Year: 2012

Yes, ORAC is practical!

November 5, 2012


Can you name this Beautiful Creature?

 

Dear Friends

In today’s email we’ll see, through peer-reviewed research, how ORAC can indeed offer a possible therapeutic window into the treatment and prevention of the diseases of aging.  The current citations over the past couple of years relate to dietary antioxidants (polyphenolics) and in vivo antioxidant status and disease. Make sure you scroll down to the clinical notes for a practical application of the following research.

  • Del Rio, D.; Agnoli, C., et al.  Total antioxidant capacity of the diet is associated with lower risk of Ischemic stroke in a large Italian cohort.  J Nutr 2011,141(1): 118-123.

          In a cross-sectional randomized intervention study of 41,620 men and women, a
diet rich in total antioxidant capacity was associated with a reduction in the
incidence of ischemic stroke and to a lesser extent in all types of stroke.

  • Detopoulou, P., et al.  Dietary antioxidant capacity and concentration of adiponectin in apparently healthy adults: the ATTICA study.  Eur J Clin Nutr 2009,64,161-8.

          In this study, positive associations were observed between dietary antioxidant
capacity and adiponectin concentration and a negative relationship with
inflammatory markers.  An adiponectin-mediated route through which antioxidant
rich foods exert beneficial effects against inflammation and cardiovascular
diseases can be hypothesized.

  • Noguer, M. A.; Cerezo, A. G., et al.  Intake of alcohol-free red wine modulates antioxidant enzyme activities in a human intervention study.  Pharmacol Res 2012,65(6): 609-614.

          Our results show for the first time that the increase in the activity of the
antioxidant
enzymes is not due to the alcohol content in wine but to the
polyphenolic composition.  Therefore, alcohol-free wine could be an excellent
source of antioxidants to protect people suffering from oxidative stress (cancer,
diabetes, alzheimer, etc) who should not consume alcohol.

  • McAnuitiy, S. R.; Nieman D.C., et al.  Effect of mixed flavonoids, n-3 fatty acids, and vitamin C on oxidative stress and antioxidant capacity before and after intense cycling. Int J Sport Nutr Exerc Metab 2011,21(4): 328-337.

          This study indicates that combining flavonoids [1000mg quercetin, 400mg
isoqueretin, 30mg epigallocatechin gallate] and antioxidants [1000mg Vit. C] with
n-3 fatty acids [400mg] is effective in reducing the immediate postexercise
increase in F(2)-isoprostanes [lipid oxidation].

  • Gifkins, D.; Olson, S. H.; Demissie, K., et al.  Total and individual antioxidant intake and endometrial cancer risk:  results from a population-based case-control study in New Jersey. Cancer Causes Control 2012,23,887-95.
  • Kolomvotsou, A. I.; Rollidis, L.S.; Mountzouris, K.C., et al.  Adherence to Mediterranean diet and close dietetic supervision increase total dietary antioxidant intake and plasma antioxidant capacity in subjects with abdominal obesity.  Eur J Nutr 2012, Epub date: 2012/01/13.    

We could site many more current scientific studies equating the power of polyphenolic compounds in food with the reduction of risk to the diseases of aging; and, the ORAC test is just one of many measures that must be used in tandum to determine the possible effectiveness of a particular fruit or vegetable.

Excellent research on flavonoids is at the leading edge of food science.  The largest subgroup of healthful foods phenols are the flavonoids, which are then divided into six categories:  Flavones (e.g., luteolin), Flavonols (e.g., quercetin), Flavonones (e.g., hesperetin), Flavanols (e.g., catechins), Isoflavones (e.g., genistein), and Anthocyanins (e.g., delphinidin).  Using ORAC in conjunction with in vivo tests for oxidative stress, clearly makes the case for a return to a regular daily consumption of fresh fruits and vegetables that are grown in conditions that promote plants with high phenolic content. Of course, it is the research that supports and guides the therapeutic foods matrix of our products.
Sincerely yours,
Seann Bardell

Clinical Note:

Consider the possible therapeutic benefits for a baby boomer patient from consuming one tsp. of the No. 7 Systemic Booster as their probiotic, along with 2 capsules of Phyto Power and 2 capsules of Cruciferous Sprout Complex.  This enables one to efficiently and effectively bring in these precious phytonutrients into their body on a daily basis, as you help them to change their diet as well.

