Microbiome

Dear Friends

Well, in just 12 days from today it’s the Hawaii Doc Talks Convention!, but who’s counting.

On Friday March 3rd we will host the breakfast in Maui and teach on a topic that gets right to the heart of the matter regarding food as medicine:  The Intelligence and Power of Therapeutic Food Supplements: Science, Research, and Protocol.

Click on the above link to the see our learning objectives for the doctors.  The third objective is: Discover the next generation probiotics — infection fighting Supernatant metabolites and immune boosting microRNA.

Remember, if you can’t join us this time around, I would be more than happy to meet you via the zoom meeting format online.  Just let me know and we’ll set it up.

The two photos below present our synbiotic formulas.  The top one highlighting our new LactORN Synbiotic and the photo below seven more probiotic offerings.

LactORNs

Understanding our microbiome is without a question one of the hottest topics in medicine. Hippocrates, 2400 years ago, said that all disease begins in the gut.  In a recent speech Dr. Francis Collins, past director of the Human Microbiome Project, and present director of the NIH said,

We are a chimera-like creatire whose healthy metabolic and physiologic functioning is governed by not only our 10 trillion human cells and their 22,000 genes but also by our human microbiome community that co-habitate our bodies, all 100 trillion of them with their 2 to 8 million genes—most of them bacteria living in our GI tract. (2015, Supercharging Science for the Superorganism)

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“An ever-growing number of studies have demonstrated that changes in the composition of our microbiomes correlate with numerous disease states, raising the possibility that manipulation of these communities could be used to treat disease.”  (HMP Home page).

The microbiome must be taken into account regarding metabolic diseases (Metabolic Syndrome, Obesity, Diabetes, Heart Disease), gastrointestinal disease (IBS, IBD), and neuroligical health.

Yours truly,

Seann Bardell CEO
BioImmersion Inc.

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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  • Dr. Francis Collins, the Director of the NIH recently said “The time of the importance of the microbiome and human health has arrived.  Our gut microbiome is of central importance for our immune system health, our neural-transmitter health, our GI tract health, and our metabolic health.

Dear Friends

A very big congratulation to our amazing and fantastic BioImmersion president, Dohrea Bardell, on becoming a PhD.  We had a wonderful and joyful celebration this past weekend at Fielding Graduate University in Santa Barbara, California.

Dohrea belongs to a very interesting group of theoretical scientists. Her PhD research is focused upon the realm of International Relations, in specific, she built a theoretical model for world peace.

Dohrea has studied the nature of theories for a long time, which as we know, frame all scientific research.

Theories create the framework for measuring and evaluating life and our experience of the world in which we live.  At this point (as I understand it from Dohrea), we are going through a major shift in our research community, and many scientists are not even aware of this important phenomenological change. As a hint, the microbiome project belongs to a very different world theory, and hence will slowly change the way we consider research and the world around us. Exciting!

Dohrea studied one of the most influential and complex philosophical thinker in the Western world, Immanuel Kant. She built a Kantian normative peace model— a theoretical model that we can enact as a law.  Peace, as Dohrea describes it, is a categorical imperative: A binding international law. A universal law that considers the dignity of Humanity as its core.

Peace as a categorical imperative has a beautiful ultimate goal – But, to find out what it is, as she told her audience at the graduation ceremony, “you’ll need to read my dissertation or monograph when it is published.”  So stay tuned. It is in the process of being published, and I will keep you posted.

Congratulations Dohrea!

Dohrea Graduation 1Dohrea Graduation 2

(Thanks to Larry Severance for the photos)

Dohrea PhD Cohort 2

Sincerely yours,

Seann Bardell

Globe_Home 3Fielding Graduate University is a school for scholar-practitioners and its focus is social change.  As they say, we are an innovative global community dedicated to educating scholars, leaders and practitioners in pursuit of a more just and sustainable world.
 

Dear Friends

Protect the gut from dysbiosis by adding good probiotics.

We are going through a phenomenal paradigm shift realizing who and what we really are; this in large part is due to the National Institute of Health (NIH) and the Human Microbiome Project (HMP).

What is this new paradigm?  Francis Collins, the Director of NIH, explains: “We should think of each host [human] and its parasites [microbiome] as a superorganism with the respective genomes yoked into a chimera of sorts” (2015, talk titled: Supercharging Science for the Superorganism). Humans are creatures of mythology.

Many researchers agree. Moeller et al. (2014) declares, “Humans are ecosystems containing trillions of microorganisms.”  Michael Pollen’s (2013) lecture at the University of Colorado, Some of my best friends are germs, summarized, “It turns out that we are only 10% human: for every human cell that is intrinsic to our body, there are about 10 resident microbes … to the extent that we are bearers of genetic information, more than 99% of it is microbial.”

Our GI tract alone is home to around 100 trillion bacteria, and that’s not counting viruses, yeast, and other microbes.  They bring 8 million bacterial genes to cohabitate with our 22,000 genes (Rob Knight’s 2015 Keystone Symposia talk, Development of the Human Microbiome).

Needless to say, the composition and makeup of the ecosystem of our gastrointestinal tract is incredibly important to our overall health and wellbeing, and dysbiosis is a condition where pathogenic microbial populations are not in harmony. The idea is that as creatures of many different life forms, we must learn to create harmonious working relations.

Therapeutic Food recipe to support a healthy GI tract microbiome, choose one or combine and interchange:

Food Science

The importance of bringing in useful strains of probiotic organisms into our diet cannot be overstated. Knowing your strains and their strengths is critical.  Secondly, having top microbiologists in your probiotic growing operation is important in order to achieve the maximum genetic potential of the carefully selected strains.  How the bugs are grown and harvested matters as to their strength.  And, thirdly, having the latest technology to accurately type the genomes of each batch of product to assure their genomic fidelity.

For example there are differences between strains of same species in certain important attributes. These include tolerance to acid, bile and pancreatin (Masco, 2007); adherence to mucus or to epithelial cells (Adlerberth et al., 1996; Pretzer et al., 2005; Collado et al. 2005; Tallon et al., 2007); enzymatic activity (Rao & Dutta, 1978); and antibiotic resistance or production of antimicrobial compounds (Olivares et al., 2006; D’Aimmo et al., 2007).

Original Synbiotic contains Lactobacillus acidophilus ATCC 4355, Lactobacillus plantarum ATCC 8014, Lactobacillus rhamnosus ATCC 7469, Steptococcus thermophilus 19258 and Bifidobacteria longum ATCC 15707, along with organic chicory root soluble fiber- inulin.  

ATCC (American Type Collection Collection) is the largest repository for bacterial collections in the world and provides the Gold Standard for genomic typing and mother culture storage.
Our probiotics are all ATCC prototypical bacterial strains with confirmed molecular identity, and demonstrate strong abilities to survival stomach acidity, and the bile and pancreatin of the small intestines.

Collectively, these specific strains have shown not only good ability to colonize and protect the epithelial GI tract mucus membrane from pathogenic organisms but are able to neutralize dietary toxins, mutagens, carcinogens and infectious organisms.  They aid in digestion, enhance absorption of minerals, are strong producers of the SCFA butyrate.  (Click above on the link above to see the Originals Synbiotic Monograph)

Beta Glucan High Potency Synbiotic contains the same powerful pedigreed probiotics as the Original but has a higher CFU and a wider collection of prebiotic fibers especially the beta gluten soluble fibers derived from gluten free oat bran. (See the technical brief on this product in the link above)

High ORAC Synbiotic contains a CFU of 20 billion probiotic (L. acidophilus, B.longum) plus blueberry extract, grape and grape seed extract, raspberry and raspberry seed extract, cranberry, strawberry, prune, tart cherry and wild bilberry extract plus 250mg inulin.
(Read more by clicking on the link above to see the High ORAC Synbiotic Monograph).

Select any one of these synbiotics to support your health promoting needs.

Bibliography

  • Adlerberth et al. (1996). A mannose-specific adherence mechanism in Lactobacillus plantarum conferring binding to the human colonic cell line HT-29. Appl Environ Microbiol; 62: 2244-2251.
  • Collado et al. (2007). Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus. Lett Appl Microbiol; 45(4): 454-460.
  • D’Aimmo et al. (2007). Antibiotic resistance of lactic acid bacteria and Bifidobacterium spp. isolated from dairy and pharmaceutical products. Int J Food Microbiol; 115(1): 35-42.
  • Marteau, P. (2011). Evidence of probiotic strain specificity makes extrapolation of results impossible from a strain to another, even fro the same species. Annals of Gastroenterology & Hepatology; 2(1): 34-36.
  • Masco et al. (2007). In vitro assessment of the gastrointestinal transit tolerance of taxonomic reference strains from human origin and probiotic product isolates of Bifidobacterium. J Dairy Sci; 90(8): 3572-3578.
  • Medine et al. (2007). Differential immunomodulatory properties of Lifidobacterium longum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol; 150(3): 531-538.
  • Moeller et al. (2014). Rapid changes in the gut microbiome during human evolution PNAS; 111(46): 16431-16455
  • Olivares et al. (2006). Antimicrobial potential of four Lactobacillus strains isolated from breast milk. J Appl Microbiol; 101(1): 72-79.
  • Pretzer et al. (2005). Biodiversity-based identification and functional characterization of the mannosespecific adhesion of Lactobacillus plantarum. J Bacteriol; 187: 6128-6136.
  • Rao MV, Dutta SM. Lactase activity of microorganisms. Folia Microbiol (Praha); 23(3): 210-215.
  • Tallon et al. (2007). Strain- and matrix-dependent adhesion of Lactobacillus plantarum is mediated by proteinaceous bacterial compounds. J Appl Microbiol; 102(2): 442-451.
  • Yoshimura et al. (2010). Prevention of Escherichia coli O157:H7 infection in gnotobiotic mice associated with Bifidobacterium strains. Antonie Van Leewenhoek; 97(2): 107-117.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners.  There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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Constructing the Microbial Biomap for Planet Earth-  The Earth Microbiome Project is a proposed massively multidisciplinary effort to analyze microbial communities across the globe.  The goal is to produce a global Gene Atlas.  Is this the Microbe Revolution?

Dear Friends,

The research demonstrating the importance of diversity of plant polyphenols in our diet and their medical benefits continues to proliferate.  As of August 2015, PubMed database contains 78,524 studies that research flavonoids alone.  Likewise, the mounting research as to the importance of the makeup of our gastrointestinal microbiome and its relationship to the overall health of our body is accumulating exponentially.

What is fascinating is the bi-directional communicative nature of the relationship between the plants we consume and the bugs in our gut.

Cardona et al. 2013. Benefits of polyphenols on gut microbiota and implications in human health. J. Nutr. Biochem;24(8):1415-22, shines important light on this subject.

Cardona maintains that the microbial profile of ones GI tract microbiome determines the bioavailability and bio-efficacy of polyphenols and their metabolites. At the same time the composition of the dietary intake of polyphenols may in turn modulate and cause fluctuations in the proportions of the microfloral populations in our GI tract.

Apart from the inter-individual variation in daily intake of polyphenols, inter-individual differences in the composition of the gut microbiota may lead to differences in bioavailability and bio-efficacy of polyphenols and their metabolites.

Recent studies have suggested that both the phenolic substrates supplied to the gut bacteria through different patterns of dietary intake and the aromatic metabolites produced may in turn modulate and cause fluctuations in the composition of the microflora populations through selective prebiotic effects and antimicrobial activities against gut pathogenic bacteria.

This is a topic we will be focusing on more fully over the next several months.

Sincerely yours,

Seann Bardell
BioImmersion.com

Clinical Note:

Phyto Power provides a wonderful and powerful array of flavonoids from Alaska’s wildcrafted berries and dandelion.

Supernatant Synbiotic formula brings in a diverse collection of proven Bulgarian strains of pedigreed probiotic organisms.

Take one capsule of each twice daily.

Green Facts

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The Marion Institute is very special.  It is a root cause solution based non-profit that acts as an incubator for programs and seridipity projects.

Round the Bend Farm- a Center for Restorative Community is one of their important projects, and Desa Van Laarhoven is its director.  Hear her keynote speach—Desa’s story.

Dear Friends,

Over the years research has shown a powerful connection between the gut and brain, some call the GI tract the second brain.

Anywhere from 40 to 90 percent of children with autism suffer from gastrointestinal symptoms (Schmidt C. 2015).

An over use of antibiotics can lead to overgrowth of the Clostridial genus, and overgrowth of Clostridia is indicated in autism and even schizophrenia (Shaw, 2010).

A compound identified as 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPH), which is produced by multiple species of anaerobic bacteria of the Clostridium genus, creates gut inflammation and depletes brain catecholamines.

Add to the above an overuse of other medications such as cortico-steroids, bad dietary patterns and too much stress, and the results you get are a weaken gastrointestinal immune system, and a leaky gut—a viscious cycle of chronic inflammation.

  • Schmidt C. 2015. Mental Health: Thinking from the Gut. Nature; 518:512-515
  • Shaw W. 2010. Increased urinary excretion of a 3-(3-hydroxphyenyl)-3-hydroxypropionic acid (HPHPH), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia. Nutritional Neuroscience; 12(3):135-143

How can the Supernatant Synbiotic and the LactORN help?

We developed the Supernatant Synbiotic formula to protect against hospital and healthcare generated infections, of which Clostridium difficile is one of the leading culprits.  C. diff. caused almost half a million infections among patients in the United States in a single year, according to a study released by the CDC (CDC Newsroom Feb. 2015).  And, Clostridial overgrowth is commonly associated with Autism Spectrum Disorder (ASD).

Our Bulgarian scientists selected strains of lactic acid bacteria that have the best hit against C. difficile— those that produced the strongest bacterocins to inhibit the overgrowth of Clostridia. We have had wonderful feedback from doctors using the Supernatant Synbiotic with patients suffering from recurrent ulcerative colitis and from those treating autistic patients.

LactORN, our newest synbiotic, highlights the power of supplying optimal amounts of the bacterial microRNA, which stimulates the innate immune system compromised by stress to be more able to defend the gut against infectious bacteria and virus.  It also recenters the adaptive immune system so that it doesn’t overreact to incompletely digested peptides, xenobiotics, and bacterial endotoxins such as LPS.

So there you have it.  See the dosing pattern in the clinical notes.

Sincerely yours,

Seann Bardell
BioImmersion.com

Clinical Note:

The suggested dosing is as follow:

Supernatant Synbiotic one capsule a day or as directed by your doctor.

The LactORN Synbiotic- two level teaspoons a week dissolved in the mouth or as directed by your doctor.

Green Facts

Globe_Home 3

The Marion Institute is very special.  It is a root cause solution based non-profit that acts as an incubator for programs and seridipity projects.

Round the Bend Farm- a Center for Restorative Community is one of their important projects, and Desa Van Laarhoven is its director.  Hear her keynote speach—Desa’s story.