Protocols for Health

Dear Friends

Original copy
The Original Synbiotic is a daily probiotic for the whole family.

The Original probiotics are researched pedigreed strains of lactic acid bacteria that support the development of a healthy GI tract microbiome.

A healthy gut microbiome is dependent on strong and proven probiotics, such as the Original strains. The Original Synbiotic provides a powerful symbiotic combination of Lactobacillus acidophilus (ATCC 4356), Streptococcus thermophilus (ATCC 19258), Lactobacillus plantarum (ATCC 8014), Lactobacillus rhamnosus (ATCC 7469) and Bifidobacterium longum (ATCC 15707).

Our chosen probiotics are foundational ATCC strains shown in research to work together with human cells to perform many functions in the body. For example, these probiotic strains help the digestive system, support and balance the immune system, and enhance our nervous system by producing neurotransmitters. They reinforce the GI barrier function to protect us from xenobiotics and pathogens, even binding heavy metals. Moreover, they neutralize carcinogens such as those caused by heterocyclic amines found in blackened meat and elements such as nitrosamines in sausage. By acidifying the epithelial membrane, they enable the absorption of minerals such as calcium and magnesium more readily. And lastly, our chosen strains also support the important task of daily regularity (Syngia et al., 2016; Hardy et al., 2013; Figueroa‐González et al., 2011; Ng et al., 2009).

The Original Synbiotic suggested daily dose: one tsp daily.

Of the many beneficial functions needed to be performed by our probiotic friends, colonizing the GI tract membrane and thereby protecting from our body from pathogens and xenobiotics, is very important. Check out these studies on colonization (Toscano et al., 2017; Underwood et al., 2015; Panigrahi et al., 2008; De Champs et al., 2003; Sarem- Damerdji et al., 1995).

See the Original Synbiotic Monograph.

References:

  • De Champs, C., Maroncle, N., Balestrino, Damien., Rich, C., Forestier, C. (2003). Persistence of Colonization of Intestinal Mucosa by A Probiotic Strain, Lactobacillus casei subsp rhamnosus Lcr35, after Oran Consumption. J Com Microbiol; 41(3): 1270-1273.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150315/
  • Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.
  • Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.
  • Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.
  • Panigrahi, P., Pradhan, L., Mohapatra, S.S., Misra, P.R., Johnson, J.A., Chaudhry, R., Taylor, S., Hanse, N.I., Gewolb, I.H. (2008). Long-term colonization of a Lactobacillus plantarum synbiotic preparation in the neonatal gut. J Pediatr Gastroenterol Nutr; 47(1):45-53. https://www.ncbi.nlm.nih.gov/pubmed/18607268
  • Sarem-Damerdji, L., Sarem, F., Marchal, L., Micolas, J.P. (1995). In vitro colonization ability of human colon mucosa by exogenous Lactobacillus strains. FEMS Microbiology Letters; 131(2):133-137. https://academic.oup.com/femsle/article-abstract/131/2/133/524865/In-vitro-colonization-ability-of-human-colon?redirectedFrom=PDF
  • Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of food science and technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0
  • Toscano, M., De Grandi, R., Stronati, L., De Vecchi, E., & Drago, L. (2017). Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study. World journal of gastroenterology, 23(15), 2696.
  • Underwood, M. A., German, J. B., Lebrilla, C. B., & Mills, D. A. (2015). Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatric research, 77, 229.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350908/

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3In today’s world the level of assault on our bodies from pollution, pathogens, and stress is so high that we need powerful food supplements.  Our bodies, after all, know exactly what and how to utilize food for therapeutic purposes.

At BioImmersion, we created the Therapeutic Food Supplement line with a new medical framework in mind: the power and intelligence of food. Our Therapeutic Foods are indeed potent food supplements that behave intelligenly in the body – repairing, healing, protecting and preventing.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Weight-Less

September 22, 2017

Dear Friends                                                                                                                                                      WL Low Cropped Jpeg

Recent research has shown the link between chronic hyperglycemia, oxidative stress, and weight gain. Hyperglycemia puts our body into a state of oxidative stress, which leads to many pathologies such as diabetes mellitus, obesity, cancer, and cardiovascular diseases (Domingueti et al., 2016).

Ingredients of Weight-Less per capsule

  • 7-Keto DHEA- 25mg (helps to burn fat)
  • 2 Brown Seaweed extracts- 200mg (help to lower and prevent high blood sugar levels, offers a strong anti-inflammatory, and supports weight loss)

Take 1 – 2 capsules of Weight-less one-half hour before meals, especially important before your carbohydrate (or meat) laden meals.* (See Green Facts on meat and diabetes)

Food Science

The ingredients in Weight-less have been shown to reduce both the states of hyperglycemia and oxidative stress. The Kelp and Bladderwrack polyphenol extracts (phlorotannins) offer organic-certified bioactive ingredients that (1) act on amylase and glucosidase enzymes to optimize post-meal blood glucose and insulin responses and (2) demonstrate that they have a high total antioxidant activity as verified by the Total ORAC 6.0 assay.