The Last Quiz Answer:

Polar bears are the lands largest carnivores.  A large male can weight 1500 lbs.  The coat can range from pure white, to creamy yellow to light brown.  And, under the coat their skin is black.  Aren’t those paws amazing? They are a foot in diameter, well padded (with little bumps on each pad, like snow tires), with five toes and very effective long claws to grab onto the ice, to walruses and to itch the body—Mother Nature’s genius.

The 350.org National Tour on the man-made causes for the catastrophic climate changes we are experiencing begins this Wednesday night in Seattle.  We’ll be there and give you a report next week.  On Thursday the tour, entitled Do The Math, goes to Portland, on Friday to Berkeley, San Francisco and Palo Alto on Saturnday, LA on Sunday, then on to the East Coast and the rest of the USA.  Check it out amd get involved!
                   
 ©2005 – 2012 BioImmersion Inc. All Rights Reserved

 

Be Thoughtful with ORAC!

October 29, 2012


Can you name this Beautiful Creature?

 

Dear Friends

The USDA recently removed ORAC values for selected foods from its data base, claiming ORAC values have been grossly misused by marketers.  Furthermore, they claimed that ORAC values are in vitro measurements that have no relevance to the effects a specific bioactive compound may have in the body.  Are we to understand that ORAC is a useless measurement?  I have spoken with David Bell, a consultant for Brunswick Laboratories to understand this issue, who has explained the issue and has given me many sources to read. There is much to this issue.

Unfortunately, the USDA has thrown the baby out with the bath water!  We’ll look at their second assertion first—”… have no relevance ….”

The ORAC (Oxygen Radical Absorbance Capacity) Assay was developed by Brunswick Laboratories in an attempt to measure the free radical neutralizing ability of food.  It has been used primarily as an in vitro analytical tool.  In the original ORAC method, the peroxyl radical was chosen for use in vitro because it represents one of the major radical sources present within the human body.  It is the value most commonly used in the market place today.  Brunswick has recently expanded their ORAC offering with their new ORAC 5.0 which measures all five of the body’s free radical catagories: peroxyl, hydroxyl, superoxide, peroxynitrite, and singlet oxygen.

Brunswick rightly cautions that no in vitro assay that quantifies a characteristic of a nutritional product describes in vivo outcomes.  This, of course, is true for all in vitro measurements including mgs per capsule of vitamins and minerals listed under Supplemental Facts on nutriceutical labels. Issues such as metabolism, bioavailability, mechanisms of action and efficacy are not measured by any such in vitro assay.  To account for these internal dynamics other in vivo tests must be brought into play.  And, it must be done on an item per item basis.  That is good science.

However, to say that ORAC has no relevance or usefulness as a scientific measure for determining the possible therapeutic benefits of a food stuff is a reactive overstatement by the USDA to the food marketing abuses in the corporate world.  ORAC is most often used in food research, and  there has never ever been any question about the validity of ORAC as an in vitro chemistry method.  Proof in point, the AOAC (Association of Analytical Communities), the worldwide provider and facilitator in the development, use and harmonization of validated analytical methods and laboratory quality assurance programs and services, has established ORAC values as reference standards.  The AOAC is the gold standard setter worldwide.

The only controversy at all is that marketing people have tried to use ORAC value as if it was some guarentee of in vivo health outcomes.  And, this is where we have to be careful.  Companies and organizations that bring a product to market simply based on a one time, one dimensional measurement as to its ORAC value, with no other corraborating tests utilized, are missing the standard of good scientific inquiry, and to that the USDA is right to speak out.  But, the ORAC test used in conjunction with other powerful in vivo tests, allows us to connect the dots as to modes of action, and to piece together the puzzle of good health benefits that can be derived from a given product or class of products.

