Cardiovascular Support

Dear Friends

Original copy
The Original Synbiotic is a daily probiotic for the whole family.

The Original probiotics are researched pedigreed strains of lactic acid bacteria that support the development of a healthy GI tract microbiome.

A healthy gut microbiome is dependent on strong and proven probiotics, such as the Original strains. The Original Synbiotic provides a powerful symbiotic combination of Lactobacillus acidophilus (ATCC 4356), Streptococcus thermophilus (ATCC 19258), Lactobacillus plantarum (ATCC 8014), Lactobacillus rhamnosus (ATCC 7469) and Bifidobacterium longum (ATCC 15707).

Our chosen probiotics are foundational ATCC strains shown in research to work together with human cells to perform many functions in the body. For example, these probiotic strains help the digestive system, support and balance the immune system, and enhance our nervous system by producing neurotransmitters. They reinforce the GI barrier function to protect us from xenobiotics and pathogens, even binding heavy metals. Moreover, they neutralize carcinogens such as those caused by heterocyclic amines found in blackened meat and elements such as nitrosamines in sausage. By acidifying the epithelial membrane, they enable the absorption of minerals such as calcium and magnesium more readily. And lastly, our chosen strains also support the important task of daily regularity (Syngia et al., 2016; Hardy et al., 2013; Figueroa‐González et al., 2011; Ng et al., 2009).

The Original Synbiotic suggested daily dose: one tsp daily.

Of the many beneficial functions needed to be performed by our probiotic friends, colonizing the GI tract membrane and thereby protecting from our body from pathogens and xenobiotics, is very important. Check out these studies on colonization (Toscano et al., 2017; Underwood et al., 2015; Panigrahi et al., 2008; De Champs et al., 2003; Sarem- Damerdji et al., 1995).

See the Original Synbiotic Monograph.

References:

  • De Champs, C., Maroncle, N., Balestrino, Damien., Rich, C., Forestier, C. (2003). Persistence of Colonization of Intestinal Mucosa by A Probiotic Strain, Lactobacillus casei subsp rhamnosus Lcr35, after Oran Consumption. J Com Microbiol; 41(3): 1270-1273.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150315/
  • Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.
  • Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.
  • Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.
  • Panigrahi, P., Pradhan, L., Mohapatra, S.S., Misra, P.R., Johnson, J.A., Chaudhry, R., Taylor, S., Hanse, N.I., Gewolb, I.H. (2008). Long-term colonization of a Lactobacillus plantarum synbiotic preparation in the neonatal gut. J Pediatr Gastroenterol Nutr; 47(1):45-53. https://www.ncbi.nlm.nih.gov/pubmed/18607268
  • Sarem-Damerdji, L., Sarem, F., Marchal, L., Micolas, J.P. (1995). In vitro colonization ability of human colon mucosa by exogenous Lactobacillus strains. FEMS Microbiology Letters; 131(2):133-137. https://academic.oup.com/femsle/article-abstract/131/2/133/524865/In-vitro-colonization-ability-of-human-colon?redirectedFrom=PDF
  • Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of food science and technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0
  • Toscano, M., De Grandi, R., Stronati, L., De Vecchi, E., & Drago, L. (2017). Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study. World journal of gastroenterology, 23(15), 2696.
  • Underwood, M. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2015). Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatric research, 77, 229.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350908/

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3In today’s world the level of assault on our bodies from pollution, pathogens, and stress is so high that we need powerful food supplements.  Our bodies, after all, know exactly what and how to utilize food for therapeutic purposes.

At BioImmersion, we created the Therapeutic Food Supplement line with a new medical framework in mind: the power and intelligence of food. Our Therapeutic Foods are indeed potent food supplements that behave intelligenly in the body – repairing, healing, protecting and preventing.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends
Phyto Power High Rez
Stull’s (2016) review, Blueberries’ Impact on Insulin Resistance and Glucose Intolerance, highlighted a multitude of in vivo and in vitro studies that demonstrated another of blueberries important attributes — the anti-diabetic effects of blueberries and berry extracts in insulin-resistant rodent, human, and cell culture models.

The scientific evidence in support of the anti-diabetic health benefits of blueberries and blueberry extract is encouraging. Epidemiological studies reported that consumption of foods rich in anthocyanins, especially from blueberries, were associated with a lower risk of type 2 diabetes (T2DM) and of peripheral insulin resistance.

Prediabetes is a condition in which blood glucose levels are higher than normal, but not high enough to be classified as T2DM.  Although the prediabetes stage is when corrective actions need to be implemented to prevent the possible development of T2DM, many studies find blueberries to have an anti-diabetic effect. See the references below.

Dinstel et al. (2013) found the blueberries in Alaska to have the highest anthocyanins content. See Green Facts below. Our Phyto Power utilizes Alaskan blueberries’ potent levels of plant phenols.

Phyto Power is comprised of several species of wildcrafted blueberries, Rose hip, and Dandelion, including their leaves, stems, roots, and flowers. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan Natives have used these power-filled berries and plants for their daily nourishment as well as ceremonial and medicinal purposes

Learn how to use Phyto Power in our research and description tabs.

References:

  • Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI: 10.3402/ijch.v72i0.21188
  • Haffner, S.M. (1996). The insulin resistance syndrome revisited. Diabetes Care,19:275-277. doi: 10.2337/diacare.19.3.275.
  • Jennings, A., Welch, A. A., Spector, T., Macgregor, A., & Cassidy, A. (2014). Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. The Journal of nutrition, 144(2), 202-208.
  • Muraki, I., Imamura, F., Manson, J. E., Hu, F. B., Willett, W. C., van Dam, R. M., & Sun, Q. (2013). Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies. Bmj, 347, f5001.
  • Stull, A. J. (2016). Blueberries’ Impact on Insulin Resistance and Glucose Intolerance. Antioxidants, 5(4), 44. doi:  10.3390/antiox5040044
  • Wedick N.M., Pan A., Cassidy A., Rimm E.B., Sampson L., Rosner B., Willett W., Hu F.B., Sun Q., van Dam R.M. (2012). Dietary flavonoid intakes and risk of type 2 diabetes in US men and women.  Am. J. Clin. Nutr, 95:925–933. doi: 10.3945/ajcn.111.028894.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.*
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends
Phyto Power High Rez
Phyto Power is comprised of several species of wildcrafted blueberries, Rose hip, and Dandelion, including their leaves, stems, roots, and flowers. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan Natives have used these power-filled berries and plants for their daily nourishment as well as ceremonial and medicinal purposes.

  • Three species of Rosehip, wildcrafted, whole fruit and seeds (100% w/w), refractory dried, three Rosa species, 200mg per capsule.
  • Four species of Dandelion, wildcrafted, aerial parts (90% w/w), root (10% w/w) with flower, refractory dried, four Taraxacum species, 200mg per capsule.
  • Four species of Blueberry, wildcrafted, fruit (>90% w/w), leaves and stem (<5% w/w), refractory dried, four Vaccinium species, 100mg per capsule.

Food Science

Alaskan wildcrafted berries and plants supply ample antioxidants, anti-inflammatory, and anti-microbial factors (Grace et al., 2014; Youself et al., 2013).

Phyto Power is indeed powerful. In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.

The Alaskan red Rose hip fruit and seeds, blue-purple Blueberries with twigs and leaves, and the Dandelion’s green leaves, stems, roots and yellow flowers are filled with potent phytonutrients. These vibrant and nutritious phytochemicals protect and enhance the health of both plants and humans (Joseph, Nadeau, & Underwood, 2003). James Duke’s (2000) substantial USDA phytochemical database illustrates the mechanism of the world of plants in the support and maintenance of our health (p. 2).

Scientific evidence links the lack of sufficient nutrients and colorful phytochemicals in our daily diets to the rise of chronic inflammation, one of the causes of metabolic syndrome, which includes cardiovascular, type 2 diabetes, as well as various cancers (Joseph, 2003; Ridker et al., 2000, 2003; Kristo et al., 2016, Ovadje et al., 2016, respectively). For this reason, García-Lafuente et al. (2009) conclude that flavonoids from berries and plants behave as anti-inflammatory agents in our body, calling for more research on the implication of these effects as protection against cancer and cardiovascular issues.

The effect of Blueberries, Rose hip, and Dandelion on Metabolic Syndrome’s risk markers is well documented and researched (Choi et al., 2010; Basu et al., 2012). For example, Andersson et al. (2011) demonstrated in a randomized, double-blind, crossover study* with 31 obese individuals that daily consumption of rose hip (drink) significantly decreased plasma cholesterol and systolic blood pressure, effectting the risk markers of type 2 diabetes and cardiovascular disease. In 2012, Andersson et al. conducted a study with lean and obese mice that were fed high-fat diet and a dietary supplement of rose hip powder. The supplement of rose hip prevented and reversed the increase in body weight. Andersson et al. (2012) concluded that rose hip supports the prevention of diabetic state in the mouse and that downregulation of the hepatic lipogenic program is one of the mechanisms underlying this antidiabetic effect.

Choi et al.’s (2010) demonstrated that supplementing rabbits that are fed with high cholesterol diets with dandelion leaf and root positively changed plasma antioxidant enzyme activities and lipid profiles, offering “hypolipidemic and antioxidant effects.”

These research findings are not new amongst scientists. Johnson et al. (1994) discovered that plants and their biologically active constituents contribute protective and anti-carcinogenic effects (Table 1, p. 193). These ‘dietary phytoprotectants’ in foods (p. 194) have continually shown in research to impart an important anti-inflammatory effect (Vendrame et al., 2015; Joseph et al., 2014), act as powerful anti-oxidants (Jedrejek et al., 2017; Skrovankova et al., 2015), and offer protection and inhibition of certain cancers (Zhan et al., 2016; Yang & Li, 2015; Li et al., 2009; Seeram, 2008; Sigstedt et al., 2008).

Although the exact mechanisms and reasons (the why) of these promising effects are still in the process of discovery, the findings suggest a regular habit of dietary supplementation with these plants and berries.

Blueberries, Rose hip, and Dandelion demonstrate in research a potential effect on different cancers. For example, blueberries are shown to inhibit growth and metastatic potential (Adams et al., 2010; Liu et al., 2013), and manage gastrointestinal tract cancers (Bishayee et al., 2016). Rose hip has shown to effect human brain cell proliferation (Cagle et al., 2012) and offer antiproliferation effect on Caco-2 human colon cancer (Jiménez et al., 2016). Dandelion was found to induce apoptosis in drug-resistant human melanoma cells (Chatterjee et al., 2011; see also Jeon et al., 2008 and Hu et al., 2003 for further reading on dandelion).

The Rose hip has a rich phytochemical profile shown to also support many different mechanisms in the human body. For example, the red berry of Rose hip is known for its antioxidant protection (Widen et al., 2012), supporting weight loss by a possible mechanism of decreasing abdominal visceral fat (Nagatomo et al., 2015). Andersson et al. (2011) examined the Rose hip antidiabetic effect, as well as the effect of Rose hip on risk markers of type 2 diabetes and cardiovascular disease in obese persons (Andersson et al., 2012). Rose hip is also found to support the liver (Nagatomo et al., 2013; Sadeghi et al., 2016), and offer relief from joint pain (Christensen et al., 2008; Willich et al., 2010; Winther et al., 2005).

For further study of the Rosa canina see Chrubasik et al. for a systemic review and clinical efficacy of the Rose hip (2008; 2006, respectively).

Dandelion is shown to have a great antioxidant activity (Hu et al., 2003), exhibiting diverse biological activities that promote energy, weight loss, and reduced risk of metabolic syndrome (Jedrejek et al., 2017; González-Castejón et al., 2012; Jeon et al., 2008). Ovadje et al. (2016) conclude that dandelion root extract effects colorectal cancer proliferation which may occur through the activation of ‘multiple death signalling pathways,’ and a selective induction of apoptosis and autophagy in human pancreatic cancer cells (2012; 2012a). Signstedt (2008) found similar results with extract of Taraxacum officinale on the growth and invasion of breast and prostate cancer cells, while Yang et al. (2015) demonstrated that Dandelion extract protects human skin fibroblasts from uvb damage.

For further study of the Taraxacum (Dandelion), see Schütz, Carle, & Schieber (2006) for a systemic review on its phytochemical and pharmacological profile.

Blueberries are rich with anthocyanins and a wide variety of phytochemicals that have been shown to effect neuro-generation (Albarracin et al., 2012). Studies are showing that a neuro-generative effect also occurs with Parkinson (Chao et al., 2012; Gao et al., 2012; Strathearn et al., 2014). Blueberries regenerate neuronal aging (Shukitt-Hale, 2012), and support memory (Krikorian et al., 2010). For more on nerve regeneration, see the Research tab of Blueberry Extract.

A daily consumption of blueberries is shown to support a lower blood pressure and arterial stiffness (Johnson et al., 2015), increase natural killer cell counts (McAnulty et al., 2014), down-regulate hepatic lipogentic program (Andersson et al., 2011), and impact insulin resistance and glucose intolerance (Stull, 2016). Zhan et al. (2016) discovered the importance of blueberries on the migration, invasion, proliferation of hepatocellular carcinoma cells. Yang et al. has shown in 2001 the inhibition of carcinogenesis by dietary polyphenolic compounds.

These impressive findings support dietary supplementation with berries as a healthy approach to various Metabolic Syndrome concerns, including cancer (Vendrame et al., 2015; Seeram, N.P., 2008; Seeram et al., 2006, respectively).

The hormetic mechanism of phyto-nutrients is an exciting area of research. Scientists have discovered that small amounts of phytochemicals offer much more than nutrients. Phytochemicals offer a hormetic mechanism; a stimulation of many pathways in our body that prevents, repairs, or reverses aging and disease (Lee et al., 2014; Davinelli et al., 2012). The concept of hormesis is defined as an adoptive response of cells and organism to low dosages of phytochemicals. This adoptive response stimulates a beneficial effect in the body (Mattson, 2008, 2008a). Calabrese et al. conducted many studies on hormetic phytochemicals and vitagenes in aging and longevity, including the effect of antioxidants such as polyphenols on neuro-generation (2012, 2011, 2009). The vitagene network of genes involved in the process of repair and maintenance is thought of as the longevity assurance processes (Rattan, 2004, 1998).

Phyto Power as a dietary supplement offers a regular serving of several species of Blueberries, Rose hip, and Dandelion, including the leaves, stems, flower, and root.

See the Research tab for additional bibliography to further understand the research, findings, application and use of Blueberries, Rose hip, and Dandelion. Visit Resources on the tool bar to find helpful protocols (Library) and summaries (News).

*Double blind, crossover study: in a double blind study A study the participants and those in contract with them (assistants) are blind to the details of the study. A crossover is when at one point in the study the participants switch from taking an active substance (such as rose hip in the Andersson study) to a placebo or vice versa.

References:

Adams, L.S., Phung, S. Yee, N., Sheeram, N.P., Li, L., & Chen, S. (2010). Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, 70(9), 3594-605. DOI: 10.1158/0008-5472.CAN-09-3565

Albarracin, S.L., Stab, B., Casas, Z., Sutachan, J.J., Samudio, I., Gonzalez, J….Barreto, G.E. (2012). Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci, 15, 1–9. DOI:10.1179/1476830511Y.0000000028

Andersson, U., Berger, K., Hogberg, A., Landin-Olsson, M., & Holm, C. (2012). Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr, 66, 585–590. DOI:10.1038/ejcn.2011.203

Andersson, U., Henriksson, E., Strom, K., Alenfall, J., Goransson, O., Holm, C. (2011). Rose hip exerts antidiabetic effects via a mechanism involving downregulation of the hepatic lipogenic program. Am J Physiol Endocrinol Metab, 300, E111–121. DOI:10.1152/ajpendo.00268.2010

Basu, A., &  Lyons,  T.J. (2012). Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives. J Agric Food Chem, 60: 5687-92. DOI:10.1021/jf203488k

Bishayee, A., Haskell, Y., Do, C., Siveen, K.S., Mohandas, N., Sethi, & G., Stoner, G.D. (2016). Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence. Crit Rev Food Sci Nutr, 56(10), 1753-75. DOI: 10.1080/10408398.2014.982243

Cagle, P., Idassi, O., Carpenter, J., Minor, R., Goktepe, I., & Martin, P. (2012). Effect of Rosehip (Rosa canina) extracts on human brain tumor cell proliferation and apoptosis. Journal of Cancer Therapy, 3(5), 13. . DOI:10.4236/jct.2012.35069

Calabrese, V., Cornelius, C., Dinkova-Kostova, A.T., Iavicoli, I., Di Paola, R., Koverech, A. … Calabrese, E.J. (2012). Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta, 1822(5), 753-83. DOI:10.1016/j.bbadis.2011.11.002

Calabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarell,i E., Calabrese, E.J. (2011). Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. Mol Aspects Med, 32(4-6):279-304. DOI:10.1016/j.mam.2011.10.007

Calabrese, V., Cornelius, C., Mancuso, C., Barone, E., Calafato, S., Bates, T., Rizzarelli, E., Kostova, A.T. (2009). Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases. Front Biosci, 14, 376-397. Abstract

Chao, J., Leung, Y., Wang, M., & Chang, R.C. (2012). Nutraceuticals and their preventive or potential therapeutic value in Parkinson’s disease. Nutr Rev, 70, 373–86. DOI:10.1111/j.1753-4887.2012.00484.x.

Chatterjee, S.J., Ovadje, P. Mousa, M., Hamm, C., & Pandey, S. (2011). The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evid Based Complement Alternat Med, 129045. DOI:10.1155/2011/129045

Choi, U.K., Lee, O.H., Yim, J.H., Ch,o C.W., Rhee, Y.K., Lim, S.I., & Kim, Y.C. (2010). Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits. Int Mol Sci, 11(1), 67-78. doi:10.3390/ijms11010067.

Christensen, R., Bartels, E.M., Altman, R.D., Astrup, A., Bliddal, H. (2008). Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?–a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage, 16, 965–972. DOI:10.1016/j.joca.2008.03.001

Chrubasik, C., Roufogalis, B.D. Muller-Lander, U., & Chrubasik, S. (2008). A systematic review on the Rosa canina effect and efficacy profiles. Phytother Res, 22(6), 725-33. DOI:10.1002/ptr.2400

Chrubasik, C., Duke, R.K., Chrubasik, S. (2006). The evidence for clinical efficacy of rose hip and seed: a systematic review. Phytother Res, 20(1), 1-3. DOI:10.1002/ptr.1729

Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI:
10.3402/ijch.v72i0.21188

Davinelli, S., Willcox, D.C., & Scapagnini, G. (2012). Extending healthy aging: nutrient sensitive pathway and centenarian population. Immun Ageing, 9, 9. DOI:10.1186/1742-4933-9-9.

Gao, X., Cassidy, A., Schwarzschild, M.A., Rimm, E.B., & Ascherio, A. (2012). Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology, 78, 1138–45. doi:  10.1212/WNL.0b013e31824f7fc4

García-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M.A., & Martínez, J.A. (2009). Flavonoids as antiinflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res, 58, 537–552. DOI:10.1007/s00011-009-0037-3

Gonzalez-Castejon, M., Visioli, F., & Rodriguez-Casado, A. (2012). Diverse biological activities of dandelion. Nutr Rev, 70(9), 534-47. DOI:10.1111/j.1753-4887.2012.00509.x

Grace, M.H., Esposito D., Dunlap K.L., & Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries. J Agric Food Chem, 62(18), 4007-17. doi:10.1021/jf403810y.

Hu, C.,  & Kitts, D.D. (2003). Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro. Journal of Agricultural and Food Chemistry, 51, (1), 301–310. DOI:10.1021/jf0258858

Duke, J. (2000). The green pharmacy herbal handbook. Emmaus, PA: Rodale Inc.

Jedrejek, D., Kontek, B., Lis, B., Stochmal, A., Olas, B. (2017). Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2/Fe. Chem Biol Interact, 262, 29-37. DOI: 10.1016/j.cbi.2016.12.003

Jeon, H.J., Kang, H. J., JungH.J. Kant, Y.S., Lim, C.J., Kim, Y.M., & Park, E.H. (2008). Anti-inflammatory activity of Taraxacum officinale. Journal of Ethnopharmacology, 115 (1), 82–88. DOI:10.1016/j.jep.2007.09.006

Jiménez, S., Gascón, S., Luquin, A., Laguna, M., Ancin-Azpilicueta, C., Rodríguez-Yoldi, M.J. (2016). Rosa canina Extracts Have Antiproliferative and Antioxidant Effects on Caco-2 Human Colon Cancer. PLoS One, 11(7), e0159136. https://doi.org/10.1371/journal.pone.0159136

Johnson, I.T., Williamson, G., & Musk, S.R.R. (1994). Anticarcinogenic factors in plant foods: A new class of nutrients? Nutr Res Rev,7, 175–204. DOI:10.1079/NRR19940011

Johnson, S.A., Figueroa, A., Navae, N. Wong, A., Ralfon, R., Ormsbee, L.T…. Arjmandi, B.H. (2015). Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. J. Acad Nutr Diet, 115(3), 369-77. DOI:10.1016/j.jand.2014.11.001

Joseph, S.V., Edirisinghe, I., & Burton-Freeman, B.M. (2014). Berries: anti-inflammatory effects in humans. J Agric Food Chem, 7; 62(18), 3886-903. DOI:10.1021/jf4044056

Joseph, J., Nadeau, D., & Underwood, A. (2003). The color code: A revolutionary eating plan for optimum health. New York, NY: The Philip Lief Group, Inc. Book

Kristo, A.S., Klimis-Zacas, D., Sikalidis, A.K. (2016). Protective Role of Dietary Berries in Cancer. Antioxidants (Basel), 5(4), 37. doi:10.3390/antiox5040037

Krikorian, R., Shidler, M.D., Nash, T.A., Kalt, W., Vingvist-tymchuk, M.R., Shukitt-Hale, B., Joseph, J.A. (2010).  Blueberry supplementation improves memory in older adults. J. Agric Food Chem, 58, 3996-4000. DOI:10.1021/jf9029332

Lee, J., Jo, D.G., Park, D., Chung, H.Y., Mattson, M.P. (2014). Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.
Pharmacol Rev, 66(3), 815-68. DOI:10.1124/pr.113.007757

Li, L., Adams, L.S., Chen, S., Killan, C., Ahmed, A., & Seeram, N.P. (2009). Eugenia jambolana Lam. [purple berries] berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. J Agric Food Chem, 57(3), 826-31. DOI:10.1021/jf803407q

Liu, W., Lu, X., He, G., Gao, X., Xu, M., Zhang, J… Luo, C. (2013). Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Int Mol Sci, 14(11), 21447-62. DOI:10.3390/ijms141121447

Mattson, M.P. (2008). Hormesis defined. Ageing Res Rev, 7(1), 1-7. doi:  10.1016/j.arr.2007.08.007

Mattson M.P. (2008). Dietary factors, hormesis and health. Ageing Res Rev, 7(1), 43-48. doi:  10.1016/j.arr.2007.08.004

McAnulty, L.S., Collier, S.R., Landram, M.J., Whittaker, D.S., Isaacs, S.E., Klemka, J.M…  McAnulty, S.R. (2014). Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females. Nutr Res, 34(7), 577-84. DOI:10.1016/j.nutres.2014.07.002

Nagatomo, A., Nishida, N., Fukuhara, I., Noro, A., Kozai, Y., Sato, H., & Matsuura, Y. (2015). Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects: a randomized, double-blind, placebo-controlled clinical trial. Diabetes Metab Syndr Obes, 8, 147–156. DOI:10.2147/DMSO.S78623

Nagatomo, A., Nishida, N., Matsuura, Y., & Shibata, N. (2013). Rosehip Extract Inhibits Lipid Accumulation in White Adipose Tissue by Suppressing the Expression of Peroxisome Proliferator-activated Receptor Gamma. Prev Nutr Food Sci, 18, 85–91. doi:  10.3746/pnf.2013.18.2.085

Ovadje, P., Ammar, S., Guerrero, J.A., Arnason, J.T., Pandey, S. (2016). Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. Oncotarget, 7(45):73080-73100. DOI:
10.18632/oncotarget.11485

Ovadje, P., Chochkeh, M., Akbari-Asl, P., Hamm, C., Pandey, S. (2012). Selective induction of apoptosis and autophagy through treatment with dandelion root extract in human pancreatic cancer cells. Pancreas, 41(7), 1039-47. DOI: 10.1097/MPA.0b013e31824b22a2

Ovadje, P., Hamm, C., Pandey, S. (2012a). Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells.
PLoS One, 7(2), e30604. doi:  10.1371/journal.pone.0030604

Rattan SI. (2008). Hormesis in aging. Ageing Res Rev, 7(1), 63-78. DOI:
10.1016/j.arr.2007.03.002

Rattan, S.I. (1998). The nature of gerontogenes and vitagenes: Antiaging effects of repeated heat shock on human fibroblasts. Annals of the New York Academy of Sciences, 854, 54-60. doi:10.1111/j.1749-6632.1998.tb09891.

Ridker, P.M., Buring, J.E., Cook, N.R., & Rifai, N. (2003). C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation, 107(3), 391-7. DOI:org/10.1161/01.CIR.0000055014.62083.05

Ridker, P.M., Hennekens, C.H., Buring, J.E., & Rifai, N. (2000). C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med, 342(12), 836-43. DOI:10.1056/NEJM200003233421202

Sadeghi, H., Hosseinzadeh, S., Akbartabar Touri, M., Ghavamzadeh, M., Jafari Barmak, M., Sayahi, M., & Sadeghi, H. (2016). Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat. Avicenna J Phytomed, 6(2), 181-8. DOI: 10.22038/ajp.2016.5481

Schütz, K, Reinhold, C., & Schieber, A. (2006). Taraxacum—A review on its phytochemical and pharmacological profile. J Ethnopharmacol, 107, 313–323. DOI: 10.1016/j.jep.2006.07.021
Seeram N.P. (2008). Berry fruits for cancer prevention: current status and future prospects. J Agric Food Chem; 56(3): 630-5. DOI:10.1021/jf072504n

Seeram, N.P., Adam, L.S., Zhang, Y., Lee, R., Sand, D., Scheuller, H.S., & Heber, D. (2006). Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem, 54(25), 9329-39. DOI:10.1021/jf061750g

Shukitt-Hale, B. (2012).  Blueberries and neuronal aging. Gerontology, 58, 518-523. DOI:10.1159/000341101

Sigstedt, S.C., Hooten, C.J., Callewaert, M.C., Jenkins, A.R., Romero, A.E., Pullin, M.J…. Steelant, W.F. (2008). Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. Int J Oncol. 32(5), 1085-90. https://doi.org/10.3892/ijo.32.5.1085

Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., Sochor, J.(2015). Bioactive Compounds and Antioxidant Activity in Different Types of Berries. Int J Mol Sci, 16(10), 24673-706. doi:10.3390/ijms161024673

Strathearn, K.E., Youself, G.G., Grace, M.H., Roy S.L., Tambe, M.A., Ferruzzi, M.G., Wu, Q.L., … Rochet, J.C. (2014). Neuroprotective effects of anthocyanin-and proanthocyanidin-rich extracts in cellular models of Parkinson’s disease. Brain Research, 1555(25), 60-77. DOI:10.1016/j.brainres.2014.01.047

Vendrame, S., & Klimis-Zacas, D. (2015). Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades. Nutr Rev, 73(6), 348-58. DOI:10.1093/nutrit/nuu066.

Widen, C., Ekholm, A., Coleman, M.D., Renvert, S., Rumpunen, K. (2012). Erythrocyte antioxidant protection of rose hips (Rosa spp.) Oxid Med Cell Longev, 621579. http://dx.doi.org/10.1155/2012/621579

Willich, S.N., Rossnagel, K., Roll, S., Wagner, A., Mune, O., Erlendson, J…Winther, K. (2010). Rose hip herbal remedy in patients with rheumatoid arthritis – a randomised controlled trial. Phytomedicine, 17(2), 87-93. DOI:10.1016/j.phymed.2009.09.003

Winther, K., Apel, K., & Thamsborg, G. (2005). A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scand J Rheumatol, 34(4), 302-8. DOI:10.1080/03009740510018624

Yang, Y.,  & Li, S. (2015). Dandelion extracts protect human skin fibroblasts from UVB damage and cellular senescence. Oxid Med Cell Longev, 619560. http://dx.doi.org/10.1155/2015/619560

Yang, C.S., Landau, J.M., Huang, M.T., & Newmark, H.L. (2001). Inhibition of carcinogenesis by dietary polyphenolic compounds. Ann Rev Nutr, 21, 381–406. DOI:
10.1146/annurev.nutr.21.1.381

Yousef, G.G., Brown, A.F., Funakoshi, Y., Mbeunkui, F., Grace, M.H., Ballington, J.R., Loraine, A., & Lila, M.A. (2013). Efficeint quantification of the health-relevant anthocyanin and phenolic acid profiles in commercial cultivars and breeding selections of blueberries (Vaccinium spp.). J Agric Food Chem, 61(20), 4806-15. DOI:
10.1021/jf400823s

Zhan, W., Liao, X., Yu, L., Tian, T., Liu, X, Liu, J., … Yang, Q. (2016). Effects of blueberries on migration, invasion, proliferation, the cell cycle and apoptosis in hepatocellular carcinoma cells. Biomed Rep, 5(5), 579-584. DOI:
10.3892/br.2016.774

Article by Dohrea Bardell, PhD.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.Green Facts:

Globe_Home 3Understanding the concept of hormesis and its relationship to plant phytonutrients opens the door to a whole new medical paradigm for reducing chronic oxidative stress.  Chronic oxidative stress increases cancer, metabolic and neurodegenerative disease risk.

See Callbrese et al. (2010) illuminating paper on this most important concept:

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends                                                                                                                                                                                                            Beta Glucan Photo jpeg 2

We are proud to have the Beta Glucan High Potency Synbiotic qualify for the American Heart Association and the FDA “Heart Healthy” seal of approval: improving lipid serum levels.*

The special heat-shearing technology used to liberate the beta-glucans from the oat is patented (US Patent # 6,060,519), and considered by the FDA as a gluten free ingredient (99.98% gluten free).*

The food ingredients in the Beta Glucan formula are chosen carefully for their highest phytonutrient potential. The proprietary mix contains: Organic matrix USDA patented hydrocolloidal beta glucan oat bran (75%), organic whole red beetroot (15%), and organic inulin from chicory fiber (10%).  Advances in microbiome research and technology allow us to grow our hardy and viable pedigreed Original probiotic strains. Our high potency Original probiotics, along with the B-Glucans, Beetroot, and Inulin offer heart healthy properties, GI support with plant fibers and probiotics, weight-management, regularity, and a boost in energy.*

Oats and oat beta glucan have enjoyed a rich cultural historicity and extensive research on heart health  (Andersson & Hellstrand, 2012). From Shaper & Jones (1959) analysis of healthy dietary habits, to the Cornell China study in 1998, and the NIH report in 2015, dietary fibers, whole plant-based foods, and exercise are shown to be essential for a healthy heart. Oats and oat beta glucan are found to reduce serum LDL cholesterol (Ho et al., 2016; Zhu et al., 2015; Whitehead et al., 2014; Wolever et al., 2010), improve liver function (Chang et al., 2013), and promote bowel regularity (Clemens, 2012; Mobley et al., 2014).*

Red beetroot offer a rich source of phyto-nutrients, including ascorbic acid (vitamin C), carotenoids, phenolic acids, and flavonoids. Beets provide a source of dietary nitrate, shown in research to have important implication for heart health (Kapil et al., 2014). Beet’s nutrients are found to prevent oxidation of LDLs, lower triglycerides, and balance blood pressure (Clifford et al., 2015; Eggenbeen et al., 2016; Hobbs et al., 2013). As a multifunctional food, beets also stimulate Phase II liver detox (Vulić et al., 2014), as well as perform a host of other health benefits, including the production of energy for exercise (Murphy et al., 2012), promotion of joint health (Pietrzkowski et al., 2010), Antioxidant (Georgiev et al., 2010), and support for individuals who undergo oncological treatments (Kapadia et al., 2013, 2011; Das et al., 2013).*

The Beta Glucan formula is comprised of our Original probiotics proprietary blend: L. acidophilus, B. longum, L. rhamnosus, L. plantarum, S. thermophilus. Our Original strains of lactic acid bacteria are pedigreed and certified, based on ATCC prototypical strains and confirmed routinely by 16sRNA sequencing to provide highest quality probiotic material. Our strains are hardy, strong, and effective.*

The Original strains are mixed into a proprietary blend of 33 billion cfu/tbl, plus a bonus of 50 billion more probiotic organism added at the time of manufacturing to boost and ensure a high potency. If taken only as a probiotic formula, 1-2 teaspoons will provide a daily dosage of up to 25 billion cfu.

Probiotics are found in research to positively support heart health (Kassaian et al., 2017; Sáez-Lara et al., 2016; DiRienzo, 2014; Delzenne et al., 2011; Saini et al., 2010), with many researchers positing the connection between heart and gut health (Serino et al., 2014; Huang et al., 2013). The Beta Glucan was formulated to nourish both heart and gut into health.*

Inulin from organic chicory root supplies food for probiotic organisms. Probiotic organisms need soluble fiber like inulin to grow and multiply. See Slavin (2013) on fiber as prebiotics, and Dehghan et al. (2013) on inulin and cardiovascular support.*

Together with probiotic, inulin is also found in research to help tighten cell junctions, which is thought to aid against leaky gut syndrome (Cani et al., 2007, 2007a, 2008, 2009).*

The Beta Glucan formula is utilized for bowel regulation. Plant and oat fibers are shown to increase bowel regularity (Schmier et al., 2014).*

The Beta Glucan is multifunctional due to its oat beta glucans, red beetroot, inulin from chicory, and strong probiotic organism. Each ingredient is shown in research to offer heart healthy food, boost energy, and support the GI tract, liver and kidneys, promoting regularity and GI comfort.

Take a look at the references below to engage in learning more about the many health applications scientists have discovered over the years. These shows a fraction of the research findings on oat beta glucan, probiotics, red beetroot, and inulin.*

*These statements have not been evaluated by the Food & Drug Administration. This products is not intended to diagnose, treat, cure or prevent any disease. The information and citations of research are for informational purposes only. Please be sure to consult your health care provider before taking this or any other product.

References:

  • Anderson, K.E., & Hellstrand, P. (2012). Dietary oats and modulation of atherogenic pathways. Mol Nutr Food Res, 56(7), 1003-13. DOI:10.1002/mnfr.201100706
  • Cani, P.D., Pssemiers, S., Van de Wiele, T., Guiot, Y., Everad, A., Rottier, O…. Delzenne, N.M. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut, 58(8), 1091-1103. DOI:10.1136/gut.2008.165886
  • Cani, P.D., Bibiloni, R., Knauf, C., waget, A., Neyrinck, A.M., Delzenne, N.M., Burcelin, R. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice. Diabetes, 57, 1470-8. DOI:10.2337/db07-1403
  • Cani, P.D., Amar, J., Iglesias, M.A., Poggi, M., Knauf, C., Bastelica, D. … Burelini, R. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56, 1761-72. DOI:10.2337/db06-1491
  • Cani, P.D., Neyrinck, A.M., Fava, F., Knauf, C., Burcelin, R.G., Tuohy, K.M. … Delzenne, N.M. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia, 50, 2374-83. DOI:10.1007/s00125-007-0791-0
  • Chang, H.C., Huang, C.N., Yeh, D.M., Wang, S.J., Peng, C.H., & Wang, C.J. (2013). Oat prevents obesity and abdominal fat distribution, and improves liver function in human. Plant Foods Hum Nutr, 68(1), 18-23. DOI:10.1007/s11130-013-0336-2
  • Clemens, R., Kranz, S., Mobley, A.R., Nicklas, T.A., Raimondi, M.P., Rodriguez, J.C., … Warshaw, H. (2012). Filling American’s fiber intake gap: Summary of roundtable to probe realistic solutions with a focus on grain-based foods. J Nutr, 142(7), 1390-1401. DOI:10.3945/jn.112.160176
  • Clifford T, Howatson G, West DJ, Stevenson EJ. (2017). Beetroot Juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. DOI:10.1139/apnm-2017-0238
  • Clifford, T., Howatson, G., West, D.J., Stevenson, E.J. (2015). The potential benefits of red beetroot supplementation in health and disease. Nutrients,7(4):2801-22. DOI: 10.3390/nu7042801
  • Das, S., Fillippone, S.M., Williams, D.S., Das, A., Kukreja, R.C. (2016). Beet root juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells. Mol Cell Biochem, 421(1-2), 89-101.
    DOI: 10.1007/s11010-016-2789-8
  • Das, S., Williams, D.S., Das, A., Kukreja, R.C. (2013). Beet root juice promotes apoptosis in oncogenic MDA-MB-231 cells while protecting cardiomyocytes under doxorubicin treatment. J. Exp. Second. Sci, 2, 1–6. Abstract
  • Dehghan, P., Pourghassem, G.B, & Asgharijafarabadi, M. (2013). Effects of high performance inulin supplementation on glycemic status and lipid profile in women with type 2 diabetes: a randomized, placebo-controlled clinical trial. Health Promot Perspect, 3(1), 55-63. DOI:10.5681/hpp.2013.007
  • Delzenne, N.M., Neyrinck, A.M., Cani, P.D. (2011). Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact, 10 Suppl 1, S10. DOI: 10.1186/1475-2859-10-S1-S10
  • DiRienzo D.B. (2014). Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets. Nutr Rev, 72(1), 18-29. DOI:10.1111/nure.12084
  • Domínguez R, Cuenca E, Maté-Muñoz JL, García-Fernández P, Serra-Paya N, Estevan MC, Herreros PV, Garnacho-Castaño MV. (2017). Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review. Nutrients, 9(1). DOI:10.1016/j.jand.2011.12.002
  • Eggenbeen, J., Kim-Shapiro, D.B., Haykowsky, M., Morgan, T.M., Basu, S., Brubaker, P., … Kitzman, D.W. (2016). One week of daily dosing with beetroot juice improves submaximal endurance and blood pressure in older patients with heart failure and preserved ejection fraction. JACC Heart Fail, 4(6), 428-37. DOI: 10.1016/j.jchf.2015.12.013
  • Georgiev, V.G., Weber, J., Kneschke, E.M., Denev, P.N., Bley, T., Pavlov, A.I. (2010). Antioxidant activity and phenolic content of betalain extracts from intact plants and hairy root cultures of the red beetroot Beta vulgaris cv. Detroit dark red.  Plant Foods Hum Nutr, 65(2):105-11. DOI:10.1007/s11130-010-0156-6
  • Ho, H.V., Sievenpiper, J.L., Zurbau, A., Blanco Mejia, S., Jovanovski, E., Au-Yeung, F… Vuksan, V. (2016). The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials. Br J Nutr. 116(8):1369-1382. DOI: 10.1017/S000711451600341X
  • Hobbs, D.A., George, T.W., Lovegrove, J.A. (2013). The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies. Nutr Res Rev, 26(2), 210-22. DOI:10.1017/S0954422413000188
  • Huang, Y., Wang, X., Wang, J., Wu, F., Sui, Y., Yang, L., Wang, Z. (2013). Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity. J Dairy Sci, 96(5), 2746-53. DOI:10.3168/jds.2012-6123
  • Kapadia, G.J., Rao, G.S., Ramachandran, C., Iida, A., Suzuki, N., & Tokuda, H. (2013). Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J Complement Integr Med., 1. DOI:10.1515/jcim-2013-0007
  • Kapadia, G.J., Azuine, M.A., Rao, G.S, Arai, T., Lida, A., & Tokuda, H. (2011), Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines. Anticancer Agents Med Chem, 11(3), 280-4. Abstract
  • Kapil, V., Weitzberg, E., Lundberg, J.O., Ahluwalia, A. (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. Nitric Oxide, 38, 45-57. DOI:10.1016/j.niox.2014.03.162
  • Kassaian, N., Aminorroaya, A., Feizi, A., Jafari, P., Amini, M. (2017). The effects of probiotic and synbiotic supplementation on metabolic syndrome indices in adults at risk of type 2 diabetes: study protocol for a randomized controlled trial. Trial, 18(1), 148. DOI:  10.1186/s13063-017-1885-8
  • Mobley, A.R., Jones, J.M., Rodriguez, J., Slavin, J., & Zelman, K.M. (2014). Identifying practical solutions to meet American’s fiber needs: Proceedings from the Food & Fiber Summit. Nutrients, 8(7), 2540-51. DOI:10.3390/nu6072540
  • Murphy, M., Eliot, K., Heuertz, R.M., Weiss, E. (2012). Whole beetroot consumption acutely improves running performance. J Acad Nutr Diet, 112(4), 548-52. DOI: 10.1016/j.jand.2011.12.002
  • Sáez-Lara, M.J., Robles-Sanchez, C., Ruiz-Ojeda, F.J., Plaza-Diaz, J., Gil, A. (2016). Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A Review of Human Clinical Trials. Int J Mol Sci, 17(6). DOI:10.3390/ijms17060928
  • Saini, R., Saini, S., & Sharma, S. (2010). Potential of probiotics in controlling cardiovascular diseases. J. Cardiovasc Dis Res,1(4), 213-214. DOI:  10.4103/0975-3583.74267
  • Schmier, J.K., Miller, P.E., Levine, J.A., Perez, V., Maki, K.C., Rains, T.M., … Alexander, D.D. (2014). Cost savings reduced constipation rates attributed to increased dietary fiber intakes: A decision-analytic model. BMC Public Health, 14-374. DOI: 10.1186/1471-2458-14-374
  • Serino, M., Blasco-Baque, V., Nicolas, S., & Burcelin, R. (2014). Far from the Eyes, Close to the Heart:  Dysbiosis of Gut Microbiota and Cardiovasuclar Consequences. Curr Cardiol Rep, 16(11), 540. DOI:10.1007/s11886-014-0540-1
  • Shaper, A.G., & Jones, K.W. (1959). Serum-cholesterol, diet, and coronary heart disease in Africans, and Asians in Uganda. The Lancet, 275(7102), 534-37. DOI: 10.1093/ije/dys137
  • Slavin, J. (2013). Fiber and prebiotics: mechanism and health benefits. Nutrients, 5(4), 1417-1435. DOI:10.3390/nu5041417
  • Vulić J.J., Ćebović T.N., Čanadanović-Brunet J.M., Ćetković G.S., Čanadanović V.M., Djilas S.M., Tumbas Šaponjac V.T. In vivo and in vitro antioxidant effects of beetroot pomace extracts. J. Funct. Foods. 2014;6:168–175. https://doi.org/10.1016/j.jff.2013.10.003
  • Whitehead A, Beck EJ, Tosh S, Wolever TM. (2014). Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials. Am J Clin Nutr, 100(6), 1413-21. DOI:10.3945/ajcn.114.086108
  • Wolever TM, Tosh SM, Gibbs AL, Brand-Miller J, Duncan AM, Hart V, Lamarche B, Thomson BA, Duss R, Wood PJ  (2010). Physicochemical properties of oat β-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial. Am J Clin Nutr, 92(4):723-32. DOI: 10.3945/ajcn.2010.29174
  • Zhu, X., Sun, X., Wang, M., Zhang, C., Cao, Y., Mo, G., Liang, J., Zhu, S.  (2015). Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects. Nutr Metab Cardiovasc Dis, 25(8), 714-23. DOI:10.1016/j.numecd.2015.04.008

Article by Dohrea Bardell, PhD.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3For those of you who missed Gabe Brown’s TED talk sited in last weeks email, I am offering it up again.  Hear this most exciting evidence for what this big scale North Dakota farmer is proving through using the One Straw Revolution technique. Here’s Gabe:  Regeneration of our Lands: A Producer’s Perspective
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

The most frightening fact about Coronary Heart Disease is that for the majority of Americans the first heart attack is sudden and unfortunately deadly (Myerburg, 2012).

How do we prevent and treat coronary heart disease? With the right foods.

The Therapeutic Food Protocol:

Beta Glucan High Potency Synbiotic– 1 heaping tbl twice daily (or two tbl once daily).
Phyto Power– 1 capsules daily
Garlic– 1 capsule daily
Cruciferous Sprouts– 2 capsules daily (preferably between meals).

It is well established in research that soluble beta glucan fibers in the diet will help in the lowering of LDL cholesterol. Two tablespoons of the Beta Glucan High Potency Synbiotic supplies enough beta glucans to significantly lower LDLs, and therefore to place the American Heart Association Seal for cardiovascular health on the label.

The pedigreed strains of probiotic bacteria utilized in the Beta Glucan Synbiotic reduce endotoxin producing bacteria in the gut, as well as, facilitate the tightening of the gut membrane so that endotoxins will not leak into the systemic circulation. Endotoxins can cause chronic systemic inflammation, which then causes a stiffening of the arteries (Erridge, 2011).

Food Science: Let’s discuss cholesterol, endotoxemia, and coronary heart disease.

There is a wide body of evidence that shows places in the world where heart disease is rare, due to dietary habits.

In the famous China Study, researchers investigated the eating habits and incidence of chronic disease among hundreds of thousands of rural Chinese.  In the Guizhou province, a region with half a million people, not a single death could be attributed to coronary artery disease among men under 65 over the course of three years (Campbell et al., 1998).

In Uganda, a country of millions in East Africa, coronary heart disease was described as “almost non-existent (Shaper, 1959). The researchers found that out of 632 people autopsied in St. Louis, Missouri, 136 had died of heart attacks, compared to the East African cohort where out of 632 people autopsied in Uganda only 1 was from a heart attack.

The almost non-existent cases of heart disease among rural Chinese and Africans was attributed to their amazingly low levels of cholesterol, averaging under 150 mg/dL.  Their diets were both centered on plant-based foods, such as grains and vegetables (De Biase, 2007).

Dietary choices at any age may prevent, stop, and even reverse heart disease before it’s too late.

William C. Roberts, editor in chief of the American Journal of Cardiology, states that the only critical risk factor for atherosclerotic plaque buildup is cholesterol, specifically elevated LDL cholesterol in your blood.  It is called bad cholesterol because it’s the vehicle by which cholesterol is deposited into our arteries.  According to Roberts, the optimal LDL cholesterol level is probably 50 to 70 mg/dL.  The population target should therefore be around a total cholesterol level under 150 mg/dL  (Benjamin, 2013).

To drastically reduce LDL cholesterol levels, you need to drastically reduce your intake of three things:  trans fat, which comes from processed foods and naturally from meat and dairy; saturated fat, found mainly in animal products and junk foods; and to a lesser extent dietary cholesterol, found exclusively in animal derived foods, especially eggs (Trumbo, 2011).

Nathan Pritikin, Dean Ornish, and Caldwell Esselstyn, all pioneers in the plant based diet, separately, within their own research, took patients with advance heart disease, and put them on the kind of diet followed by the African and Asians population sited above, and their patients got better— as their LDL cholesterol levels dramatically decreased, so too did the plaque in their arteries, resulting in improved circulation to their heart (Esslestyn, 2010).

Endotoxemia:  A single fast food meal of sausage and egg McMuffins can stiffen your arteries within hours, and this reduced elasticity will last for around 5 hours.  Eating these kinds of meat and fat laden foods daily shifts the gut microflora toward endotoxic producing bacteria, and when these kind of bacteria (or their cell wall parts, such as LPSs) enter into circulation, our immune system reacts causing the stiffening of arteries (Vogel, 1997).  Cardiac patients can experience relief [from angina] when placed on a diet composed primarily of plant foods (Ornish, 1998).

Note: This week I focused on the Beta Glucan High Potency Synbiotic, and its relevance in lowering cholesterol and reducing endotoxemia.  In subsequent emails we will focus on the other three products.

Bibliography:

  • Benjamin MM., & Roberts. WC. (2013). Facts and principles learned at the 19th Annual Williamsburg Conference on Heart Disease. Proc (Bayl Univ Med Cent); 26(2): 124-36.
  • Campbell et al. (1998). Diet, lifestyle, and the etiology of coronary artery disease: the Cornell China Study. Am J Cardio; 82(108): 18T-21T.
  • De Biase et al. (2007). Vegetarian diet and cholesterol and triglycerides levels. Arq. Bras Cardiol; 88(1): 35-9.
  • Erridge, C. (2011). The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4. Br J Nutr; 105(1): 15-23.
  • Esslestyn, C.B. (2010). Is the present therapy for coronary artery disease the radical mastectomy of the twenty-first century? Am J Cardiol; 106(6): 902-4.
  • Myerburg, R.J., & Junttila M.J. (2012). Sudden cardiac death cause by coronary heart disease. Circulation 28; 125 (8): 1043-52.
  • Ornish et al. (1998). Intensive lifestyle changes for reversal of coronary heart disease. JAMA; 280(23): 2001-7.
  • Shaper A.G., & Jones K.W. (1959). Serum-cholesterol, diet, and coronary heart disease in Africans, and Asians in Uganda. Int J Epidemiol; 41(5): 1221-5.
  • Trumbo, P.R., & Shimakawa T. (2011). Tolerable upper intake levels for trans fats, saturated fat, and cholesterol. Nutr Res; 69(5): 270-5.
  • Vogel et al. (1997). Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol; 79(3): 350-4.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3The Food Revolution Network is committed to healthy, sustainable, humane and conscious food for all. The network aims to empower individuals, build community, and transform food systems to support healthy people and a healthy planet.