Detoxification Support

Dear Friends

GS Photo JPEGBroccoli sprouts provide an exceptionally rich source of sulforaphane – a potent inducer of enzymes that protect against chemical carcinogens.  In fact, three-day-old sprouts of broccoli contain 10-100 times higher levels of glucoraphanin (the glucosinolate of sulforaphane) than do the mature broccoli plants.  Broccoli sprouts are the richest natural source for sulforaphanes, and the BioImmersion organic broccoli sprouts selected for the Glucosinolate & Sulforaphane are at the 100 fold level.

Our Glucosinolate & Sulforaphane replaces the Cruciferous Sprout Complex as it supplies 6-8 times the potency of the most important phytochemical, sulforaphane.

Glucosinolate & Sulforaphane comes in two sizes: the 120 capsule size as shown to the right and is in stock now, and the 60 capsule size bottle that will be available in three weeks.  With a dose being 1-2 capsules a day, the larger bottle will give a 2-4 month supply.

Food Science

Broccoli sprouts are a rich source of glucosinolates and isothiocyanates, shown in research to induce phase 2 detoxication enzymes, boost antioxidant status, and protect animals against chemically induced cancer.  Glucosinolates are hydrolyzed by myrosinase (an enzyme found in plants and bowel microflora) to form isothiocyanates.  Glucosinolates are inert as phase 2 enzyme inducers and must be hydrolyzed (break-down) to generate the active isothiocyanates (Shapiro et al., 2001).

Sulforaphane (SFN) is a compound derived from cruciferous vegetables with numerous bioactivities (Su et al., 2018). In fact, Broccoli and especially broccoli sprouts, accumulate significant amounts of the phytonutrient glucoraphanin, which is metabolized in vivo to the biologically active sulforaphane (SFN).  The preponderance of evidence available from in vitro, animal and human studies supports the association of sulforaphane with phase II enzyme induction (James et al., 2012), moreover, SFN strongly displays both anticarcinogenic and anticancer activity by modulating ‘key signaling pathways and genes involved in the induction of apoptosis, cell cycle arrest, and inhibition of angiogenesis’ (Su et al., 2018; see also Peng et al., 2015; Zhang & Tang, 2007).

SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN (Peng et al., 2015).

Sulforaphane is found in research to have many different health benefits:  Alzheimer’s (Kim et al., 2013), Cardiovascular Disorders (Angeloni et al., 2009), Diabetes (Bahadoran et al., 2012), Asthma- upper airway congestion, (Riedl et al., 2009) and Detoxification in all cells, and in particular with Liver Phase II detoxification enhancement (Riedl et al., 2009).

Sulforaphane (SFN) has been demonstrated to be an effective chemopreventive agent for many years (Shapiro et al., 2001), with positive effects against different kinds of cancers, such as cervical (Chen et al., 2016; Abdull et al., 2013), breast (Peng et al., 2015; Li et al., 2010), bladder (Leone et al., 2017), renal cell carcinoma (Juengel et al., 2016), non-small-cell lung cancer (Wang et al., 2017), and colon and prostate cancers (Clarke et al., 2008; Abdull et al., 2013).

We will continue to examine the research on this important food in the next few weeks.

References

Abdull Razis, A. F., Konsue, N., & Ioannides, C. (2018). Isothiocyanates and Xenobiotic Detoxification. Molecular nutrition & food research62(18), 1700916.

Abdull, R., Ahmad, F., & Noor, N. M. (2013). Cruciferous vegetables: dietary phytochemicals for cancer prevention. Asian Pacific Journal of cancer prevention, 14(3), 1565-1570.

Angeloni, C., Leoncini, E., Malaguti, M., Angelini, S., Hrelia, P., & Hrelia, S. (2009). Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential. Journal of agricultural and food chemistry57(12), 5615-5622.

Bahadoran, Z., Tohidi, M., Nazeri, P., Mehran, M., Azizi, F., & Mirmiran, P. (2012). Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. International journal of food sciences and nutrition63(7), 767-771.

Cheng, Y. M., Tsai, C. C., & Hsu, Y. C. (2016). Sulforaphane, a dietary isothiocyanate, induces G2/M arrest in cervical cancer cells through cyclinB1 downregulation and GADD45β/CDC2 association. International journal of molecular sciences, 17(9), 1530.

Clarke, J. D., Dashwood, R. H., & Ho, E. (2008). Multi-targeted prevention of cancer by sulforaphane. Cancer letters, 269(2), 291-304.

Fahey, J. W., Zhang, Y., & Talalay, P. (1997). Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proceedings of the National Academy of Sciences, 94(19), 10367-10372.  http://www.pnas.org/content/94/19/10367

James, D., Devaraj, S., Bellur, P., Lakkanna, S., Vicini, J., & Boddupalli, S. (2012). Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition reviews70(11), 654-665.

Juengel, E., Maxeiner, S., Rutz, J., Justin, S., Roos, F., Khoder, W., … & Blaheta, R. A. (2016). Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro. Oncotarget, 7(51), 85208.

Kim, H. V., Kim, H. Y., Ehrlich, H. Y., Choi, S. Y., Kim, D. J., & Kim, Y. (2013). Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model. Amyloid20(1), 7-12.

Li, Y., Zhang, T., Korkaya, H., Liu, S., Lee, H. F., Newman, B., … & Sun, D. (2010). Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clinical Cancer Research, 1078-0432.

Peng, X., Zhou, Y., Tian, H., Yang, G., Li, C., Geng, Y., … & Wu, W. (2015). Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells. Oncology reports34(3), 1565-1572.

Riedl, M. A., Saxon, A., & Diaz-Sanchez, D. (2009). Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clinical immunology130(3), 244-251.

Shapiro, T. A., Fahey, J. W., Wade, K. L., Stephenson, K. K., & Talalay, P. (2001). Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.Cancer Epidemiology and Prevention Biomarkers, 10(5), 501-508.  http://cebp.aacrjournals.org/content/10/5/501.long

Su, X., Jiang, X., Meng, L., Dong, X., Shen, Y., & Xin, Y. (2018). Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity2018.

Wang, D. X., Zou, Y. J., Zhuang, X. B., Chen, S. X., Lin, Y., Li, W. L., … & Lin, Z. Q. (2017). Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3β/β-catenin signaling pathways. Acta Pharmacologica Sinica, 38(2), 241.

Zhang, Y., & Tang, L. (2007). Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta pharmacologica Sinica, 28(9), 1343-1354.


Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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The Environmental Working Group is a most important organization to get to know.  Their mission is to empower people to live healthier lives in a healthier environment. With breakthrough research and education, they drive consumer choice and civic action.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Dear Friends

We are excited to announce our new and incredibly potent: organic broccoli cruciferous sprout. Our Glucosinolates & Sulforaphanes is a powerhouse, providing a four fold increase in the phase 2 enzymes inducing and cancer preventing molecules for which it is named.

G and S

Notice that the label above guarantees a Glucosinolate level of 15,000 ppm, a Glucoraphanin level of 10,000 ppm and a Sulforaphane potential of 4,000 ppm.  However, as you can see in the Certificate of Analysis below, the actual levels of these three most important ingredients are much higher, with the Glucosinolates at 21,359 ppm, the Glucoraphanins at 19,407 ppm, and the Sulforaphane yield at 8,733 ppm.  Our old beloved Cruciferous Sprouts product offered a 1500 ppm sulforaphane potential yield.

Organic Broc Sprout CofA

Recommended dose:  one to two capsules daily. Excellent before bed for liver detox.

Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer‐related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis.   Zhang and Tang (2007) review its discovery and development as a cancer chemopreventive agent.

The preponderance of evidence available from in vitro, animal, and human studies supports the association of sulforaphane with phase II enzyme inductions.  Broccoli sprouts are the richest source of glucoraphanin which is the direct precursor to sulforaphane.  Since broccoli sulforaphane is one of the most potent inducers of phase II enzymes, exploration into broccoli’s impact on other areas of human health, such as cardiovasucular health and upper airway immunity, has been suggested (James et al., 2012).

In Qidong, China, a region where exposures to food-and air-borne carcinogens has been considerable, clinical trials indicate that interventions with well characterized preparations of broccoli sprouts may enhance the detoxication of aflatoxins and air-borne toxins, which may in turn attenuate their associated health risks including cancer in exposed individuals (Kensler et al., 2012).

We will continue to discuss this powerhouse product in our next email.

References:

  • James, D., Devaraj, S., Bellur, P., Lakkanna, S., Vicini, J., & Boddupalli, S. (2012). Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutrition reviews, 70(11), 654-665.
  • Kensler, T. W., Egner, P. A., Agyeman, A. S., Visvanathan, K., Groopman, J. D., Chen, J. G., … & Talalay, P. (2012). Keap1–nrf2 signaling: a target for cancer prevention by sulforaphane. In Natural Products in Cancer Prevention and Therapy(pp. 163-177). Springer, Berlin, Heidelberg.
  • Zhang, Y., & Tang, L. (2007). Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta pharmacologica Sinica, 28(9), 1343-1354.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

The Environmental Working Group is a most important organization to get to know.  Their mission is to empower people to live healthier lives in a healthier environment. With breakthrough research and education, they drive consumer choice and civic action.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

A flu/cold immune booster

December 24, 2017

All this week, through to January 2nd, we are offering 15% off on all our products.

An exciting BioImmersion product to consider, especially for the flu and cold season is our LactORN – the next generation probiotic. A flu/cold immune booster.

LactORN Bottle 2What is LactORN and how does it work?

LactORN contains the probiotic Lactobacillus casei grown in a way to retain its natural oligoribonucleotides (ORNs). Plus it contains the prebiotic inulin derived from organic chicory root. Dairy free. Soy free. Gluten free.

Take one tsp 1 and dissolve in the mouth,  2-3 times a week for immune boosting.  If you have a cold/flu, take a teaspoon of LactORN plus a capsule or two of our Organic Garlic.

The Lactobacillus casei‘s ORNs are also called microRNAs, our immune boosting communication molecules. Across animal species, the LactORN has been shown to support immune system competencies to prevent infections caused by viruses and bacteria. It helps the body to protect itself from toxins.  Plus, it keeps the adaptive immune system from overreacting into septic shock.

Your pets can benefit from it as well.  Just add a tsp  to their food once or twice a week.

Sincerely yours,

Seann and Dohrea Bardell

Green Facts:

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To learn more about ORNs or microRNAs:

Wahid, F., Shehzad, A., Khan, T., & Kim, Y. Y. (2010). MicroRNAs: synthesis, mechanism, function, and recent clinical trials. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1803(11), 1231-1243.


 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Original copy
The Original Synbiotic is a daily probiotic for the whole family.

The Original probiotics are researched pedigreed strains of lactic acid bacteria that support the development of a healthy GI tract microbiome.

A healthy gut microbiome is dependent on strong and proven probiotics, such as the Original strains. The Original Synbiotic provides a powerful symbiotic combination of Lactobacillus acidophilus (ATCC 4356), Streptococcus thermophilus (ATCC 19258), Lactobacillus plantarum (ATCC 8014), Lactobacillus rhamnosus (ATCC 7469) and Bifidobacterium longum (ATCC 15707).

Our chosen probiotics are foundational ATCC strains shown in research to work together with human cells to perform many functions in the body. For example, these probiotic strains help the digestive system, support and balance the immune system, and enhance our nervous system by producing neurotransmitters. They reinforce the GI barrier function to protect us from xenobiotics and pathogens, even binding heavy metals. Moreover, they neutralize carcinogens such as those caused by heterocyclic amines found in blackened meat and elements such as nitrosamines in sausage. By acidifying the epithelial membrane, they enable the absorption of minerals such as calcium and magnesium more readily. And lastly, our chosen strains also support the important task of daily regularity (Syngia et al., 2016; Hardy et al., 2013; Figueroa‐González et al., 2011; Ng et al., 2009).

The Original Synbiotic suggested daily dose: one tsp daily.

Of the many beneficial functions needed to be performed by our probiotic friends, colonizing the GI tract membrane and thereby protecting from our body from pathogens and xenobiotics, is very important. Check out these studies on colonization (Toscano et al., 2017; Underwood et al., 2015; Panigrahi et al., 2008; De Champs et al., 2003; Sarem- Damerdji et al., 1995).

See the Original Synbiotic Monograph.

References:

  • De Champs, C., Maroncle, N., Balestrino, Damien., Rich, C., Forestier, C. (2003). Persistence of Colonization of Intestinal Mucosa by A Probiotic Strain, Lactobacillus casei subsp rhamnosus Lcr35, after Oran Consumption. J Com Microbiol; 41(3): 1270-1273.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150315/
  • Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.
  • Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.
  • Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.
  • Panigrahi, P., Pradhan, L., Mohapatra, S.S., Misra, P.R., Johnson, J.A., Chaudhry, R., Taylor, S., Hanse, N.I., Gewolb, I.H. (2008). Long-term colonization of a Lactobacillus plantarum synbiotic preparation in the neonatal gut. J Pediatr Gastroenterol Nutr; 47(1):45-53. https://www.ncbi.nlm.nih.gov/pubmed/18607268
  • Sarem-Damerdji, L., Sarem, F., Marchal, L., Micolas, J.P. (1995). In vitro colonization ability of human colon mucosa by exogenous Lactobacillus strains. FEMS Microbiology Letters; 131(2):133-137. https://academic.oup.com/femsle/article-abstract/131/2/133/524865/In-vitro-colonization-ability-of-human-colon?redirectedFrom=PDF
  • Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of food science and technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0
  • Toscano, M., De Grandi, R., Stronati, L., De Vecchi, E., & Drago, L. (2017). Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study. World journal of gastroenterology, 23(15), 2696.
  • Underwood, M. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2015). Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatric research, 77, 229.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350908/

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3In today’s world the level of assault on our bodies from pollution, pathogens, and stress is so high that we need powerful food supplements.  Our bodies, after all, know exactly what and how to utilize food for therapeutic purposes.

At BioImmersion, we created the Therapeutic Food Supplement line with a new medical framework in mind: the power and intelligence of food. Our Therapeutic Foods are indeed potent food supplements that behave intelligenly in the body – repairing, healing, protecting and preventing.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Dr. George Kessler, Dr. Artemis Morris, and myself have started to work on a Therapeutic Food’s protocol book.

This first protocol from Dr. Kessler and myself is designed to support the detoxification process.

In today’s modern world we battle a monster, which is the underlying cause or at least a contributing factor of many or most of our health problems.  It can make us express or create genetic weakness, feel ill in numerous ways and create the diseases of modern life.  I am, of course, referring to environmental toxins, the bane of modern civilization.

A Therapeutic Food protocol to support detoxification:

Scientific Rational:

Excessive exposure to toxic heavy metals or persistent organic pollutants (POPs) from diet or environment is inevitable amid [our present energy based] industrialization and [the subsequent] pollution.  Understanding of the detoxification ability amongst nutrients in plant based food offers therapeutic and preventive effects against these toxins (Chung, 2015).

Garlic prevents methyl mercury-induced cytotoxicity in peripheral blood leukocytes (Abdalla, 2010), and protects against methyl mercury neurotoxicity in the brain (Belle, 2009). Garlic prevents cadmium-induced kidney damage and decreases the oxidative damage due to lead in rats (Suru, 2008); as well as reduces tissue lead concentrations (Senapati, 2001).

Chlorella supports the detoxification of polycyclic aromatic hydrocarbons (Yang et al., 2015) and inorganic mercury (Wu & Wang, 2014). Researchers investigated the influence of Chlorella on the excretion and tissue accumulation of methylmercury in mice.  The reduction of Hg levels in the kidney and brain were significant (Siao, 2011).

Phyto Power with its combination of wild-crafted rosehip, blueberry and dandelion supports the shifting of the body’s reserves to become more alkaline which enhances its ability to detoxify (Minich, 2007). Denev et al., (2014) found rosehips and blueberries to supply the most potent inhibitors for lipid peroxidation.

Beta Glucan High Potency Synbiotic contains powerful pedigreed strains of Lactobacillus and Bifidobacterium species. Research demonstrates that probiotic supports the binding of lead and cadmium to their cell surface and hold on to them through defecation.  Singh and Sharma (2010) showed that L. acidophilus was able to bind and remove arsenic found in drinking water.  Robinson and Tuovinenn (1984) demonstrated that L. rhamnosus reduces the bioaccumulation of mercury and arsenic in pregnant women and children.  Shrivastava et al. (2003) found that Lactobacilli can transform chromium (CrVI) to its less toxic form (CRIII). The fibers and probiotic combination in the Beta Glucan support the regularity of the GI tract to remove toxins and help those with IBS or other gastrointestinal disorders (Lacey at al., 2015; Sarowska et al., 2013).

Cruciferous vegetables contain secondary metabolites termed glucosinolates that break down to products that upregulate hepatic detoxification enzymes.  These enzymes are called phase II enzymes and are responsible for phase II liver detoxification—a critical component in the body’s detoxification processes (Nho CW, Jeffery E., 2001).  Our cruciferous sprouts magnify production of the glucosinolates 100 fold.

References:

  • Abdalla et al. (2010). Allium sativum L. extract prevents methyl mercury-induced cytotoxicity in peripheral blood leukocytes (LS). Food and Chemical toxicology; 48(1): 4147-421.
  • Belle et al. (2009). Comparative Evaluation of Adenosine Deaminase Activity in Cerebral cortex and Hippocampus of young and Ault Rats: Effect of Garlic Extract (Allium sativum L.) on their Susceptibility to Heavy Metal Exposure. BCPT; 104(5): 408-413.
  • Chung R.T. (2015). Detoxification effects of phytonutrients against environmental toxicants and sharing of clinical experience on practical applications. Environ Sci Pollut Res; doi:10.1007/s 11256-015-5263-3.
  • Denev at al. (2014) Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health. Food Chem; 157: 37-44. doi: 10.1016/j.foodchem.2014.02.022.
  • Haittunen et al. (2007) Rapid removal of lead and cadmium from water by specific lactic acid bacteria. Nit J Food Microbiol; 114:30-35.
  • Lacey at al. (2015). New and emerging treatment options for irritable blowel syndrome. Gastroenterol Hepatol (NY); 11(4) (suppl 2); 1-9.
  • Minich D. M, Bland L. S. (2007). Acid-alkaline balance: role in chronic disease and detoxification. Altern Ther Health Med; 13(4): 62-5.
  • Nho CW, Jeffery E. (2001). The Synergistic Upregulation of Phase II Detoxification Enzymes by Glucosinolate Breakdown Products in Cruciferous Vegetables. Tox and Appl Pharm; 174(2):146-152.
  • Robinson J. B, Tuovinen OH. (1984). Mechanisms of microbial resistance and detoxification of mercury and organomercury compounds: physiological, biochemical, and genetic analyses. Microbiol Rev; 48:95-124.
  • Sarowska et al. (2013). The therapeutic effect of probiotic bacteria on gastrointestinal disease. Adv Clin Exp Med; 22(5): 759-66.
  • Senapati et al. (2001). Effect of garlic (Allium sativum L.) extract on tissue lead level in rats. J Ethnopharmacol; 76(3): 229-32.
  • Shrivastava et al. (2003). Various cells of the immune system and intestine differ in their capacity to reduce hexavalent chromium. FEMS immunol med microbio; 38:65-70.
  • Singh et al. (2010). Removal of arsenic (III) from wastewater using Lactobacillus acidophilus. Bioremediat j; 14:92-97
  • Suru S. M. (2008). Onion and garlic extracts lessen cadmium-induced nephrotoxicity in rats. Biometals; 21(6): 623-33.
  • Wu Y, Wang W. X. (2014). Intracellular speciation and transformation of inorganic mercury in marine phytoplankton. Aquat Toxicol; 148:122-9.
  • Yang et al. (2015). Epigenetic modulation of Chlorella (Chlorella vulgaris) on exposure to polycyclic aromatic hydorcarbons. Environ Toxicol Pharmacol; 40(3): 758-63.
Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health.  Please  use our products under the advisement of your doctor.

Green Facts:

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The Environmental Working Group empowers people to live healthier lives in a healthier environment.  With breakthrough research and education they drive consumer choice and civic action.