We’ll go deeper into this important topic over the next couple of weeks, using a variety of recently peer reviewed articles relative to ORAC value in conjunction with other testing method—stay tuned.

Sincerely yours,
Seann Bardell

Clinical Note:

Each ingredient within each of our Therapeutic Foods supplements are evaluated through the lense of multiple research tests, and the multitude of outcomes proported by good peer reviewed research.  For example, our Wild Blueberry Extract has been extensively analysed over the last decade as to its ORAC values, NF Kappa B reducing ability (in vivo), isoprostate levels (in vivo), COX 2 levels (in vivo), and to the most current of new and exciting methods of analysis such as TBARS (in vivo).  This kind of scientific scrutiny is applied to the BioImmersion products, and is what makes them truly therapeutic.  

The Last Quiz Answer:

These beauties are Gentoo Penguins.  They populate the Antartic Penisula and numerous islands around this most southern continent.

Gentoos are the 3rd largest species of penguins (there are 17), reaching heights of 30 inches and weights of 12 lbs.

As mates they form long lasting bonds and are highly nurturing as parents.  Their streamlined bodies allow them to swim at speeds of around 22 mph.  Gentoos can remain under water up to 7 minutes and dive as deep as 655 feet.  Whow!

On Tuesday this week Dohrea and I were in Berkeley doing business.  I made reservations for us to have dinner at Chez Panisse Cafe, the restaurant of the ledgendary organic restaurateur, Alice Waters.  What an incredible treat it was.  I had Hog Island clam stew cooked in the fireplace with red wine, fennel and toasted bread crumbs and Dohrea’s dish was Salmon Creek Ranch duck with green bean and chicory salad.  Most times apparently Alice is at her restaurant but this week she was in Italy lecturing at the Slow Foods conference.  If you are not familiar with Ms. Waters you need be.  Here is a video of her interview on 60 Minutes.

                    ©2005 – 2012 BioImmersion Inc. All Rights Reserved

 

Loose Weight, Burn Fat

October 18, 2012

 

Can you name this Beautiful Creature?

Dear Friends

As we age we tend to store more fat, simply because our body is less efficient converting stored body fat to energy. So then we diet and employ a caloric restriction, but our body, very quickly, slows down its metabolism, which makes it more difficult to loose fat weight.

But the good news is that in studies, 7-Keto DHEA and Seaweed Extract, demonstarte healthy support of weight loss as 7-Keto enhances metabolic rate by promoting thermogenisis (fat burning), while seaweed polyphenols help facilitate the balancing of healthy insulin levels.

No. 4 Systemic Booster:  Metabolic Balance addresses weight loss issues—the reduced metabolic rate and the rate of absorption of calories through its two components: 7-Keto DHEA which is a downstream metabolite of DHEA and seaweed extract from kelp and bladderwrack.

7-Keto DHEA

Clinically- Proven 200% More Weight Loss Than Diet and Exercise Alone.

  • A Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl 7 Oxo-Dehydroepiandrosterone in Healthy Over Weight Adults,  Curr Ther Res 2000;61(7):435-442.
  • The Effect of 7-Keto Naturalean on Weight Loss: A Randomized, Double-Blind, Placebo-Controlled Trial.  Curr Ther Res 2002:63(4).

Majority of Weight Loss is Fat Loss.

  • A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Thermogenic and Body Composition Effects of 3-Acetyl-7oxo- Dehydroepiandrosterone (7-Keto) Clinical Study Final Report, Humanetics Archives.
  • A Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Healthy Over Weight Adults.  Curr Ther Res 2000;61(7):435-442.
  • The Effect of 7-Keto Naturalean on Weight Loss: A Randomized, Double-Blind, Placebo-Controlled Trial.  Curr Ther Res 2002:63(4).

Promotes Weight Loss Without Use of Stimulants.

  • A Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl 7 Oxo-Dehydroepiandrosterone in Healthy Over Weight Adults,  Curr Ther Res 2000;61(7):435-442.
  • The Effect of 7-Keto Naturalean on Weight Loss: A Randomized, Double-Blind, Placebo-Controlled Trial.  Curr Ther Res 2002:63(4).

Awarded U.S. Patent for Metabolic Rate Increase and Weight Loss.

  • United States Patent Number 7,199,116.

Augments What the Body Naturally Produces.

  • Ergosteroids II: Biologically Active Metabolites and Synthetic Derivatives of Dehydroepiandrosterone.  Steroids 1998;63:158-165.
  • Induction of Thermogenic Enzymes by DHEA and its Metabolites, In: Bellino F, Daynes RA, Hornsby PJ, Lavrin HD, Nestler JE, eds.  Dehydroepiandrosterone (DHEA) and Aging.  New York:New York Academy of Sciences; 1995:171-179.
  • Studies in Steroid Metabolism: Isolation and Characterizartion of New Urinary Studies. J Biol Chem 1954;210:129-137.

Clinically- Proven Weight and Fat Loss

  • A Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl 7 Oxo-Dehydroepiandrosterone in Healthy Over Weight Adults,  Curr Ther Res 2000;61(7):435-442.
  • The Effect of 7-Keto Naturalean on Weight Loss: A Randomized, Double-Blind, Placebo-Controlled Trial.  Curr Ther Res 2002:63(4).

Safe, When Used As Directed

  • Safety and Pharmacokinetic study with escalating doses of 3-acetyl-7-Oxo-Dehydroepiandrosterone in healthy male volunteers. Clin Invest Med 2000;23(5):300-310.
  • A Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl 7 Oxo-Dehydroepiandrosterone in Healthy Over Weight Adults,  Curr Ther Res 2000;61(7):435-442.
  • Humanetics Affidavit, Humanetics Archives.

Activate 3 Thermogenic Enzymes- Promotes Thermogenesis by Burning Fat.

  • Ergosteroids II: Biologically Active Metabolites and Synthetic Derivatives of Dehydroepiandrosterone.  Steroids 1998;63:158-165.
  • The Effects of  the Ergosteroid 7-oxo-dehydroepiandrosterone on Mitochondrial Membrane Potential: Possible Relationship to Thermogenesis, Arch Biochem Biophys 1997;341:122-128.
  • A Randomized, Double-Blind, Placebo-Controlled Study of 3-Acetyl 7 Oxo-Dehydroepiandrosterone in Healthy Over Weight Adults,  Curr Ther Res 2000;61(7):435-442.

Natural 7 Keto Levels Decline With Age

  • Marench LP. Secretion of Testosterone, Epitestosterone, Androstenedione, and 7-KEto-Dehydroepiandrosterone in Healthy Men of Different Ages. Prob Endokrino. 1979;25(4):28-31.

Increases Metabolism 5.4% Without Use of Stimulants.

  • HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone:  each increases the resting metabolic rate of overweight adults. J Nutr Biochem 2007;18:629-634.

Brown Seaweed:  Ascophyllum nodosum (Kelp) and Fucus vesiculosus (bladdwrack)

Consumption of brown seaweed extract inhibits activities of alpha glucosidase and alpha amylase.

  • Roy M, Anguenot R, Fillion C, Beaulieu M, Berube J, and Richard D. 2011.  Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo.  Food Res Int. 44(9): 3026-3029, doi:10,1016/j.foodres.20011.07.023.
  • Apostolidis E, Lee CM.  In vitro potential of Ascophyllum nodosum phenolic antioxidant-mediated alpha glucosidase and alpha amylase inhibition.  J Food Sci. Apr 2010 75(3):H97-H102.

Digestion of carbs is slowed down, not blocked.  You eat 100 calories, you digest 100 calories.

  • Roy M, Anguenot R, Fillion C, Beaulieu M, Berube J, and Richard D. 2011.  Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo.  Food Res Int. 44(9): 3026-3029, doi:10,1016/j.foodres.20011.07.023.

Lowers postprandial plasma  glucose and insulin levels.

  • Paradis ME, Couture P and Lamarche B.  2011.  A randomized crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women.  Anal Physiol Nutr Metab. 36:913-919 (2011)

Sincerely yours,

Seann Bardell
Clinical Note:

 

No.4 d

The beauty of the combination is that they help the body to burn stored body fat for energy, thereby helping one to loose weight as body fat.

For weight loss the capsules need to be taken 15-30 minutes before meal, to allow disintegration and blending of the ingredient with stomoach content before digestion occurs.  Do not take with enzyme supplements.  Take with you largest meals of the day.

The Last Quiz Answer:

 

Grey langurs are a genus of Old World monkeys once thought to be a single species. Seven distinct species are now recognised, which are widespread throughout south Asia. The most northerly species are generally larger and heavier than the southern langurs and walk with their tails pointing forward, while southern langurs point their tails backwards. Grey langurs, with their black hands and face, are also known as Hanuman langurs after the monkey-god, and so are considered sacred in the Hindu religion. (BBC Nature)

The Chital deer and the langur monkeys work together to warn each other of danger, like a hungry tiger.  Imagine yourself out in the Land of the Tiger witnessing this drama between the between a tiger and its prey, the deer and the monkey.

Have you been watching the presidential debates?  Notice the lack of even the slightest mention of our environmental crisis?  Isn’t is very clear that big oil’s lobbiests have silenced our politicians?  We need to wake them up!!!  350.org is facilitating our wake up call.

©2005 – 2012 BioImmersion Inc. All Rights Reserved

Can you name this Beautiful Creature?

Dear Friends

It is with great joy that we are able to greet you today from our brand new home, our refreshing, redesigned website: Welcome to BioImmersion.com.

Plus, we are very excited to share with you more regarding the exciting features and benefits of our newest Therapeutic Food: No. 4 Systemic Booster: Metabolic Balance.

In the last decade we have all witnessed the weight gain of our fellow Americans. According to the latest figures from the CDC under Adult Obesity Facts: More than one-third of U.S. adults (35.7%) are obese, that’s around 67 million. Additionally, 65% of Americans—193 million— are overweight. This, of course, is a very serious public health issue for, as we all know, obesity-related conditions increase the risk of heart disease, diabetes, cancer, and many other disease related conditions.

No. 4 Systemic Booster: Metabolic Balance offers you a powerful new tool in your arsenal to battle weight gain, and can be the perfect addition to weight management programs you already have in place—particularly for those patients in the baby boomer generation. 

Features and Benefits

  • No. 4 Systemic Booster is made up of two basic components:  7-Keto DHEA which is a downstream metabolite of DHEA, and seaweed extract derived from two different species of wild brown seaweeds—kelp and bladderwrack.
  • 7-Keto is a DHEA ring that has an oxygen molecule added at the seven position.  That makes is technically 7-oxo DHEA.
  • Due to its chemistry 7-Keto cannot be metabolized to the sex hormones- testosterone or estrogens.  This has been proven in a double-blinded, placebo-controlled human clincial trial.
  • In animal and in-vitro research studies 7-Keto have shown to be up to 10 times more potent that DHEA (on a unit for unit basis) in the areas of immune system modulation, memory enhancement and weight loss.
  • Regarding weight loss, 7-Keto promotes thermogenesis, the process of burning stored body fat for energy.
  • The older we get the less efficient we are in converting body fat into energy as levels of DHEA and 7-Keto fall dramatically.  Supplementing with 7-Keto opens up the fat burning pathways.
  • Extract of two selected wild brown seaweeds are especially rich in polyphenols and poor in iodine (lower content than iodized salt).
  • Dual-action inhibitor of alpha amylase (digestion of starch and maltodextrin) and alpha glucosidase (digestion of table sugar).  No lactase inhibition.
  • Digestion of carbs is slowed down, not blocked.  You eat 100 calories, you digest 100 calories, but in a healthier way (lowers the need for insulin).
  • The mechanism for slowing down sugar absorption by two seaweeds is entirely located inside the digestive tract. What is absorbed from them is just good antioxidants.
  • In clinical trails relative to our specific combinaton of two seaweeds, the following was observed:  (1) reduced post-meal blood glucose by 48% after a starch meal; (2) reduced post-meal insulin by 12% after a starch meal, (3) increase insulin sensitivity by 8% after a starch meal; (4) has a similar effect in healthy and diabetic individuals; (5) put the body in a state of low insulin—perfect for weight loss.
We will continue our discussion regarding this exciting product next week.  It will be available by months end.

Sincerely yours,


Seann Bardell


Clinical Note:

 

No.4 dThe beauty of the combination is that they help the body to burn stored body fat for energy, thereby helping one to loose weight as body fat.

For weight loss the capsules need to be taken 15-30 minutes before meal, to allow disintegration and blending of the ingredient with stomoach content before digestion occurs.  Do not take with enzyme supplements.  Take with your largest meals of the day.

The Last Quiz Answer:

The Axis Deer, also known as the Chital Deer, is the native animal of the Indian Subcontinent.  It is one of the most beautiful of animals.  Tigers love them a lot.

An interesting relationship exists between the Chital and troops of Plains Gray Langur, a widespread leaf-eating monkey (see the creature picture above).  The Langurs serve as look-outs from the tree top, for the grazing deer, helping to raise the alrm when a predator approaches.

The Story of Stuff Project will be coming out with their nineth movie, which they are calling The Story of Solutions.  The Story of Solutions will offer the what … namely, the big ideas that will get us closer to the more sustainable and just future we all want.  If you’ve never looked at their website, check them out.  They are a very important group in our fight to right our world.

©2005 – 2012 BioImmersion Inc. All Rights Reserved


Can you name this Beautiful Creature?

Dear Friends,

This week in Clinical Notes below, you will see the label for our new No. 4 Systemic Booster: Metabolic Balance, with a brief explanation.  It will be the first of six new products that will join with No. 7 Systemic Booster to make up the expanded Systemic Booster Range within the Therapeutic Foods Line; coming into being this Fall season.  The ETA for No. 4 is the end of October. I’ll keep you posted as we will be uploading concepts and research surrounding this exciting product over the next couple emails.

I received an email today from The Global Oneness Project and I thought that I must pass it to you—to lift your spirits.  I can’t say enough about the Global Oneness Project.  It is like a glass of clean, pure, fresh mountain water.  It nourishes your soul; opens your heart, gives you hope.  It urges courage and compassion.

There are so many trippy things to click on.  Here are three: on to you—to lift your spirits.  I can’t say enough about the Global Oneness Project.  It is like a glass of clean, pure, fresh mountain water.  It nourishes your soul; opens your heart, gives you hope.  It urges courage and compassion.

  • Read Parker Palmer’s short essay, Five Habits to Heal the Heart of Democracy.
  • View the trailer of the film Elemental.
  • Hear the enlightening reflections of The Sheikh and the Rabbi:  A Jerusalem Fable.

Enjoy!

Sincerely yours,
Seann Bardell
Clinical Note:

No.4 d

No. 4 Systemic Booster is made up of two basic components:  7-Keto DHEA which is a downstream metabolite of DHEA, and seaweed extract derived from two different species of seaweed.  The beauty of the combination is that they help the body to burn stored body fat for energy, thereby helping one to loose weight as body fat.  Next week we will get into the research regarding these two ingredients. You’ll be excited.

The Last Quiz Answer:

The Greater Bulldog Bat from the jungles of Belize had a two foot wingspan.  After dark the hunters hunt.  Nick named the Fisherman, they have enlarged feet and claws to grab fish as they fly over the water at 40 miles per hour.

Look closely and you can make out the bulldogish face with mouth open, exposing a set of menacing looking teeth.  Most bulldog Bats feed only on insects.  This Belize variety takes fish, frogs and crustaceans as well.


Too many of us are giving away our power at the polls by simply not showing up. The U.S. has a lower average voter turnout than in most countries in Europe, Asia and Central and South America … Let’s vote.

Have you tuned in to Anne Leonard’s important work—The Story of Change?

©2005 – 2012 BioImmersion Inc. All Rights Reserved