Dear Friends

In this weeks Forward Thinking we will continue with our cancer support protocol focusing on Phyto Power and Beta Glucan High Potency Synbiotic.

Last week we looked at vegetables, and research siting their most potent anti-cancer fighters. This week we are getting into the intelligent use of fruits, fibers and probiotics for preventive cancer support.

A Therapeutic Food protocol to support our ability to prevent and aid in treating cancer:

  • Garlic, organic– 1 to 2 capsules daily (more is okay, but not enough so that your skin has a garlic odor)
  • Cruciferous Sprout Complex 3-4 capsules daily, preferably on an empty stomach
  • Phyto Power, wild crafted– 1-2 capsules daily
  • Beta Glucan High Potency Synbiotic– 2 tablespoons daily

Food Science:

Berry fruits have beneficial effects against several types of human cancers; and the evidence is overwhelming.  Their anticancer potential benefits are related to their polyphenols (flavonoids, proanthocyanidins, gallotannis, phenolic acids), stilbenoids, lignans and triterpennoids (Seeram NP., 2008).

Their benefits mediated through to:

  • Counteract, reduce and repair damage from oxidative stress and inflammation.
  • Regulating carcinogen and xenobiotic metabolizing enzymes, transcription and growth factors, inflammatory cytokines, and cellular signaling pathways of cancer cell proliferation, apoptosis and angiogenesis.
  • Sensitize tumor cells to chemotherapeutic agents by inhibiting pathways that lead to treatment resistance.
  • Provide protection from therapy-associated toxicities.

Phyto Power– each capsule contains 3 species of Alaskan wildcrafted rosehips (the whole fruit and seeds), four species of wildcrafted blueberry (fruit >95% w/w and leaves and stems <5% w/w), and four species of wildcrafted dandelions (aerial parts 90% w/w, roots 10% w/w and flower).

The environment from which a plant comes has a tremendous effect on its nutrient potency.
When plants are farmed organically their nutrient values tend to be higher, especially when we are considering the micronutrients.  They don’t have the crutch of relying on an herbicide or pesticide for their protection and they must produce more of their own phyto-chemicals to fend off invaders and survive.

Alaska is a challenging environment.  The growing season has intense sun 20 hours a day. Yet, the ground is still partially frozen due to the lattitude.  It is a mountainous region of the world where the wild soil is very rich in volcanic ash—resulting in an abundance of minerals and organic nutrients for the plants.  Berries tend to be tart and are loaded with phenolic actives—the very phytochemicals that we need for protection from chronic diseases.

Rosehip derives its orange color from its abundance of lycopene, a carotenoid known for providing protection from cancer.  For example, prospective and retrospective epidemio-logical studies indicate an inverse relationship between lycopene intake and prostate cancer risk (vanBreemen RB., Paklpvoc M., 2008).

Scientist investigated the efficacy of rosehip extracts in preventing cell proliferation of three human glioblastoma cell lines.  Each line treated demonstrated a signficant decrease in cell proliferation. The rosehip decrease was equal to or better than the decrease of cell proliferation observed when inhibitors of the MAPK or AKT signaling pathways were utilized (Cagle et a.. 2012).

Rosehip is loaded with Vitamin C, organic acids, catechins and other flavonoids to help provide strong support for cancer protection.

Blueberry are rich in anthocyanins, which exhibit strong antioxidant and anti- inflammatory properties all important for cancer protection.  They have been shown to reduce COX-2, NFkB in the blood, as well as isoprostane, a marker for lipid oxidation.

Anthocyanins from blueberry have demonstrated the ability to inhibit not only the intiation stages of chemically induced carcinogenesis but also the later promotion and proliferation stages (Lila, 2004).

What researchers, McAnulty et al. discovered is that blueberries are strong stimulators for the body’s production the NK cells.  It is the job of natural killer cells to provide immunosurvellance for tumors and their eradication (McAnulty et al., 2011; Waldhauer & Steinle., 2008).

Dandelion roots, leaves and flowers providing a diversity of health benefits.  The roots stimulate bile flow, the leave provide a rich supply of chlorophyll, the flowers the pigment lutein, a powerful antioxidant.

Beta Glucan High Potency Synbiotic provides 33 billion cfu/tbl of certified stains of pedigreed probiotic with Therapeutic Foods in a synbiotic formula of L. acidophilus, B.longum, L. rhamnosus, L. plantarum, S. thermophilus and 5 grams of patented oat bran (75%) with high levels of beta glucan (10%), whole red beet root (15%) and inulin derived for chicory fiber (10%).

Prebiotic:

Reactive oxygen species and reactive nitrogen species play an important role in the pathogenesis of many diseases.  Beta-glucans participate in the processes of repair, metabolism and detoxification.  They counteract the pathological conditions of ROS and RNS (Jurczynska et al., 2012).

Beta-glucans, naturally occurring polysaccharides, are present as constituents of cell wall of cereal grains, mushrooms, algae, or microbes including bacteria, fungi, and yeast.  Since Pillemer et al. first prepared and investigated zymosan in the 1940s and others followed with the investigation in the 60s and 70s, researchers have well established the significant role of B-glucans on the immune system relative to cancer treament, infection, immunity, and restoration of damaged bone marrow (Yoon TJ., 2013).

It is well established that glucans enhance the efficacy of anti-cancer and anti-infection immunotherapy, both in clinical and experimental conditions (Vetvicka V., 2013).

Probiotic:

There is a large body of evidence that suggests probiotic reduce the inflammatory response and oxidative stress, as well as increase the expression of adhesion proteins with the intestinal epithelium, reducing intestinal permeability.  The net result of which is the reduction of chronic inflammation, a leading cause for cancer initiating and developing (Bordalo et al., 2016; Kasinska & Drzeworski, 2015; Idzior-Walu & Walus-Miarka, 2015; Yan et al., 2015; Gomes et al., 2014).  These selected strains are particularly successful in this endeavor.

Finally, our other probiotic formulas can be considered here in this protocol as well.  The High ORAC Synbiotic provides along with probiotics a collection of powerful berry extracts. So to does our Cranberry Pomegranate Synbiotic and our No. 7 Systemic Booster.  I have provided the links for them here.

Bibliography:

  • Abduli Razis AF, Noor NM. (2013). Cruciferous vegetables: dietary phytochemicals for cancer prevention. Asian Pac J Cancer Prev; 14(3): 1565-70.
  • Anand et al. (2008). Cancer is a preventable disease that requires major lifestyle changes. Pharm Res; 25(9): 2097-2116.
  • Bhuvaneswari V, Nagini S. (2005). Lycopene: A Review of its Potential as an Anticancer Agent. Current Medicinal Chemistry—anti-Cancer Agents; 5(6): 627-635.
  • Boivin et al. (2009). Antiproliferative and antioxidant activities of common vegetables: A comparative Study. Food Chemistry; 112(20): 374-380.
  • Bordalo et al. (2015). Clinical Application of Probiotic in Diabetes Mellitus:  Therapeutics and New Perspectives. Crit Rev Food Sci Nutr; 1015 Oct 25: 0.
  • Cao et al. (2014). Garlic-derived allyl sulfides in cancer therapy. Anticancer Agents Med Chem;14(6):793-9.
  • Cagle et al. Effect of Rosehip (Rosa canina) Extracts on Human Brain Tumor Cell Proliferation and Apoptosis. Journal of Cancer Therapy. 3(5): 13 pages.
  • Grooms et al. (2013). Dietart Fiber Intake and Cardiometabolic Risks among US Adults: NHANES 1999-2919. Am J Med; 126(12): 1059-1067.
  • Idzior-Walu B, Walus-Miarka M. (2015). Is now the time for probiotics in diabetes management? Pol Arch Med Wewn; 125(11): 797-8.
  • Jurczynska et al. Beta-glucan as a natural anticancer agent. Europe PMC; 33(196): 217-220.
  • Kasinska MA, Drzewoski J. (2015). Effectiveness of probiotics in type 2 diabetes: a meta-analysis. Pol Arch Med Wewn; 125(11): 803-13.
  • Lila MA. (2004). Anthocyanins and Human Health:  An in Vitro Investigative Approach. J Biomed Biotechnol; 2004(5): 306-313.
  • McAnulty et al. (2011). Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5 h of running. Appl Physiol Nutr Metab; 36(6): 976-84.
  • Melino S., Sabelli R, Paci M. (2011). Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy. Amino Acids;41(1):103-12.
  • Nepravishta et al. (2012). Oxidative species and s-glutathionyl conjugates in the apoptosis induction by allyl thiosulfate. FEBS J; 279(1): 154-67.
  • Romagnolo DF, Davis CD, Milner JA. (2012). Phytoalexins in cancer prevention. Front Biosci (Landmark Ed); 17: 2035-58.
  • Seeram NP. (2008). Berry fruits for cancer prevention: current status and future prospects. J Agric Food Chem; 56(3): 630-5.
  • Steinkellner et al. (2001). Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; 480-481: 285-297.
  • van Breemen RB, Pajkovic M. (2008). Multitargeted therapy of cancer by lycopene.  Cancer Letters; 269(2): 339-351.
  • Vetvocla  V. (2013). Synthetic oligossacharides: clinical application in cancer therapy. Anticancer Agents Md Chem; 13(5): 720-4.
  • Walhauer I, Steinle A. (2008). NK cells and cancer immunosurveillance. Oncogene; 27: 5932-5943.
  • Yan Q, Li X, Feng B. (2015). The efficacy and safety of probiotics intervention in preventing conversion of impaired glucose tolerance to diabetes: study protocol for a randomized, double-blinded, placebo controlled trial of the Probiotics Prevention Diabetes Programme (PPDP). BMC Endocr Discord; 15(1): 74.
  • Yoon et al. 2013. The effects of B-glucans on cancer metastasis. Anticancer Agents Med Chem; 13(5): 699-708.

Sincerely yours,

Seann Bardell

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

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February is Cancer Prevention Month and The American Institute for Cancer Research provides a great website for support in the fight against cancer.  Check our their site and these ten recommendations for cancer prevention.