Year: 2017

Endotoxemia and Chlorella

December 14, 2017

Dear Friends

Chlorella HZ 2

Chlorella and inulin reduce endotoxemia and protect the intestinal mucosa barrier.

What is an endotoxin, and what causes endotoxemia? How does chlorella reduce endotoxemia, and how does inulin produce a healthy microbiome?  Let’s take a look at a few studies.

An endotoxin is often used synonymously with LPS.  Lipopolysaccharides (LPSs) are the major components of the outer membrane of Gram-negative bacteria. Rietschel et al. found in 1994 that LPSs induce strong inflammatory responses from the immune systems of all animals.

Liver Diseases are associated with leaky gut syndrome, which allows for the passage LPS molecules into the systemic circulation, causing chronic inflammation, and a condition called endotoxemia. A large enough load of LPSs in the systemic circulations can cause septic shock.

In fact, severe sepsis is a common and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction. It is especially common in the elderly and is likely to increase substantially as the U.S. population ages (Angus et al., 2001)

Bedirli et al. (2009) investigated the role of different microalgae (Chlorella sp. and Spirulina sp.) extracts in intestinal barrier function and oxidative stress in experimentally jaundice rats.

The main outcomes measured were endotoxin concentrations in plasma [e.g. LPS levels], evidence of bacterial translocation in mesenteric lymph nodes and liver oxidative stress, and histology.

Their findings: A Chlorella sp. supplemented diet significantly demonstrated protective effects on the intestinal mucosa barrier in obstructive jaundice, and reduced intestinal translocation of bacteria and endotoxin.  Spirulina had no significant effect.

Original copyCani et al. (2008) found that a high animal fat diet changes the GI tract microbiome into a population of increasing numbers of Gram-negative bacteria, which raises the level of LPS endotoxins within the gut lumen and allows their passing through the GI tract membrane into the plasma.

The research team concluded that the plasma concentration of lipopolysaccharides (LPS) controls the inflammatory tone of the body.  This means that high concentrations of LPS set the stage for endotoxemia, resulting in metabolic diseases (obesity, diabetes, CVD) and cancer.

They further demonstrated in the study that increased fibers in the diet, such as inulin, increase the populations of Bifidobacterial sp. and Lactobacillus sp. which reduce both the load of Gram-negative bacteria and the permeability of the gastrointestinal membrane.

Our Suggestion: Take 4 to 8 tablets of Organic Chlorella daily.
Take 1 tsp. of Original Synbiotic daily.
References:

  • Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001). Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine, 29(7), 1303-1310.
  • Bedirli, A., Kerem, M., Ofluoglu, E., Salman, B., Katircioglu, H., Bedirli, N., … & Pasaoglu, H. (2009). Administration of Chlorella sp. microalgae reduces endotoxemia, intestinal oxidative stress and bacterial translocation in experimental biliary obstruction. Clinical nutrition, 28(6), 674-678.
  • Cani et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat induced obesity and diabetes in mice, Diabetes; 57:1470-8.
  • Rietschel, E. T., Kirikae, T., Schade, F. U., Mamat, U., Schmidt, G., Loppnow, H., … & Di Padova, F. (1994). Bacterial endotoxin: molecular relationships of structure to activity and function. The FASEB Journal, 8(2), 217-225.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3
What kind of world do you want to wake up to 30 years from now?
The Biomimicry Institute aspires to a world where what we make is inspired by, and connected to, the natural world.  This means cities are resilient, emission targets are achieved, and industrial processes create healthy air, water, and soil.  It also means all species are thriving because our human designs restore the planet as nature’s desgns do.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Chlorella HZ 2

Chlorella enhances the immune system’s ability to defend against and fight upper respiratory tract infections (URTI), and reactivation of dormant Epstein Barr Virus (EBV).

The adaptive immune system plays a crucial role in our mucosal membrane’s ability to ward off pathogenic microbial invasion.

Otsuki et al.’s (2011) research showed that chlorella supplementation increases mucosal SigA levels thereby enhancing our body’s mucous membrane’s barrier protection from bacteria and viruses.

In another 2011 study, Yamauchi et al. found that during intense training of athletes, those that showed a reduced level of SIgA had a greater chance of coming down with upper respiratory tract infections and/or an reactivation of latent viruses such as Epstein-Barr virus (EBV).  In their study, the EBV-DNA levels tended to be higher in subjects who exhibit sore throat and cough.  The SIgA level was significantly lower one day before the EBV-DNA expression.

Our Suggestion: Take 4 to 8 tablets of Organic Chlorella daily.

References:

  • Daele, J., & Zicot, A. F. (2000). Humoral immunodeficiency in recurrent upper respiratory tract infections. Some basic, clinical and therapeutic features. Acta oto-rhino-laryngologica belgica, 54(3), 373-390.
  • Otsuki, T., Shimizu, K., Iemitsu, M., & Kono, I. (2011). Salivary secretory immunoglobulin A secretion increases after 4-weeks ingestion of chlorella-derived multicomponent supplement in humans: a randomized cross over study. Nutrition Journal, 10(1), 91.
  • Yamauchi, R., Shimizu, K., Kimura, F., Takemura, M., Suzuki, K., Akama, T., … & Akimoto, T. (2011). Virus activation and immune function during intense training in rugby football players. International Journal of Sports Medicine, 32(05), 393-398.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Immunoglobulin’s deficiency may exist in a significant percentage of patients with chronic or recurrent infections of the upper respiratory tract.  Adequate surface protection of the upper airway tract depends on intimate cooperation between natural non-specific defense mechanisms such as ciliary function and acquired adaptive immunity such as healthy SIgA levels (Daeli J, 2000).

An immunologic screening should be extended to patients who have persistent sinus infection, and Organic Chlorella is an option well worse using.

 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Dear Friends

Chlorella HZ 2

Fallah et al.’s ( 2017) meta-analysis, Effect of Chlorella supplementation on cardiovascular risk factors: A meta-analysis of randomized controlled trials, found that Chlorella decreased several risks leading to cardiovascular disease.

The meta-analysis on 19 randomized controlled trials (RCTs) with 797 subjects showed that Chlorella administration significantly decreased the following risk factors:

  • Decreased the levels of total cholesterol
  • Decreased the levels of LDL cholesterol
  • Decreased systolic blood pressure
  • Decreased diastolic blood pressure
  • Decreased fasting blood glucose

Subgroup analyses based on intervention duration and chlorella dosages revealed that administration of chlorella for 8 weeks or higher with dosages higher than 4 g/day significantly reduced the above risk markers in both people with healthy levels and unhealthy levels.

Over all, the results of their meta-analysis indicated that Chlorella supplementation clearly supports the reduction of key risk factors for cardiovascular disease.

Our Suggestion: Take 8 tablets of Organic Chlorella once a day.

Reference:

Fallah, A. A., Sarmast, E., Dehkordi, S. H., Engardeh, J., Mahmoodnia, L., Khaledifar, A., & Jafari, T. (2017). Effect of Chlorella supplementation on cardiovascular risk factors: A meta-analysis of randomized controlled trials. Clinical Nutrition. https://doi.org/10.1016/j.clnu.2017.09.019

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3For cardiovascular health we suggest a plant-based diet that is accompanied by 2 tablespoons of Beta Glucan Synbiotic Formula, with the American Heart Assoc. seal of approval. Add the Be Regular for more gluten free fiber, and Weight-Less, 2 caps. before each meal to lower the glycemic load, and boost metabolism.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Chlorella for fatty liver

November 29, 2017

Dear Friends

Chlorella HZ 2

Can Chlorella supplementation help with Non-Alcoholic Fatty Liver Disease (NAFLD)?

Ebrahimi-Mameghani et al. (2016) sought to answer this question in their study entitled, Glucose homeostasis, insulin resistance and inflammatory biomarkers in patients with non-alcoholic fatty liver disease:  Beneficial effects of supplementation with microalgae Chlorella vulgaris: A double-blind placebo-controlled randomized clincial trail.

The authors researched the effects of C. vulgaris supplementation on glucose homeostasis, insulin resistance and inflammatory biomarkers in patients with NAFLD.

70 non-alcoholic fatty liver disease (NAFLD) patients confirmed by ultra-sonographic findings were randomly assigned into intervention group (four 300 mg tablets of C. vulgaris) or placebo group (four 300 mg tablets of placebos) for 8 weeks.

Anthropometric measurements, liver enzymes, fasting serum glucose (FSG), insulin, high sensitive C-reactive protein (hs-CRP), and tumor necrosis factor-alpha (TNF-a) were assessed and homeostatic model assessment (HOMA) score for insulin resistance was estimated before and after the intervention.

The results show the following:

  • Mean reduction in weight was significantly higher in C. vulgaris- treated group compared to placebo group.
  • Serum concentrations of liver enzymes, FSG and hs-CRP also significantly decreased.
  • Serum insulin concentration and HOMA score increased significantly only in C. vulgaris-treated group (insulin secretion was balanced).
  • Mean change in serum glucose and TNF-a levels were significant between the groups even after adjusting for the serum insulin and baseline values of variables.

The authors conclusion was that L. vulgaris supplementation could be considered as an adjunctive therapy to decrease weight and improve glycemic status and reducing hs-CRP as well as improving liver function in patients with NAFLD.

Take 3 tablets a day, 1500mg of Organic Chlorella, to meet the researched amounts of 1200mg a day.

References:

  • Ebrahimi-Mameghani, M., Sadeghi, Z., Farhangi, M. A., Vaghef-Mehrabany, E., & Aliashrafi, S. (2016). Glucose homeostasis, insulin resistance and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: Beneficial effects of supplementation with microalgae Chlorella vulgaris: A double-blind placebo-controlled randomized clinical trial. Clinical Nutrition; 36(4): 1001-1006.
  • Ebrahimi-Mameghani, M., Aliashrafi, S., Javadzadeh, Y., & AsghariJafarabadi, M. (2014). The effect of chlorella vulgaris supplementation on liver enzymes, serum glucose and lipid profile in patients with non-alcoholic fatty liver disease. Health Promotion Perspectives, 4(1), 107.
  • Care, D. (2007). Insulin sensitivity and insulin secretion determined by homeostasis model assessment (HOMA) and risk of diabetes in a multiethnic cohort of women: the women’s health initiative observational study. Diabetes Care, 30(7), 1747-1752.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Globe_Home 3One bottle of BioImmersions Organic Chlorella contains 120 tablets, with each tablet containing 500 mgs of pure organic chlorella.  Therefore, according to the above researched dose of 1200 mgs per day for NAFLD, the BioImmersion equivalent dose would be three tablets/d.
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved

Chlorella for Fat Burning?

November 25, 2017

Dear Friends

Chlorella HZ 2
Chlorella is not often thought of as part of a weight loss protocol but with its powerful green nutrients, amino acids, vitamins, minerals and more, cholorella in fact can help with metabolic diseases such as obesity and diabetes.

Chlorella for fat burning?  Mizoguchi et al. (2008) concluded in their study, Nutrigenomic studies of effects of chlorella on subjects with high-risk factors for lifestyle-related disease, that chlorella intake resulted in noticeable reductions in body fat percentage, serum total cholesterol, and fasting blood glucose levels.

The researchers conducted Chlorella ingestion tests on 17 subjects with high risk factors for lifestyle-related diseases and 17 healthy subjects over a 16-week period including a 4-week post-observation period.

They utilized standard blood biochemical tests and also nutrigenomic analyses: analyzing gene expression profiles in whole blood cells in the peripheral blood before and after Chlorella intake.

Chlorella influences a myriad of metabolic pathways.  These included genes involved in fat metabolism and insulin signaling pathways.  There were clear variations in the expression profiles of genes directly related to uptake of glucose resulting from Chlorella intake, indicating that the activation of insulin signaling pathways could be the reason for the hypoglycemic effects of Chlorella.

The results of Mizoguchi et al. research as well as other studies (see below) showed that Chlorella intake brings about improvements in both fat and glucose metabolism.

References:

  • Grundy, S. M. (2004). Obesity, metabolic syndrome, and cardiovascular disease. The Journal of Clinical Endocrinology & Metabolism, 89(6), 2595-2600.
  • Mizoguchi et al. (2008). Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease.  J Med Food; 11(3): 395-404.
  • Vecina et al. (2014). Chlorella modulate insulin signaling pathway and prevents high-fat diet–induced insulin resistance in mice. Life Sci; 95(1): 45-52.

Sincerely yours,

Seann

We have developed our products based on scientific research and/or the practical experience of many healthcare practitioners. There is a growing body of literature on food based nutrition and supplements and their application in support of our health. Please use our products under the advisement of your doctor.

Green Facts:

Globe_Home 3Using Chlorella as a daily dietary supplement facilitates many functions in the body that affect our metabolism. The suggested dosage is 4-6 tablets twice daily in order to duplicate the amounts used in the study.  However, much less amounts can be tried for achieving positive results, as you can see in the Forward Thinking Newsletter entitled Chlorella for Fatty Liver (Nov. 29, 2017).
 

©2005 – 2017 BioImmersion Inc. All Rights Reserved