The phenols in the kelp and bladderwrack have superior antioxidant activity – a neutralizing effect – on the primary free radical superoxide anion. Superoxide  anion is known as the “mother of  free radicals” because  it also can become a hydroxyl ROS, a nitrogen RNS and a hydrogen peroxide ROS.

Thus, Weight-Less helps prevent post-meal hyperglycemia and has a direct scavenging action on excess free radical generation.  The key is not to totally neutralize all free radical activity but to bring about a healthy redox homeostasis.

References:

  • Domingueti, C. P., Dusse, L. M. S. A., das Graças Carvalho, M., de Sousa, L. P., Gomes, K. B., & Fernandes, A. P. (2016). Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. Journal of diabetes and its complications, 30(4), 738-745.
  • Hulsmans, M., & Holvoet, P. (2010). The vicious circle between oxidative stress and inflammation in atherosclerosis. Journal of cellular and molecular medicine, 14(1‐2), 70-78.
  • InterAct Consortium. (2013). Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study. Diabetologia, 56(1), 47-59
  • Gutowski, M., & Kowalczyk, S. (2013). A study of free radical chemistry: their role and pathophysiological significance. Acta Biochimica Polonica, 60(1), 1-16.
  • Valko, M., Rhodes, C., Moncol, J., Izakovic, M. M., & Mazur, M. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions, 160(1), 1-40.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3High meat intake is also shown in research to generate oxidatative stress and hyperglacemia. We will discuss this in another email but meanwhile, see Dr. Greger’s informative video on Why is meat a risk factor for diabetes?
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends
CPLow copy 3

Urinary tract infection (UTI) is one of the most common bacterial infections (Foxman, 2014), often caused by Gram-negative bacteria, enterobacteriaceae (Bader, Loeb & Brooks, 2017), and more specifically within this large bacterial family, the familiar Escherichia coli (Jensen et al., 2017).

In recent years, more women suffer from chronic UTIs due to the climbing rise of antibiotic resistant bacteria. As a natural alternative or a supportive adjunct treatment with antibiotics, the Cranberry Pomegranate Synbiotic Formula offers well-researched phyto nutrients, probiotics, prebiotics, and D- mannose. Studies and clinical trials find cranberries (Bader et al., 2017; Jensen et al., 2017; de Llano et al., 2015), Pomegranates (Pagliarulo et al., 2016; Heber, 2011; Duman et al., 2009), along with probiotics, prebiotics, and D- mannose (Spaulding et al., 2017; 2017a; Domenici et al., 2016), to offer effective management and support for UTI.*

Historically, cranberries and cranberry juice have long been used to alleviate urinary tract infections, with research linking the ability of cranberries’ proanthocyanidins (Krueger et al., 2013) to inhibit adhesion of E. coli bacteria (Neto, 2007). As early as 1933, research by Fellers et al. has shown cranberries to positively effect urinary health. Cowan’s (1999) seminal work on plant products as antimicrobial agents, which includes cranberries, has been cited in approximately 7,500 research articles. Studies on cranberries show not only an alternative to antibiotic but also as a daily supplement for a steady prevention of UTIs.*

Recent studies continue to observe and explain cranberries’ excellent antimicrobial properties, especially the phenol elements and mechanism that are beneficial for the management and prevention of UTI (Jensen et al., 2017; Rodríguez-Pérez et al., 2017; Baranowska & Bartoszek, 2016; Sagdic et al, 2006; Lee, 2000). As stated above, proanthocyanidins in cranberries are found to prevent the adherence of Escherichia coli to uroepithelial cells in the urinary tract (Sun et al., 2015; Rowley, 2012; Burger et al., 2000), and disrupt hard to treat biofilm-mediated infections caused by Pseudomonas aeruginosa (Ulrey et al., 2014).*

Cranberries also pack other antimicrobial, antioxidant and anti-inflammatory benefits. With their powerful anti-adhesion properties, cranberries are found to inhibit growth of Helicobacter Pylori (Shmuely et al., 2007; Zhang et al., 2005; Burger et al., 2002), suppress tumor cell proliferation and offer support during cancer treatment (Bshayee et al., 2016; Kresty et al., 2015), as well as lower markers of cardio-metabolic risk (Novotny et al., 2015), and enhance the GI’s microbiota (Blumberg et al., 2016). Cranberries are shown to be effective agents for health.*

Pomegranate has enjoyed an exalted status since ancient times, and no wonder (Parseh et al., 2012). Studies show pomegranates contain 124 different phyto-nutrients with curative and preventative qualities. The pomegranate fruit is actually considered a berry, or more accurately, each pomegranate contains 600 seeds, each surrounded by fleshy white to dark red pulp (Rahimi et al., 2012).*

With their potent polyphenolic flavonoids, pomegranates show higher concentrations of antioxidants than green tea (Noda et al., 2002; Nori-Okamoto et al., 2004), cranberries, apples, grapes, or pears (Hmid et al., 2017; Heber, 2011; Heber et al., 2006). The pomegranate’s high concentration of polyphenols wields an inhibitory effect on pathogenic Staphylococcus aureus and Escherichia coli, serving as natural antimicrobial agents (Pagliarulo et al., 2016; Naz et al., 2007; Voravuthikunchai et al., 2005). Other microbial organisms are shown to be sensitive to the pomegranate phenolic flavonoids. Nascimento et al. (2000) tested extracts from a variety of plants in search of a natural support against antibiotic resistant microorganisms and found the pomegranate to be especially effective against Pseudomonas aeruginosa. Machado et al. (2002) identified antimicrobial ellagitannin of the pomegranate to be valuable to treat methicillin-resistant Staphylococcus aureus (MRSA) strains.*

Similarly, the pomegranate’s antioxidants work as scavengers and metal chelators (Kulkarni et al., 2007). The antioxidant, antimalarial, and antimicrobial activities of the tannin-rich fractions, ellagitannins and phenolic acids from pomegranates offer excellent daily dietary food supplement to enhance the immune system (Reddy et al., 2007).*

Probiotics and Supernatant are important to the health of our urogenital system. The genus Lactobacillus has been studied for their promising preventative and/or treatment potential against UTIs (de Llano et al., 2017). Three strains of lactobacillus were tested for their capabilities to inhibit pathogenic adherence of E. coli, E. faecalis, and Staphylococcus epidermidis to T24 epithelial bladder cells. L. salivarious, L. acidophilus showed a significantly inhibited the adherence of pathogens (de Llano et al., 2017; see also Shim et al., 2016). Lactobacillus species were also studies with infants experiencing acute pyelonephritis [kidney infection], and found effective in the prevention of urinary tract infections (Lee et al., 2016).*

The “anti-infective activities” of lactobacillus strains are exhibiting a great promise as innovative anti-infectious agents (Liévin-Le Moal et al., 2014), and especially for recurrent UTIs (Manzoor et al., 2016).*

Depletion of vaginal Lactobacilli has also found in research to be linked with UTI risk, which suggests that repletion (re-colonization of Lactobacilli) might be beneficial (Syngai et al., 2016; Fontana et al., 2013; Maurya et al., 2014).*

Supernatant is the fermented medium created during the culturing process of probiotics. Supernatant is the fermented “soup” that contains important probiotic metabolites which is comprised of enzymes, peptides, proteins, vitamins, and other nutrients and factors, including antimicrobials such as bacitracins. Supernatant is shown in research to have powerful antimicrobial properties with the potential to block adhesion, invasion and translocation of E. coli, yet it is gentle enough to be used to ‘enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense’ (He et al., 2017). In fact, Lazar et al. (2009) in vitro study concluded that the soluble probiotic metabolites, or supernatant, might actually interfere with the beginning stages of adherence and colonization of selected E. coli. This means that the supernatant itself exudes protective effects (Lazar et al., 2009), as well as work synergistically with probiotics organism to stimulate the immune system against pathogenic invasion (Ditu et al., 2014).*

D-mannose has long shown an ability to support acute UTIs, inhibiting bacterial adhesion to the urothelium (Domenici et al., 2016; Kranjčec et al., 2014). Testing more sensitive populations, such as people with multiple sclerosis (MS) who suffer from recurrent UTIs, showed that D-mannose effected a reduction in the number of UTIs as well as reduction for the need of antibiotics (Panicker et al., 2016).*

Since 150 million people suffer from UTIs annually, using natural foods and nutriceutical agents to combat recurrence of UTI infections is advisable (Spaulding et al., 2017). The use of cranberries, pomegranates, probiotics, supernatant, and D-mannose form a potent synergistic effect that is shown in research to be very effective (Vicarotto, 2014).*

There are many more health functions that cranberries and pomegranates perform. For many years cranberries and pomegranates were studied to understand their anti-tumorigenic elements (e.g., Castonguay et al., 1997). More recent studies continue to reveal and explain the bioactivity of pomegranate (Panth et al., 2017; Bishayee et al., 2016; Faria & Calhau, 2011) and cranberries (Kresty et al., 2015; Hochman et al., 2008; Ferguson et al., 2006) as promising suppressants and inhibitors of different kinds of cancer cells (Weh et al., 2016; Liberty et al., 2009; Adams et al., 2006).*

And there is more: Research studies find pomegranate and cranberries phenolics to contribute to heart health (Taheri et al., 2017; Novotny et al., 2015; Aviram et al., 2008, 2002), to balance the gut microbiota (Blumberg et al., 2016), and to offer liver support (Bishayee et al., 2013, 2011). Check the Research Tab for more in depth studies.*

The Cranberry Pomegranate Synbiotic Formula is an excellent choice for UTIs. Cranberries, Pomegranates, Probiotics, supernatant, and D-mannose have all shown in research to provide a potent effect against UTIs. The combination of these ingredients offers a promising natural supplement to prevent and maintain a healthy balance of the urogenital system.

We suggest 2-4 capsules twice daily for UTI management, and 1-2 capsules daily for preventative support.


References:

Bader, M. S., Loeb, M., & Brooks, A. A. (2017). An update on the management of urinary tract infections in the era of antimicrobial resistance. Postgraduate medicine, 129(2), 242-258. http://dx.doi.org/10.1080/00325481.2017.1246055

Baranowska, M., & Bartoszek, A. (2016). Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry. Postepy higieny i medycyny doswiadczalnej (Online), 70, 1460-1468. DOI: 10.5604/17322693.1227896

Bishayee, A., Mandal, A., Bhattacharyya, P., Bhatia, D. (2016). Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Nutr Cancer, 68(1), 120-30. DOI: 10.1080/01635581.2016.1115094

Blumberg, J.B., Basu, A., Krueger, C.G., Lila, M.A., Neto, C.C., Novotny, JA… Toner, C.D. (2016). Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015. Adv Nutr, 7(4), 759S-70S. DOI:10.3945/an.116.012583

Burger, O., Weiss, E., Sharon, N., Tabak, M., Neeman, I., Ofek, I. (2002). Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice. Crit Rev Food Sci Nutr, 42(3), 279-84. DOI: 10.1080/10408390209351916

Cowan, M. M. (1999). Plant products as antimicrobial agents. Clinical microbiology reviews, 12(4), 564-582. Abstract

de Llano, D. G., Arroyo, A., Cárdenas, N., Rodríguez, J. M., Moreno-Arribas, M., & Bartolomé, B. (2017). Strain-specific inhibition of the adherence of uropathogenic bacteria to bladder cells by probiotic Lactobacillus spp. Pathogens and Disease, 75(4). DOI:10.1093/femspd/ftx043

de Llano, D.G., Esteban-Fernández, A., Sánchez-Patán, F., Martínlvarez, P.J., Moreno-Arribas, M.V., Bartolomé, B. (2015). Anti-Adhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Escherichia coli in Bladder Epithelial Cell Cultures. Int J Mol Sci, 16(6), 12119-30. DOI:10.3390/ijms160612119

Ditu, L.M., Chifiriuc, M.C., Bezirtzoglou, E., Marutescu, L., Bleotu, C., Pelinescu, D., Mihaescu, G., Lazar, V. (2014). Immunomodulatory effect of non-viable components of probiotic culture stimulated with heat-inactivated Escherichia coli and Bacillus cereus on holoxenic mice. Microb Ecol Health Dis, 25. DOI:10.3402/mehd.v25.23239

Domenici, L., Monti, M., Bracchi, C., Giorgini, M., Colagiovanni, V., Muzii, L., & Panici, P. B. (2016). D-mannose: a promising support for acute urinary tract infections in women. A pilot study. Eur Rev Med Pharmacol Sci, 20(13), 2920-5. Article

Ermel, G., Georgeault, S., Inisan, C., Besnard, M. (2012). Inhibition of adhesion of uropathogenic Escherichia coli bacteria to uroepithelial cells by extracts from cranberry. J Med Food, 15(2):126-34. DOI: 10.1089/jmf.2010.0312

Fellers, C. R., Redmon, B. C., & Parrott, E. M. (1933). Effect of cranberries on urinary acidity and blood alkali reserve. Journal of Nutrition, 6, 455-463. Abstract

Fontana, L., Bermudez-Brito, M., Plaza-Diaz, J., Munoz-Quezada, S., & Gil, A. (2013). Sources, isolation, characterisation and evaluation of probiotics. British journal of nutrition, 109(S2), S35-S50. DOI:10.1017/S0007114512004011

Foxman B. (2014). Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden. Infect. Dis. Clin. North. Am. 28, 1–13. DOI:10.1016/j.idc.2013.09.003

He, X., Zeng, Q., Puthiyakunnon, S., Zeng, Z., Yang, W., Qiu, J… Cao H…(2017). Lactobacillus rhamnosus GG [ATCC 53103] supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense. Sci Rep, 7, 43305. DOI: 10.1038/srep43305

Heber, D. (2011). Pomegranate Ellagitannins. In I.F.F., Benzie, & S. Wachtel-Galor (Eds.), Herbal medicine: Biomolecular and clinical aspects. 2nd edition. Boca Raton, FL: CRC Press/Taylor & Francis. https://www.ncbi.nlm.nih.gov/books/NBK92772/

Heber, D., Schulman, R. N., & Seeram, N. P. (Eds.). (2006). Pomegranates: ancient roots to modern medicine. CRC press. Summary

Hmid, I., Elothmani, D., Hanine, H., Oukabli, A., & Mehinagic, E. (2017). Comparative study of phenolic compounds and their antioxidant attributes of eighteen pomegranate (Punica granatum L.) cultivars grown in Morocco. Arabian Journal of Chemistry, 10, S2675-S2684. https://doi.org/10.1016/j.arabjc.2013.10.011

Hochman, N., Houri-Haddad, Y., Koblinski, J., Wahl, L., Roniger, M., Bar-Sinai, A. …Hochman, J. (2008). Cranberry juice constituents impair lymphoma growth and augment the generation of antilymphoma antibodies in syngeneic mice. Nutr Cancer, 60, 511–7. DOI:10.1080/01635580801956493

Jensen, H.D., Carsten, S., Christensen, S.B., & Krogfelt, K.A. (2017). Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection. Front Microbiol, 8, 542. doi: 10.3389/fmicb.2017.00542

Kresty, L.A., Weh, K.M., Zeyzus-Johns, B., Perez, L.N., Howell, A.B. (2015). Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation. Oncotarget, 6, 33438–33455. DOI:10.18632/oncotarget.5586

Krueger, C. G., Reed, J. D., Feliciano, R. P., & Howell, A. B. (2013). Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health. Analytical and bioanalytical chemistry, 405(13), 4385-4395. DOI: 10.1007/s00216-013-6750-3

Kulkarni, A. P., Mahal, H. S., Kapoor, S., & Aradhya, S. M. (2007). In vitro studies on the binding, antioxidant, and cytotoxic actions of punicalagin. Journal of agricultural and food chemistry, 55(4), 1491-1500. DOI:10.1021/jf0626720

Lazar, V., Miyazaki, Y., Hanawa, T., Chifiriuc, M. C., Ditu, L. M., Marutescu, L., … & Kamiya, S. (2009). The influence of some probiotic supernatants on the growth and virulence features expression of several selected enteroaggregative E. coli clinical strains. Roum Arch Microbiol Immunol, 68(4), 207-214. Abstract

Lee, S. J., Cha, J., & Lee, J. W. (2016). Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts. World Journal of Pediatrics, 12(4), 425-429. DOI: 10.1007/s12519-016-0013-2

Lee, Y. L., Owens, J., Thrupp, L., & Cesario, T. C. (2000). Does cranberry juice have antibacterial activity?. Jama, 283(13), 1691-1691.

Liberty, A.M., Amoroso, J.W., Hart, P.E., Neto, C.C. (2009). Cranberry PACs and triterpenoids: anti-cancer activities in colon tumor cell lines. Proceedings of the Second International Symposium on Human Health Effects of Fruits and Vegetables. Acta Horticulturae, 841, 61–66. DOI: 10.17660/ActaHortic.2009.841.4

Liévin-Le Moal, V., & Servin, A. L. (2014). Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents. Clinical microbiology reviews, 27(2), 167-199. DOI: 10.1128/CMR.00080-13

Machado, T. D. B., Leal, I. C., Amaral, A. C. F., Santos, K., Silva, M. G. D., & Kuster, R. M. (2002). Antimicrobial ellagitannin of Punica granatum fruits. Journal of the Brazilian Chemical Society, 13(5), 606-610. Article

Manzoor, A., Ul-Haq, I., Baig, S., Qazi, J. I., & Seratlic, S. (2016). Efficacy of locally isolated lactic acid bacteria against antibiotic-resistant uropathogens. Jundishapur journal of microbiology, 9(1). DOI:10.5812/jjm.18952

Maurya, P., Mogra, R., & Bajpai, P. (2014). Probiotics: an approach towards health and disease. Trends in Biosciences, 7(20), 3107-3113. Abstract

Noda, Y., Kaneyuki, T., Mori, A., Packer, L. (2002). Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. J Agric Food Chem, 50(1), 166-71. DOI: 10.1021/jf0108765

Mori-Okamoto J, Otawara-Hamamoto Y, Yamato H, Yoshimura H. (2004). Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. J Ethnopharmacol, 92(1), 93-101. https://doi.org/10.1016/j.jep.2004.02.006

Novotny, J. A., Baer, D. J., Khoo, C., Gebauer, S. K., & Charron, C. S. (2015). Cranberry juice consumption lowers markers of cardiometabolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults. The Journal of nutrition, 145(6), 1185-1193. DOI:10.3945/jn.114.203190

Pagliarulo, C., De Vito, V., Picariello, G., Colicchio, R., Pastore, G., Salvatore, P., & Volpe, M. G. (2016). Inhibitory effect of pomegranate (Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli. Food chemistry, 190, 824-831. DOI: 10.1016/j.foodchem.2015.06.028

Panth, N., Manandhar, B., Paudel, K.R. (2017). Anticancer Activity of Punica granatum (Pomegranate): A Review. Phytother Res, 31(4), 568-578. DOI:10.1002/ptr.5784

Parseh, H., Hassanpour, S., Emam-Djome, Z., Lavasani, A. S., Mahmoodabady, H. Z., CHabok, M., … & Ghahsareh, A. M. (2012, April). Antimicrobial properties of Pomegranate (Punica granatum L.) as a Tannin rich Fruit: a review. In The 1st International and The 4th National Congress on Recycling of Organic Waste in Agriculture. Iran.

Quinlan, J. D., & Jorgensen, S. K. (2017). Recurrent UTIs in women: how you can refine your care. Journal of Family Practice, 66(2), 94-100. Article

Reddy, M. K., Gupta, S. K., Jacob, M. R., Khan, S. I., & Ferreira, D. (2007). Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum L. Planta medica, 53(05), 461-467. DOI: 10.1055/s-2007-967167

Rodríguez-Pérez, C., Quirantes-Piné, R., Uberos, J., Jiménez-Sánchez, C., Peña, A., & Segura-Carretero, A. (2016). Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli. Food & function, 7(3), 1564-1573. DOI:10.1039/c5fo01441g

Sagdic, O., Aksoy, A., & Ozkan, G. (2006). Evaluation of the antibacterial and antioxidant potentials of cranberry (gilaburu, Viburnum opulus L.) fruit extract. Acta Alimentaria, 35(4), 487-492. https://doi.org/10.1556/AAlim.35.2006.4.12

Shmuely, H., Burger, O., Neeman, I., Yahav, J., Samra, Z., Niv, Y…. Ofek, I. (2004). Susceptibility of Helicobacter pylori isolates to the antiadhesion activity of a high-molecular-weight constituent of cranberry. Diagn Microbiol Infect Dis, 50(4), 231-5. DOI:10.1016/j.diagmicrobio.2004.08.011

Spaulding, C. N., Klein, R. D., Ruer, S., Kau, A. L., Schreiber, H. L., Cusumano, Z. T., … & Remaut, H. (2017). Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist. Nature, 546(7659), 528-532. DOI:10.1038/nature22972

Spaulding, C. N., Kau, A. L., Klein, R. D., Janetka, J. W., Gordon, J. I., & Hultgren, S. J. (2017a). Small-molecule inhibitors against type 1 pili selectively target uropathogenic E. coli in the gut and bladder. The FASEB Journal, 31(1 Supplement), 939-9. Abstract

Sun, J., Marais, J. P., Khoo, C., LaPlante, K., Vejborg, R. M., Givskov, M., … & Rowley, D. C. (2015). Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli. Journal of functional foods, 17, 235-242. DOI:10.1016/j.jff.2015.05.016

Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of food science and technology, 53(2), 921-933. DOI: 10.1007/s13197-015-2011-0

Vicariotto, F. (2014). Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study. Journal of clinical gastroenterology, 48, S96-S101. DOI:10.1097/MCG.0000000000000224

Voravuthikunchai, S. P., Sririrak, T., Limsuwan, S., Supawita, T., Iida, T., & Honda, T. (2005). Inhibitory effects of active compounds from Punica granatum pericarp on verocytotoxin production by enterohemorrhagic Escherichia coli O157: H7. Journal of health science, 51(5), 590-596. DOI:10.1016/j.foodchem.2015.06.028

Article by Dohrea Bardell, PhD

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Extraintestinal pathogenic Escherichia coli is the most common cause of community-acquired and hospital-acquired extraintestinal infections.  Could poultry-meat be part of the problem?

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

The New High ORAC Synbiotic

September 18, 2017

Dear Friends
HO Front Low Rez
We are very excited to present to you our High ORAC Synbiotic.  It’s back with an enhanced formula and a new look—a beautiful new label.

What’s new?

A higher probiotics count:  We’ve increased the CFUs (Colony Forming Units) to 25 billion per capsule.

More berries and extracts: We have added Quercetin, Resveratrol, and Strawberry.

Higher ORAC value:  The berry mixture provides 3000 ORAC (Oxygen Radical Absorbent Capacity)!

Let’s look at the new proprietary blend per capsule:

  • L. acidophilus & B. longum– 250mg
  • Grape Seed Extract, Wild Blueberry, Quercetin, Resveratrol, Wild Bliberry, Cranberry, Tart Cherry, Prune, Raspberry Seed, Strawberry & Inulin- 250mg.

Please notice that underneather the High ORAC Synbiotic name on the label it say:  “Post Antibiotic Care”.  (See Food Science and the References below for the scientific  conversation on this topic.)

Food Science:

The problem with antibiotics is that along with killing off the bad bacteria, antibiotics also kill the good gut bacteria — the protective bacteria such as Lactobaccilus and Bifidobacteria.  For many years researchers have warned us that antibiotics destroy the protective layer of good bacteria on our gut membrane, resulting in chronic inflammation (Barbut,f. & Petit, J.C., 2001; Bergogne-Berezin, E., 2000).

Both the Bifidobacteria longum and the Lactobacillus acidophilus strains are used in the High ORAC Synbiotic Formula to re-colonize and protect the GI membrane after antibiotic therapy. Bifidobacteria longum and Lactobacillus acidophilus colonize the GI tract membrane, thereby blocking out the pathogens; and also kill pathogenic microorganisms by producing antimicrobial peptides (bacterocins) against them (Hickson et al., 2007; Syngai et al., 2016).

The large offering of berry polyphenols, organic acids, and other phytochemicals offer a powerful antimicrobial and anti-inflammatory support (Grace et al., 2014; Nohynek et al., 2006) . Along with the inulin (a soluble fiber derived from organic chicory root), berries are also a great prebiotic for these good lactic acid bacteria (Puupponen-Pimia et al., 2005; Vendrame et al., 2011). (See the links to the references below for scientific support.)

References:

  • Barbut, F., & Petit, J. C. (2001). Epidemiology of Clostridium difficile‐associated infections. Clinical Microbiology and Infection, 7(8), 405-410.
  • Bergogne-Berezin, E. (2000). Treatment and prevention of antibiotic associated diarrhea. International journal of antimicrobial agents, 16(4), 521-526.
  • Cardona, F., Andrés-Lacueva, C., Tulipani, S., Tinahones, F. J., & Queipo-Ortuño, M. I. (2013). Benefits of polyphenols on gut microbiota and implications in human health. The Journal of nutritional biochemistry, 24(8), 1415-1422. http://www.sciencedirect.com/science/article/pii/S0955286313000946
  • Cremonini FI, Di Caro SI, Nista EC, Bartolozzi F, Capelli GI, Gasbarrini G, Gasbarrini AN. (2002). Meta‐analysis: the effect of probiotic administration on antibiotic‐associated diarrhoea. Alimentary pharmacology & therapeutics, 16(8), 1461-1467.
  • Figueroa‐González, I., Quijano, G., Ramírez, G., & Cruz‐Guerrero, A. (2011). Probiotics and prebiotics—perspectives and challenges. Journal of the Science of Food and Agriculture, 91(8), 1341-1348.
  • Grace, M.H., Esposito D., Dunlap K.L., & Lila M.A. (2014). Comparative analysis of phenolic content and profile, antioxidant capacity, and anti-inflammatory bioactivity in wild Alaskan and commercial Vaccinium berries. J Agric Food Chem, 62(18), 4007-17. doi: 10.1021/jf403810y.
  • Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. Nutrients, 5(6), 1869-1912.
  • Haslam, E., Lilley, T. H., Warminski, E., Liao, H., Cai, Y., Martin, R., … & Luck, G. (1992). Polyphenol complexation: a study in molecular recognition. ACS Publications.
  • Hattori, M., Kusumoto, I. T., Namba, T., Ishigami, T., & Hara, Y. (1990). Effect of tea polyphenols on glucan synthesis by glucosyltransferase from Streptococcus mutans. Chemical and Pharmaceutical Bulletin, 38(3), 717-720.
  • Joseph, S.V., Edirisinghe, I., & Burton-Freeman, B.M. (2014). Berries: anti-inflammatory effects in humans. J Agric Food Chem, 7; 62(18), 3886-903. DOI:10.1021/jf4044056
  • Kemperman, R.A., Bolca, S., Roger, L.C., Vaughan, E.E. (2010). Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities
    Microbiology, 156 (11), pp. 3224-3231
  • Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009). Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases, 15(2), 300-310.
  • Nohynek, L. J., Alakomi, H. L., Kähkönen, M. P., Heinonen, M., Helander, I. M., Oksman-Caldentey, K. M., & Puupponen-Pimiä, R. H. (2006). Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens. Nutrition and cancer, 54(1), 18-32.
  • Puupponen-Pimiä, R., Nohynek, L., Hartman-Schmidlin, S., Kähkönen, M. Heinonen, M., Mata-Riihinen, K. et al.(2005). Berry phenolics selectively inhibit the growth of intestinal pathogens.  J. Appl Microbiol, 98, pp. 991-1000
  • Sirk, T. W., Friedman, M., & Brown, E. F. (2011). Molecular binding of black tea theaflavins to biological membranes: relationship to bioactivities. Journal of agricultural and food chemistry, 59(8), 3780-3787.
  • Sirk, T. W., Brown, E. F., Friedman, M., & Sum, A. K. (2009). Molecular binding of catechins to biomembranes: relationship to biological activity. Journal of agricultural and food chemistry, 57(15), 6720-6728.
  • Stapleton, P. D., Shah, S., Ehlert, K., Hara, Y., & Taylor, P. W. (2007). The β-lactam-resistance modifier (−)-epicatechin gallate alters the architecture of the cell wall of Staphylococcus aureus. Microbiology, 153(7), 2093-2103.
  • Syngai, G. G., Gopi, R., Bharali, R., Dey, S., Lakshmanan, G. A., & Ahmed, G. (2016). Probiotics-the versatile functional food ingredients. Journal of Food Science and Technology, 53(2), 921-933. doi:  10.1007/s13197-015-2011-0
  • Vendrame, S., & Klimis-Zacas, D. (2015). Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-κB and mitogen-activated protein kinase signaling cascades. Nutr Rev, 73(6), 348-58. DOI:10.1093/nutrit/nuu066.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Bacteria in an average human body number ten times more than human cells, for a total of about 1000 more genes than are present in the human genome.  An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.   Check out NIH’s the Human Microbiome Projects 2017 website.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends
Phyto Power High Rez
Stull’s (2016) review, Blueberries’ Impact on Insulin Resistance and Glucose Intolerance, highlighted a multitude of in vivo and in vitro studies that demonstrated another of blueberries important attributes — the anti-diabetic effects of blueberries and berry extracts in insulin-resistant rodent, human, and cell culture models.

The scientific evidence in support of the anti-diabetic health benefits of blueberries and blueberry extract is encouraging. Epidemiological studies reported that consumption of foods rich in anthocyanins, especially from blueberries, were associated with a lower risk of type 2 diabetes (T2DM) and of peripheral insulin resistance.

Prediabetes is a condition in which blood glucose levels are higher than normal, but not high enough to be classified as T2DM.  Although the prediabetes stage is when corrective actions need to be implemented to prevent the possible development of T2DM, many studies find blueberries to have an anti-diabetic effect. See the references below.

Dinstel et al. (2013) found the blueberries in Alaska to have the highest anthocyanins content. See Green Facts below. Our Phyto Power utilizes Alaskan blueberries’ potent levels of plant phenols.

Phyto Power is comprised of several species of wildcrafted blueberries, Rose hip, and Dandelion, including their leaves, stems, roots, and flowers. Growing wild and strong in remote areas of Alaska, these berries and plants are handpicked at the peak of their phytonutrient potential. For centuries, indigenous tribes of Alaskan Natives have used these power-filled berries and plants for their daily nourishment as well as ceremonial and medicinal purposes

Learn how to use Phyto Power in our research and description tabs.

References:

  • Dinstel R.R., Cascio J., & Koukel S. (2013). The antioxidant level of Alaska’s wild berries: high, higher and highest. Int J Circumpolar Health, 72. DOI: 10.3402/ijch.v72i0.21188
  • Haffner, S.M. (1996). The insulin resistance syndrome revisited. Diabetes Care,19:275-277. doi: 10.2337/diacare.19.3.275.
  • Jennings, A., Welch, A. A., Spector, T., Macgregor, A., & Cassidy, A. (2014). Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. The Journal of nutrition, 144(2), 202-208.
  • Muraki, I., Imamura, F., Manson, J. E., Hu, F. B., Willett, W. C., van Dam, R. M., & Sun, Q. (2013). Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies. Bmj, 347, f5001.
  • Stull, A. J. (2016). Blueberries’ Impact on Insulin Resistance and Glucose Intolerance. Antioxidants, 5(4), 44. doi:  10.3390/antiox5040044
  • Wedick N.M., Pan A., Cassidy A., Rimm E.B., Sampson L., Rosner B., Willett W., Hu F.B., Sun Q., van Dam R.M. (2012). Dietary flavonoid intakes and risk of type 2 diabetes in US men and women.  Am. J. Clin. Nutr, 95:925–933. doi: 10.3945/ajcn.111.028894.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Dinstel et al. (2013) found the antioxidant levels of Alaska’s wild berries to be extremely high, ranging from 3 to 5 times higher in ORAC values than cultivated berries from 48 other states. For example, cultivated blueberries have an ORAC scale of 30. Alaska wild dwarf blueberries measure 85. When the berries were dehydrated, per gram the ORAC values increased.*
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved