.  Each capsule contains 500mg of this precious extract, equivalent to one and a quarter cups of blueberries.  In fact,  it takes 80 lbs. of blueberries to get 1 lb. of this extract!

Recommended dose:  one capsule daily.

References:

  • Whyte, A. R., Schafer, G., & Williams, C. M. (2016). Cognitive effects following acute wild blueberry supplementation in 7-to 10-year-old children. European journal of nutrition, 55(6), 2151-2162.
  • Miller, M. G., Hamilton, D. A., Joseph, J. A., & Shukitt-Hale, B. (2018). Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. European journal of nutrition, 57(3), 1169-1180.
  • Schrager, M. A., Hilton, J., Gould, R., & Kelly, V. E. (2015). Effects of blueberry supplementation on measures of functional mobility in older adults. Applied Physiology, Nutrition, and Metabolism, 40(6), 543-549.
  • Khalid, S., Barfoot, K. L., May, G., Lamport, D. J., Reynolds, S. A., & Williams, C. M. (2017). Effects of acute blueberry flavonoids on mood in children and young adults. Nutrients, 9(2), 158.
  • Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: the PANAS scales. Journal of personality and social psychology, 54(6), 1063.
  • Miller, M. G., & Shukitt-Hale, B. (2012). Berry fruit enhances beneficial signaling in the brain. Journal of agricultural and food chemistry, 60(23), 5709-5715.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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One of the world’s great organization for learning how to work with nature is the Biomimicry Institute.  Check them out:  Global Design Challenge.  They are truly one of the bright rays of hope for bonding with Mother Nature and learning from her 3 billion years of life experience on Earth .

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved