Cardiovascular Support

Dear Friends

Reduce blood sugar levels with polyphenols!

Americans have a serious problem with chronic hyperglycemia.

Untreated hyperglycemia can cause long-term complications. These include:

  • Cardiovascular disease
  • Nerve damage (neuropathy)
  • Kidney damage (diabetic nephropathy) or kidney failure
  • Damage to the blood vessels of the retina (diabetic retinopathy), potentially leading to blindness
  • Clouding of the normally clear lens of your eye (cataract)
  • Feet problems caused by damaged nerves or poor blood flow that can lead to serious infections, and in some severe cases, amputation
  • Bone and joint problems
  • Skin problems, including bacterial infections, fungal infections and non-healing wounds
  • Teeth and gum infections

What are its causes?  There are multiple, and some may surprise you.

The diet for many Americans contains an overwhelming amount of carbohydrates, with a high proportion coming from added sugars.  To give you an idea, the annual added sugar intake has been reported to range from over 50 lb (median value) in the Dutch population to 142 lb in Americans (Wells & Buzby, 2008).

This means that almost every meal is followed by hyperglycemic conditions.  Recent studies indicate that hyperglycemia induces overproduction of Superoxide Anion (O2-) by the mitochondrial electron transport chain (Node & Inoue, 2009).  O2- is known as a primary free radical, because it converts either spontaneously or through enzymatic assistance into H2O2, peroxynitrite or hydroxyl radical (Gutowski & Kowalczyk, 2014).

Intervention aiming to reduce postprandial hyperglycemia are thus believed to benefit health through prevention of oxidative stress from glucose-overloaded mitochondria.

No. 4 Systemic Booster: Weight-less accomplishes this in two ways: WL Photo 2

  • It contains a powerful mix of wild crafted brown seaweed extracts of Ascophyllum nodosum (kelp) and Fucus vesiculosus (bladderwrack) along with 7-Keto DHEA.
  • These phlorotannin extracts are a class of polyphenols found exclusively in brown seaweed that act on amylase and glucosidase enzymes to optimize post-meal blood glucose and insulin responses.
  • Brown seaweed phlorotannins have a high Total ORAC and the extracts in Weight-less showed the highest antioxidant potency against superoxide anion of all antioxidants tested.
  • Dosage:  take one capsule 20 minutes before your meals.

Since post-meal glycemic fluctuations lead to oxidative stress, these results suggest that Weight-less could have a superior action against free radicals by preventing post-meal hyperglycemia as well as having a direct scavenging action.

References

  • Gutowski, M., & Kowalczyk, S. (2013). A study of free radical chemistry: their role and pathophysiological significance. Acta Biochimica Polonica, 60(1).
  • Node, K., & Inoue, T. (2009). Postprandial hyperglycemia as an etiological factor in vascular failure. Cardiovascular Diabetology, 8(1), 23.
  • Roy, M. C., Anguenot, R., Fillion, C., Beaulieu, M., Bérubé, J., & Richard, D. (2011). Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo. Food research international, 44(9), 3026-3029.
  • Wells, H. F., & Buzby, J. C. (2008). Dietary assessment of major trends in US food consumption, 1970-2005. Washington: US Department of Agriculture, Economic Research Service.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3

In our next Forward Thinking newsletter we will look at how fat causes insulin resistance and therefore hyperglycemia.

 

©2005 – 2018 BioImmersion Inc. All Rights Reserved
Dear Friends

Did you know that polyphenols from berries and plants are the most favored foods for the probiotics genera Lactobacillus and Bifidobacterium in the gut?

The berries and plants enhance the growth of Lactobacillus and Bifidobacterium inside the gut microbiome, while inhibiting many pathogenic organsims.

For example, Possemiers et al.’s (2011)  “The intestinal microbioime: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals,” explains that rich polyphenolic molecules from berries and plants are broken down by probiotic organisms into many important sub-molecules that are more bioavailable yet still contain their classic polyphenolic structure to serve the body as antioxidants, anti-inflammatories, antimicrobials, anti cancer, anti diabetes and more  … no wonder berries and plants are the preferred prebiotics foods for the Lactobacillus and Bifidobacteria!

 

Phyto Power– 1 capsule daily
Phyto Power Photo 6

  • Three species of Rosehip, wildcrafted, whole fruit and seeds (100% w/w), refractory dried, three Rosa species, 200mg per capsule.
  • Four species of Dandelion, wildcrafted, aerial parts (90% w/w), root (10% w/w) with flower, refractory dried, four Taraxacum species, 200mg per capsule.
  • Four species of Blueberry, wildcrafted, fruit (>90% w/w), leaves and stem (<5% w/w), refractory dried, four Vaccinium species, 100mg per capsule.

 

 

Original Synbiotic: 1 tsp. dailyOriginal Photo 4

Contains:  20 billion cfu/tsp of certified strains of pedigreed probiotics (L. acidophilus,  B. longum, L. rhamnosus, L. plantarum and S. thermophilus) and 3.5 grams of inulin derived from organic chicory fiber.  Advanced freeze-drying technology.

120 grams/bottle. 4 grams/ tsp.  Dairy free.  Soy free. Gluten free. No excipients.

References

 

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor

Green Facts:

Globe_Home 3Phyto Power is indeed powerful. In fact, Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.*
 

©2005 – 2018 BioImmersion Inc. All Rights Reserved

Endotoxemia and Chlorella

December 14, 2017

Dear Friends

Chlorella HZ 2

Chlorella and inulin reduce endotoxemia and protect the intestinal mucosa barrier.

What is an endotoxin, and what causes endotoxemia? How does chlorella reduce endotoxemia, and how does inulin produce a healthy microbiome?  Let’s take a look at a few studies.

An endotoxin is often used synonymously with LPS.  Lipopolysaccharides (LPSs) are the major components of the outer membrane of Gram-negative bacteria. Rietschel et al. found in 1994 that LPSs induce strong inflammatory responses from the immune systems of all animals.

Liver Diseases are associated with leaky gut syndrome, which allows for the passage LPS molecules into the systemic circulation, causing chronic inflammation, and a condition called endotoxemia. A large enough load of LPSs in the systemic circulations can cause septic shock.

In fact, severe sepsis is a common and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction. It is especially common in the elderly and is likely to increase substantially as the U.S. population ages (Angus et al., 2001)

Bedirli et al. (2009) investigated the role of different microalgae (Chlorella sp. and Spirulina sp.) extracts in intestinal barrier function and oxidative stress in experimentally jaundice rats.

The main outcomes measured were endotoxin concentrations in plasma [e.g. LPS levels], evidence of bacterial translocation in mesenteric lymph nodes and liver oxidative stress, and histology.

Their findings: A Chlorella sp. supplemented diet significantly demonstrated protective effects on the intestinal mucosa barrier in obstructive jaundice, and reduced intestinal translocation of bacteria and endotoxin.  Spirulina had no significant effect.

Original copyCani et al. (2008) found that a high animal fat diet changes the GI tract microbiome into a population of increasing numbers of Gram-negative bacteria, which raises the level of LPS endotoxins within the gut lumen and allows their passing through the GI tract membrane into the plasma.

The research team concluded that the plasma concentration of lipopolysaccharides (LPS) controls the inflammatory tone of the body.  This means that high concentrations of LPS set the stage for endotoxemia, resulting in metabolic diseases (obesity, diabetes, CVD) and cancer.

They further demonstrated in the study that increased fibers in the diet, such as inulin, increase the populations of Bifidobacterial sp. and Lactobacillus sp. which reduce both the load of Gram-negative bacteria and the permeability of the gastrointestinal membrane.

Our Suggestion: Take 4 to 8 tablets of Organic Chlorella daily.
Take 1 tsp. of Original Synbiotic daily.
References:

  • Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001). Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine, 29(7), 1303-1310.
  • Bedirli, A., Kerem, M., Ofluoglu, E., Salman, B., Katircioglu, H., Bedirli, N., … & Pasaoglu, H. (2009). Administration of Chlorella sp. microalgae reduces endotoxemia, intestinal oxidative stress and bacterial translocation in experimental biliary obstruction. Clinical nutrition, 28(6), 674-678.
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Rietschel, E. T., Kirikae, T., Schade, F. U., Mamat, U., Schmidt, G., Loppnow, H., … & Di Padova, F. (1994). Bacterial endotoxin: molecular relationships of structure to activity and function. The FASEB Journal, 8(2), 217-225.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3
What kind of world do you want to wake up to 30 years from now?
The Biomimicry Institute aspires to a world where what we make is inspired by, and connected to, the natural world.  This means cities are resilient, emission targets are achieved, and industrial processes create healthy air, water, and soil.  It also means all species are thriving because our human designs restore the planet as nature’s desgns do.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Chlorella HZ 2

Fallah et al.’s ( 2017) meta-analysis, Effect of Chlorella supplementation on cardiovascular risk factors: A meta-analysis of randomized controlled trials, found that Chlorella decreased several risks leading to cardiovascular disease.

The meta-analysis on 19 randomized controlled trials (RCTs) with 797 subjects showed that Chlorella administration significantly decreased the following risk factors:

  • Decreased the levels of total cholesterol
  • Decreased the levels of LDL cholesterol
  • Decreased systolic blood pressure
  • Decreased diastolic blood pressure
  • Decreased fasting blood glucose

Subgroup analyses based on intervention duration and chlorella dosages revealed that administration of chlorella for 8 weeks or higher with dosages higher than 4 g/day significantly reduced the above risk markers in both people with healthy levels and unhealthy levels.

Over all, the results of their meta-analysis indicated that Chlorella supplementation clearly supports the reduction of key risk factors for cardiovascular disease.

Our Suggestion: Take 8 tablets of Organic Chlorella once a day.

Reference:

Fallah, A. A., Sarmast, E., Dehkordi, S. H., Engardeh, J., Mahmoodnia, L., Khaledifar, A., & Jafari, T. (2017). Effect of Chlorella supplementation on cardiovascular risk factors: A meta-analysis of randomized controlled trials. Clinical Nutrition. https://doi.org/10.1016/j.clnu.2017.09.019

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3For cardiovascular health we suggest a plant-based diet that is accompanied by 2 tablespoons of Beta Glucan Synbiotic Formula, with the American Heart Assoc. seal of approval. Add the Be Regular for more gluten free fiber, and Weight-Less, 2 caps. before each meal to lower the glycemic load, and boost metabolism.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Care For Your Heart

November 14, 2017

Dear Friends                                                                                                                                                      

Metabolic Syndrome is considered the leading cause of Heart Disease, the number one killer in the United States.

Three of our Therapeutic Food Supplements are designed with intelligent ingredients that are shown in research to support and help reverse both heart disease and the different conditions associated with metabolic syndrome: Beta Glucan High Potency Synbiotic, Weight-less Systemic Booster, and Organic Chlorella.

  • Beta Glucan High Potency Synbiotic– 1 heaping tbl twice daily before two largest meals.
  • Weight-less:  NO. 4 Systemic Booster– 2 capsules one-half hour before meals. A must do before a high carb meal or snack.
  • Organic Chlorella– 4 tablets taken with meals.

Food Science

Metabolic Syndrome is a disorder affecting approximately one-quarter of the American population. It is in fact considered a worldwide epidemic (NIH: NHLBI, 2015).

The risk factors for Metabolic Syndrome are:  Abdominal obesity, Atherogenic dyslipidemia, Raised blood pressure, Insulin resistance, Pro-inflammatory state, and Pro-thrombotic state (McCullough 2011, Grundy 2004).
Beta Glucan HZ 3
The Beta Glucan High Potency Synbiotic contains powerful soluble and insoluble fibers and pedigreed strains of probiotics.

Multitude research articles strongly indicate that as dietary fiber goes up the risk of Metabolic Syndrome goes down (Grooms, 2013).

A healthy gut microbiome supports the maintenance of a healthy GI tract membrane barrier function.  Cani et al. (2008) found that bacterial lipopolysaccharide (LPS) levels set the tone of insulin sensitivity and the onset of obesity and diabetes.  An increased gut permeability allowed for the passage of LPS through the gut wall into the systemic circulation.  Thus, lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.

Cani et al. (2007, 2007a, 2008, 2009) demonstrated that adding soluble fibers to our daily diet, such as inulin and oat bran beta glucan (containing oligofructose chains found in the Beta Glucan Synbiotic), stimulates the growth of Bifidobacteria sp., which caused a reduction in gut permeability, thereby reducing the levels of LPS systemically, which initiates weight loss, and reduction of metabolic disorders.
WL Low Cropped Jpeg 2
Weight-less is a smart metabolic booster formula – the mix supports weight loss and effectively boosting energy levels.  Weight-less contains wild brown seaweed extracts from kelp and bladderwrack as well as 7-Keto DHEA.  Brown seaweeds are shown in research to lower the glycemic load of complex and simple carbohydrates for better insulin management, as well as offer a power-filled phenolic activity for antioxidant and anti-inflammation effect (Roy et al., 2011). The 7-Keto has been used for many years to turn on fat burning mechanism and offer an effective and safe way to lose weight (Bobyleva et al., 1997).

Together, Weight-less promotes a sustained energy level throughout the day as it modulates carbohydrate digestion and absorption for better weight management and metabolic health (Gabbia et al., 2017; Catarino et al., 2017).
Chlorella HZ
Organic Chlorella– New studies show that Chlorella supports reduction of body fat, improves fat and glucose metabolism, decrease weight, and reduce the risk factors involved with Metabolic Disease.

Mizoguchi et al. (2008) in their research, Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease, demonstrated that Chlorella intake, in 17 subjects with high risk factors for lifestyle-related disease (obesity, diabetes or hyperlipidemia) and 17 healthy subjects, results in noticeable reductions in body fat percentage, total blood serum cholesterol, and fasting blood glucose levels.

Their research confirmed that Chlorella intake brings about improvements in both fat metabolism and glucose metabolism.  The expression of genes involved in the insulin signaling pathway were also affected by Chlorella vulgaris intake, especially those related to glucose uptake in tissue, providing support for the observation that Chlorella lowers blood glucose levels.

Vecina et al.’s (2014), Chlorella modulates insulin signaling pathway and prevents high-fat-diet- induces insulin resistance in mice, research goal was to evaluate the prophylactic effect Chlorella vulgaris on body weight, lipid profile, blood glucose and insulin signaling in liver, skeletal muscle and adipose tissue of diet-induced obese mice.

Their conclusion was that C. vulgaris supplementation (Chlorella) could be considered as an adjunctive therapy to decrease weight and improve glycemic status and reducing hs-CRP as well as improving liver function in patients with NAFLD.

References:

  • Bobyleva, V., Bellei, M., Kneer, N., & Lardy, H. (1997). The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Archives of biochemistry and biophysics, 341(1), 122-128. https://doi.org/10.1006/abbi.1997.9955
  • Cani et al. (2009). Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability. Gut; 58(8): 1091-1103
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
    Cani et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes; 56:1761-72.
  • Cani et al. (2007a). Selective increases of Bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia; 50: 2374-83.
  • Catarino, M. D., Silva, A., & Cardoso, S. M. (2017). Fucaceae: A source of bioactive phlorotannins. International journal of molecular sciences, 18(6), 1327. Article
  • Gabbia, D., Dall’Acqua, S., Di Gangi, I. M., Bogialli, S., Caputi, V., Albertoni, L., … & De Martin, S. (2017). The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH. Marine drugs, 15(2), 41. DOI:10.3390/md15020041
  • Grooms et al. (2013). Dietary Fiber Intake and Cardiometablic Risk among US Adults: NHANES 1999-2010. Am J Med; 126(12): 1059-1067.
  • Grundy, S. M. (2004). Obesity, metabolic syndrome, and cardiovascular disease. The Journal of Clinical Endocrinology & Metabolism, 89(6), 2595-2600.
  • Mizoguchi et al. (2008). Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease.  J Med Food; 11(3): 395-404.
  • Roy, M. C., Anguenot, R., Fillion, C., Beaulieu, M., Bérubé, J., & Richard, D. (2011). Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo. Food research international, 44(9), 3026-3029. https://doi.org/10.1016/j.foodres.2011.07.023
  • Vecina et al. (2014). Chlorella modulate insulin signaling pathway and prevents high-fat diet–induced insulin resistance in mice. Life Sci; 95(1): 45-52.
  • Whaley-Connell, A., McCullough, P. A., & Sowers, J. R. (2011). The role of oxidative stress in the metabolic syndrome. Reviews in cardiovascular medicine, 12(1), 21-29.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.Green Facts:

Globe_Home 3Choosing a healthy diet: Research studies link the emerging global pattern of metabolic syndrome and weight gain to the prevalence of Westernized diet of daily meats, dairy, eggs, simple and processed carbohydrates, and too much sugar (Chai et al., 2017; Azadbakht & Esmaillzadeh, 2009; Lutsey et al., 2008). Although there are conflicting views on dietary guidelines, many scientists and health organizations agree that a focus on whole food plant-based diet is the healthiest guideline for metabolic syndrome and weight loss (Yokoyama et al., 2017; Satija et al., 2017; Kahleova et al., 2017; Hever et al., 2017; Turner et al., 2017; UN Report, 2016; Wang et al., 2015; Tilman & Clark, 2014; WHO/FAO, 2003).*

The Plates, Pyramids, Planet report, compiled in collaboration with the Food Climate Research Network (FCRN) at the University of Oxford, concludes that a plant-based diet has many advantages for health and the environment (UN Report, 2016).*

The type and nature of carbohydrates that improve our metabolic health (obesity, cardiovascular, and diabetes) are comprised of whole plants with fiber (Wright et al., 2017). Whereas low carbs diets with high fat content is shown to increase metabolic syndrome (Lamont et al., 2017; UN Report, 2016).*

A diet that is 80-90% whole food plant-based is highly recommeded by many health organizations and medical universities around the world.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved